Targeting of Neuropharmaceuticals by Chemical Delivery Systems

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces

Volumn 1, Issue , 2007, Pages 463-500

  Bodor, Nicholas ^a   Buchwald, Peter ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b IVAX Research Inc   (United States)

Author keywords

Blood brain barrier; Brain targeted drug delivery; Chemical delivery systems; Drug delivery to the brain; Molecular packaging; Targeting of neuropharmaceuticals

Indexed keywords

DELIVERY SYSTEMS;

EID: 84891005452     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527611225.ch20     Document Type: Chapter

References (300)

1. Regier, D. A., Boyd, J. H., Burke, J. D. Jr., Rae, D.S., Myers, J. K., Kramer, M., Robins, L. N., George, L. K., Karno, M., Locke, B. Z. 1988, Arch. Gen. Psychiat. 45, 977-986.
2. Miller, G. 2002, Science 297, 1116-1118.
3. Pardridge, W. M. 2002, Drug Discov. Today 7, 5-7.
4. Crone, C., Thompson, A.M. 1970, in Capillary Permeability. The Transfer of Molecules and Ions between Capillary Blood and Tissue, ed. C. Crone, N. A. Lassen, Munksgaard, Copenhagen, pp. 447-453.
5. Oldendorf, W.H. 1974, Proc. Soc. Exp. Biol. Med. 147, 813-816.
6. Rapoport, S. I. 1976, Blood-Brain Barrier in Physiology and Medicine, Raven Press, New York.
7. Bradbury, M. 1979, The Concept of a Blood-Brain Barrier, Wiley, New York.
8. Bodor, N., Brewster, M.E. 1983, Pharmacol. Ther. 19, 337-386.
9. Fenstermacher, J. D., Rapoport, S. I. 1984, in Microcirculation, Part 2, Vol. 4, ed. E.M. Renkin, C. C. Michel, American Physiology Society, Bethesda, pp. 969-1000.
10. Goldstein, G.W., Betz, A. L. 1986, Sci. Am. 255, 74-83.
11. Bradbury, M.W.B. (ed.) 1992, Physiology and Pharmacology of the Blood-Brain Barrier, Springer, Berlin.
12. Begley, D. J. 1996, J. Pharm. Pharmacol. 48, 136-146.
13. Schlossauer, B., Steuer, H. 2002, Curr. Med. Chem. CNS Agents 2, 175-186.
14. Betz, A. L., Goldstein, G.W. 1984, in Structural Elements of the Nervous System, vol. 7, ed. A. Lajtha, Plenum, New York, pp. 465-484.
15. Pardridge, W.M. 1991, Peptide Drug Delivery to the Brain, Raven Press, New York.
16. Abbott, N. J., Bundgaard, M., Cserr, H. F. 1986, In The Blood-Brain Barrier in Health and Disease, ed. A. J. Suckling, M.G. Rumsby, M.W.B. Bradbury, Ellis Horwood, Chichester, pp. 52-72.
17. Lo, E. H., Singhal, A. B., Torchilin, V. P., Abbott, N. J. 2001, Brain Res. Rev. 38, 140-148.
18. Smith, Q. R. 1989, In Implications of the Blood-Brain Barrier and its Manipulation, ed. E. A. Neuwelt, Plenum, New York, pp. 85-113.
19. Stewart, P. A., Tuor, U. I. 1994, J. Comp. Neurol. 340, 566-576.
20. Siegal, T., Zylber-Katz, E. 2002, Clin. Pharmacokinet. 41, 171-186.
21. Ehrlich, P. 1885, Das Sauerstoff Bedürfnis des Organismus. Eine farbenanalytische Studie, Hirschwald, Berlin.
22. Janzer, R. C., Raff, M.C. 1987, Nature 325, 253-257.
23. Spatz, H. 1933, Arch. Psychiat. Nervenkrank. 101, 267-358.
24. Crone, C. 1961, The Diffusion of Some Organic Nonelectrolytes from Blood to Brain Tissue (in Danish, English summary), Munksgaard, Copenhagen.
25. Reese, T. S., Karnovsky, M. J. 1967, J. Cell Biol. 34, 207-217.
26. Brightman, M.W., Reese, T. S. 1969, J. Cell Biol. 40, 648-677.
27. Crone, C. 1986, in The Blood-Brain Barrier in Health and Disease, ed. A. J. Suckling, M. G. Rumsby, M.W.B. Bradbury, Ellis Horwood, Chichester, pp. 17-40.
28. Minn, A., Ghersi-Egea, J. F., Perrin, R., Leininger, B., Siest, G. 1991, Brain Res. Brain Res. Rev. 16, 65-82.
29. Ghersi-Egea, J. F., Leninger-Muller, B., Suleman, G., Siest, G., Minn, A. 1994, J. Neurochem. 62, 1089-1096.
30. Graff, C. L., Pollack, G.M. 2004, Curr. Drug Metab. 5, 95-108.
31. Brownlees, J., Williams, C.H. 1993, J. Neurochem. 60, 793-803.
32. Witt, K. A., Gillespie, T. J., Huber, J. D., Egleton, R. D., Davis, T. P. 2001, Peptides 22, 2329-2343.
33. Krogh, A. 1946, Proc. R. Soc. Lond. B 133, 140-200.
34. Crone, C. 1965, J. Physiol. 181, 103-113.
35. Lund-Andersen, H. 1979, Physiol. Rev. 59, 305-352.
36. Audus, K. L., Chikhale, P. J., Miller, D.W., Thompson, S. E., Borchardt, R.T. 1992, Adv. Drug Res. 23, 1-64.
37. Tamai, I., Tsuji, A. 2000, J. Pharm. Sci. 89, 1371-1388.
38. Taylor, E.M. 2002, Clin. Pharmacokinet. 41, 81-92.
39. Barza, M. 1993, Eur. J. Clin. Microbiol. Infect. Dis. 12, S31-S35.
40. Deguchi, Y., Nozawa, K., Yamada, S., Yokoyama, Y., Kimura, R. 1997, J. Pharmacol. Exp. Ther. 280, 551-560.
41. Suzuki, H., Terasaki, T., Sugiyama, Y. 1997, Adv. Drug Deliv. Rev. 25, 257-285.
42. Penzotti, J. E., Lamb, M.L., Evensen, E., Grootenhuis, P. D. 2002, J. Med. Chem. 45, 1737-1740.
43. Juliano, R. L., Ling, V. 1976, Biochim. Biophys. Acta 455, 152-162.
44. Lin, J. H., Yamazaki, M. 2003, Clin. Pharmacokinet. 42, 59-98.
45. Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M.R., Bertino, J. R. 1989, Proc. Natl Acad. Sci. USA 86, 695-698.
46. Tsuji, A., Tamai, I., Sakata, A., Tenda, Y., Terasaki, T. 1993, Biochem. Pharmacol. 46, 1096-1099.
47. Schinkel, A. H., Smit, J. J. M., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Walk, M.A., Robanus-Maadag, E. C., te Riele, H.P. J., et al. 1994, Cell 77, 491-502.
48. Schinkel, A. H., Wagenaar, E., Mol, C. A. A. M., van Deemter, L. 1996, J. Clin. Invest. 97, 2517-2524.
49. Tsuji, A., Tamai, I. 1997, Adv. Drug Deliv. Rev. 25, 287-298.
50. van Asperen, J., Mayer, U., van Tellingen, O., Beijnen, J.H. 1997, J. Pharm. Sci. 86, 881-884.
51. Schinkel, A.H. 1999, Adv. Drug Deliv. Rev. 36, 179-194.
52. Stein, W. D. 1997, Physiol. Rev. 77, 545-590.
53. Habgood, M.D., Begley, D. J., Abbott, N. J. 2000, Cell. Mol. Neurobiol. 20, 231-253.
54. Thorne, R. G., Frey, W.H. 2nd 2001, Clin. Pharmacokinet. 40, 907-946.
55. Filmore, D. 2002, Mod. Drug Discov. 5, 22-27.
56. Bodor, N., Buchwald, P. 2003, Am. J. Drug Deliv. 1, 13-26.
57. Mertsch, K., Maas, J. 2002, Curr. Med. Chem. CNS Agents 2, 187-201.
58. Overton, E. 1897, Z. Phys. Chem. 22, 189-209.
59. Overton, E. 1901, Studien über die Narkose, zugleich ein Beitrag zur allgemeiner Pharmakologie, Gustav Fischer, Jena.
60. Meyer, H. 1899, Arch. Exp. Pathol. Pharmakol. 42, 109-118.
61. Meyer, H. 1901, Arch. Exp. Pathol. Pharmakol. 46, 338-346.
62. Collander, R. 1951, Acta Chem. Scand. 5, 774-780.
63. Buchwald, P., Bodor, N. 1998, Curr. Med. Chem. 5, 353-380.
64. Franks, N. P., Lieb, W. R. 1978, Nature 274, 339-342.
65. Young, R. C., Mitchell, R. C., Brown, T. H., Ganellin, C. R., Griffiths, R., Jones, M., Rana, K. K., Saunders, D., Smith, I. R., Sore, N. E., et al. 1988, J. Med. Chem. 31, 656-671.
66. Abraham, M.H., Chadha, H.S., Mitchell, R. C. 1994, J. Pharm. Sci. 83, 1257-1268.
67. Lombardo, F., Blake, J. F., Curatolo, W. J. 1996, J. Med. Chem. 39, 4750-4755.
68. Crivori, P., Cruciani, G., Carrupt, P.-A., Testa, B. 2000, J. Med. Chem. 43, 2204-2216.
69. Iyer, M., Mishra, R., Han, Y., Hopfinger, A. J. 2002, Pharm. Res. 19, 1611-1621.
70. Lobell, M., Molnár, L., Keserü, G.M. 2003, J. Pharm. Sci. 92, 360-370.
71. Bodor, N., Buchwald, P. 1999, Adv. Drug Deliv. Rev. 36, 229-254.
72. van de Waterbeemd, H., Smith, D.A., Beaumont, K., Walker, D.K. 2001, J. Med. Chem. 44, 1313-1333.
73. Lewis, D.F.V., Dickins, M. 2002, Drug Discov. Today 7, 918-925.
74. Smith, D., Schmid, E., Jones, B. 2002, Clin. Pharmacokinet. 41, 1005-1019.
75. Lin, J. H., Lu, A.Y. 1997, Pharmacol. Rev. 49, 403-449.
76. Lombardo, F., Obach, R. S., Shalaeva, M.Y., Gao, F. 2004, J. Med. Chem. 47, 1242-1250.
77. Buchwald, P., Bodor, N., Drugs Future 27, 577-588.
78. King, L. A., Moffat, A. C. 1981, Lancet 1, 387-388.
79. Hansch, C., Björkroth, J. P., Leo, A. 1987, J. Pharm. Sci. 76, 663-687.
80. Gupta, S. P. 1989, Chem. Rev. 89, 1765-1800.
81. Abraham, M.H. 2004, Eur. J. Med. Chem. 39, 235-240.
82. Sippl, W. 2002, Curr. Med. Chem. CNS Agents 2, 212-227.
83. de Boer, A. G., Gaillard, P. J. 2002, Curr. Med. Chem. CNS Agents 2, 203-209.
