Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors

British Journal of Pharmacology

Volumn 167, Issue 1, 2012, Pages 48-66

  Norenberg W ^a   Sobottka, H ^a   Hempel, C ^a   Plotz T ^a   Fischer, W ^a   Schmalzing, G ^b   Schaefer, M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

ATP pharmacology; ivermectin; ligand gated channel; P2X4; P2X7; pore dilation; purinergic signalling; species differences

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; IVERMECTIN; MEGLUMINE; PURINERGIC P2X7 RECEPTOR; RECOMBINANT PROTEIN; RECOMBINANT PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BIOPHYSICS; CALCIUM TRANSPORT; CELL LEVEL; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; EXTRACELLULAR MATRIX; FLUOROMETRY; HUMAN; HUMAN CELL; ION CURRENT; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; ANTIPARASITIC AGENTS; ASTROCYTES; BENZOXAZOLES; CALCIUM; CELLS, CULTURED; FLUORESCENT DYES; HEK293 CELLS; HUMANS; IVERMECTIN; MACROPHAGES; MICE; MICE, INBRED C57BL; MONOCYTES; QUINOLINIUM COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2X4; RECEPTORS, PURINERGIC P2X7; SPECIES SPECIFICITY;

EID: 84864723315     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01987.x     Document Type: Article

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