Effects of 7β-estradiol on cytokine-induced endothelial cell adhesion molecule expression

Journal of Clinical Investigation

Volumn 98, Issue 1, 1996, Pages 36-42

  Caulin Glaser, T ^a,b   Watson, C A ^a,b   Pardi, R ^c   Bender, J R ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

atherosclerosis; estrogen receptor; gene regulation; leukocyte; vascular endothelium

Indexed keywords

CHEMOTACTIC FACTOR; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ESTRADIOL; ESTROGEN RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; VASCULAR CELL ADHESION MOLECULE 1; CELL ADHESION MOLECULE; MESSENGER RNA;

ARTICLE; ATHEROSCLEROSIS; ENDOTHELIUM CELL; GENE ACTIVATION; GENE CONTROL; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; ARTERIOSCLEROSIS; BIOSYNTHESIS; CELL CULTURE; CELL FRACTIONATION; CELL NUCLEUS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM;

ARTERIOSCLEROSIS; CELL ADHESION MOLECULES; CELL NUCLEUS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ESTRADIOL; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-1; RECEPTORS, ESTROGEN; RNA, MESSENGER; SUBCELLULAR FRACTIONS; TRANSCRIPTION, GENETIC; UMBILICAL VEINS;

EID: 0029666339     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118774     Document Type: Article

References (50)

1. Ross, R. 1986. Medical progress: the pathogenesis of atherosclerosis - an update. N. Engl. J. Med. 314:488-500.
2. Cotran, R., and J. Pober. 1990. Cytokine-endothelial interactions in inflammation, immunity and vascular injury. J. Am. Soc. Nephrol. 1:225-235.
3. Cybulsky, M.I., and M.A. Gimbrone. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science (Wash. DC). 251:788-791.
4. van der Wal, A., P. Das, A. Tigges, and B. Ae. 1992. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am. J. Pathol. 141:1427-1433.
5. Gossland, I.F., V. Wynn, D. Crook, and N.E. Miller. 1987. Sex, plasma lipoproteins and atherosclerosis: prevailing assumptions and outstanding questions. Am. Heart J. 114:1467-1503.
6. Stampfer, M.J., G.A. Colditz, W.C. Willett, J.E. Manson, B. Rosner, F.E. Speizer, and C.H. Hennekens, 1991. Postmenopausal estrogen therapy and cardiovascular disease. N. Engl. J. Med. 325:756-762.
7. Adams, M.R., T.B. Clarkson, J.R. Kaplan, and D.R. Kortnik. 1990. Ovarian secretions and atherosclerosis. In Ovarian Secretions and Cardiovascular and Neurological Function. F. Naftolin, J.N. Gutmann, A.H. DeCherney, and P.M. Sarrel, editors. Raven Press, New York. 151-159.
8. Sarrel, P.M. 1988. Effects of ovarian steroids on the cardiovascular system. In Circulation in the Female. J. Ginsburg, editor. Parthenon Press, Carsforth, United Kingdom. 117-141.
9. Wolinsky, H. 1992. Effects of estrogen and progestogen treatment on the response of the aorta of male rats to hypertension: morphological and chemical studies. Circ. Res. 30:341-349.
10. Williams, J.K., M.R. Adams, and H.S. Klopfenstein. 1990. Estrogen modulates responses of atherosclerotic coronary arteries. Circulation. 81:1680-1687.
11. Wagner, J.D., T.B. Clarkson, R.W. St. Clair, D.C. Schwenke, C.A. Shively, and M.R. Adams. 1991. Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J. Clin. Invest. 88:1995-2002.
12. Wakasugi, M., T. Noguchi, Y.-I. Kazama, Y. Kanemaru, and T. Onaya. 1989. The effects of sex hormones on the synthesis of prostacyclin (PGI 2) by vascular tissue. Prostaglandins. 37:401-410.
13. Beato, M. 1989. Gene regulation by steroid hormones. Cell. 56:335-344.
14. Shyamala, G., and M.C. Guiot. 1992. Activation of kB-specific proteins by estradiol. Proc. Natl. Acad. Sci. USA. 89:10628-10632.
15. Gaub, M.P., M. Bellard, I. Scheuer, P. Chambon, and P. Sassone-Corsi. 1990. Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex. Cell. 63:1267-1276.
16. Montgomery, K.F., L. Osborn, C. Hession, R. Tizard, D. Goff, C. Vassallo. P.I. Tarr, K. Bomsztyk, R. Lobb, J.M. Harlan, and T.H. Pohlman. 1991. Activation of endothelial-leukocyte adhesion molecule I (ELAM-I) gene transcription. Proc. Natl. Acad. Sci. USA. 88:6523-6527.
17. Iadermarco, M., J. McQuillan, G. Rosen, and D. Dean. 1992. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 267:16323-16329.
18. Degitz, K., L. Lian-Jie, and S.W. Caughman. 1991. Cloning and characterization of the 5′ transcriptional regulatory region of the human intercellular adhesion molecule 1 gene. J. Biol. Chem. 266:14024-14030.
19. Gimbrone, M.A. 1976. Culture of vascular endothelium. In Progress in Hemostasis and Thrombosis. T.H. Spaet, editor. Grune and Stratton Inc., New York. 1-28.
20. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
21. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Extraction, purification, and analysis of messenger RNA from eukaryotic cells. In Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 7.38-7.52.
22. Lainier, L.L., E.G. Engleman, P. Gatenenby, G.F. Babcock, N.L. Warner, and L.A. Herzenberg. 1983. Correlation of functional properties of human lymphocyte subsets and surface marker phenotype using multiparameter analysis and flow cytometry. Immunol. Rev. 74:143-148.
23. Bender, J.R., R. Pardi, M.A. Karasek, and E.G. Engleman. 1987. Phenotypic and functional characterization of lymphocytes that bind in vitro. J. Clin. Invest. 79:1679-1688.
24. Green, S., P. Walter. V. Kumar, A. Krust, J.-M. Bornent, P. Argos, and P. Chambon. 1986. Human estrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (Lond.). 320:134-139.
25. Keri, R.A., B. Andersen, G.C. Kennedy, D.L. Hamerik, C.M. Clay, A.D. Brace, T.M. Nett, A.C. Notides, and J.H. Nilson. 1991. Estradiol inhibits transcription of the human glycoprotein hormone α-subunit gene despite the absence of a high affinity binding site for estrogen receptor. Mol. Endocrinol. 5: 725-733.