84. Kerns, E.H. 2001, J. Pharm. Sci. 90, 1838-1858.
85. Golden, P. L., Pollack, G.M. 1998, Biopharm. Drug Dispos. 19, 263-272.
86. Sadeque, A. J., Wandel, C., He, H., Shah, S., Wood, A. J. 2000, Clin. Pharmacol. Ther. 68, 231-237.
87. Savolainen, J., Edwards, J. E., Morgan, M.E., McNamara, P. J., Anderson, B. D. 2002, Drug Metab. Dispos. 30, 479-482.
88. Fellner, S., Bauer, B., Miller, D. S., Schaffrik, M., Fankhänel, M., Spruss, T., Bernhardt, G., Graeff, C., Färber, L., Gschaidmeier, H., et al. 2002, J. Clin. Invest. 110, 1309-1318.
89. Bodor, N., Buchwald, P. 2003, in Drug Discovery and Drug Development, Burger's Medicinal Chemistry and Drug Discovery, Vol. 2, 6th edn, ed. D.J. Abraham, Wiley, New York, pp. 533-608.
90. Hunt, C. A., MacGregor, R. D., Siegel, R. A. 1986, Pharm. Res. 3, 333-344.
91. Bodor, N., Brewster, M.E. 1991, in Targeted Drug Delivery, Vol. 100, ed. R. L. Juliano, Springer, Berlin, pp. 231-284.
92. Ishikura, T., Senou, T., Ishihara, H., Kato, T., Ito, T. 1995, Int. J. Pharm. 116, 51-63.
93. Pop, E. 1997, Curr. Med. Chem. 4, 279-294.
94. Somogyi, G., Nishitani, S., Nomi, D., Buchwald, P., Prokai, L., Bodor, N. 1998, Int. J. Pharm. 166, 15-26.
95. Somogyi, G., Buchwald, P., Nomi, D., Prokai, L., Bodor, N. 1998, Int. J. Pharm. 166, 27-35.
96. Bodor, N., Farag, H.H., Barros, M.D. C., Wu, W.-M., Buchwald, P. 2002, J. Drug Target. 10, 63-71.
97. Rydström, J., Hoek, J. B., Ernster, L. 1976, in The Enzymes, Vol. 13, ed. P. D. Boyer, Academic Press, New York.
98. Hoek, J. B., Rydström, J. 1988, Biochem. J. 254, 1-10.
99. Bodor, N., Brewster, M. E., Kaminski, J. J. 1990, J. Mol. Struct. 206, 315-334.
100. Brewster, M. E., Estes, K. S., Perchalski, R., Bodor, N. 1988, Neurosci. Lett. 87, 277-282.
101. Bodor, N., Roller, R. G., Selk, S. J. 1978, J. Pharm. Sci. 67, 685-687.
102. Palomino, E., Kessel, D., Horwitz, J. P. 1989, J. Med. Chem. 32, 622-625.
103. Bodor, N., Farag, H.H., Brewster, M.E. 1981, Science 214, 1370-1372.
104. Bodor, N., Farag, H.H. 1983, J. Med. Chem. 26, 313-318.
105. Bodor, N., Abdelalim, A.M. 1985, J. Pharm. Sci. 74, 241-245.
106. Tedjamulia, M.L., Srivastava, P. C., Knapp, F. F. Jr. 1985, J. Med. Chem. 28, 1574-1580.
107. Bodor, N., Nakamura, T., Brewster, M. E. 1986, Drug Des. Deliv. 1, 51-64.
108. Bodor, N., Farag, H.H., Polgar, P. 2001, J. Pharm. Pharmacol. 53, 889-894.
109. Bodor, N., Farag, H.H. 1984, J. Pharm. Sci. 73, 385-389.
110. Bodor, N., Abdelalim, A.M. 1986, J. Pharm. Sci. 75, 29-35.
111. Anderson, W. R., Simpkins, J.W., Brewster, M. E., Bodor, N. 1988, Drug Des. Del. 2, 287-298.
112. Brewster, M. E., Estes, K. S., Bodor, N. 1986, Pharm. Res. 3, 278-285.
113. Brewster, M. E., Deyrup, M., Czako, K., Bodor, N. 1990, J. Med. Chem. 33, 2063-2065.
114. Brewster, M. E., Estes, K. S., Bodor, N. 1988, Ann. NY Acad. Sci. 529, 298-300.
115. Anderson, W. R., Simpkins, J.W., Brewster, M. E., Bodor, N. 1989, Neuroendocrinology 50, 9-16.
116. Siegal, T., Soti, F., Biegon, A., Pop, E., Brewster, M.E. 1997, Pharm. Res. 14, 672-675.
117. Pop, E., Brewster, M. E., Prókai-Tátrai, K., Bodor, N. 1994, Org. Prep. Proced. Int. 26, 379-382.
118. Bodor, N., McCornack, J., Brewster, M.E. 1987, Int. J. Pharm. 35, 47-59.
119. Simpkins, J.W., McCornack, J., Estes, K. S., Brewster, M. E., Shek, E., Bodor, N. 1986, J. Med. Chem. 29, 1809-1812.
120. Anderson, W. R., Simpkins, J.W., Brewster, M. E., Bodor, N. 1987, Pharmacol. Biochem. Behav. 27, 265-271.
121. Estes, K. S., Brewster, M. E., Simpkins, J.W., Bodor, N. 1987, Life Sci. 40, 1327-1334.
122. Estes, K. S., Brewster, M. E., Bodor, N.S. 1988, Life Sci. 42, 1077-1084.
123. Anderson, W. R., Simpkins, J. W., Brewster, M. E., Bodor, N. 1988, Endocr. Res. 14, 131-148.
124. Brewster, M. E., Estes, K. S., Bodor, N. 1988, J. Med. Chem. 31, 244-249.
125. Mullersman, G., Derendorf, H., Brewster, M. E., Estes, K. S., Bodor, N. 1988, Pharm. Res. 5, 172-177.
126. Howes, J., Bodor, N., Brewster, M. E., Estes, K., Eve, M. 1988, Abstract 181, J. Clin. Pharmacol. 28, 951.
127. Simpkins, J.W., Anderson, W. R., Dawson, R., Jr., Seth, E., Brewster, M., Estes, K. S., Bodor, N. 1988, Physiol. Behav. 44, 573-580.
128. Simpkins, J.W., Anderson, W. R., Dawson, R. Jr., Bodor, N. 1989, Pharm. Res. 6, 592-600.
129. Sarkar, D. K., Friedman, S. J., Yen, S. S. C., Frautschy, S. A. 1989, Neuroendocrinology 50, 204-210.
130. Millard, W. J., Romano, T. M., Bodor, N., Simpkins, J.W. 1990, Pharm. Res. 7, 1011-1018.
131. Brewster, M. E., Simpkins, J.W., Bodor, N. 1990, Rev. Neurosci. 2, 241-285.
132. Estes, K. S., Dewland, P. M., Brewster, M. E., Derendorf, H., Bodor, N. 1991, Pharm. Z. Wiss. 136, 153-158.
133. Brewster, M. E., Bartruff, M.S. M., Anderson, W. R., Druzgala, P. J., Bodor, N., Pop, E. 1994, J. Med. Chem. 37, 4237-4244.
134. Estes, K. S., Brewster, M. E., Bodor, N. 1994, Adv. Drug Deliv. Rev. 14, 167-175.
135. Simpkins, J.W., Rajakumar, G., Zhang, Y.-Q., Simpkins, C. E., Greenwald, D., Yu, C. J., Bodor, N., Day, A.L. 1997, J. Neurosurg. 87, 724-730.
136. Rabbani, O., Panickar, K. S., Rajakumar, G., King, M.A., Bodor, N., Meyer, E. M., Simpkins, J.W. 1997, Exp. Neurol. 146, 179-186.
137. Bodor, N., Buchwald, P. 2002, Drug Discov. Today 7, 766-774.
138. Tapfer, M. K., Sebestyen, L., Kurucz, I., Horvath, K., Szelenyi, I., Bodor, N. 2004, Pharmacol. Biochem. Behav. 77, 423-429.
139. Pop, E., Wu, W.-M., Shek, E., Bodor, N. 1989, J. Med. Chem. 32, 1774-1781.
140. Pop, E., Wu, W.-M., Bodor, N. 1989, J. Med. Chem. 32, 1789-1795.
141. Wu, W.-M., Pop, E., Shek, E., Bodor, N. 1989, J. Med. Chem. 32, 1782-1788.
142. Wu, W.-M., Pop, E., Shek, E., Clemmons, R., Bodor, N. 1990, Drug Des. Delivery 7, 33-43.
143. Brewster, M. E., Deyrup, M., Seyda, K., Bodor, N. 1991, Int. J. Pharm. 68, 215-229.
144. Venkatraghavan, V., Shek, E., Perchalski, R., Bodor, N. 1986, Pharmacologist 28, 145.
145. Rand, K., Bodor, N., El-Koussi, A., Raad, I., Miyake, A., Houck, H., Gildersleeve, N. 1986, J. Med. Virol. 20, 1-8.
146. El-Koussi, A., Bodor, N. 1987, Drug Des. Deliv. 1, 275-283.
147. Canonico, P. G., Kende, M., Gabrielsen, B. 1988, Adv. Virus Res. 35, 271-312.
148. Bhagrath, M., Sidwell, R., Czako, K., Seyda, K., Anderson, W., Bodor, N., Brewster, M.E. 1991, Antiviral Chem. Chemother. 2, 265-286.
149. Deyrup, M., Sidwell, R., Little, R., Druzgala, P., Bodor, N., Brewster, M.E. 1991, Antiviral Chem. Chemother. 2, 337-355.
150. Morin, K.W., Wiebe, L. I., Knaus, E. E. 1993, Carbohydr. Res. 249, 109-116.
151. Morin, K.W., Knaus, E. E., Wiebe, L. I. 1994, J. Labelled Comp. Radiopharm. 35, 205-207.
152. Balzarini, J., Morin, K.W., Knaus, E. E., Wiebe, L. I., De Clercq, E. 1995, Gene Therapy 2, 317-322.
153. Pop, E., Anderson, W., Vlasak, J., Brewster, M. E., Bodor, N. 1992, Int. J. Pharm. 84, 39-48.
154. Brewster, M. E., Little, R., Venkatraghavan, V., Bodor, N. 1988, Antiviral Res. 9, 127.
155. Little, R., Bailey, D., Brewster, M. E., Estes, K. S., Clemmons, R. M., Saab, A., Bodor, N. 1990, J. Biopharm. Sci. 1, 1-18.
