Effect of a chemical delivery system for]Dexamethasone (Dex-CDS) on peritumoral edema in an experimental brain tumor model

Pharmaceutical Research

Volumn 14, Issue 5, 1997, Pages 672-675

  Siegal, Tali ^a   Soti, Ferenc ^b   Biegon, Anat ^c   Pop, Emil ^b   Brewster, Marcus E ^b,c  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b Pharmos Corporation   (United States)

^c PHARMOS LTD   (Israel)

Author keywords

Blood brain barrier (BBB); Brain tumor; Chemical delivery system (CDS); Dexamethasone; Edema

Indexed keywords

DEXAMETHASONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN TUMOR; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOTRANSFORMATION; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; BRAIN EDEMA; BRAIN NEOPLASMS; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; EVANS BLUE; FEMALE; RATS; RATS, INBRED F344; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030947274     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012173616427     Document Type: Article

References (15)

1. M. R. Fetell and B. M. Stein. In L. P. Rowland (ed.), Merritt's Textbook of Neurology, Lea and Febiger, Philadelphia, 1989, pp. 275-285.
2. N. H. Greig. In E. A. Neuwelt (ed.), Implications of the Blood-Brain Barrier and its Manipulations, Volume 2, Plenum Medical Book Company, New York, 1989, pp. 77-106.
3. G. R. Criscuolo, Yale J. Biol. Med. 66:277-314 (1993).
4. D. E. Weissman and S. A. Grossman. J. Neurosci. Methods 23:207-210 (1988).
5. N. B. Ruderman and T. C. Hall. Cancer 18:298-306 (1965).
6. C. Andersen, J. Astrup, and C. Gyldensted. J. Comput. Assist. Tomogr. 18:509-518 (1994).
7. W. R. Anderson, J. W. Simpkins, M. E. Brewster, and N. S. Bodor. Neumendocrinol. 50:9-16 (1989).
8. N. Bodor, H. Farag and M. Brewster. Science 214:1370-1372 (1981).
9. M. Brewster and N. Bodor. NIDA Res. Monogr. 120:169-201 (1992).
10. M. E. Brewster, W. R. Anderson, J. W. Simpkins, and N. Bodor. Pharm. Res. 5:S-62 (1988).
11. M. Brewster. In: D. Duchene (ed.), New Trends in Cyclodextrins, Editions de Sante Publishers, Paris, 1991, pp. 313-350.
12. T. Siegal, A. Horwitz, and A. Gabizon. J. Neurosurg. 83:1029-1037 (1995).
13. Y. Shoshan and T. Siegal. Neurosurg. 39:1206-1214 (1996).
14. T. Loftsson, M. Brewster, H. Derendorf, and N. Bodor. Pharmazeutische Zeitung-Wissenschaft 4:5-10 (1991).
15. D. G. Waller and C. F. George. Br. J. Clin. Pharmacol. 28:497-507 (1989).