-
1
-
-
0028016286
-
The epidemiology of viral hepatitis in the United Stales
-
Alter, M. J., and E. E. Mast. 1994, The epidemiology of viral hepatitis in the United Stales. Gastroenterol. Clin. North Am. 23:437-455.
-
(1994)
Gastroenterol. Clin. North Am.
, vol.23
, pp. 437-455
-
-
Alter, M.J.1
Mast, E.E.2
-
2
-
-
0027287798
-
Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4A and NS4/5 junctions
-
Bartunschlager, R., L. Ahlborn-Laaku, J. Mous, and H. Jacobsen. 1993. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4A and NS4/5 junctions, J. Virol. 67:3835-3844.
-
(1993)
J. Virol.
, vol.67
, pp. 3835-3844
-
-
Bartunschlager, R.1
Ahlborn-Laaku, L.2
Mous, J.3
Jacobsen, H.4
-
3
-
-
0028241489
-
Kinetic and structural analyses of hepatitis C virus polyprolein processing
-
Bartenschlager, K., L. Ahlborn-Lauke, J. Mous, and H. Jacobsen. 1994. Kinetic and structural analyses of hepatitis C virus polyprolein processing. J. Virol. 68:5045-5055.
-
(1994)
J. Virol.
, vol.68
, pp. 5045-5055
-
-
Bartenschlager, K.1
Ahlborn-Lauke, L.2
Mous, J.3
Jacobsen, H.4
-
4
-
-
0028820118
-
Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation
-
Bartenschlager, R., V. Lohmann, T. Wikinson, and J. O. Koch. 1995. Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation. J. Virol. 69:7519-7528.
-
(1995)
J. Virol.
, vol.69
, pp. 7519-7528
-
-
Bartenschlager, R.1
Lohmann, V.2
Wikinson, T.3
Koch, J.O.4
-
5
-
-
0029155434
-
Complete replication of poliovirus in vitro: Preinitiation RNA replication complexes require soluble cellular factors for the synthesis of VPg-linkcd RNA
-
Barton, D. J., E. P. Black, and J. B. Flanegan. 1995. Complete replication of poliovirus in vitro: preinitiation RNA replication complexes require soluble cellular factors for the synthesis of VPg-linkcd RNA. J. Virol, 69:5516-5527.
-
(1995)
J. Virol
, vol.69
, pp. 5516-5527
-
-
Barton, D.J.1
Black, E.P.2
Flanegan, J.B.3
-
6
-
-
0026519212
-
Structural and functional characterization of the poliovirus replication complex
-
Bicnz, K., D. Egger. T. Pfistcr, and M. Troxlcr. 1992. Structural and functional characterization of the poliovirus replication complex. J. Virol. 66: 2740-2747.
-
(1992)
J. Virol.
, vol.66
, pp. 2740-2747
-
-
Bicnz, K.1
Egger, D.2
Pfistcr, T.3
Troxlcr, M.4
-
7
-
-
0025236535
-
Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region
-
Bienz, K., D. Egger, M. Troxler, and L. Pasamontes. 1990 Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region. J. Virol. 64:1156-1163.
-
(1990)
J. Virol.
, vol.64
, pp. 1156-1163
-
-
Bienz, K.1
Egger, D.2
Troxler, M.3
Pasamontes, L.4
-
8
-
-
0024509701
-
Isolation of a cDNA clone derived from a Mood-borne non-A, non-B viral hepatitis genome
-
Choo, Q.-L., G. Kuo. A. J. Weiner, L. R. Overby, U. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a Mood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.-L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, U.W.5
Houghton, M.6
-
9
-
-
0027170423
-
The hepatitis C virus encodes a serine protease involved in processing of the putative nonstruciural proteins from the viral polyprotein precursor
-
Eckart, M. K., M. Selby, F. Masiarz, C. Lee, K. Berger, K. Crowford, C. Kuo, G. Kuo, M. Houghton, and Q.-L. Choo. 1993. The hepatitis C virus encodes a serine protease involved in processing of the putative nonstruciural proteins from the viral polyprotein precursor. Biochem. Biophys. Res. Commun. 192:399-406.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.192
, pp. 399-406
-
-
Eckart, M.K.1
Selby, M.2
Masiarz, F.3
Lee, C.4
Berger, K.5
Crowford, K.6
Kuo, C.7
Kuo, G.8
Houghton, M.9
Choo, Q.-L.10
-
10
-
-
0028290579
-
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonsiructural proteins
-
Failla, C., L. Tomei, and R. DeFnincesco. 1994. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonsiructural proteins. J. Virol. 68:3753-3760.
-
(1994)
J. Virol.
, vol.68
, pp. 3753-3760
-
-
Failla, C.1
Tomei, L.2
DeFnincesco, R.3
-
11
-
-
0028851296
-
An amino-terminal domain of the hepatitis C NS3 proteasc is essential for interaction with NS4A
-
Failla, C., L. Tomei, and R. DeFrancesco. 1995. An amino-terminal domain of the hepatitis C NS3 proteasc is essential for interaction with NS4A. J Virol. 69:1764-1777.
-
(1995)
J Virol.
, vol.69
, pp. 1764-1777
-
-
Failla, C.1
Tomei, L.2
DeFrancesco, R.3
-
12
-
-
0027414062
-
Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dcpendent polyprotein cleavage sites
-
Gnikoui, A., U. W. McCourt, C. Wychowski, S. M. Felnstone, and C. M. Rlce, 1993. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dcpendent polyprotein cleavage sites. J. Virol. 67:2832-2843.
-
(1993)
J. Virol.
, vol.67
, pp. 2832-2843
-
-
Gnikoui, A.1
McCourt, U.W.2
Wychowski, C.3
Felnstone, S.M.4
Rlce, C.M.5
-
13
-
-
0027436831
-
A second hepatitis C virus-encoded proteinase
-
Grakoui, A., D. W. McCourt, C. Wychowski, S. M. Feinstone, and C. M. Rice. 1993. A second hepatitis C virus-encoded proteinase. Proc. Natl. Acad. Sci USA 90:10583-10587.
-
(1993)
Proc. Natl. Acad. Sci USA
, vol.90
, pp. 10583-10587
-
-
Grakoui, A.1
McCourt, D.W.2
Wychowski, C.3
Feinstone, S.M.4
Rice, C.M.5
-
14
-
-
0027476809
-
Expression and identification of hepatitis C virus polyprotein cleavage prod-ucts
-
Grakoui, A., C. Wychowski, C. Lin, S. M. Feinstone, and C. M. Rice. 1993. Expression and identification of hepatitis C virus polyprotein cleavage prod-ucts. J. Virol. 67:1385-1395.
-
(1993)
J. Virol.
, vol.67
, pp. 1385-1395
-
-
Grakoui, A.1
Wychowski, C.2
Lin, C.3
Feinstone, S.M.4
Rice, C.M.5
-
15
-
-
0028988541
-
Interleukin-lβ converting enzyme requires oligomcrization for activity of processed forms in vivo
-
Gu, Y., J. Wu, C. Faucheu, J.-L. Lnlanne. A. Diu. D. J. Livingston, and M. S.-S. Su. 1995. Interleukin-lβ converting enzyme requires oligomcrization for activity of processed forms in vivo. EMBO J. 14:1923-1931.
-
(1995)
EMBO J.
, vol.14
, pp. 1923-1931
-
-
Gu, Y.1
Wu, J.2
Faucheu, C.3
Lnlanne, J.-L.4
Diu, A.5
Livingston, D.J.6
Su, M.S.-S.7
-
16
-
-
0025991559
-
Gene mapping of the putative structural region of the hepatitis C. virus genome by in vitro processing analysis
-
Hijfkata, M., N. Kato, Y. Ootsuyama, M. Nakagawa, and K. Shimotohno, 1991. Gene mapping of the putative structural region of the hepatitis C. virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88:5547-5551.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 5547-5551
-
-
Hijfkata, M.1
Kato, N.2
Ootsuyama, Y.3
Nakagawa, M.4
Shimotohno, K.5
-
17
-
-
0027163740
-
Two distinct protcinasc activities required for the processing of a putative nonstructural precursor of hepatitis C virus
-
Hijikata, M., H. Mizushima, T. Akagi, S. Mori, N. Kakiuchi, N. Kato, N. Tanaka. and K. Shimotohno. 1993. Two distinct protcinasc activities required for the processing of a putative nonstructural precursor of hepatitis C virus. J. Virol. 67:4665-4675.
-
(1993)
J. Virol.
, vol.67
, pp. 4665-4675
-
-
Hijikata, M.1
Mizushima, H.2
Akagi, T.3
Mori, S.4
Kakiuchi, N.5
Kato, N.6
Tanaka, N.7
Shimotohno, K.8
-
18
-
-
0029950090
-
Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using thc herpes simplex virus amplicon system
-
Hong. Z., E. Ferrari, J. Wright-Minogue, R. Chase, C. Risano, G. Seelig, C.-G. Lee, and A. D. Kwong. 1996. Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using thc herpes simplex virus amplicon system. J. Virol. 70:4261-4268.
-
(1996)
J. Virol.
, vol.70
, pp. 4261-4268
-
-
Hong, Z.1
Ferrari, E.2
Wright-Minogue, J.3
Chase, R.4
Risano, C.5
Seelig, G.6
Lee, C.-G.7
Kwong, A.D.8
-
19
-
-
0000361013
-
Hepatitis C viruses
-
B. N. Fields, D. M. Knipe. and P. M. Howlcy (ed.). Raven Press. New York. N.Y.
-
Houghton, M. 1996. Hepatitis C viruses, p. 1035-1055. In B. N. Fields, D. M. Knipe. and P. M. Howlcy (ed.). Fields virology. 3rd ed. Raven Press. New York. N.Y.
-
(1996)
Fields Virology. 3rd Ed.
, pp. 1035-1055
-
-
Houghton, M.1
-
20
-
-
16044364658
-
Crystal structure of the hepatitis C virus NS3 protease domain completed with a synthetic NS4A cofactor peptide
-
Kirn, J. L., K. A. Morgenstern, C. Lin, T. Fox, M. D. Dwyer, J. A. Landro, S. P. Chambers, W. Markland, C. A. Lepre, E. T. O'Malley, S. L. Harbeson, C. M. Rice, M. A. Murcko, P. R. Caron, and J. A. Thomson. 1996. Crystal structure of the hepatitis C virus NS3 protease domain completed with a synthetic NS4A cofactor peptide. Cell 87:343-355.
-
(1996)
Cell
, vol.87
, pp. 343-355
-
-
Kirn, J.L.1
Morgenstern, K.A.2
Lin, C.3
Fox, T.4
Dwyer, M.D.5
Landro, J.A.6
Chambers, S.P.7
Markland, W.8
Lepre, C.A.9
O'Malley, E.T.10
Harbeson, S.L.11
Rice, C.M.12
Murcko, M.A.13
Caron, P.R.14
Thomson, J.A.15
-
21
-
-
0027999994
-
Specificity of the hepatitis C virus NS3 serine protease: Effects of substitutions at the 3/4A, 4A/4B. 4B/5A. and 5A/5B cleavage sites on polyprotein processing
-
Kolykhalov, A. A., E. V. Agapov, and C. M. Rice. 1994. Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B. 4B/5A. and 5A/5B cleavage sites on polyprotein processing. J. Virol. 68:7525-7533.
-
(1994)
J. Virol.
, vol.68
, pp. 7525-7533
-
-
Kolykhalov, A.A.1
Agapov, E.V.2
Rice, C.M.3
-
22
-
-
0029938477
-
Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
-
Kolykhalov, A. A., S. M. Feinstone, and C. M. Rice. 1996. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J. Virol. 70:3363-3371.
-
(1996)
J. Virol.
, vol.70
, pp. 3363-3371
-
-
Kolykhalov, A.A.1
Feinstone, S.M.2
Rice, C.M.3
-
23
-
-
0024511734
-
An assay for circulating antibodies to a major eliotogic virus of human non-A, non-B hepatitis
-
Kuo, G., Q.-L. Choo, H. J. Alter, G. L. Gitnich, A. G. Redeker, R. H. Pureell, T. Miyamura. J. L. Dienstag, M. J. Alter, C. E. Stevens, G. E. Tegtmeier, F. Bonino, M. Colombo, W.-S. Lee, C. Kuo, K. Berger, J. R. Shuster, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. An assay for circulating antibodies to a major eliotogic virus of human non-A, non-B hepatitis. Science 244:362-364.
-
(1989)
Science
, vol.244
, pp. 362-364
-
-
Kuo, G.1
Choo, Q.-L.2
Alter, H.J.3
Gitnich, G.L.4
Redeker, A.G.5
Pureell, R.H.6
Miyamura, T.7
Dienstag, J.L.8
Alter, M.J.9
Stevens, C.E.10
Tegtmeier, G.E.11
Bonino, F.12
Colombo, M.13
Lee, W.-S.14
Kuo, C.15
Berger, K.16
Shuster, J.R.17
Overby, L.R.18
Bradley, D.W.19
Houghton, M.20
more..
-
24
-
-
1842278102
-
-
Unpublished data
-
23a.Lin, C. Unpublished data.
-
-
-
Lin, C.1
-
25
-
-
0027186129
-
Mutagencsis of conserved residues at the yellow fever virus 3/4A and 4B/5 dibasic cleavage site: Effects on cleavage efficiency and polyprotein processing
-
Lin, C., T. J. Chambers, and C. M. Rice. 1993. Mutagencsis of conserved residues at the yellow fever virus 3/4A and 4B/5 dibasic cleavage site: effects on cleavage efficiency and polyprotein processing, Virology 192:596-604.
-
(1993)
Virology
, vol.192
, pp. 596-604
-
-
Lin, C.1
Chambers, T.J.2
Rice, C.M.3
-
26
-
-
0028290389
-
Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
-
Lin, C., B. D. Lindenbach, B. M. Pragai, U. W. McCourt. and C. M. Rice. 1994, Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J. Virol. 68:5063-5073.
-
(1994)
J. Virol.
, vol.68
, pp. 5063-5073
-
-
Lin, C.1
Lindenbach, B.D.2
Pragai, B.M.3
McCourt, U.W.4
Rice, C.M.5
-
27
-
-
0028089739
-
Hepatitis C virus NS3 serine proteinase: Trans-cleavage requirements and processing kinetics
-
Lin, C., B. M. Pragai, A. Grakoui, J. Xu, and C. M. Rice. 1904. Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J. Virol. 68:81,47-8157.
-
(1904)
J. Virol.
, vol.68
, pp. 81
-
-
Lin, C.1
Pragai, B.M.2
Grakoui, A.3
Xu, J.4
Rice, C.M.5
-
28
-
-
0029094449
-
The hepatitis C virus NS3 serine proteinase and NS4A eofactor: Establishment of a cell-free trans-proeessing assay
-
Lin, C., and C. M. Rice. 1995. The hepatitis C virus NS3 serine proteinase and NS4A eofactor: establishment of a cell-free trans-proeessing assay. Proc. Natl. Acad. Sci. USA 92:7622-7626.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7622-7626
-
-
Lin, C.1
Rice, C.M.2
-
29
-
-
0029074519
-
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
-
Lin, C., J. A. Thomson, and C. M. Rice. 1995. A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J. Virol. 69:4373-4380.
-
(1995)
J. Virol.
, vol.69
, pp. 4373-4380
-
-
Lin, C.1
Thomson, J.A.2
Rice, C.M.3
-
30
-
-
0030592514
-
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
-
Love. R. A., H. E. Purge, J. A. Wickershum, Z. Hostomsky, N. Habuka, E. W. Moomaw, T. Adachi, and Z. Hostomska. 1996. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 87:331-342.
-
(1996)
Cell
, vol.87
, pp. 331-342
-
-
Love, R.A.1
Purge, H.E.2
Wickershum, J.A.3
Hostomsky, Z.4
Habuka, N.5
Moomaw, E.W.6
Adachi, T.7
Hostomska, Z.8
-
31
-
-
0028332810
-
Production of nonstruc-Lural proteins of hepatitis C virus requires a putative viral protease encoded by NS3
-
Manabe, S., I. Fuke, O. Tankshita, C. Kaji, Y. Gomi, S. Yoshida, C. Mori, A. Takamizawa, I. Yoshida, and H. Okayamu. 1994. Production of nonstruc-Lural proteins of hepatitis C virus requires a putative viral protease encoded by NS3. Virology 198:636-644.