156. Brewster, M. E., Anderson, W., Bodor, N. 1991, J. Pharm. Sci. 80, 843-845.
157. Pop, E., Brewster, M. E., Anderson, W. R., Bodor, N. 1992, Med. Chem. Res. 2, 457-466.
158. Pop, E., Liu, Z. Z., Vlasak, J., Anderson, W., Brewster, M. E., Bodor, N. 1993, Drug Deliv. 1, 143-149.
159. Mizrachi, Y., Rubinstein, A., Harish, Z., Biegon, A., Anderson, W. R., Brewster, M. E. 1995, AIDS 9, 153-158.
160. Brewster, M. E., Anderson, W. R., Webb, A. I., Pablo, L. M., Meinsma, D., Moreno, D., Derendorf, H., Bodor, N., Pop, E. 1997, Antimicrob. Agents Chemother. 41, 122-128.
161. Torrence, P.T., Kinjo, J., Lesiak, K., Balzarini, J., DeClerq, E. 1988, FEBS Lett. 234, 135-140.
162. Gogu, S. R., Aggarwal, S. K., Rangan, S. R. S., Agrawal, K. C. 1989, Biochem. Biophys. Res. Commun. 160, 656-661.
163. Aggarwal, S. K., Gogu, S. R., Rangan, S. R. S., Agrawal, K. C. 1990, J. Med. Chem. 33, 1505-1510.
164. Lupia, R. H., Ferencz, N., Aggarwal, S. K., Agrawal, K. C., Lertora, J. J. L. 1990, Clin. Res. 38, 15A.
165. Lupia, R. H., Ferencz, N., Lertora, J. J. L., Aggarwal, S. K., George, W. J., Agrawal, K. C. 1993, Antimicrob. Agents Chemother. 37, 818-824.
166. Gallo, J., Boubinot, F., Doshi, D., Etse, J., Bhandti, V., Schinazi, R., Chu, C. K. 1989, Pharm. Res. 6, S161.
167. Chu, C. K., Bhadti, V. S., Doshi, K. J., Etse, J.T., Gallo, J. M., Boudinot, F. D., Schinazi, R. F. 1990, J. Med. Chem. 33, 2188-2192.
168. Gallo, J. M., Etse, J.T., Doshi, K. J., Boudinot, F. D., Chu, C. K. 1991, Pharm. Res. 8, 247-253.
169. Palomino, E., Kessel, D., Horwitz, J. P. 1992, Nucleosides Nucleotides 11, 1639-1649.
170. Torrence, P. F., Kinjo, J., Khamnei, S., Greig, N.H. 1993, J. Med. Chem. 36, 529-537.
171. Brewster, M. E., Raghavan, K., Pop, E., Bodor, N. 1994, Antimicrob. Agents Chemother. 38, 817-823.
172. Camplo, M., Charvet Faury, A. S., Borel, C., Turin, F., Hantz, O., Trabaud, C., Niddam, V., Mourier, N., Graciet, J. C., Chermann, J. C., et al. 1996, Eur. J. Med. Chem. 31, 539-546.
173. Raghavan, K., Shek, E., Bodor, N. 1987, Anticancer Drug Des. 2, 25-36.
174. Raghavan, K., Loftsson, T., Brewster, M. E., Bodor, N. 1992, Pharm. Res. 9, 743-749.
175. Bodor, N., Venkatraghavan, V., Winwood, D., Estes, K., Brewster, M.E. 1989, Int. J. Pharm. 53, 195-208.
176. Bodor, N., Simpkins, J.W. 1983, Science 221, 65-67.
177. Bodor, N., Farag, H.H. 1983, J. Med. Chem. 26, 528-534.
178. Simpkins, J.W., Bodor, N., Enz, A. 1985, J. Pharm. Sci. 74, 1033-1036.
179. Omar, F. A., Farag, H.H., Bodor, N. 1994, J. Drug Target. 2, 309-316.
180. Carelli, V., Liberatore, F., Scipione, L., Impicciatore, M., Barocelli, E., Cardellini, M., Giorgioni, G. 1996, J. Controlled Release 42, 209-216.
181. Anderson, W. R., Simpkins, J.W., Woodard, P. A., Winwood, D., Stern, W. C., Bodor, N. 1987, Psychopharmacology 92, 157-163.
182. Woodard, P. A., Winwood, D., Brewster, M. E., Estes, K. S., Bodor, N. 1990, Drug Des. Deliv. 6, 15-28.
183. Kourounakis, A., Bodor, N., Simpkins, J. 1996, Int. J. Pharm. 141, 239-250.
184. Kourounakis, A., Bodor, N., Simpkins, J. 1997, J. Pharm. Pharmacol. 49, 1-9.
185. Shek, E., Murakami, T., Nath, C., Pop, E., Bodor, N.S. 1989, J. Pharm. Sci. 78, 837-843.
186. Pop, E., Bodor, N. 1992, Epilepsy Res. 13, 1-16.
187. Boddy, A.V., Zhang, K., Lepage, F., Tombret, F., Slatter, J. G., Baillie, T. A., Levy, R.H. 1991, Pharm. Res. 8, 690-697.
188. Yiu, S. H., Knaus, E. E. 1996, J. Med. Chem. 39, 4576-4582.
189. Pop, E., Prókai-Tátrai, K., Anderson, W., Lin, J.-L., Brewster, M. E., Bodor, N. 1990, Eur. J. Pharmacol. 183, 1909-1919.
190. Prókai-Tátrai, K., Pop, E., Anderson, W., Lin, J.-L., Brewster, M. E., Bodor, N. 1991, J. Pharm. Sci. 80, 255-261.
191. Brewster, M. E., Robledo-Luiggi, C., Miyakeb, A., Pop, E., Bodor, N. 1989, in Novel Approaches to the Treatment of Alzheimer's Disease, ed. E.M. Meyer, J. W. Simpkins, J. Yamamoto, Plenum Press, New York, pp. 173-183.
192. Pop, E., Prókai-Tátrai, K., Scott, J. D., Brewster, M. E., Bodor, N. 1990, Pharm. Res. 7, 658-664.
193. Pop, E., Soti, F., Anderson, W. R., Panetta, J. A., Estes, K. S., Bodor, N. S., Brewster, M.E. 1996, Int. J. Pharm. 140, 33-44.
194. Bailey, D., Perchalski, R., Bhagrath, M., Shek, E., Winwood, D., Bodor, N. 1991, J. Biopharm. Sci. 2, 205-218.
195. Phelan, M.J., Bodor, N. 1989, Pharm. Res. 6, 667-676.
196. Pop, E., Anderson, W., Prókai-Tátrai, K., Vlasak, J., Brewster, M. E., Bodor, N. 1992, Med. Chem. Res. 2, 16-21.
197. Anderson, W., Pop, E., Lee, S.-K., Bodor, N., Brewster, M. 1991, Med. Chem. Res. 1, 74-79.
198. Pop, E., Anderson, W., Prókai-Tátrai, K., Brewster, M. E., Fregly, M., Bodor, N. 1990, J. Med. Chem. 33, 2216-2221.
199. Pop, E., Prókai-Tátrai, K., Brewster, M. E., Bodor, N. 1994, Org. Prep. Proced. Int. 26, 687-690.
200. Bodor, N., Prokai, L., Wu, W.-M., Farag, H.H., Jonnalagadda, S., Kawamura, M., Simpkins, J. 1992, Science 257, 1698-1700.
201. Prokai-Tatrai, K., Prokai, L., Bodor, N. 1996, J. Med. Chem. 39, 4775-4782.
202. Prokai, L., Ouyang, X.-D., Wu, W.-M., Bodor, N. 1994, J. Am. Chem. Soc. 116, 2643-2644.
203. Prokai, L., Ouyang, X., Prokai-Tatrai, K., Simpkins, J.W., Bodor, N. 1998, Eur. J. Med. Chem. 33, 879-886.
204. Prokai, L., Prokai-Tatrai, K., Ouyang, X., Kim, H.-S., Wu, W.-M., Zharikova, A., Bodor, N. 1999, J. Med. Chem. 42, 4563-4571.
205. Yoon, S.-H., Wu, J., Wu, W.-M., Prokai, L., Bodor, N. 2000, Bioorg. Med. Chem. 9, 1059-1063.
206. Wu, J., Yoon, S.-H., Wu, W.-M., Bodor, N. 2002, J. Pharm. Pharmacol. 54, 945-950.
207. Prokai-Tatrai, K., Perjési, P., Zharikova, A. D., Li, X., Prokai, L. 2002, Bioorg. Med. Chem. Lett. 12, 2171-2174.
208. Prokai, L., Prokai-Tatrai, K., Zharikova, A. D., Nguyen, V., Perjesi, P., Stevens, S.M. Jr. 2004, J. Med. Chem. 47, 6025-6033.
209. Bodor, N., Buchwald, P. 1998, Chem. Ber. 34, 36-40.
210. Chen, P., Bodor, N., Wu, W.-M., Prokai, L. 1998, J. Med. Chem. 41, 3773-3781.
211. Prokai, L., Prokai-Tatrai, K., Bodor, N. 2000, Med. Res. Rev. 20, 367-416.
212. Williams, C. L., Stancel, G.M. 1996, in Goodman & Gilman's Pharmacological Basis of Therapeutics, ed. J.G. Hardman, L. E. Limbird, McGraw-Hill, New York, pp. 1411-1440.
213. Kaplan, N.M. 1978, Annu. Rev. Med. 29, 31-40.
214. Fotherby, K. 1985, Contraception 31, 367-394.
215. Lobo, R. A. 1995, Am. J. Obstet. Gynecol. 173, 982-989.
216. Yager, J. D., Liehr, J.G. 1996, Annu. Rev. Pharmacol. Toxicol. 36, 203-232.
217. Beral, V., Banks, E., Reeves, G., Appleby, P. 1999, J. Epidemiol. Biostat. 4, 191-210.
218. Wells, G., Herrington, D.M. 1999, Drugs Aging 15, 419-422.
219. Meade, T.W., Vickers, M.R. 1999, J. Epidemiol. Biostat. 4, 165-190.
220. Rossouw, J. E., Anderson, G. L., Prentice, R. L., LaCroix, A. Z., Kooperberg, C., Stefanick, M.L., Jackson, R. D., Beresford, S. A. A., Howard, B.V., Johnson, K. C., et al. 2002, JAMA 288, 321-333.
221. Hays, J., Ockene, J. K., Brunner, R. L., Kotchen, J. M., Manson, J. E., Patterson, R. E., Aragaki, A. K., Shumaker, S. A., Brzyski, R. G., LaCroix, A. Z., et al. 2003, N. Engl. J. Med. 348, 1839-1854.
