The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1

Clinical and Experimental Immunology

Volumn 118, Issue 3, 1999, Pages 376-383

  Goulding, Nicolas J ^c   Ogbourn, S ^b   Pipitone, N ^b   Biagini, P ^a   Gerli, R ^a   Pitzalis, C ^b  

^a Ctr for the Stud of Rheum Dis   (Italy)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Annexin I; Cell adhesion; Glucocorticoid; Lipocortin 1; Lymphocyte

Indexed keywords

CELL ADHESION MOLECULE; DEXAMETHASONE; GLUCOCORTICOID; LIPOCORTIN 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; LEUKOCYTE AGGREGATION; LYMPHOCYTE; MONOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANNEXIN A1; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD2; BINDING, COMPETITIVE; CELL AGGREGATION; CELLS, CULTURED; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLUCOCORTICOIDS; HUMANS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOCYTES; MONOCYTES; PHAGOCYTOSIS;

EID: 0032693767     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01059.x     Document Type: Article

References (46)

1. 1 Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G. A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89:9991-5.
2. 2 Tessier PA, Cattaruzzi P, McColl SR. Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression. Arthritis Rheum 1996; 39:226-34.
3. 3 Pitzalis C, Pipitone N, Bajocchi G et al. Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect. J Immunol 1997; 158:5007-16.
4. 4 Wehling M. Specific, nongenomic actions of steroid hormones. Annu Rev Physiol 1997; 59:365-93.
5. 5 Buttgereit F, Wehling M, Burrnester G-D. A new hypothesis of modular glucocorticoid actions - steroid treatment of the rheumatic diseases revisited. Arthritis Rheum 1998; 41:761-7.
6. 6 Raynal P, Pollard HB. Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium-and phospholipid-binding proteins. Biochim Biophys Acta 1994; 1197:63-93.
7. 7 Cirino G, Flower RJ, Browning JL, Sinclair LK, Pepinsky RB. Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung. Nature 1987; 328:270-2.
8. 8 Cirino G, Peers SH, Flower RJ, Browning JL, Pepinsky RB. Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. Proc Natl Acad Sci USA 1989; 86:3428-32.
9. 9 Goulding NJ, Godolphin JL, Sharland PR et al. Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone. Lancet 1990; 335:1416-8.
10. 10 Solito E, Raugei G, Melli M, Parente L. Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells. FEBS Letters 1991; 291:238-44.
11. 11 Perretti M, Flower RJ. Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation. Br J Pharmacol 1996; 118:605-10.
12. 12 Vishwanath BS, Frey FJ, Bradbury M, Dallman MF, Frey BM. Adrenalectomy decreases lipocortin-I messenger ribonucleic acid and tissue protein content in rats. Endocrinology 1992; 130:585-91.
13. 13 Peers SH, Smillie F, Elderfield A-J, Flower RJ. Glucocorticoid and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leukocytes in vivo. Br J Pharmacol 1993; 108:66-72.
14. 14 Coméra C, Russo-Marie F. Glucocorticoid annexin I secretion by monocytes and peritoneal leukocytes. Br J Pharmacol 1995; 115:1043-7.
15. 15 Perretti M, Flower RJ. Modulation of IL-I-induced neutrophil migration by dexamethasone and lipocortin 1. J Immunol 1993; 150:992-9.
16. 16 Flower RJ, Rothwell NJ. Lipocortin-1: cellular mechanisms and clinical relevance. TIPS 1994; 15:71-76.
17. 17 Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R, Flower RJ. Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nature Medicine 1996; 2:1259-62.
18. 18 Mancuso F, Flower RJ, Perretti M. Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of lipocortin I. J Immunol 1995; 155:377-86.
19. 19 Wu CC, Thiemermann C, Szabo C et al. Lipocortin 1 mediates the inhibitory effect of dexamethasone on the induction of nitric oxide synthase in vivo and in vitro. Can J Physiol Pharmacol 1994; 72 (Suppl. 1):465.
20. 20 Morand EF, Rickard D, Goulding NJ. Lack of involvement of lipocortin-1 in dexamethasone suppression of IL-1 release. Med Inflamm 1993; 2:49-52.
21. 21 Pitzalis C. Role of adhesion mechanisms in the pathogenesis of chronic synovitis. Br J Rheumatol 1996; 35:1198-215.
