Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors

Purinergic Signalling

Volumn 9, Issue 4, 2013, Pages 621-632

  Popova, Maya ^a   Trudell, James ^c   Li, Kaixun ^a   Alkana, Ronald ^a,b   Davies, Daryl ^a   Asatryan, Liana ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b School of Pharmacy   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

ATP gated P2X4 receptors; Ethanol and ivermectin sensitivity; GluCl; Homology model; Molecular model; Position 46; Site directed mutagenesis; Whole cell two electrode voltage clamp; Xenopus oocytes; Zebrafish

Indexed keywords

ALANINE; ALCOHOL; COMPLEMENTARY RNA; IVERMECTIN; PURINERGIC P2X4 RECEPTOR; TRYPTOPHAN; PROTEIN BINDING;

ALCOHOL CONSUMPTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SENSITIVITY; GENE EXPRESSION SYSTEM; MODULATION; MOLECULAR DYNAMICS; NONHUMAN; OOCYTE; RAT; RECEPTOR SENSITIVITY; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS; ANIMAL; BINDING SITE; CELL CULTURE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; MOUSE;

ANIMALS; BINDING SITES; CELLS, CULTURED; COMPUTER SIMULATION; ETHANOL; IVERMECTIN; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, PURINERGIC P2X4; TRYPTOPHAN; XENOPUS LAEVIS;

EID: 84890558560     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-013-9373-4     Document Type: Article

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