222. Anderson, G. L., Limacher, M., Assaf, A. R., Bassford, T., Beresford, S. A., Black, H., Bonds, D., Brunner, R., Brzyski, R., Caan, B., et al. 2004, JAMA 291, 1701-1712.
223. Aldridge, S. 1998, Magic Molecules: How Drugs Work, Cambridge University Press, Cambridge.
224. Greendale, G. A., Lee, N. P., Arriola, E. R. 1999, Lancet 353, 571-580.
225. McEwen, B. S., Alves, S. E. 1999, Endocr. Rev. 20, 279-307.
226. Cyr, M., Calon, F., Morissette, M., Grandbois, M., Callier, S., Di Paolo, T. 2000, Curr. Pharm. Des. 6, 1287-1312.
227. Shepherd, J. E. 2001, J. Am. Pharm. Assoc. 41, 221-228.
228. Sharpe, R.M. 1998, Trends Endocrin. Metabol. 9, 371-377.
229. Upton, G.V. 1984, J. Reprod. Med. 29, 71-79.
230. Maggi, A., Perez, J. 1985, Life Sci. 37, 893-906.
231. García-Segura, L. M., Chowen, J. A., Párducz, A., Naftolin, F. 1994, Progr. Neurobiol. 44, 279-307.
232. Ohkura, T., Isse, K., Akazawa, K., Hamamoto, M., Yaoi, Y., Hagino, N. 1994, Endocr. J. 41, 361-371.
233. Tang, M.-X., Jacobs, D., Stern, Y., Marder, K., Schofield, P., Gurland, B., Andrews, H., Mayeux, R. 1996, Lancet 346, 429-432.
234. Jacobs, D.M., Tang, M.-X., Stern, Y., Sano, M., Marder, K., Bell, K. L., Schofield, P., Dooneief, G., Gurland, B., Mayeux, R. 1998, Neurology 50, 368-373.
235. Yaffe, K., Sawaya, G., Lieberburg, I., Grady, D. 1998, JAMA 279, 688-695.
236. Asthana, S., Craft, S., Baker, L. D., Raskind, M.A., Birnbaum, R. S., Lofgreen, C. P., Veith, R. C., Plymate, S. R. 1999, Psychoneuroendocrinology 24, 657-677.
237. Costa, M.M., Reus, V. I., Wolkowitz, O.M., Manfredi, F., Lieberman, M. 1999, Biol. Psychiatry 46, 182-188.
238. Janocko, L., Lamer, J. M., Hochberg, R. B. 1984, Endocrinology 114, 1180-1186.
239. Shepherd, J. E. 2002, J. Am. Pharm. Assoc. 42, 479-488.
240. Laumann, E. O., Paik, A., Rosen, R. C. 1999, JAMA 281, 537-544.
241. Dennerstein, L., Randolph, J., Taffe, J., Dudley, E., Burger, H. 2002, Fertil. Steril. 77[Suppl. 4], S42-S48.
242. Juhász, A., Howes, J., Mantelle, L., Halabi, A., Bodor, N. 2003, Proc. N. Am. Menopause Soc. 14.
243. Juhász, A., Howes, J., Halabi, A., Bodor, N. 2004, Proc. N. Am. Menopause Soc. 15.
244. Saenger, W. 1980, Angew. Chem. Int. Ed. Engl. 19, 344-362.
245. Szejtli, J. 1982, Cyclodextrins and Their Inclusion Complexes, Akadémiai Kiadó, Budapest.
246. Pagington, J. S. 1987, Chem. Ber. 23, 455-458.
247. Szejtli, J. 1998, Chem. Rev. 98, 1743-1753.
248. Buchwald, P. 2002, J. Phys. Chem. B 106, 6864-6870.
249. Brewster, M. E., Estes, K. E., Loftsson, T., Perchalski, R., Derendorf, H., Mullersman, G., Bodor, N. 1988, J. Pharm. Sci. 77, 981-985.
250. Pitha, J., Pitha, J. 1985, J. Pharm. Sci. 74, 987-990.
251. Pitha, J., Milecki, J., Fales, H., Pannell, L., Uekama, K. 1986, Int. J. Pharm. 29, 73-82.
252. Yoshida, A., Arima, H., Uekama, K., Pitha, J. 1988, Int. J. Pharm. 46, 217-222.
253. Brewster, M. E., Estes, K. S., Bodor, N. 1990, Int. J. Pharm. 59, 231-243.
254. Pop, E., Loftsson, T., Bodor, N. 1991, Pharm. Res. 8, 1044-1049.
255. Kastin, A. J., Ehrensing, R. H., Banks, W. A., Zadina, J. E. 1987, in Neuropeptides and Brain Function, vol. 72, ed. E. R. de Kloet, V.M. Wiegant, D. de Wied, Elsevier, Amsterdam, pp. 223-234.
256. Nemeroff, C. B. E. 1988, Neuropeptides in Psychiatric and Neurological Disorders, John Hopkins University Press, Baltimore.
257. Hoyle, C.H.V. 1996, Neuropeptides. Essential Data, Wiley, Chichester.
258. Banks, W. A., Kastin, A. J. 1990, Adv. Exp. Med. Biol. 274, 59-69.
259. Ermisch, A., Brust, P., Kretzschmar, R., Rühle, H.-J. 1993, Physiol. Rev. 73, 489-527.
260. Oliyai, R., Stella, V. J. 1993, Annu. Rev. Pharmacol. Toxicol. 33, 521-544.
261. Bodor, N., Prokai, L. 1995, in Peptide-Based Drug Design: Controlling Transport and Metabolism, ed. M. Taylor, G. Amidon, American Chemical Society, Washington, D.C., pp. 317-337.
