A proteasome inhibitor, an antioxidant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-inducible expression of P- selectin in human endothelial cells

Blood

Volumn 91, Issue 5, 1998, Pages 1625-1632

  Xia, Lijun ^b   Pan, Junliang ^b   Yao, Longbiao ^b   McEver, Rodger P ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; DEXAMETHASONE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; N ACETYLLEUCINYLLEUCINYL NORLEUCINAL; NONSTEROID ANTIINFLAMMATORY AGENT; ONCOSTATIN M; PADGEM PROTEIN; PYRROLIDINE DITHIOCARBAMATE; RECOMBINANT INTERLEUKIN 4; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; SALICYLATE SODIUM; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0032032313     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.5.1625.1625_1625_1632     Document Type: Article

References (66)

1. Springer TA: Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 57:827, 1995
2. Zimmerman GA, McIntyre TM, Prescott SM: Adhesion and signaling in vascular cell-cell interactions. J Clin Invest 98:1699, 1996
3. Kansas GS: Selectins and their ligands: Current concepts and controversies. Blood 88:3259, 1996
4. McEver RP, Cummings RD: Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest 100:485, 1997
5. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA: The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 128:1243, 1995
6. Berlin C, Bargatze RF, Campbell JJ, Von Andrian UH, Szabo MC, Hasslen SR, Nelson RD, Berg EL, Erlandsen SL, Butcher EC: α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80:413, 1995
7. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T: Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J 9:899, 1995
8. Siebenlist U, Franzoso G, Brown K: Structure, regulation and function of NF-κB. Annu Rev Cell Biol 10:405, 1995
9. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA: Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J Exp Med 175:1181, 1992
10. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T: The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor and the activation of NF-κB. Cell 78:773, 1994
11. Kopp E, Ghosh S: Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956, 1994
12. Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T: Salicylates inhibit IκB-α phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol 156:3961, 1996
13. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr: Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283, 1995
14. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286, 1995
15. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS Jr: Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 15:943, 1995
16. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM: Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 92:1866, 1993
17. Weber C, Erl W, Pietsch A, Strobel M, Ziegler-Heitbrock HWL, Weber PC: Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-κB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb 14:1665, 1994
18. Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T: The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity 2:493, 1995
19. Weber C, Erl W, Pietsch A, Weber PC: Aspirin inhibits nuclear factor-κB mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 91:1914, 1995
20. Cronstein BN, Kimmel SC, Levin RI, Martiniuk F: A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 89:9991, 1992
21. Brostjan C, Anrather J, Csizmadia V, Natarajan G, Winkler H: Glucocorticoids inhibit E-selectin expression by targeting NF-κB and not ATF/c-Jun. J Immunol 158:3836, 1997
22. Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF: A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol 101:880, 1985
23. Berman CL, Yeo EL, Wencel-Drake JD, Furie BC, Ginsberg MH, Furie B: A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. J Clin Invest 78:130, 1986
24. McEver RP, Beckstead JH, Moore KL, Marshall-Carl son L, Bainton DF: GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84:92, 1989
25. Bonfanti R, Furie BC, Furie B, Wagner DD: PADGEM (GMP 140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 73:1109, 1989
26. Geng J-G, Bevilacqua MP, Moore KL, McIntyre TM, Prescott SM, Kim JM, Bliss GA, Zimmerman GA, McEver RP: Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature 343:757, 1990
27. Hamburger SA, McEver RP: GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood 75:550, 1990
28. Larsen E, Celi A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie B: PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 59:305, 1989
29. Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ: Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J Biol Chem 264:7768, 1989
30. Green SA, Setiadi H, McEver RP, Kelly RB: The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes. J Cell Biol 124:435, 1994
31. Subramaniam M, Koedam JA, Wagner DD: Divergent fates of P- and E-selectins after their expression on the plasma membrane. Mol Biol Cell 4:791, 1993
