17 β-estradiol attenuates fimbrial lesion-induced decline of ChAT- immunoreactive neurons in the rat medial septum

Experimental Neurology

Volumn 146, Issue 1, 1997, Pages 179-186

  Rabbani, Omid ^a   Panickar, Kiran S ^a   Rajakumar, Gopal ^a   King, Michael A ^a   Bodor, Nicholas ^a   Meyer, Edwin M ^a   Simpkins, James W ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL;

ACETYLCHOLINE BRAIN LEVEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN LEVEL; BRAIN PROTECTION; CHOLINERGIC NERVE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; IMMUNOREACTIVITY; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT;

EID: 0031194114     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6516     Document Type: Article

References (35)

1. 1. Amaral, D. G., and J. Kurz. 1985. An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat. J. Comp. Neurol. 240: 37-59.
2. 2. Armstrong, D. M., R. D. Terry, R. M. Deteresa, G. Bruce, L. B. Hersh, and F. H. Gage. 1987. Response of septal cholinergic neurons to axotomy. J. Comp. Neurol. 264: 421-436.
3. 3. Bishop, J., and J. W. Simpkins. 1994. Estradiol treatment increases viability of glioma and neuroblastoma cells in vitro. Mol. Cell. Neurosci. 5: 303-308.
4. 4. Bodor, N., J. McCornack, and M. E. Brewster. 1987. Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems. Int. J. Pharmacol. 35: 47-59.
5. 5. Brecht, S., A. Martin-Villalba, W. Zuschratter, R. Bravo, and T. Herdegen. 1995. Transection of rat fimbria-fornix induces lasting expression of c-jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitric oxide synthase. Exp. Neurol. 134: 112-125.
6. 6. Coyle, J. T., D. L. Price, and M. R. Delong. 1983. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 219: 1184-1190.
7. NGFR and ChAT expression in the medial septum and diagonal band of Broca. Exp. Neurol. 116: 23-39.
8. 8. Hefti, F. 1986. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci. 6: 2155-2162.
9. 9. Hoffman, D., L. Wahlberg, and P. Aebischer. 1990. NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion. Exp. Neurol. 110: 39-44.
10. 10. Luine, V. N. 1985. Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats. Exp. Neurol. 89: 484-490.
11. 11. Mesulam, M. M., E. J. Mufson, B. H. Wainer, and A. I. Levey. 1983. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10: 1185-1201.
12. 12. Montero, C. N., and F. Hefti. 1988. Rescue of lesioned septal cholinergic neurons by nerve growth factor: Specificity and requirement for chronic treatment. J. Neurosci. 8: 2986-2999.
13. 13. Morse, J. K., S. J. Wiegand, K. Anderson, Y. You, N. Cai, J. Carnahan, J. Miller, P. S. DiStefano, C. A. Altar, R. M. Lindsay, and R. F. Alderson. 1993. Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection. J. Neurosci. 13: 4146-4156.
14. 14. Naumann, T., P. Kermer, and M. Frotscher. 1994. Fine structure of rat septohippocampal neurons. III. Recovery of choline acetyltransferase immunoreactivity after fimbria-fornix transection. J. Comp. Neurol. 350: 161-170.
15. 15. Naumann, T., P. Kermer, V. Seydewitz, R. Ortmann, F. D'Amato, and M. Frotscher. 1994. Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons? Neurosci. Lett. 173: 213-215.
16. 16. O'Brien, T. S., C. N. Svendsen, O. Isacson, and M. V. Sofroniew. 1990. Loss of True blue labelling from the medial septum following transection of the fimbria-fornix: Evidence for the death of cholinergic and non-cholinergic neurons. Brain Res. 508: 249-256.
17. 17. O'Malley, C. A., R. D. Hautamaki, M. Kelley, and E. M. Meyer. 1987. Effects of ovariectomy and estradiol benzoate on high affinity choline uptake, Ach synthesis, and release from rat cerebral cortical synaptosomes. Brain Res. 403: 389-392.
18. 18. Paganini-Hill, A., and V. W. Henderson. 1994. Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 140: 256-261.
19. 19. Paxinos, G., and C. Watson. 1986. The Rat Brain in Stereotaxic Atlas, 2nd ed. Academic Press, London.
20. 20. Peterson, G. M. 1994. Differential projections to the hippocampus by neurons of the medial septum and vertical limb of the diagonal band. Brain Res. 646: 129-134.
21. 21. Peterson, G. M., G. W. Lanford, and E. W. Powell. 1990. Fate of septohippocampal neurons following fimbria-fornix transection: A time course analysis. Brain Res. Bull. 25: 129-137.
22. 22. Rahimy, M. H., N. Bodor, and J. W. Simpkins. 1989. A rapid, sensitive method for the simultaneous quantitation of estradiol and estradiol conjugates in a variety of tissues: Assay development and evaluation of the distribution of a brain-enhanced estradiol-chemical delivery system. J. Steroid Biochem. 33: 179-187.
23. 23. Rahimy, M. H., J. W. Simpkins, and N. Bodor. 1990. Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain. I. Tissue distribution. Pharmacol. Res. 7: 1061-1067.
24. 24. Rye, D. B., B. H. Wainer, M. M. Mesulam, E. J. Mufson, and C. B. Saper. 1984. Cortical projections arising from the basal forebrain: A study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase. Neuroscience 13: 627-643.
25. 25. Singh, M., E. M. Meyer, F. S. Huang, W. J. Millard, and J. W. Simpkins. 1993. Ovariectomy reduces ChAT activity and NGF mRNA levels in the frontal cortex and hippocampus of the female Sprague-Dawley rat. Soc. Neurosci. Abstr. 19: 1254.
26. 26. Singh, M., E. M. Meyer, W. J. Millard, and J. W. Simpkins. 1994. Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Res. 644: 305-312.
27. 27. Singh, M., E. M. Meyer, and J. W. Simpkins. 1995. The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology 136: 2320-2324.
28. 28. Sofroniew, M. V., N. P. Galletly, O. Isacson, and C. N. Svendsen. 1990. Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science 247: 338-342.
29. 29. Sofroniew, M. V., R. C. A. Pearson, and T. P. S. Powell. 1987. The cholinergic nuclei of the basal forebrain of the rat: Normal structure, development and experimentally induced degeneration. Brain Res. 411: 310-331.
30. 30. Sohrabji, F, L. A. Greene, R. C. Miranda, and C. D. Toran-Allerand. 1994. Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J. Neurobiol. 25: 974-88.
31. 31. Swanson, L. W. 1977. The anatomical organization of septohippocampal projections. Ciba Found. Symp. 58: 25-48.
32. 32. Toran-Allerand, D., R. C. Miranda, W. D. L. Bentham, F. Sohrabji, T. J. Brown, R. B. Hochberg, and N. J. MacLusky. 1992. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc. Natl. Acad. Sci. USA 89: 4668-4672.
33. 33. Tuszynski, M. H., D. M. Armstrong, and F. H. Gage. 1990. Basal forebrain cell loss following fimbria/fornix transection. Brain Res. 8: 241-248.
34. 34. Whitehouse, P. J., D. L. Price, R. G. Struble, A. W. Clark, J. T. Coyle, and M. R. DeLong. 1982. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215: 1237-1239.
35. 35. Williams, L. R., S. Varon, G. M. Peterson, K. Wictorin, W. Fischer, A. Bjorklund, and F. H. Gage. 1986. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc. Natl. Acad. Sci. USA 83: 9231-9235.