262. Hughes, J., Smith, T.V., Kosterlitz, H.W., Fothergill, L., Morgan, B. A., Morris, H.R. 1975, Nature 258, 577-579.
263. Olson, G. A., Olson, R. D., Kastin, A. J. 1985, Peptides 6, 769-791.
264. Olson, G. A., Olson, R. D., Kastin, A. J. 1992, Peptides 13, 1247-1287.
265. Bicknell, R. J. 1985, J. Endocrinol. 107, 437-446.
266. Millan, M.J., Herz, A. 1985, Int. Rev. Neurobiol. 26, 1-83.
267. Yen, S. S. C., Quigley, M. E., Reid, R. L., Ropert, J. F., Cetel, N. S. 1985, Am. J. Obstet. Gynecol. 152, 485-493.
268. Sandyk, R. 1985, Life Sci. 37, 1655-1663.
269. Frenk, H. 1983, Brain Res. Rev. 6, 197-210.
270. Tortella, F. C., Long, J. B., Holaday, J.W. 1985, Brain Res. 332, 174-178.
271. Baile, C. A., McLaughlin, C. L., Della-Fera, M.A. 1986, Physiol. Rev. 66, 172-234.
272. Schmauss, C., Emrich, H.M. 1985, Biol. Psychiatry 20, 1211-1231.
273. Izquierdo, I., Netto, C. A. 1985, Ann. NY Acad. Sci. 444, 162-177.
274. Holaday, J.W. 1983, Annu. Rev. Pharmacol. Toxicol. 23, 541-594.
275. Johnson, M.W., Mitch, W. E., Wilcox, C. S. 1985, Prog. Cardiovasc. Dis. 27, 435-450.
276. Porreca, F., Burks, T. F. 1983, J. Pharmacol. Exp. Ther. 227, 22-27.
277. D'Amour, F. E., Smith, D.L. 1941, J. Pharmacol. Exp. Ther. 72, 74-79.
278. Kastin, A. J., Pearson, M.A., Banks, W. A. 1991, Pharmacol. Biochem. Behav. 40, 771-774.
279. Szirtes, T., Kisfaludy, L., Pálosi, É., Szporny, L. 1984, J. Med. Chem. 27, 741-745.
280. Santori, E. M., Schmidt, D.E. 1980, Regul. Pept. 1, 69-74.
281. Itoh, Y., Ogasawara, T., Mushiroi, T., Yamazaki, A., Ukai, Y., Kimura, K. 1994, J. Pharmacol. Exp. Therap. 271, 884-890.
282. Kelly, J.A. 1995, Essays Biochem. 30, 133-149.
283. Bennett, G.W., Ballard, T. M., Watson, C. D., Fone, K. C. 1997, Exp. Gerontol. 32, 451-469.
284. Yarbrough, G. G. 1983, Life Sci. 33, 111-118.
285. Faden, A. I., Vink, R., McIntosh, T. K. 1989, Ann. NY Acad. Sci. 553, 380-384.
286. Mellow, A. H., Sunderland, T., Cohen, R. M., Lawlor, B. A., Hill, J. L., Newhouse, P. A., Cohen, M.R., Murphy, D.L. 1989, Psychopharmacology 98, 403-407.
287. Horita, A., Carino, M.A., Zabawska, J., Lai, H. 1989, Peptides 10, 121-124.
288. Horita, A., Carino, M.A., Smith, J. R. 1976, Pharmacol. Biochem. Behav. 5[Suppl. 1], 111-116.
289. Horita, A., Carino, M.A., Lai, H. 1986, Fed. Proc. Fed. Am. Soc. Exp. Biol. 45, 795.
290. Rolka, K., Oslisok, E., Krupa, J., Kruszinsky, M., Baran, L., Przegalinska, E., Kupryszewski, G. 1983, Pol. J. Pharmacol. Pharm. 35, 473-480.
291. Takagi, H., Shiomi, H., Ueda, H., Amano, H. 1979, Nature 282, 410-412.
292. Godlevsky, L. S., Shandra, A. A., Mikhaleva, I. I., Vastyanov, R. S., Mazarati, A.M. 1995, Brain Res. Bull. 37, 223-226.
293. Arima, T., Kitamura, Y., Nishiya, T., Takagi, H., Nomura, Y. 1996, Neurosci. Lett. 212, 1-4.
294. Arima, T., Kitamura, Y., Nishiya, T., Taniguchi, T., Takagi, H., Nomura, Y. 1997, Neurochem. Int. 30, 605-611.
295. Summy-Long, J.Y., Bui, V., Gestl, S., Koehler-Stec, E., Liu, H., Terrell, M.L., Kadekaro, M. 1998, Brain Res. Bull. 45, 395-403.
296. Zincke, T. 1903, Ann. Chem. 330, 361-374.
297. Lettré, H., Haede, W., Ruhbaum, E. 1953, Ann. Chem. 579, 123-132.
298. Génisson, Y., Marazano, C., Mehmandoust, M., Gnecco, D., Das, B. C. 1992, Synlett 1992, 431-434.
299. Rivier, J., Vale, W., Monahan, M., Ling, N., Burgus, R. 1972, J. Med. Chem. 15, 479-482.
300. Wallace, B. M., Lasker, J.S. 1993, Science 260, 912-913.