22. 22 Perretti M, Ahluwalia A, Harris JG, Goulding NJ, Flower RJ. Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse: a qualitative comparison with an anti-CD11b monoclonal antibody. J Immunol 1993; 151:4306-14.
23. 23 Pepinsky RB, Sinclair LK, Dougas I, Liang C-M, Lawton P, Browning JL. Monoclonal antibodies to lipocortin-1 as probes for biological function. FEBS Letters 1990; 261:247-52.
24. 24 Rothlein R, Springer TA. The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester. J Exp Med 1986; 163:1132.
25. 25 Pitzalis C, Kingsley GH, Covelli M, Meliconi R, Murkey A, Panayi GS. Selective migration of the human helper-inducer memory T cell subsets confirmation by in vivo cellular kinetic studies. Eur J Immunol 1995; 21:369-76.
26. 26 Morand EF, Hutchinson P, Hargreaves A, Goulding NJ, Boyce NW, Holdsworth SR. Detection of intracellular lipocortin 1 in human leukocyte subsets. Clin Immunol Immunopathol 1995; 76:195-202.
27. 27 Ryan TC, Weil GJ, Newburger PE, Haugland R, Simons ER. Measurement of superoxide release in the phagovacuoles of immune complex-stimulated buman neutrophils. J Immunol Methods 1990; 130:223-33.
28. 28 Perretti M, Wheller SK, Flower RJ, Pitzalsi C. Migration of human leukocytes into artificial skin blisters modulates cellular lipocortin 1 levels. Br J Rheumatol 1998; 37 (Suppl. 1):22.
29. 29 Droogan AC, Crockard AD, McMillan SA, Hawkins SA. Effects of intravenous methylprednisolone therapy on leukocyte and soluble adhesion molecule expression in MS. Neurology 1998; 50:224-9.
30. 30 Kadioglu A, Sheldon P. Steroid pulse therapy for rheumatoid arthritis: effect on lymphocyte subsets and mononuelcar cell adhesion. Br J Rheumalol 1998; 37:282-6.
31. 31 Pitzalis C, Sharrack B, Gray IA, Lee A, Hughes RA. Comparison of the e effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis. J Neuroimmunol 1997; 74:62-68.
32. 32 Youssef PP, Triantafillou S, Parker A et al. Effects of pulse methylprednisolone on cell adhesion molecules in the synovial membrane in rheumatoid arthritis. Reduced E-selectin and intercellular adhesion molecule 1 expression. Arthritis Rheum 1995; 39:1970-9.
33. 33 Jilma B, Voltmann J, Albinni S et al. Dexamethasone down-regulates the expression of L-selectin on the surface of neutrophils and lymphocytes in humans. Clin Pharmacol Therap 1997; 62:562-8.
34. 34 Tarcic N, Levitan G, Ben Yosef D, Prous D, Ovadia H, Weiss DW. Restraint stress-induced changes in lymphocyte subsets and the expression of adhesion molecules. Neuroimmunomodulation 1995; 2:249-57.
35. 35 Schule R, Rangarajan P, Kliewer S et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990; 62:1217-26.
36. 36 Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990; 62:1205-15.
37. 37 Paliogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J Clin Invest 1993; 91:1481-9.
38. 38 Sheppard KA, Phelps KM, Williams AJ, Thanos D, Glass CK, Rosenfeld MG, Gerritsen ME, Collins T. Nuclear integration of glucoconrticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. J Biol Chem 1998; 273:29291-4.
39. 39 Goulding NJ, Guyre PM. Glucocorticoids, lipocortins and the immune response. Curr Opin Immunol 1993; 5:108-13.
40. 40 Goulding NJ, Pan L, Wardwell K, Guyre VC, Guyre PM. Evidence for specific annexin I-binding proteins on human monocytes. Biochem J 1996; 316:593-7.
41. 41 Perretti M, Flower RJ, Goulding NJ. The ability of murine leukocytes to bind lipoconin 1 is lost during acute inflammation. Biochem Biophys Res Commun 1993; 192:345-50.
42. 42 Dransfield I, Cabanas C, Craig A, Hogg N. Divalent cation regulation of the function of the leukocyte integrin LFA-1. J Cell Biol 1992; 116:219-26.
43. 43 Hogg N, Landis RC. Adhesion molecules in cell interactions. Curr Opin Immunol 1993; 5:383-90.
44. 44 Lollo BA, Chan KW, Hanson EM, Moy VT, Brian AA. Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells. J Biol Chem 1993; 268:21693-700.
45. 45 Laudanna C, Campbell JJ, Butcher EC. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 1996; 271:981-3.
46. 46 Goulding NJ, Guyre PM. Lipocortin 1 binding to human leukocytes correlates with its ability to inhibit IgG interactions with Fc receptors. Biochem Biophys Res Commun 1993; 192:351-8.