The mechanism by which ethanol inhibits rat P2X 4 receptors is altered by mutation of histidine 241

British Journal of Pharmacology

Volumn 145, Issue 5, 2005, Pages 576-586

  Xiong, Keming ^a   Hu, Xiang Qun ^a,b   Stewart, Randall R ^a   Weight, Forrest F ^a   Li, Chaoying ^a,c  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Competitive inhibition; Ethanol; Histidine; Mutation; Noncompetitive inhibition; P2X; P2X 4 receptor; PPADS; Suramin

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; HISTIDINE; PURINE P2X4 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RECOMBINANT PURINE P2X4 RECEPTOR; RECOMBINANT RECEPTOR; SURAMIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE MUTATION; HUMAN; HUMAN CELL; MEDIAN EFFECTIVE CONCENTRATION; MEMBRANE CURRENT; MEMBRANE POTENTIAL; NONCOMPETITIVE INHIBITION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; SITE DIRECTED MUTAGENESIS; XENOPUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; HISTIDINE; HUMANS; KIDNEY; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, PURINERGIC P2; RECOMBINANT PROTEINS; XENOPUS;

EID: 22744456836     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706192     Document Type: Article

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