CD99 plays a major role in the migration of monocytes through endothelial junctions

Nature Immunology

Volumn 3, Issue 2, 2002, Pages 143-150

  Schenkel, Alan R ^a   Mamdouh, Zahra ^a   Chen, Xia ^a   Liebman, Ronald M ^a   Muller, William A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD99 ANTIGEN; CELL ADHESION MOLECULE; CELL MEMBRANE PROTEIN; GLYCOSYLATED PROTEIN; MONOCLONAL ANTIBODY;

ANTIGEN EXPRESSION; ARTICLE; CELL JUNCTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE MIGRATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ANTIGENS, CD; ANTIGENS, CD31; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CELL POLARITY; ENDOTHELIUM, VASCULAR; GLYCOPROTEINS; HUMANS; INTERCELLULAR JUNCTIONS; INTERLEUKIN-1; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036167093     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni749     Document Type: Article

References (49)

1. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
2. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
3. Chemokines and the arrest of lymphocytes rolling under flow conditions
4. Endothelial cell-associated platelet-activating factor: A novel mechanism for signaling inercellular adhesion
5. PECAM-I is required for transendothelial migration of leukocytes
6. Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-I
7. 2 integrin activation
8. Soluble domain I of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo
9. Monoclonal antibody to murine PECAM-I [PECAM-I] blocks acute inflammation in vivo
10. Neutrophil platelet endothelial cell adhesion molecule-I participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation
11. Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury
12. Involvement of platelet-endothelial cell adhesion molecule-I in neutrophil recruitment in vivo
13. Transgenic mice expressing different levels of soluble platelet/endothelial cell adhesion molecule-IgG display distinct inflammatory phenotypes
14. Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-I (PECAM-I): PECAM-I-deficient mice reveal PECAM-I-dependent and PECAM-I-independent functions
15. The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product
16. + thymocytes
17. Engagement of CD99 induces up-regulation of TCR and MHC class I and II molecules on the surface of human thymocytes
18. Apoptosis of immature thymocytes mediated by E2/CD99
19. CD99 (MIC2) regulates the LFA-I/ICAM-1-mediated adhesion of lymphocytes, and its gene encodes both positive and negative regulators of cellular adhesion
20. CD99 engagement on human peripheral blood T cells results in TCR/CD3-dependent cellular activation and allows for Th1-restricted cytokine production
21. A role for CD99 in T cell activation
22. 1-dependent T cell adhesion at inflamed vascular endothelium under flow conditions
23. A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions
24. PECAM-I [PECAM-I] cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
25. Vascular endothelial cadherin (VE-Cadherin): Cloning and role in endothelial cell-cell adhesion
26. Cloning of the human platelet FII receptor: A cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation
27. Monocyte-selective transendothelial migration: Dissection of the binding and transmigration phases by an in vitro assay
28. Blockade of platelet endothelial cell adhesion molecule-I protects against myocardial ischemia and reperfusion injury in cats
29. A soluble gradient of endogenous monocyte chemoattractant protein-I promotes the transendothelial migration of monocytes in vitro
30. Localization of specificity determining sites in cadherin cell adhesion molecules
31. Cell binding function of E-Cadherin is regulated by the cytoplasmic domain
32. Differential effects of the cytoplasmic domains of cell adhesion molecules on cell aggregation and sorting-out
33. A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule-I [PECAM-I]
34. Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule-I
35. Platelet/endothelial cell adhesion molecule-I (PECAM-I)-mediated cellular aggregation involves cell surface glycosaminoglycans
36. Platelet/endothelial cell adhesion molecule-I (PECAM-I) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression
37. The MIC2 gene product: Epitope mapping and structural prediction analysis define an integral membrane protein
38. The biochemical characterization of E2, a T cell surface molecule involved in rosettes
39. PBDX is the XG blood group gene
40. Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp
41. PKCα mediates modulation of T cell adhesion events under CD99 engagement
42. Chemotactic factors regulate lectin adhesion molecule I (LECAM-I)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro
43. Shear stress affects migration behavior of polymorphonuclear cells arrested on endothelium
44. Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow
45. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines
46. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria