-
1
-
-
84973436381
-
Flaviviridae
-
In Knipe DM, Howley PM (ed),6th ed, vol . Lippincott Williams & Wilkins, Philadelphia, PA
-
Lindenbach BD, Murray CL, Thiel HJ, Rice CM. 2013. Flaviviridae, p 712-746. In Knipe DM, Howley PM (ed), Fields virology, 6th ed, vol 1. Lippincott Williams & Wilkins, Philadelphia, PA.
-
(2013)
Fields virology
, vol.1
, pp. 712-746
-
-
Lindenbach, B.D.1
Murray, C.L.2
Thiel, H.J.3
Rice, C.M.4
-
2
-
-
25844523297
-
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
-
Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M, Murphy DG, Okamoto H, Pawlotsky JM, Penin F, Sablon E, Shin IT, Stuyver LJ, Thiel HJ, Viazov S, Weiner AJ, Widell A. 2005. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42:962-973. http://dx.doi.org/10.1002/hep.20819.
-
(2005)
Hepatology
, vol.42
, pp. 962-973
-
-
Simmonds, P.1
Bukh, J.2
Combet, C.3
Deleage, G.4
Enomoto, N.5
Feinstone, S.6
Halfon, P.7
Inchauspe, G.8
Kuiken, C.9
Maertens, G.10
Mizokami, M.11
Murphy, D.G.12
Okamoto, H.13
Pawlotsky, J.M.14
Penin, F.15
Sablon, E.16
Shin, I.T.17
Stuyver, L.J.18
Thiel, H.J.19
Viazov, S.20
Weiner, A.J.21
Widell, A.22
more..
-
3
-
-
84855544169
-
An updated analysis of hepatitisCvirus genotypes and subtypes based on the complete coding region
-
Nakano T, Lau GM, Lau GM, Sugiyama M, Mizokami M. 2012. An updated analysis of hepatitisCvirus genotypes and subtypes based on the complete coding region. Liver Int. 32:339-345. http://dx.doi.org/10 .1111/j.1478-3231.2011.02684.x.
-
(2012)
Liver Int.
, vol.32
, pp. 339-345
-
-
Nakano, T.1
Lau, G.M.2
Lau, G.M.3
Sugiyama, M.4
Mizokami, M.5
-
4
-
-
11144246127
-
Novel insights into hepatitis C virus replication and persistence
-
Bartenschlager R, Frese M, Pietschmann T. 2004. Novel insights into hepatitis C virus replication and persistence. Adv. Virus Res. 63:71-180. http://dx.doi.org/10.1016/S0065-3527(04)63002-8.
-
(2004)
Adv. Virus Res.
, vol.63
, pp. 71-180
-
-
Bartenschlager, R.1
Frese, M.2
Pietschmann, T.3
-
5
-
-
0028831056
-
Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing
-
Tanji Y, Hijikata M, Satoh S, Kaneko T, Shimotohno K. 1995. Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J. Virol. 69:1575-1581.
-
(1995)
J. Virol.
, vol.69
, pp. 1575-1581
-
-
Tanji, Y.1
Hijikata, M.2
Satoh, S.3
Kaneko, T.4
Shimotohno, K.5
-
6
-
-
0242456017
-
Subcellular localization, stability, and transcleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines
-
Wölk B, Sansonno D, Kräusslich HG, Dammacco F, Rice CM, Blum HE, Moradpour D. 2000. Subcellular localization, stability, and transcleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines. J. Virol. 74:2293-2304. http: //dx.doi.org/10.1128/JVI.74.5.2293-2304.2000.
-
(2000)
J. Virol.
, vol.74
, pp. 2293-2304
-
-
Wölk, B.1
Sansonno, D.2
Kräusslich, H.G.3
Dammacco, F.4
Rice, C.M.5
Blum, H.E.6
Moradpour, D.7
-
7
-
-
19944386940
-
Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein
-
Gosert R, Jendrsczok W, Berke JM, Brass V, Blum HE, Moradpour D. 2005. Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein. J. Virol. 79:7911-7917. http://dx.doi.org/10.1128/JVI.79.12.7911 -7917.2005.
-
(2005)
J. Virol.
, vol.79
, pp. 7911-7917
-
-
Gosert, R.1
Jendrsczok, W.2
Berke, J.M.3
Brass, V.4
Blum, H.E.5
Moradpour, D.6
-
8
-
-
55749102288
-
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
-
Brass V, Berke JM, Montserret R, Blum HE, Penin F, Moradpour D. 2008. Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex. Proc. Natl. Acad. Sci. U. S. A. 105:14545-14550. http://dx.doi.org/10.1073/pnas.0807298105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14545-14550
-
-
Brass, V.1
Berke, J.M.2
Montserret, R.3
Blum, H.E.4
Penin, F.5
Moradpour, D.6
-
9
-
-
0028290579
-
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
-
Failla C, Tomei L, De Francesco R. 1994. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J. Virol. 68:3753-3760.
-
(1994)
J. Virol.
, vol.68
, pp. 3753-3760
-
-
Failla, C.1
Tomei, L.2
De Francesco, R.3
-
10
-
-
0029074519
-
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
-
Lin C, Thomson JA, Rice CM. 1995. A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J. Virol. 69:4373-4380.
-
(1995)
J. Virol.
, vol.69
, pp. 4373-4380
-
-
Lin, C.1
Thomson, J.A.2
Rice, C.M.3
-
11
-
-
16044364658
-
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
-
Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA. 1996. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 87:343-355. http://dx.doi.org/10.1016 /S0092-8674(00)81351-3.
-
(1996)
Cell
, vol.87
, pp. 343-355
-
-
Kim, J.L.1
Morgenstern, K.A.2
Lin, C.3
Fox, T.4
Dwyer, M.D.5
Landro, J.A.6
Chambers, S.P.7
Markland, W.8
Lepre, C.A.9
O'Malley, E.T.10
Harbeson, S.L.11
Rice, C.M.12
Murcko, M.A.13
Caron, P.R.14
Thomson, J.A.15
-
12
-
-
0028096675
-
Production of two phosphoproteins from the NS5A region of the hepatitisCviral genome
-
Kaneko T, Tanji Y, Satoh S, Hijikata M, Asabe S, Kimura K, Shimotohno K. 1994. Production of two phosphoproteins from the NS5A region of the hepatitisCviral genome. Biochem. Biophys. Res. Commun. 205:320-326. http://dx.doi.org/10.1006/bbrc.1994.2667.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.205
, pp. 320-326
-
-
Kaneko, T.1
Tanji, Y.2
Satoh, S.3
Hijikata, M.4
Asabe, S.5
Kimura, K.6
Shimotohno, K.7
-
13
-
-
0031060172
-
The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation
-
Asabe SI, Tanji Y, Satoh S, Kaneko T, Kimura K, Shimotohno K. 1997. The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation. J. Virol. 71:790-796.
-
(1997)
J. Virol.
, vol.71
, pp. 790-796
-
-
Asabe, S.I.1
Tanji, Y.2
Satoh, S.3
Kaneko, T.4
Kimura, K.5
Shimotohno, K.6
-
14
-
-
34548188701
-
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication
-
Lindenbach BD, Prágai BM, Montserret R, Beran RK, Pyle AM, Penin F, Rice CM. 2007. The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication. J. Virol. 81:8905-8918. http://dx.doi.org/10.1128/JVI.00937-07.
-
(2007)
J. Virol.
, vol.81
, pp. 8905-8918
-
-
Lindenbach, B.D.1
Prágai, B.M.2
Montserret, R.3
Beran, R.K.4
Pyle, A.M.5
Penin, F.6
Rice, C.M.7
-
15
-
-
78651399012
-
The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly
-
Phan T, Kohlway A, Dimberu P, Pyle AM, Lindenbach BD. 2011. The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. J. Virol. 85:1193-1204. http://dx.doi.org/10 .1128/JVI.01889-10.
-
(2011)
J. Virol.
, vol.85
, pp. 1193-1204
-
-
Phan, T.1
Kohlway, A.2
Dimberu, P.3
Pyle, A.M.4
Lindenbach, B.D.5
-
16
-
-
0030860853
-
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
-
Lin C, Wu JW, Hsiao K, Su MS. 1997. The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins. J. Virol. 71: 6465-6471.
-
(1997)
J. Virol.
, vol.71
, pp. 6465-6471
-
-
Lin, C.1
Wu, J.W.2
Hsiao, K.3
Su, M.S.4
-
17
-
-
0033978737
-
A genomic approach of the hepatitis C virus generates a protein interaction map
-
Flajolet M, Rotondo G, Daviet L, Bergametti F, Inchauspe G, Tiollais P, Transy C, Legrain P. 2000. A genomic approach of the hepatitis C virus generates a protein interaction map. Gene 242:369-379. http://dx .doi.org/10.1016/S0378-1119(99)00511-9.
-
(2000)
Gene
, vol.242
, pp. 369-379
-
-
Flajolet, M.1
Rotondo, G.2
Daviet, L.3
Bergametti, F.4
Inchauspe, G.5
Tiollais, P.6
Transy, C.7
Legrain, P.8
-
18
-
-
78951472458
-
Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes
-
Stapleford KA, Lindenbach BD. 2011. Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J. Virol. 85: 1706-1717. http://dx.doi.org/10.1128/JVI.02268-10.
-
(2011)
J. Virol.
, vol.85
, pp. 1706-1717
-
-
Stapleford, K.A.1
Lindenbach, B.D.2
-
19
-
-
0032489233
-
Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus
-
Ishido S, Fujita T, Hotta H. 1998. Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus. Biochem. Biophys. Res. Commun. 244:35-40. http://dx.doi.org/10.1006/bbrc.1998.8202.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.244
, pp. 35-40
-
-
Ishido, S.1
Fujita, T.2
Hotta, H.3
-
20
-
-
0036891628
-
Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
-
Florese RH, Nagano-Fujii M, Iwanaga Y, Hidajat R, Hotta H. 2002. Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus. Virus Res. 90:119-131. http://dx.doi.org/10 .1016/S0168-1702(02)00146-6.
-
(2002)
Virus Res.
, vol.90
, pp. 119-131
-
-
Florese, R.H.1
Nagano-Fujii, M.2
Iwanaga, Y.3
Hidajat, R.4
Hotta, H.5
-
21
-
-
0036139053
-
Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo
-
Kato J, Kato N, Yoshida H, Ono-Nita SK, Shiratori Y, Omata M. 2002. Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo. J. Med. Virol. 66:187-199. http://dx.doi.org/10.1002/jmv.2129.
-
(2002)
J. Med. Virol.
, vol.66
, pp. 187-199
-
-
Kato, J.1
Kato, N.2
Yoshida, H.3
Ono-Nita, S.K.4
Shiratori, Y.5
Omata, M.6
-
22
-
-
33845433207
-
Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A
-
Kou YH, Chou SM, Wang YM, Chang YT, Huang SY, Jung MY, Huang YH, Chen MR, Chang MF, Chang SC. 2006. Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A. J. Biomed. Sci. 13:861-874. http://dx.doi.org/10.1007/s11373-006-9104-8.
-
(2006)
J. Biomed. Sci.
, vol.13
, pp. 861-874
-
-
Kou, Y.H.1
Chou, S.M.2
Wang, Y.M.3
Chang, Y.T.4
Huang, S.Y.5
Jung, M.Y.6
Huang, Y.H.7
Chen, M.R.8
Chang, M.F.9
Chang, S.C.10
-
23
-
-
14544280209
-
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
-
Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Jr, Lemon SM. 2005. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. U. S. A. 102:2992-2997. http://dx.doi .org/10.1073/pnas.0408824102.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 2992-2997
-
-
Li, K.1
Foy, E.2
Ferreon, J.C.3
Nakamura, M.4
Ferreon, A.C.5
Ikeda, M.6
Ray, S.C.7
Gale, M.8
Lemon, S.M.9
-
24
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167- 1172. http://dx.doi.org/10.1038/nature04193.
-
(2005)
Nature
, vol.437
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
Bartenschlager, R.6
Tschopp, J.7
-
25
-
-
38049184252
-
Regulation of innate immunity against hepatitis C virus infection
-
Saito T, Gale M, Jr. 2008. Regulation of innate immunity against hepatitis C virus infection. Hepatol. Res. 38:115-122.
-
(2008)
Hepatol. Res.
, vol.38
, pp. 115-122
-
-
Saito, T.1
Gale, M.2
-
26
-
-
65349178926
-
Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein
-
Hara H, Aizaki H, Matsuda M, Shinkai-Ouchi F, Inoue Y, Murakami K, Shoji I, Kawakami H, Matsuura Y, Lai MM, Miyamura T, Wakita T, Suzuki T. 2009. Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein. J. Virol. 83:5137-5147. http://dx.doi.org/10.1128/JVI.02179-08.
-
(2009)
J. Virol.
, vol.83
, pp. 5137-5147
-
-
Hara, H.1
Aizaki, H.2
Matsuda, M.3
Shinkai-Ouchi, F.4
Inoue, Y.5
Murakami, K.6
Shoji, I.7
Kawakami, H.8
Matsuura, Y.9
Lai, M.M.10
Miyamura, T.11
Wakita, T.12
Suzuki, T.13
-
27
-
-
0037404536
-
Protein-protein interactions between hepatitis C virus nonstructural proteins
-
Dimitrova M, Imbert I, Kieny MP, Schuster C. 2003. Protein-protein interactions between hepatitis C virus nonstructural proteins. J. Virol. 77:5401-5414. http://dx.doi.org/10.1128/JVI.77.9.5401-5414.2003.
-
(2003)
J. Virol.
, vol.77
, pp. 5401-5414
-
-
Dimitrova, M.1
Imbert, I.2
Kieny, M.P.3
Schuster, C.4
-
28
-
-
55549117151
-
Hepatitis C virus infection protein network
-
de Chassey B, Navratil V, Tafforeau L, Hiet MS, Aublin-Gex A, Agaugue S, Meiffren G, Pradezynski F, Faria BF, Chantier T, Le Breton M, Pellet J, Davoust N, Mangeot PE, Chaboud A, Penin F, Jacob Y, Vidalain PO, Vidal M, Andre P, Rabourdin-Combe C, Lotteau V. 2008. Hepatitis C virus infection protein network. Mol. Syst. Biol. 4:230. http://dx.doi.org/10.1038/msb.2008.66.
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 230
-
-
de Chassey, B.1
Navratil, V.2
Tafforeau, L.3
Hiet, M.S.4
Aublin-Gex, A.5
Agaugue, S.6
Meiffren, G.7
Pradezynski, F.8
Faria, B.F.9
Chantier, T.10
Le Breton, M.11
Pellet, J.12
Davoust, N.13
Mangeot, P.E.14
Chaboud, A.15
Penin, F.16
Jacob, Y.17
Vidalain, P.O.18
Vidal, M.19
Andre, P.20
Rabourdin-Combe, C.21
Lotteau, V.22
more..
-
29
-
-
0030979410
-
Structure of the hepatitisCvirusRNAhelicase domain
-
Yao N, Hesson T, Cable M, Hong Z, Kwong AD, Le HV, Weber PC. 1997. Structure of the hepatitisCvirusRNAhelicase domain. Nat. Struct. Biol. 4:463-467. http://dx.doi.org/10.1038/nsb0697-463.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 463-467
-
-
Yao, N.1
Hesson, T.2
Cable, M.3
Hong, Z.4
Kwong, A.D.5
Le, H.V.6
Weber, P.C.7
-
30
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
Lesburg CA, Cable MB, Ferrari E, Hong Z, Mannarino AF, Weber PC. 1999. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat. Struct. Biol. 6:937-943. http://dx.doi.org/10.1038/13305.
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
31
-
-
19644393931
-
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
-
Tellinghuisen TL, Marcotrigiano J, Rice CM. 2005. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 435:374-379. http://dx.doi.org/10.1038/nature03580.
-
(2005)
Nature
, vol.435
, pp. 374-379
-
-
Tellinghuisen, T.L.1
Marcotrigiano, J.2
Rice, C.M.3
-
32
-
-
66149115122
-
Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitisCvirus
-
Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN. 2009. Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitisCvirus. J. Virol. 83:4395-4403. http://dx.doi.org/10.1128/JVI.02352 -08.
-
(2009)
J. Virol.
, vol.83
, pp. 4395-4403
-
-
Love, R.A.1
Brodsky, O.2
Hickey, M.J.3
Wells, P.A.4
Cronin, C.N.5
-
33
-
-
78751584740
-
Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV
-
Appleby TC, Anderson R, Fedorova O, Pyle AM, Wang R, Liu X, Brendza KM, Somoza JR. 2011. Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV. J. Mol. Biol. 405:1139-1153. http://dx.doi.org/10.1016/j.jmb.2010.11.034.
-
(2011)
J. Mol. Biol.
, vol.405
, pp. 1139-1153
-
-
Appleby, T.C.1
Anderson, R.2
Fedorova, O.3
Pyle, A.M.4
Wang, R.5
Liu, X.6
Brendza, K.M.7
Somoza, J.R.8
-
34
-
-
0036100578
-
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
-
Egger D, Wölk B, Gosert R, Bianchi L, Blum HE, Moradpour D, Bienz K. 2002. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J. Virol. 76: 5974-5984. http://dx.doi.org/10.1128/JVI.76.12.5974-5984.2002.
-
(2002)
J. Virol.
, vol.76
, pp. 5974-5984
-
-
Egger, D.1
Wölk, B.2
Gosert, R.3
Bianchi, L.4
Blum, H.E.5
Moradpour, D.6
Bienz, K.7
-
35
-
-
0345144016
-
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons
-
Gosert R, Egger D, Lohmann V, Bartenschlager R, Blum HE, Bienz K, Moradpour D. 2003. Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J. Virol. 77:5487-5492. http://dx.doi.org/10.1128/JVI.77.9.5487-5492.2003.
-
(2003)
J. Virol.
, vol.77
, pp. 5487-5492
-
-
Gosert, R.1
Egger, D.2
Lohmann, V.3
Bartenschlager, R.4
Blum, H.E.5
Bienz, K.6
Moradpour, D.7
-
36
-
-
27144513392
-
Quantitative analysis of the hepatitis C virus replication complex
-
Quinkert D, Bartenschlager R, Lohmann V. 2005. Quantitative analysis of the hepatitis C virus replication complex. J. Virol. 79:13594-13605. http://dx.doi.org/10.1128/JVI.79.21.13594-13605.2005.
-
(2005)
J. Virol.
, vol.79
, pp. 13594-13605
-
-
Quinkert, D.1
Bartenschlager, R.2
Lohmann, V.3
-
37
-
-
77957957374
-
Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNAdependent RNA polymerase
-
Brass V, Gouttenoire J, Wahl A, Pal Z, Blum HE, Penin F, Moradpour D. 2010. Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNAdependent RNA polymerase. J. Virol. 84:11580-11584. http://dx.doi.org /10.1128/JVI.01519-10.
-
(2010)
J. Virol.
, vol.84
, pp. 11580-11584
-
-
Brass, V.1
Gouttenoire, J.2
Wahl, A.3
Pal, Z.4
Blum, H.E.5
Penin, F.6
Moradpour, D.7
-
38
-
-
0037474296
-
GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane
-
Schneider D, Engelman DM. 2003. GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane. J. Biol. Chem. 278:3105-3111. http://dx.doi.org/10.1074/jbc.M206287200.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3105-3111
-
-
Schneider, D.1
Engelman, D.M.2
-
39
-
-
5144227144
-
Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions
-
Schneider D, Engelman DM. 2004. Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J. Mol. Biol. 343:799-804. http://dx.doi.org/10.1016/j.jmb.2004.08.083.
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 799-804
-
-
Schneider, D.1
Engelman, D.M.2
-
40
-
-
33646078118
-
The stability of transmembrane helix interactions measured in a biological membrane
-
Finger C, Volkmer T, Prodohl A, Otzen DE, Engelman DM, Schneider D. 2006. The stability of transmembrane helix interactions measured in a biological membrane. J. Mol. Biol. 358:1221-1228. http://dx.doi.org /10.1016/j.jmb.2006.02.065.
-
(2006)
J. Mol. Biol.
, vol.358
, pp. 1221-1228
-
-
Finger, C.1
Volkmer, T.2
Prodohl, A.3
Otzen, D.E.4
Engelman, D.M.5
Schneider, D.6
-
41
-
-
0031908629
-
A new LexA-based genetic system for monitoring and analyzing protein heterodimerization in Escherichia coli
-
Dmitrova M, Younes-Cauet G, Oertel-Buchheit P, Porte D, Schnarr M, Granger-Schnarr M. 1998. A new LexA-based genetic system for monitoring and analyzing protein heterodimerization in Escherichia coli. Mol. Gen. Genet. 257:205-212. http://dx.doi.org/10.1007 /s004380050640.
-
(1998)
Mol. Gen. Genet.
, vol.257
, pp. 205-212
-
-
Dmitrova, M.1
Younes-Cauet, G.2
Oertel-Buchheit, P.3
Porte, D.4
Schnarr, M.5
Granger-Schnarr, M.6
-
42
-
-
0029143698
-
Fos leucine zipper variants with increased association capacity
-
Porte D, Oertel-Buchheit P, Granger-Schnarr M, Schnarr M. 1995. Fos leucine zipper variants with increased association capacity. J. Biol. Chem. 270:22721-22730. http://dx.doi.org/10.1074/jbc.270.39.22721.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22721-22730
-
-
Porte, D.1
Oertel-Buchheit, P.2
Granger-Schnarr, M.3
Schnarr, M.4
-
43
-
-
0033514311
-
TOXCAT: a measure of transmembrane helix association in a biological membrane
-
Russ WP, Engelman DM. 1999. TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc. Natl. Acad. Sci. U. S. A. 96:863-868. http://dx.doi.org/10.1073/pnas.96.3.863.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 863-868
-
-
Russ, W.P.1
Engelman, D.M.2
-
44
-
-
0029115282
-
Membrane insertion of the bacterial signal transduction protein ToxR and requirements of transcription activation studied by modular replacement of different protein substructures
-
Kolmar H, Hennecke F, Gotze K, Janzer B, Vogt B, Mayer F, Fritz HJ. 1995. Membrane insertion of the bacterial signal transduction protein ToxR and requirements of transcription activation studied by modular replacement of different protein substructures. EMBO J. 14:3895-3904.
-
(1995)
EMBO J.
, vol.14
, pp. 3895-3904
-
-
Kolmar, H.1
Hennecke, F.2
Gotze, K.3
Janzer, B.4
Vogt, B.5
Mayer, F.6
Fritz, H.J.7
-
45
-
-
0028951388
-
Analysis of Vibrio cholerae ToxR function by construction of novel fusion proteins
-
Ottemann KM, Mekalanos JJ. 1995. Analysis of Vibrio cholerae ToxR function by construction of novel fusion proteins. Mol. Microbiol. 15: 719-731.
-
(1995)
Mol. Microbiol.
, vol.15
, pp. 719-731
-
-
Ottemann, K.M.1
Mekalanos, J.J.2
-
46
-
-
0030575833
-
Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator
-
Langosch D, Brosig B, Kolmar H, Fritz HJ. 1996. Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator. J. Mol. Biol. 263:525-530. http://dx.doi .org/10.1006/jmbi.1996.0595.
-
(1996)
J. Mol. Biol.
, vol.263
, pp. 525-530
-
-
Langosch, D.1
Brosig, B.2
Kolmar, H.3
Fritz, H.J.4
-
47
-
-
0030059639
-
The ToxR protein of Vibrio cholerae forms homodimers and heterodimers
-
Ottemann KM, Mekalanos JJ. 1996. The ToxR protein of Vibrio cholerae forms homodimers and heterodimers. J. Bacteriol. 178:156-162.
-
(1996)
J. Bacteriol.
, vol.178
, pp. 156-162
-
-
Ottemann, K.M.1
Mekalanos, J.J.2
-
48
-
-
80054762434
-
Multi-Tox: application of the ToxRtranscriptional reporter assay to the study of multi-pass protein transmembrane domain oligomerization
-
Joce C, Wiener AA, Yin H. 2011. Multi-Tox: application of the ToxRtranscriptional reporter assay to the study of multi-pass protein transmembrane domain oligomerization. Biochim. Biophys. Acta 1808: 2948-2953. http://dx.doi.org/10.1016/j.bbamem.2011.07.008.
-
(2011)
Biochim. Biophys. Acta
, vol.1808
, pp. 2948-2953
-
-
Joce, C.1
Wiener, A.A.2
Yin, H.3
-
49
-
-
0017251379
-
Subunit structure of human erythrocyte glycophorin A
-
Furthmayr H, Marchesi VT. 1976. Subunit structure of human erythrocyte glycophorin A. Biochemistry 15:1137-1144. http://dx.doi.org/10 .1021/bi00650a028.
-
(1976)
Biochemistry
, vol.15
, pp. 1137-1144
-
-
Furthmayr, H.1
Marchesi, V.T.2
-
50
-
-
0027050182
-
Sequence specificity in the dimerization of transmembrane alpha-helices
-
Lemmon MA, Flanagan JM, Treutlein HR, Zhang J, Engelman DM. 1992. Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry 31:12719-12725. http://dx.doi.org/10.1021/bi00166a002.
-
(1992)
Biochemistry
, vol.31
, pp. 12719-12725
-
-
Lemmon, M.A.1
Flanagan, J.M.2
Treutlein, H.R.3
Zhang, J.4
Engelman, D.M.5
-
51
-
-
0030777759
-
The effect of point mutations on the free energy of transmembrane alpha-helix dimerization
-
Fleming KG, Ackerman AL, Engelman DM. 1997. The effect of point mutations on the free energy of transmembrane alpha-helix dimerization. J. Mol. Biol. 272:266-275. http://dx.doi.org/10.1006/jmbi.1997 .1236.
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 266-275
-
-
Fleming, K.G.1
Ackerman, A.L.2
Engelman, D.M.3
-
52
-
-
0030932407
-
A transmembrane helix dimer: structure and implications
-
MacKenzie KR, Prestegard JH, Engelman DM. 1997. A transmembrane helix dimer: structure and implications. Science 276:131-133. http://dx .doi.org/10.1126/science.276.5309.131.
-
(1997)
Science
, vol.276
, pp. 131-133
-
-
MacKenzie, K.R.1
Prestegard, J.H.2
Engelman, D.M.3
-
53
-
-
77955656071
-
The membrane environment modulates self-association of the human GpA TM domain-implications for membrane protein folding and transmembrane signaling
-
Anbazhagan V, Schneider D. 2010. The membrane environment modulates self-association of the human GpA TM domain-implications for membrane protein folding and transmembrane signaling. Biochim. Biophys. Acta 1798:1899-1907. http://dx.doi.org/10.1016/j.bbamem.2010 .06.027.
-
(2010)
Biochim. Biophys. Acta
, vol.1798
, pp. 1899-1907
-
-
Anbazhagan, V.1
Schneider, D.2
-
54
-
-
0031956790
-
The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues
-
Brosig B, Langosch D. 1998. The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues. Protein Sci. 7:1052-1056.
-
(1998)
Protein Sci.
, vol.7
, pp. 1052-1056
-
-
Brosig, B.1
Langosch, D.2
-
55
-
-
0034711953
-
The GxxxG motif: a framework for transmembrane helix-helix association
-
Russ WP, Engelman DM. 2000. The GxxxG motif: a framework for transmembrane helix-helix association. J. Mol. Biol. 296:911-919. http: //dx.doi.org/10.1006/jmbi.1999.3489.
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 911-919
-
-
Russ, W.P.1
Engelman, D.M.2
-
56
-
-
0037076540
-
GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles
-
Kleiger G, Grothe R, Mallick P, Eisenberg D. 2002. GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles. Biochemistry 41:5990-5997. http://dx.doi.org/10 .1021/bi0200763.
-
(2002)
Biochemistry
, vol.41
, pp. 5990-5997
-
-
Kleiger, G.1
Grothe, R.2
Mallick, P.3
Eisenberg, D.4
-
57
-
-
1942469334
-
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication
-
Melnyk RA, Kim S, Curran AR, Engelman DM, Bowie JU, Deber CM. 2004. The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J. Biol. Chem. 279: 16591-16597. http://dx.doi.org/10.1074/jbc.M313936200.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16591-16597
-
-
Melnyk, R.A.1
Kim, S.2
Curran, A.R.3
Engelman, D.M.4
Bowie, J.U.5
Deber, C.M.6
-
58
-
-
0034711958
-
Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions
-
Senes A, Gerstein M, Engelman DM. 2000. Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. J. Mol. Biol. 296:921-936. http://dx.doi.org/10.1006/jmbi .1999.3488.
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 921-936
-
-
Senes, A.1
Gerstein, M.2
Engelman, D.M.3
-
59
-
-
0037085373
-
The single transmembrane domains of ErbB receptors self-associate in cell membranes
-
Mendrola JM, Berger MB, King MC, Lemmon MA. 2002. The single transmembrane domains of ErbB receptors self-associate in cell membranes. J. Biol. Chem. 277:4704-4712. http://dx.doi.org/10.1074/jbc .M108681200.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 4704-4712
-
-
Mendrola, J.M.1
Berger, M.B.2
King, M.C.3
Lemmon, M.A.4
-
60
-
-
0035979146
-
The Calpha- H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions
-
Senes A, Ubarretxena-Belandia I, Engelman DM. 2001. The Calpha- H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc. Natl. Acad. Sci. U. S. A. 98:9056- 9061. http://dx.doi.org/10.1073/pnas.161280798.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
-
-
Senes, A.1
Ubarretxena-Belandia, I.2
Engelman, D.M.3
-
61
-
-
84859742466
-
Unipro UGENE: a unified bioinformatics toolkit
-
UGENE team.
-
Okonechnikov K, Golosova O, Fursov M; UGENE team. 2012. Unipro UGENE: a unified bioinformatics toolkit. Bioinformatics 28:1166-1167. http://dx.doi.org/10.1093/bioinformatics/bts091.
-
(2012)
Bioinformatics
, vol.28
, pp. 1166-1167
-
-
Okonechnikov, K.1
Golosova, O.2
Fursov, M.3
-
62
-
-
0029019484
-
Control of the Escherichia coli rrnB P1 promoter strength by ppGpp
-
Zhang X, Bremer H. 1995. Control of the Escherichia coli rrnB P1 promoter strength by ppGpp. J. Biol. Chem. 270:11181-11189. http://dx .doi.org/10.1074/jbc.270.19.11181.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11181-11189
-
-
Zhang, X.1
Bremer, H.2
-
63
-
-
0020042649
-
Filamentous phage pre-coat is an integral membrane protein: analysis by a new method of membrane preparation
-
Russel M, Model P. 1982. Filamentous phage pre-coat is an integral membrane protein: analysis by a new method of membrane preparation. Cell 28:177-184. http://dx.doi.org/10.1016/0092-8674(82)90387-7.
-
(1982)
Cell
, vol.28
, pp. 177-184
-
-
Russel, M.1
Model, P.2
-
64
-
-
73349087177
-
The single transmembrane domains of human receptor tyrosine kinases encode self-interactions
-
Finger C, Escher C, Schneider D. 2009. The single transmembrane domains of human receptor tyrosine kinases encode self-interactions. Sci. Signal. 2:ra56. http://dx.doi.org/10.1126/scisignal.2000547.
-
(2009)
Sci. Signal.
, vol.2
-
-
Finger, C.1
Escher, C.2
Schneider, D.3
-
65
-
-
0029557910
-
Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban
-
Adams PD, Arkin IT, Engelman DM, Brunger AT. 1995. Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban. Nat. Struct. Biol. 2:154- 162. http://dx.doi.org/10.1038/nsb0295-154.
-
(1995)
Nat. Struct. Biol.
, vol.2
-
-
Adams, P.D.1
Arkin, I.T.2
Engelman, D.M.3
Brunger, A.T.4
-
66
-
-
0029847652
-
Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching
-
Adams PD, Engelman DM, Brunger AT. 1996. Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching. Proteins 26:257-261. http: //dx.doi.org/10.1002/(SICI)1097-0134(199611)26:3257::AID-PROT23 .0.CO;2-B.
-
(1996)
Proteins
, vol.26
, pp. 257-261
-
-
Adams, P.D.1
Engelman, D.M.2
Brunger, A.T.3
-
68
-
-
74249090260
-
Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: four approaches that performed well in CASP8
-
Krieger E, Joo K, Lee J, Lee J, Raman S, Thompson J, Tyka M, Baker D, Karplus K. 2009. Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: four approaches that performed well in CASP8. Proteins 77(Suppl 9):114-122. http://dx.doi.org /10.1002/prot.22570.
-
(2009)
Proteins
, vol.77
, Issue.SUPPL. 9
, pp. 114-122
-
-
Krieger, E.1
Joo, K.2
Lee, J.3
Lee, J.4
Raman, S.5
Thompson, J.6
Tyka, M.7
Baker, D.8
Karplus, K.9
-
69
-
-
33847233683
-
How important are transmembrane helices of bitopic membrane proteins? Biochim
-
Zviling M, Kochva U, Arkin IT. 2007. How important are transmembrane helices of bitopic membrane proteins? Biochim. Biophys. Acta 1768:387-392. http://dx.doi.org/10.1016/j.bbamem.2006.11.019.
-
(2007)
Biophys. Acta
, vol.1768
, pp. 387-392
-
-
Zviling, M.1
Kochva, U.2
Arkin, I.T.3
-
70
-
-
3843102625
-
Sequence context modulates the stability of a GxxxG-mediated transmembrane helix-helix dimer
-
Doura AK, Kobus FJ, Dubrovsky L, Hibbard E, Fleming KG. 2004. Sequence context modulates the stability of a GxxxG-mediated transmembrane helix-helix dimer. J. Mol. Biol. 341:991-998. http://dx.doi .org/10.1016/j.jmb.2004.06.042.
-
(2004)
J. Mol. Biol.
, vol.341
, pp. 991-998
-
-
Doura, A.K.1
Kobus, F.J.2
Dubrovsky, L.3
Hibbard, E.4
Fleming, K.G.5
-
71
-
-
0344687314
-
Side-chain contributions to membrane protein structure and stability
-
Faham S, Yang D, Bare E, Yohannan S, Whitelegge JP, Bowie JU. 2004. Side-chain contributions to membrane protein structure and stability. J. Mol. Biol. 335:297-305. http://dx.doi.org/10.1016/j.jmb.2003.10.041.
-
(2004)
J. Mol. Biol.
, vol.335
, pp. 297-305
-
-
Faham, S.1
Yang, D.2
Bare, E.3
Yohannan, S.4
Whitelegge, J.P.5
Bowie, J.U.6
-
72
-
-
0031740601
-
Hydrophobic interactions of peptides with membrane interfaces
-
White SH, Wimley WC. 1998. Hydrophobic interactions of peptides with membrane interfaces. Biochim. Biophys. Acta 1376:339-352. http: //dx.doi.org/10.1016/S0304-4157(98)00021-5.
-
(1998)
Biochim. Biophys. Acta
, vol.1376
, pp. 339-352
-
-
White, S.H.1
Wimley, W.C.2
-
73
-
-
0033609498
-
The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane
-
Braun P, von Heijne G. 1999. The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane. Biochemistry 38:9778-9782. http://dx.doi.org/10 .1021/bi990923a.
-
(1999)
Biochemistry
, vol.38
, pp. 9778-9782
-
-
Braun, P.1
von Heijne, G.2
-
74
-
-
6344236852
-
Complex interactions at the helix-helix interface stabilize the glycophorin A transmembrane dimer
-
Doura AK, Fleming KG. 2004. Complex interactions at the helix-helix interface stabilize the glycophorin A transmembrane dimer. J. Mol. Biol. 343:1487-1497. http://dx.doi.org/10.1016/j.jmb.2004.09.011.
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 1487-1497
-
-
Doura, A.K.1
Fleming, K.G.2
-
75
-
-
46049088691
-
Protein-protein interactions in the membrane: sequence, structural, and biological motifs
-
Moore DT, Berger BW, DeGrado WF. 2008. Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure 16:991-1001. http://dx.doi.org/10.1016/j.str.2008.05.007.
-
(2008)
Structure
, vol.16
, pp. 991-1001
-
-
Moore, D.T.1
Berger, B.W.2
DeGrado, W.F.3
-
76
-
-
0030982098
-
Structural perspectives of phospholamban, a helical transmembrane pentamer
-
Arkin IT, Adams PD, Brunger AT, Smith SO, Engelman DM. 1997. Structural perspectives of phospholamban, a helical transmembrane pentamer. Annu. Rev. Biophys. Biomol. Struct. 26:157-179. http://dx .doi.org/10.1146/annurev.biophys.26.1.157.
-
(1997)
Annu. Rev. Biophys. Biomol. Struct.
, vol.26
, pp. 157-179
-
-
Arkin, I.T.1
Adams, P.D.2
Brunger, A.T.3
Smith, S.O.4
Engelman, D.M.5
-
77
-
-
84860817692
-
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
-
Li YP, Ramirez S, Gottwein JM, Scheel TK, Mikkelsen L, Purcell RH, Bukh J. 2012. Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains. Proc. Natl. Acad. Sci. U. S. A. 109:E1101- 1110. http://dx.doi.org/10.1073/pnas.1203829109.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
-
-
Li, Y.P.1
Ramirez, S.2
Gottwein, J.M.3
Scheel, T.K.4
Mikkelsen, L.5
Purcell, R.H.6
Bukh, J.7
-
78
-
-
84870372937
-
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
-
Li YP, Ramirez S, Jensen SB, Purcell RH, Gottwein JM, Bukh J. 2012. Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system. Proc. Natl. Acad. Sci. U. S. A. 109:19757-19762. http://dx.doi.org/10.1073/pnas.1218260109.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 19757-19762
-
-
Li, Y.P.1
Ramirez, S.2
Jensen, S.B.3
Purcell, R.H.4
Gottwein, J.M.5
Bukh, J.6
-
79
-
-
0032732426
-
Detergents modulate dimerization, but not helicity, of the glycophorin A transmembrane domain
-
Fisher LE, Engelman DM, Sturgis JN. 1999. Detergents modulate dimerization, but not helicity, of the glycophorin A transmembrane domain. J. Mol. Biol. 293:639-651. http://dx.doi.org/10.1006/jmbi.1999 .3126.
-
(1999)
J. Mol. Biol.
, vol.293
, pp. 639-651
-
-
Fisher, L.E.1
Engelman, D.M.2
Sturgis, J.N.3
-
80
-
-
0242353821
-
Effect of detergents on the association of the glycophorin a transmembrane helix
-
Fisher LE, Engelman DM, Sturgis JN. 2003. Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys. J. 85: 3097-3105. http://dx.doi.org/10.1016/S0006-3495(03)74728-6.
-
(2003)
Biophys. J.
, vol.85
, pp. 3097-3105
-
-
Fisher, L.E.1
Engelman, D.M.2
Sturgis, J.N.3
-
81
-
-
33646902110
-
Folding and stability of alpha-helical integral membrane proteins
-
Mackenzie KR. 2006. Folding and stability of alpha-helical integral membrane proteins. Chem. Rev. 106:1931-1977. http://dx.doi.org/10 .1021/cr0404388.
-
(2006)
Chem. Rev.
, vol.106
, pp. 1931-1977
-
-
Mackenzie, K.R.1
-
82
-
-
84857529575
-
Transmembrane helix-helix interactions are modulated by the sequence context and by lipid bilayer properties
-
Cymer F, Veerappan A, Schneider D. 2012. Transmembrane helix-helix interactions are modulated by the sequence context and by lipid bilayer properties. Biochim. Biophys. Acta 1818:963-973. http://dx.doi.org/10 .1016/j.bbamem.2011.07.035.
-
(2012)
Biochim. Biophys. Acta
, vol.1818
, pp. 963-973
-
-
Cymer, F.1
Veerappan, A.2
Schneider, D.3
-
83
-
-
84879022013
-
ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication through altering the composition of viral replication complexes
-
29 April Antimicrob. Agents Chemother
-
Yang W, Sun Y, Hou X, Zhao Y, Fabrycki J, Chen D, Wang X, Agarwal A, Phadke A, Deshpande M, Huang M. 29 April 2013. ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication through altering the composition of viral replication complexes. Antimicrob. Agents Chemother. http://dx.doi.org/10.1128/AAC.02630-12.
-
(2013)
-
-
Yang, W.1
Sun, Y.2
Hou, X.3
Zhao, Y.4
Fabrycki, J.5
Chen, D.6
Wang, X.7
Agarwal, A.8
Phadke, A.9
Deshpande, M.10
Huang, M.11
-
84
-
-
44449099603
-
Selection of replicon variants resistant to ACH-806, a novel hepatitis C virus inhibitor with no cross-resistance to NS3 protease and NS5B polymerase inhibitors
-
Yang W, Zhao Y, Fabrycki J, Hou X, Nie X, Sanchez A, Phadke A, Deshpande M, Agarwal A, Huang M. 2008. Selection of replicon variants resistant to ACH-806, a novel hepatitis C virus inhibitor with no cross-resistance to NS3 protease and NS5B polymerase inhibitors. Antimicrob. Agents Chemother. 52:2043-2052. http://dx.doi.org/10.1128 /AAC.01548-07.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 2043-2052
-
-
Yang, W.1
Zhao, Y.2
Fabrycki, J.3
Hou, X.4
Nie, X.5
Sanchez, A.6
Phadke, A.7
Deshpande, M.8
Agarwal, A.9
Huang, M.10
-
85
-
-
0001041988
-
Probing the folding and unfolding of wildtype and mutant forms of bacteriorhodopsin in micellar solutions: evaluation of reversible unfolding conditions
-
Chen GQ, Gouaux E. 1999. Probing the folding and unfolding of wildtype and mutant forms of bacteriorhodopsin in micellar solutions: evaluation of reversible unfolding conditions. Biochemistry 38:15380 - 15387. http://dx.doi.org/10.1021/bi9909039.
-
(1999)
Biochemistry
, vol.38
-
-
Chen, G.Q.1
Gouaux, E.2
-
86
-
-
23644460494
-
Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor
-
Thévenin D, Lazarova T, Roberts MF, Robinson CR. 2005. Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor. Protein Sci. 14:2177-2186. http://dx.doi.org/10.1110/ps.051409205.
-
(2005)
Protein Sci.
, vol.14
, pp. 2177-2186
-
-
Thévenin, D.1
Lazarova, T.2
Roberts, M.F.3
Robinson, C.R.4
-
87
-
-
33645645084
-
Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus
-
Mackintosh SG, Lu JZ, Jordan JB, Harrison MK, Sikora B, Sharma SD, Cameron CE, Raney KD, Sakon J. 2006. Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J. Biol. Chem. 281:3528- 3535. http://dx.doi.org/10.1074/jbc.M512100200.
-
(2006)
J. Biol. Chem.
, vol.281
-
-
Mackintosh, S.G.1
Lu, J.Z.2
Jordan, J.B.3
Harrison, M.K.4
Sikora, B.5
Sharma, S.D.6
Cameron, C.E.7
Raney, K.D.8
Sakon, J.9
-
88
-
-
2542468381
-
The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity
-
Levin MK, Wang YH, Patel SS. 2004. The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity. J. Biol. Chem. 279:26005-26012. http://dx.doi.org/10.1074/jbc .M403257200.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26005-26012
-
-
Levin, M.K.1
Wang, Y.H.2
Patel, S.S.3
-
89
-
-
64149127878
-
NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations
-
Jennings TA, Mackintosh SG, Harrison MK, Sikora D, Sikora B, Dave B, Tackett AJ, Cameron CE, Raney KD. 2009. NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations. J. Biol. Chem. 284:4806-4814. http://dx.doi.org/10.1074/jbc.M805540200.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 4806-4814
-
-
Jennings, T.A.1
Mackintosh, S.G.2
Harrison, M.K.3
Sikora, D.4
Sikora, B.5
Dave, B.6
Tackett, A.J.7
Cameron, C.E.8
Raney, K.D.9
-
90
-
-
59049088498
-
Establishing a mechanistic basis for the large kinetic steps of the NS3 helicase
-
Serebrov V, Beran RK, Pyle AM. 2009. Establishing a mechanistic basis for the large kinetic steps of the NS3 helicase. J. Biol. Chem. http://dx.doi .org/10.1074/jbc.M805460200. 284:2512-2521.
-
(2009)
J. Biol. Chem.
-
-
Serebrov, V.1
Beran, R.K.2
Pyle, A.M.3
-
91
-
-
33745823112
-
Mechanisms of helicases
-
Patel SS, Donmez I. 2006. Mechanisms of helicases. J. Biol. Chem. 281:18265-18268. http://dx.doi.org/10.1074/jbc.R600008200.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 18265-18268
-
-
Patel, S.S.1
Donmez, I.2
-
92
-
-
0036500976
-
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
-
Pang PS, Jankowsky E, Planet PJ, Pyle AM. 2002. The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding. EMBO J. 21:1168-1176. http://dx.doi.org/10.1093/emboj /21.5.1168.
-
(2002)
EMBO J.
, vol.21
, pp. 1168-1176
-
-
Pang, P.S.1
Jankowsky, E.2
Planet, P.J.3
Pyle, A.M.4
-
93
-
-
72849147739
-
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication
-
Assenberg R, Mastrangelo E, Walter TS, Verma A, Milani M, Owens RJ, Stuart DI, Grimes JM, Mancini EJ. 2009. Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication. J. Virol. 83:12895-12906. http: //dx.doi.org/10.1128/JVI.00942-09.
-
(2009)
J. Virol.
, vol.83
, pp. 12895-12906
-
-
Assenberg, R.1
Mastrangelo, E.2
Walter, T.S.3
Verma, A.4
Milani, M.5
Owens, R.J.6
Stuart, D.I.7
Grimes, J.M.8
Mancini, E.J.9
-
94
-
-
79955383686
-
Unmasking the active helicase conformation of nonstructural protein 3 from hepatitis C virus
-
Ding SC, Kohlway AS, Pyle AM. 2011. Unmasking the active helicase conformation of nonstructural protein 3 from hepatitis C virus. J. Virol. 85:4343-4353. http://dx.doi.org/10.1128/JVI.02130-10.
-
(2011)
J. Virol.
, vol.85
, pp. 4343-4353
-
-
Ding, S.C.1
Kohlway, A.S.2
Pyle, A.M.3
-
95
-
-
77953306294
-
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications
-
Luo D, Wei N, Doan DN, Paradkar PN, Chong Y, Davidson AD, Kotaka M, Lescar J, Vasudevan SG. 2010. Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications. J. Biol. Chem. 285: 18817-18827. http://dx.doi.org/10.1074/jbc.M109.090936.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 18817-18827
-
-
Luo, D.1
Wei, N.2
Doan, D.N.3
Paradkar, P.N.4
Chong, Y.5
Davidson, A.D.6
Kotaka, M.7
Lescar, J.8
Vasudevan, S.G.9
-
96
-
-
33846005485
-
Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro
-
Clarke D, Griffin S, Beales L, Gelais CS, Burgess S, Harris M, Rowlands D. 2006. Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro. J. Biol. Chem. 281: 37057-37068. http://dx.doi.org/10.1074/jbc.M602434200.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 37057-37068
-
-
Clarke, D.1
Griffin, S.2
Beales, L.3
Gelais, C.S.4
Burgess, S.5
Harris, M.6
Rowlands, D.7
-
97
-
-
69149090877
-
The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy
-
Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N. 2009. The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. Proc. Natl. Acad. Sci. U. S. A. 106:12712-12716. http://dx.doi.org/10 .1073/pnas.0905966106.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 12712-12716
-
-
Luik, P.1
Chew, C.2
Aittoniemi, J.3
Chang, J.4
Wentworth, P.5
Dwek, R.A.6
Biggin, P.C.7
Vénien-Bryan, C.8
Zitzmann, N.9
-
98
-
-
33747452685
-
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
-
Lorenz IC, Marcotrigiano J, Dentzer TG, Rice CM. 2006. Structure of the catalytic domain of the hepatitis C virus NS2-3 protease. Nature 442:831-835. http://dx.doi.org/10.1038/nature04975.
-
(2006)
Nature
, vol.442
, pp. 831-835
-
-
Lorenz, I.C.1
Marcotrigiano, J.2
Dentzer, T.G.3
Rice, C.M.4
-
99
-
-
78649398569
-
Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B
-
Gouttenoire J, Roingeard P, Penin F, Moradpour D. 2010. Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B. J. Virol. 84:12529-12537. http://dx.doi.org/10.1128/JVI.01798-10.
-
(2010)
J. Virol.
, vol.84
, pp. 12529-12537
-
-
Gouttenoire, J.1
Roingeard, P.2
Penin, F.3
Moradpour, D.4
-
100
-
-
79960406328
-
NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes
-
Paul D, Romero-Brey I, Gouttenoire J, Stoitsova S, Krijnse-Locker J, Moradpour D, Bartenschlager R. 2011. NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes. J. Virol. 85:6963-6976. http://dx.doi.org/10.1128/JVI.00502-11.
-
(2011)
J. Virol.
, vol.85
, pp. 6963-6976
-
-
Paul, D.1
Romero-Brey, I.2
Gouttenoire, J.3
Stoitsova, S.4
Krijnse-Locker, J.5
Moradpour, D.6
Bartenschlager, R.7
-
101
-
-
78649430973
-
Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins
-
Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, Raney KD, Kao CC, Cameron CE. 2010. Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J. Virol. 84:12480-12491. http://dx.doi.org/10 .1128/JVI.01319-10.
-
(2010)
J. Virol.
, vol.84
, pp. 12480-12491
-
-
Hwang, J.1
Huang, L.2
Cordek, D.G.3
Vaughan, R.4
Reynolds, S.L.5
Kihara, G.6
Raney, K.D.7
Kao, C.C.8
Cameron, C.E.9
-
102
-
-
0037127306
-
Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase
-
Qin W, Luo H, Nomura T, Hayashi N, Yamashita T, Murakami S. 2002. Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase. J. Biol. Chem. 277:2132-2137. http://dx.doi.org/10.1074/jbc.M106880200.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2132-2137
-
-
Qin, W.1
Luo, H.2
Nomura, T.3
Hayashi, N.4
Yamashita, T.5
Murakami, S.6
-
103
-
-
38549142580
-
RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase
-
Jennings TA, Chen Y, Sikora D, Harrison MK, Sikora B, Huang L, Jankowsky E, Fairman ME, Cameron CE, Raney KD. 2008. RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase. Biochemistry 47:1126-1135. http://dx.doi.org/10 .1021/bi701048a.
-
(2008)
Biochemistry
, vol.47
, pp. 1126-1135
-
-
Jennings, T.A.1
Chen, Y.2
Sikora, D.3
Harrison, M.K.4
Sikora, B.5
Huang, L.6
Jankowsky, E.7
Fairman, M.E.8
Cameron, C.E.9
Raney, K.D.10
-
104
-
-
22544470874
-
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
-
Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Krausslich HG, Mizokami M, Bartenschlager R, Liang TJ. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11:791-796. http: //dx.doi.org/10.1038/nm1268.
-
(2005)
Nat. Med.
, vol.11
, pp. 791-796
-
-
Wakita, T.1
Pietschmann, T.2
Kato, T.3
Date, T.4
Miyamoto, M.5
Zhao, Z.6
Murthy, K.7
Habermann, A.8
Krausslich, H.G.9
Mizokami, M.10
Bartenschlager, R.11
Liang, T.J.12
-
105
-
-
21544440397
-
Robust hepatitis C virus infection in vitro
-
Zhong J, Gastaminza P, Cheng G, Kapadia S, Kato T, Burton DR, Wieland SF, Uprichard SL, Wakita T, Chisari FV. 2005. Robust hepatitis C virus infection in vitro. Proc. Natl. Acad. Sci. U. S. A. 102:9294- 9299. http://dx.doi.org/10.1073/pnas.0503596102.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
-
-
Zhong, J.1
Gastaminza, P.2
Cheng, G.3
Kapadia, S.4
Kato, T.5
Burton, D.R.6
Wieland, S.F.7
Uprichard, S.L.8
Wakita, T.9
Chisari, F.V.10
-
106
-
-
33144471074
-
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells
-
Yi M, Villanueva RA, Thomas DL, Wakita T, Lemon SM. 2006. Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc. Natl. Acad. Sci. U. S. A. 103:2310-2315. http://dx.doi.org/10.1073/pnas.0510727103.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 2310-2315
-
-
Yi, M.1
Villanueva, R.A.2
Thomas, D.L.3
Wakita, T.4
Lemon, S.M.5
-
107
-
-
23044437222
-
Complete replication of hepatitis C virus in cell culture
-
Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. 2005. Complete replication of hepatitis C virus in cell culture. Science 309:623-626. http://dx.doi.org/10.1126/science.1114016.
-
(2005)
Science
, vol.309
, pp. 623-626
-
-
Lindenbach, B.D.1
Evans, M.J.2
Syder, A.J.3
Wolk, B.4
Tellinghuisen, T.L.5
Liu, C.C.6
Maruyama, T.7
Hynes, R.O.8
Burton, D.R.9
McKeating, J.A.10
Rice, C.M.11
-
108
-
-
84867398704
-
Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone
-
Date T, Kato T, Kato J, Takahashi H, Morikawa K, Akazawa D, Murayama A, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Wakita T. 2012. Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone. J. Virol. 86:10805-10820. http://dx.doi.org/10.1128/JVI .07235-11.
-
(2012)
J. Virol.
, vol.86
, pp. 10805-10820
-
-
Date, T.1
Kato, T.2
Kato, J.3
Takahashi, H.4
Morikawa, K.5
Akazawa, D.6
Murayama, A.7
Tanaka-Kaneko, K.8
Sata, T.9
Tanaka, Y.10
Mizokami, M.11
Wakita, T.12
-
109
-
-
84860378553
-
Replication and infectivity of a novel genotype 1b hepatitis C virus clone
-
Date T, Morikawa K, Tanaka Y, Tanaka-Kaneko K, Sata T, Mizokami M, Wakita T. 2012. Replication and infectivity of a novel genotype 1b hepatitis C virus clone. Microb. Immunol. 56:308-317. http://dx.doi.org /10.1111/j.1348-0421.2012.00437.x.
-
(2012)
Microb. Immunol.
, vol.56
, pp. 308-317
-
-
Date, T.1
Morikawa, K.2
Tanaka, Y.3
Tanaka-Kaneko, K.4
Sata, T.5
Mizokami, M.6
Wakita, T.7
-
110
-
-
0036568229
-
Interhelical hydrogen bonds and spatial motifs in membrane proteins: polar clamps and serine zippers
-
Adamian L, Liang J. 2002. Interhelical hydrogen bonds and spatial motifs in membrane proteins: polar clamps and serine zippers. Proteins 47:209-218. http://dx.doi.org/10.1002/prot.10071.
-
(2002)
Proteins
, vol.47
, pp. 209-218
-
-
Adamian, L.1
Liang, J.2
-
111
-
-
34250865507
-
In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5
-
Sakai A, Takikawa S, Thimme R, Meunier JC, Spangenberg HC, Govindarajan S, Farci P, Emerson SU, Chisari FV, Purcell RH, Bukh J. 2007. In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells. J. Virol. 81:7208-7219. http://dx.doi.org/10.1128/JVI.01774-06.
-
(2007)
cells. J. Virol.
, vol.81
, pp. 7208-7219
-
-
Sakai, A.1
Takikawa, S.2
Thimme, R.3
Meunier, J.C.4
Spangenberg, H.C.5
Govindarajan, S.6
Farci, P.7
Emerson, S.U.8
Chisari, F.V.9
Purcell, R.H.10
Bukh, J.11
-
112
-
-
0033568548
-
Hepatitis C virus: an infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras
-
Yanagi M, Purcell RH, Emerson SU, Bukh J. 1999. Hepatitis C virus: an infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras. Virology 262:250-263. http: //dx.doi.org/10.1006/viro.1999.9889.
-
(1999)
Virology
, vol.262
, pp. 250-263
-
-
Yanagi, M.1
Purcell, R.H.2
Emerson, S.U.3
Bukh, J.4
-
113
-
-
84863264794
-
Control of innate immune signaling and membrane targeting by the hepatitis C virus NS3/4A protease are governed by the NS3 helix alpha0
-
Horner SM, Park HS, Gale M, Jr. 2012. Control of innate immune signaling and membrane targeting by the hepatitis C virus NS3/4A protease are governed by the NS3 helix alpha0. J. Virol. 86:3112-3120. http: //dx.doi.org/10.1128/JVI.06727-11.
-
(2012)
J. Virol.
, vol.86
, pp. 3112-3120
-
-
Horner, S.M.1
Park, H.S.2
Gale, M.3
-
114
-
-
34147130190
-
Computational design of peptides that target transmembrane helices
-
Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. 2007. Computational design of peptides that target transmembrane helices. Science 315:1817-1822. http://dx.doi.org/10.1126/science.1136782.
-
(2007)
Science
, vol.315
, pp. 1817-1822
-
-
Yin, H.1
Slusky, J.S.2
Berger, B.W.3
Walters, R.S.4
Vilaire, G.5
Litvinov, R.I.6
Lear, J.D.7
Caputo, G.A.8
Bennett, J.S.9
DeGrado, W.F.10
-
115
-
-
77956623666
-
Receptor tyrosine kinase transmembrane domain interactions: potential target for "interceptor" therapy
-
jc6
-
Najumudeen AK. 2010. Receptor tyrosine kinase transmembrane domain interactions: potential target for "interceptor" therapy. Sci. Signal. 3:jc6. http://dx.doi.org/10.1126/scisignal.3138jc6.
-
(2010)
Sci. Signal.
, vol.3
-
-
Najumudeen, A.K.1
|