-
(1994)
Virology
, vol.198
, pp. 636-644
-
-
Manabe, S.1
Fuke, I.2
Tankshita, O.3
Kaji, C.4
Gomi, Y.5
Yoshida, S.6
Mori, C.7
Takamizawa, A.8
Yoshida, I.9
Okayamu, H.10
-
32
-
-
0031000887
-
Polynucleotide modulation of the protease. nucleoside triphosphatase and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from trnnsfected COS cells
-
Morgenstern, K. A., J. A. Landro, K. Hsiao, C. Lin, Y. Gu, M. S.-S. Su, and J. A. Thomson. 1997. Polynucleotide modulation of the protease. nucleoside triphosphatase and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from trnnsfected COS cells. J. Virol. 71:3767-3775.
-
(1997)
J. Virol.
, vol.71
, pp. 3767-3775
-
-
Morgenstern, K.A.1
Landro, J.A.2
Hsiao, K.3
Lin, C.4
Gu, Y.5
Su, M.S.-S.6
Thomson, J.A.7
-
33
-
-
0029076837
-
The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stuhle complex formation with NS4A
-
Satoh, S., Y. Tanji, M. Hijikata, K. Kimura, and K. Shimotohno. 1995. The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stuhle complex formation with NS4A. J. Virol. 69:4255-4260.
-
(1995)
J. Virol.
, vol.69
, pp. 4255-4260
-
-
Satoh, S.1
Tanji, Y.2
Hijikata, M.3
Kimura, K.4
Shimotohno, K.5
-
34
-
-
0027522145
-
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS5 region
-
Simmonds, P., E. C. Holmes, T.-A. Cha, S.-W. Chan, F. MeOmish, B. Irvine, E. Beall, P. L. Yap, J. Kolberg, and M. S. Urdea. 1993. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS5 region. J. Gen. Virol. 74:2391-2399.
-
(1993)
J. Gen. Virol.
, vol.74
, pp. 2391-2399
-
-
Simmonds, P.1
Holmes, E.C.2
Cha, T.-A.3
Chan, S.-W.4
Meomish, F.5
Irvine, B.6
Beall, E.7
Yap, P.L.8
Kolberg, J.9
Urdea, M.S.10
-
35
-
-
0023850352
-
SR alpha promoter: An efficient and versatile mammalian : cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat
-
Takebe, Y., M. Seiki, J. Fujisawa, P. Hoy, K. Yokota, K. Arai M. Yoshida, and N. Arai. 1988. SR alpha promoter: an efficient and versatile mammalian : cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:400-472.
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 400-472
-
-
Takebe, Y.1
Seiki, M.2
Fujisawa, J.3
Hoy, P.4
Yokota, K.5
Arai, K.6
Yoshida, M.7
Arai, N.8
-
36
-
-
0028785460
-
A novel sequence found at the 3′ terminus of hepatitis C virus genome
-
Tanaka, T., N. Kato, M.-J. Chu, and K. Shimotohno. 1995. A novel sequence found at the 3′ terminus of hepatitis C virus genome. Biochem. Biophys. Res. Commun. 215:744-749.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.215
, pp. 744-749
-
-
Tanaka, T.1
Kato, N.2
Chu, M.-J.3
Shimotohno, K.4
-
37
-
-
0028831056
-
Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing
-
Tanji, Y., M. Hijikata, S. Satoh, T. Kaneku, and K. Shimotohno. 1995. Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J. Virol. 69:1575-1581.
-
(1995)
J. Virol.
, vol.69
, pp. 1575-1581
-
-
Tanji, Y.1
Hijikata, M.2
Satoh, S.3
Kaneku, T.4
Shimotohno, K.5
-
38
-
-
0027176287
-
NS3 is a serine protease required for processing hepiitiiis C virus polypmtein
-
Tomei, L., C. Failla, E. Santolini, R. DeFrnncesco, and N. LaMonica. 1993. NS3 is a serine protease required for processing hepiitiiis C virus polypmtein. J. Virol. 67:4017-4026.
-
(1993)
J. Virol.
, vol.67
, pp. 4017-4026
-
-
Tomei, L.1
Failla, C.2
Santolini, E.3
DeFrnncesco, R.4
LaMonica, N.5
|