Regulation of endothelial nitric oxide synthase: Location, location, location

Annual Review of Physiology

Volumn 64, Issue , 2002, Pages 749-774

  Shaul, Philip W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Caveolae; Epithelium; Estrogen; High density lipoprotein; Low density lipoprotein

Indexed keywords

CALCIUM ION; ESTROGEN RECEPTOR ALPHA; G PROTEIN COUPLED RECEPTOR; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

CALCIUM SIGNALING; CAVEOLA; CELL SPECIFICITY; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; ENZYME LOCALIZATION; ENZYME REGULATION; EPITHELIUM CELL; GOLGI COMPLEX; HUMAN; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; CAVEOLAE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RESPIRATORY MUCOSA;

EID: 0036199988     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.64.081501.155952     Document Type: Review

References (100)

1. The L-arginine-nitric oxide pathway
2. Nitric oxide: A physiologic messenger molecule
3. Regulation of biosynthesis of nitric oxide
4. Endothelial dysfunction in atherosclerosis
5. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease
6. Atherosclerosis or lipoprotein-induced endothelial dysfunction: Potential mechanisms underlying reduction in EDRF/nitric oxide activity
7. The biology of nitrogen oxides in the airways
8. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
9. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism
10. Nitric oxide and airway disease
11. Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep
12. Nitric oxide decreases lung liquid production in fetal lambs
13. Role of endogenous NO in modulating airway contraction mediated by muscarinic receptors during development
14. Effect of exogenous and endogenous nitric oxide on the airway and tissue components of lung resistance in the newborn piglet
15. Virus-induced airway hyperresponsiveness in guinea pigs is related to a deficiency in nitric oxide
16. Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells
17. Localization and regulation of endothelial NO synthase mRNA expression in rat kidney
18. Immunohistochemical localization of endothelial nitric oxide synthase in human testis, epididymis, and vas deferens suggests a possible role for nitric oxide in spermatogenesis, sperm maturation, and programmed cell death
19. Immunocytochemical localization of nitric oxide synthase-III in reproductive organs of female rats during the oestrous cycle
20. Nitric oxide synthases: Which, where, how, and why
21. Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: Physiological implications
22. Molecular control of nitric oxide synthases in the cardiovascular system
23. Enzymatic function of nitric oxide synthases
24. Cellular regulation of endothelial nitric oxide synthase
25. Nitric oxide synthase isoform expression in the developing lung epithelium
26. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
27. Localization of endothelial NOS at the basal microtubule membrane in ciliated epithelium of rat lung
28. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene
29. Endothelial nitric oxide synthase is expressed in cultured human bronchiolar epithelium
30. Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium
31. Functional analysis of the human eNOS promoter
32. A vascular bed-specific pathway regulates cardiac expression of endothelial nitric oxide synthase
33. Potocytosis: Sequestration and transport of small molecules by caveolae
34. Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate
35. Purification and characterization of smooth muscle cell caveolae
36. Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps
37. Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae
38. Caveolae and their coat proteins, the caveolins: From electron microscopic novelty to biological launching pad
39. Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme iosform
40. Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a motif for dual acylation and subcellular targeting
41. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling
42. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization
43. The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: A green fluorescent protein study
44. Trafticking of endothelial nitric-oxide synthase in living cells. Quantitative evidence supporting the role of palmitoylation as a kinetic trapping mechanism limiting membrane diffusion
45. Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium
46. Probucol and other antioxidants prevent the inhibition of endothelium-dependent relaxation by low density lipoproteins
47. Oxidized low-density lipoprotein displaces eNOS from plasmalemmal caveolae and impairs eNOS activation
48. Cholesterol and coronary heart disease. A new era
49. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis
50. The "best" of cholesterols, the "worst" of cholesterols: A tale of two receptors
51. High density lipoprotein receptors, binding proteins, and ligands
52. High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae
53. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
54. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
55. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin
56. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity
57. 2+-calmodulin and caveolin
58. Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase
59. The endothelial nitric-oxide synthase-caveolin regulatory cycle
60. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins
61. Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide
62. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
63. Bradykinin sequesters B2 bradykinin receptors and the receptor-coupled Galpha subunits Galphaq and Galphai in caveolae in DDT1 MF-2 smooth muscle cells
64. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase
65. Dynamic activation of endothelial nitric oxide synthase by Hsp90
66. NOSIP, a novel modulator of endothelial nitric oxide synthase activity
67. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase
68. 2+ homeostasis and formation of cGMP and prostacyclin
69. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
70. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells
71. 2+-independent activation of the endothelial nitric oxide synthase
72. Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling
73. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress
74. Estrogen receptor alpha mediates nongenomic activation of eNOS by estrogen
75. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase
76. Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells
77. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells
78. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
79. Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
80. The Akt kinase signals directly to endothelial nitric oxide synthase
81. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
82. AMP-activated protein kinase phosphorylation of endothelial NO synthase
83. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
84. Role of plasmalemmal caveolae in signal transduction
85. The protective effects of estrogen on the cardiovascular system
86. Estrogen acutely stimulates endothelial nitric oxide synthase in H441 human airway epithelium
87. ERà and eNOS are organized into a functional signaling module in caveolae
88. High-density lipoprotein - The clinical implications of recent studies
89. Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration
90. Expression cloning of SRBI, a CD36-related class B scavenger receptor
91. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
92. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
93. 2+ entry
94. Calcium signal transduction from caveolae
95. 2+ waves preferentially originate at specific loci in caveolin-rich cell edges
96. Inositol trisphosphate and calcium signaling
97. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
98. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
99. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase
100. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase