Genomic and non-genomic effects of estrogens on endothelial cells

Steroids

Volumn 69, Issue 8-9, 2004, Pages 537-542

  Simoncini, Tommaso ^a   Mannella, Paolo ^a   Fornari, Letizia ^a   Caruso, Antonella ^a   Varone, Gaetano ^a   Genazzani, Andrea Riccardo ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Endothelial cell; Estrogens; Non genomic effects

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCOCORTICOID; ION CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; STEROID HORMONE; STEROID RECEPTOR;

ATHEROSCLEROSIS; BLOOD VESSEL WALL; CARDIOVASCULAR DISEASE; CELL MEMBRANE; CONFERENCE PAPER; DRUG MECHANISM; ENDOTHELIUM CELL; EPITHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENOME; HORMONE ACTION; HUMAN; MACROPHAGE; POSTMENOPAUSE; PROTEIN INDUCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASODILATATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL MEMBRANE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ESTROGENS; GLUCOCORTICOIDS; HUMANS; ION CHANNELS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; PROTEIN-TYROSINE KINASES; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; VASODILATION;

EID: 3543026352     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2004.05.009     Document Type: Conference Paper

References (46)

1. Truss M., Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev. 14:1993;459-479
2. Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature. 320:1986;134-139
3. Mosselman S., Polman J., Dijkema R. ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392:1996;49-53
4. Pietras R.J., Szego C.M. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells. Nature. 265:1977;69-72
5. Levin E.R. Cellular functions of the plasma membrane estrogen receptor. Trends Endocrinol Metab. 10:1999;374-377
6. Tesarik J., Mendoza C. Non-genomic effects of 17 beta-estradiol on maturing human oocytes: relationship to oocyte developmental potential. J Clin Endocrinol Metab. 80:1995;1438-1443
7. Nakajima T., Kitazawa T., Hamada E., Hazama H., Omata M., Kurachi Y. 17beta-estradiol inhibits the voltage-dependent L-type Ca2+ currents in aortic smooth muscle cells. Eur J Pharmacol. 294:1995;625-635
8. Valverde M.A., Rojas P., Amigo J., Cosmelli D., Orio P., Bahamonde M.I., et al. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science. 285:1999;1929-1931
9. Kelly M.J., Wagner E.J. Estrogen modulation of G-protein-coupled receptors. Trends Endocrinol Metab. 10:1999;369-374
10. Migliaccio A., Di Domenico M., Castoria G., de Falco A., Bontempo P., Nola E., et al. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15:1996;1292-1300
11. Waiters J.J., Campbell J.S., Cunningham M.J., Krebs E.G., Dorsa D.M. Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology. 138:1997;4030-4033
12. Aronica S.M., Kraus W.L., Katzenellenbogen B.S. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA. 91:1994;8517-8521
13. Le Mellay V., Grosse B., Lieberherr M. Phospholipase C beta and membrane action of calcitriol and estradiol. J Biol Chem. 272:1997;11902-11907
14. Razandi M., Pedram A., Greene G.L., Levin E.R. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol Endocrinol. 13:1999;307-319
15. Manolagas S.C., Kousteni S. Perspective: nonreproductive sites of action of reproductive hormones. Endocrinology. 142:2001;2200-2204
16. Braunwald E. Shattuck lecture - cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med. 337:1997;1360-1369
17. Grodstein F., Stampfer M., Manson J., Coditz G., Willett W., Rosner B., et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 335:1996;453-461
18. Grodstein F., Stampfer M.J., Colditz G.A., Willett W.C., Manson J.E., Joffe M., et al. Postmenopausal hormone therapy and mortality. N Engl J Med. 336:1997;1769-1775
19. Mendelsohn M.E., Karas R.H. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 340:1999;1801-1811
20. Simoncini T., Genazzani A.R. Direct vascular effects of estrogens and selective estrogen receptor modulators. Curr Opin Obstet Gynecol. 12:2000;181-187
21. Venkov C.D., Rankin A.B., Vaughan D.E. Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Circulation. 94:1996;727-733
22. Karas R.H., Patterson B.L., Mendelsohn M.E. Human vascular smooth muscle cells contain functional estrogen receptor. Circulation. 89:1994;1943-1950
23. Simoncini T., Maffei S., Basta G., Barsacchi G., Genazzani A.R., Liao J.K., et al. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res. 87:2000;19-25
24. Register T.C., Adams M.R. Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor beta. J Steroid Biochem Mol Biol. 64:1998;187-191
25. Lindner V., Kim S.K., Karas R.H., Kuiper G.G., Gustafsson J.A., Mendelsohn M.E. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ Res. 83:1998;224-229
26. Sudhir K., Chou T.M., Messina L.M., Hutchison S.J., Korach K.S., Chatterjee K., et al. Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet. 349:1997;1146-1147
27. Sudhir K., Chou T.M., Chatterjee K., Smith E.P., Williams T.C., Kane J.P., et al. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation. 96:1997;3774-3777
28. Pare G., Krust A., Karas R.H., Dupont S., Aronovitz M., Chambon P., et al. Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res. 90:2002;1087-1092
29. Zhu Y., Bian Z., Lu P., Karas R.H., Bao L., Cox D., et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science. 295:2002;505-508
30. Russell K.S., Haynes M.P., Sinha D., Clerisme E., Bender J.R. Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc Natl Acad Sci USA. 97:2000;5930-5935
31. Stefano G.B., Prevot V., Beauvillain J.C., Cadet P., Fimiani C., Welters I., et al. Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. Circulation. 101:2000;1594-1597
32. Gilligan D.M., Quyyumi A.A., Cannon R.O. III Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation. 89:1994;2545-2551
33. Liao JK. Endothelial nitric oxide and vascular inflammation. In: Panza JA, Cannon ROI, editors. Endothelium, nitric oxide and atherosclerosis. Armonk, NY: Futura Publishing Co., Inc., 1999. p. 119-32.
34. Guetta V., Quyyumi A.A., Prasad A., Panza J.A., Waclawiw M., Cannon R.O. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women. Circulation. 96:1997;2795-2801
35. Caulin-Glaser T., Garcia-Cardena G., Sarrel P., Sessa W.C., Bender J.R. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release independent of cytosolic Ca2+ mobilization. Circ Res. 81:1997;885-892
36. Lantin-Hermoso R.L., Rosenfeld C.R., Yuhanna I.S., German Z., Chen Z., Shaul P.W. Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium. Am J Physiol. 273:1997;L119-L126
37. Chen Z., Yuhanna I.S., Galcheva-Gargova Z., Karas R.H., Mendelsohn M.E., Shaul P.W. Estrogen receptor alpha mediates the non-genomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest. 103:1999;401-406
38. Garcia-Cardena G., Fan R., Shah V., Sorrentino R., Cirino G., Papapetropoulos A., et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 392:1998;821-824
39. Simoncini T., Hafezi-Moghadam A., Brazil D., Ley K., Chin W.W., Liao J.K. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 407:2000;538-541
40. Simoncini T., Rabkin E., Liao J.K. Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells. Arterioscler Thromb Vasc Biol. 23:2003;198-203
41. Hisamoto K., Ohmichi M., Kurachi H., Hayakawa J., Kanda Y., Nishio Y., et al. Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem. 276:2001;3459-3467
42. Chambliss K.L., Yuhanna I.S., Mineo C., Liu P., German Z., Sherman T.S., et al. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res. 87:2000;E44-E52
43. Carpenter C.L., Duckworth B.C., Auger K.R., Cohen B., Schaflhausen B.S., Cantley L.C. Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem. 265:1990;19704-19711
44. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399:1999;601-605
45. Fulton D., Gratton J.P., McCabe T.J., Fontana J., Fujio Y., Walsh K., et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399:1999;597-601
46. Hafezi-Moghadam A., Simoncini T., Yang E., Limbourg F.P., Plumier J.C., Rebsamen M.C., et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med. 8:2002;473-479