Synthesis and antiviral activity of N-4'-dihydropyridinyl and dihydroquinolinylcarbonyl-2-hydroxymethyl-5-[cytosin-1'-yl]-1, 3-oxathiolane derivatives against human immunodeficiency virus and duck hepatitis B virus

European Journal of Medicinal Chemistry

Volumn 31, Issue 7-8, 1996, Pages 539-546

  Camplo, M ^a,b   Charvet Faury, A S ^a,b   Borel, C ^b   Turin, F ^b   Hantz, O ^b   Trabaud, C ^a,b   Niddam, V ^a,b   Mourier, N ^a,b   Graciet, J C ^a,b   Chermann, J C ^b   Kraus, J L ^a,b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSERM   (France)

Author keywords

2 Hydroxymethyl 5 cytosin 1' yl 1,3 oxathiolane analogue; Anti HIV activity; Antiviral activity; Duck hepatitis B virus; Prodrug; Pyridinyl derivative; Quinolinyl derivative

Indexed keywords

1,3 OXATHIOLANE DERIVATIVE; ANTIVIRUS AGENT; DIHYDROPYRIDINE DERIVATIVE; DIHYDROQUINOLINE DERIVATIVE; LAMIVUDINE; LAMIVUDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG SYNTHESIS; DUCK; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; LIPOPHILICITY; LIVER CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTITION COEFFICIENT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0029812322     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)89550-X     Document Type: Article

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