26. Yuan, H., D.A. Bowlby, T.J. Brown, R.B. Hochberg, and N.J. Maclusky. 1995. Distribution of occupied and unoccupied estrogen receptors in the rat brain: effects of physiological gonadal steroid exposure. Endocrinology. 136:96-105.
27. Wakeling, A.E. 1990. Novel pure antiestrogens: mode of action and therapeutic prospects. Ann. NY Acad. Sci. 595:348-356.
28. Nelken, N.A., S.R. Coughlin, D. Gordon, and J.N. Wilcox. 1991. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88:1121-1130.
29. Sica, A., J.M. Wang, F. Colotta, E. Dejana, A. Mantovani, J.T. Oppenheim, C.G. Larsen, C.O.C. Zachariae, and K. Matsushima. 1990. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J. Immunol. 144:3034-3038.
30. Bergman, M.D., B.S. Schachter, K. Karelus, E.P. Combatsiaris, T. Garcia, and J.F. Nelson. 1992. Up-regulation of the uterine estrogen-receptor and its messenger ribonucleic acid during the mouse estrous cycle: the role of estradiol. Endocrinology. 130:1923-1930.
31. Kumar, V., and P. Chambon. 1988. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell. 55:145-156.
32. Ray, A., K.E. Prefontaine, and P. Ray. 1994. Down-modulation of interleukin-6 gene expression by 17β-estradiol by the estrogen receptor. J. Biol. Chem. 269:12940-12946.
33. Weisz, A., and R. Rosales. 1990. Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-I transcription factor. Nucl. Acids Res. 18:5097-5106.
34. Krishnan, V., X. Wang, and S. Safe. 1994. Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast tissue. J. Biol. Chem. 269:15912-15917.
35. Cronstein, B., S. Kimmel, R. Levin, F. Martiniuk, and G. Weissmann. 1992. A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 89:9991-9995.
36. Nakai, K., C. Itoh, K. Hotta, T. Itoh, M. Yoshizumi, and K. Hiramori. 1994. Estradiol-17β regulates the induction of VCAM-1 mRNA expression by interleukin-1β in human umbilical vein endothelial cells. Life Sci. 54:221-227.
37. Cid, M.C., H.K. Kleinman, D.S. Grant, H.W. Schnaper, A.S. Fauci, and G.S. Hoffman. 1994. Estradiol enhances leukocyte binding to tumor necrosis factor (TNF) stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-seleclin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J. Clin. Invest. 93:17-25.
38. Kaszubska, W., R.H. van Huijsduijnen, P. Ghersa, A.M. DeRaemy-Schenk, B.P. Chen, T. Hai, J.F. DeLamarter, and J. Whelan. 1993. Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selectin promoter in response to cytokines. Mol. Cell Biol. 13: 7180-7190.
39. DeLuca, L., D. Johnson, M. Whitley, T. Collins, and J. Pober. 1994. cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter. J. Biol. Chem. 269:19193-19196.
40. Neish, A.S., A.J. Williams, H.J. Palmer, M.Z. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176:1583-1593.
41. Hou, J., V. Baichwal, and Z. Cao. 1994. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 91: 11641-11645.
42. Read, M.A., M.Z. Whitley, A.J. Williams, and T. Collins. 1994. NF-κB and IκBα: an inducible regulatory system in endothelial activation. J. Exp. Med. 179:503-512.
43. Keaney, J.F., G.T. Shwaery, A. Xu, R.J. Nicolosi, J. Loscalzo, T. Foxall, and J. Vita. 1994. 17β-estradiol preserves endothelial vasodilator function and limits low density lipoprotein oxidation in hypercholesterolemic swine. Circulation. 89:2251-2259.
44. Negre-Salvayre, A., M.T. Pierassi, L. Mobile, and R. Salvayre. 1993. Protective effects of 17 β-estradiol against the cytotoxicity of minimally oxidized LDL to cultured bovine aortic endothelial cells. Atherosclerosis. 99:207-217.
45. Marui, N., M.K. Offermann, R. Swerlick, C. Kunsch, C.A. Rosen, M. Ahmad, R.W. Alexander, and R.M. Medford. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92:1866-1874.
46. Mooradian, A.D. 1993. Antioxidant properties of steroids. J. Steroid Biochem. Mol. Biol. 45:509-511.
47. Rhee, C.Y., T.H. Spaet, M.B. Stemerman, F. Lajam, and H.H. Shiang. 1977. Estrogen suppression of surgically induced vascular intimai hyperplasia in rabbits. J. Lab. Clin. Med. 90:77-84.
48. Foegh, M.L., B.S. Khirabadi, T. Nakanishi, R. Vargas, and P.W. Ramwell. 1987. Estradiol protects against experimental cardiac transplant atherosclerosis. Transplant. Proc. 19:90-95.
49. Williams, J.K., M.R. Adam, and H.S. Klopfenstein. 1990. Estrogen modulates responses of atherosclerotic coronary arteries. Circulation. 81:1680-1687.
50. Weigensberg, B.I., J. Lough, R.H. More, E. Katz, E. Pugash, and C. Peniston. 1984. Effects of estradiol on myointimal thickening from catheter injury and on organizing white mural non-occlusive thrombi. Atherosclerosis. 52: 253-265.