32. Grober JS, Bowen BL, Ebling H, Athey B, Thompson CB, Fox DA, Stoolman LM; Monocyte-endothelial adhesion in chronic rheumatoid arthritis: In situ detection of selection and integrin-dependent interactions. J Clin Invest 91:2609, 1993
33. Johnson-Tidey RR, McGregor JL, Taylor PR, Poston RN: Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. Am J Pathol 144:952, 1994
34. Symon FA, Walsh GM, Watson SR, Wardlaw AJ: Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent. J Exp Med 180:371, 1994
35. Sanders WE, Wilson RW, Ballantyne CM, Beaudet AL: Molecular cloning and analysis of in vivo expression of murine P-selectin. Blood 80:795, 1992
36. Weller A, Isenmann S, Vestweber D: Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor. J Biol Chem 267:15176, 1992
37. Hahne M, Jäger U, Isenmann S, Hallmann R, Vestweber D: Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J Cell Biol 121:655, 1993
38. Burns SA, DeGuzman BJ, Newburger JW, Mayer JE Jr, Neufeld EJ, Briscoe DM: P-selectin expression in myocardium of children undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 110: 924, 1995
39. Yao L, Pan J, Setiadi H, Patel KD, McEver RP: Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and potein in human endothelial cells. J Exp Med 184:81, 1996
40. Pan J, McEver RP: Characterization of the promoter for the human P-selectin gene. J Biol Chem 268:22600, 1993
41. Pan J, McEver RP: Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-κB/Rel family. J Biol Chem 270:23077, 1995
42. Zimmerman GA, McIntyre TM, Prescott SM: Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J Clin Invest 76:2235, 1985
43. Johnson GI, Cook RG, McEver RP: Cloning of GMP-140, a granule membrane protein of platelets and endothelium: Sequence similarity to proteins involved in cell adhesion and inflammation. Cell 56:1033, 1989
44. Harpold MM, Evans RM, Salditt-Georgieff M, Darnell JE: Production of mRNA in Chinese hamster ovary cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell 17:1025, 1979
45. Ushiyama S, Laue TM, Moore KL, Erickson HP, McEver RP: Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. J Biol Chem 268:15229, 1993
46. b class I major histocompatibility gene. Mol Cell Biol 7:305, 1987
47. Baldwin AS Jr, Sharp PA: Two transcription factors, NF-κB and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter. Proc Natl Acad Sci USA 85:723, 1988
48. Scheinman RI, Beg AA, Baldwin AS Jr: NF-κB p100 (lyt-10) is a component of H2TF1 and can function as an IκB-like molecule. Mol Cell Biol 13:3557, 1993
49. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL: Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761, 1994
50. Iademarco MF, Barks JL, Dean DC: Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-α in cultured endothelial cells. J Clin Invest 95:264, 1995
51. McCarty JM, Yee EK, Deisher TA, Harlan JM, Kaushansky K: Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NFκB-independent mechanism. FEBS Lett 372:194, 1995
52. Cobb RR, Felts KA, Parry GCN, Mackman N: Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-κB. Eur J Immunol 26:839, 1996
53. Kim TK, Maniatis T: Regulation of interferon-γ-activated STAT1 by the ubiquitin-proteasome pathway. Science 273:1717, 1996
54. Yu C-L, Burakoff SJ: Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J Biol Chem 272:14017, 1997
55. Haspel RL, Salditt-Georgieff M, Darnell JE Jr: The rapid inactivation of nuclear tyrosine phosphorylated Stal 1 depends upon a protein tyrosine phosphatase. EMBO J 15:6262, 1996
56. s6k activation. J Biol Chem 271:23650, 1996
57. Sen CK, Packer L: Antioxidant and redox regulation of gene transcription. FASEB J 10:709, 1996
58. Martin ME, Chinenov Y, Yu M, Schmidt TK, Yang X-Y: Redox regulation of GA-binding protein-α DNA binding activity. J Biol Chem 271:25617, 1996
59. Knebel A, Rahmsdorf HJ, Ullrich A, Herrlich P: Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants, oralkylating agents. EMBO J 15:5314, 1996
60. Haynes DP, Wright P, Gadd S, Whitehouse M, Vernon-Roberts B: Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites? Agents Actions 39:49, 1993
61. Asako H, Kubes P, Wallace J, Wolf R, Granger DN: Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology 103:146, 1992
62. Sagone A, Husney R: Oxidation of salicylates by stimulated granulocytes: Evidence that these drugs act as free radical scavengers in biological systems. J lmmunol 138:2177, 1987
63. Frantz B, O'Neill EA: The effect of sodium salicylate and aspirin on NF-κB. Science 270:2017, 1995
64. Brostjan C, Anrather J, Csizmadia V, Stroka D, Soares M, Bach FH, Winkler H: Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis. J Biol Chem 271:19612, 1996
65. Stocklin E, Wissler M, Gouilleux F, Groner B: Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383:726, 1996
66. Paliogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT: Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J Clin Invest 91:1481, 1993