In vitro and in vivo evaluations of dihydroquinoline- and dihydroisoquinoline-based targetor moieties for brain-specific chemical delivery systems

Journal of Drug Targeting

Volumn 10, Issue 1, 2002, Pages 63-71

  Bodor, Nicholas ^a   Farag, Hassan H ^a   Barros, M Dulce C ^a   Wu, Whei Mei ^a   Buchwald, Peter ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Brain targeted delivery; Dihydropyridine; Hydrocortisone; Redox; Testosterone

Indexed keywords

1,4 DIHYDROPYRIDINE; ACID; AMIDE; DIHYDROQUINOLINE DERIVATIVE; ESTER DERIVATIVE; HYDROCORTISONE; ISOQUINOLINE DERIVATIVE; TESTOSTERONE;

ACIDITY; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BRAIN TISSUE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TARGETING; HYDRATION; IN VITRO STUDY; IN VIVO STUDY; METABOLISM; MOLECULAR STABILITY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT; SHELF LIFE; TISSUE SPECIFICITY;

ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FERRICYANIDES; HYDROCORTISONE; HYDROGEN PEROXIDE; INDICATORS AND REAGENTS; ISOQUINOLINES; KINETICS; MALE; OXIDANTS; OXIDATION-REDUCTION; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SILVER NITRATE; TESTOSTERONE; TISSUE DISTRIBUTION;

EID: 0036119336     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860290007540     Document Type: Article

References (29)

1. "A study of the primary acid reaction on model compounds of reduced diphosphopyridine nucleotide"
2. "Brain-enhanced delivery of testosterone using a chemical delivery system complexed with 2-hydroxypropyl-β-cyclodextrin"
3. "Redox drug delivery systems for targeting drugs to the brain"
4. "Improved delivery through biological membranes XX: Nicotinamide-dihydronicotinamide based ester-linked redox carrier systems"
5. "Chemical delivery systems"
6. "Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems"
7. "Improved delivery through biological membranes XIV: Brain-specific, sustained delivery of testosterone using a redox chemical delivery system"
8. "Correlation between hydride transfer and one-electron oxidation of dihydropyridines and heterocycles"
9. "Site-specific, sustained release of drugs to the brain"
10. "Reactivity of biologically important reduced pyridines. 4. Effect of substitution on ferricyanide-mediated oxidation rates of various 1,4-dihydropyridines"
11. "Contributions of molecular orbital techniques to the study of dihydropyridines"
12. "Octanol-water partition: Searching for predictive models"
13. "Spontaneous reactions of 1,3-substituted 1,4-dihydropyridines with acids in water at neutrality. II. Nuclear magnetic resonance studies"
14. "AM1: A new general purpose quantum mechanical molecular model"
15. "The chemistry of dihydropyridines"
16. "Acid-catalyzed hydration of reduced nicotinamide adenine-dinucleotide and its analogs"
17. "Direct determination of C-protonation and hydrolysis rates in enamines - Application to ethyl β-cyanomethylaminocrotonate"
18. "Conductor-like screening model for real solvents - A new approach to the quantitative calculation of solvation phenomena"
19. "Reduced quinolines and quinolinium compounds I. Reduction of quinoline analogs of model compounds for coenzyme I"
20. "N-methylpyrrolidone as solvent for reaction of aryl halides with cuprous cyanide"
21. "Brain-specific chemical delivery system of β-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin"
22. "A dihydroisoquinoline targetor-based acid resistant chemical delivery system of azidothymidine (AZT)"
23. "Substituent effects on the stability of 1,4-dihydropyridines"
24. "Targeting drugs to the brain by redox chemical delivery systems"
25. "Coenzyme models.16. Studies of general-acid catalysis in the NADH model reduction"
26. "Targeted drug delivery to the brain via phosphonate derivatives I. Design, synthesis, and evaluation of an anionic chemical delivery system for testosterone"
27. "Recent advances in the chemistry of dihydropyridines"
28. "Obtainment of a stable cyclic enamine during borohydride reduction of an isoquinoleinium salt substituted at 4-position"
29. "Brain-specific chemical delivery systems for β-lactam antibiotics in vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats"