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Volumn 45, Issue 13, 2013, Pages 1002-1008

The role of obestatin in glucose and lipid metabolism

Author keywords

adipogenesis; beta cells; human adipose tissue; insulin secretion; insulin sensitivity; lipid metabolism

Indexed keywords

ABC TRANSPORTER A1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 39; GHRELIN; GHRELIN RECEPTOR; GLUCOKINASE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROGENIN 3; NOTCH RECEPTOR; OBESTATIN; PROTEIN KINASE B; S6 KINASE; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; VISUAL PIGMENT;

EID: 84890548781     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1351325     Document Type: Review
Times cited : (19)

References (90)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature: 1999; 402 656 660 (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 3
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
    • DOI 10.1016/j.cell.2008.01.017, PII S0092867408001177
    • Yang J., Brown M. S., Liang G., Grishin N. V., Goldstein J. L. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell: 2008; 132 387 396 (Pubitemid 351192001)
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 4
    • 79958156703 scopus 로고    scopus 로고
    • Ghrelin axis genes, peptides and receptors: Recent findings and future challenges
    • Seim I., Josh P., Cunningham P., Herington A., Chopin L. Ghrelin axis genes, peptides and receptors: recent findings and future challenges. Mol Cell Endocrinol: 2011; 340 3 9
    • (2011) Mol Cell Endocrinol , vol.340 , pp. 3-9
    • Seim, I.1    Josh, P.2    Cunningham, P.3    Herington, A.4    Chopin, L.5
  • 5
    • 84867569409 scopus 로고    scopus 로고
    • Mechanisms in endocrinology: Ghrelin: The differences between acyl- and des-acyl ghrelin
    • Delhanty P. J., Neggers S. J., van der Lely A. J. Mechanisms in endocrinology: Ghrelin: the differences between acyl- and des-acyl ghrelin. Eur J Endocrinol: 2012; 167 601 608
    • (2012) Eur J Endocrinol , vol.167 , pp. 601-608
    • Delhanty, P.J.1    Neggers, S.J.2    Van Der Lely, A.J.3
  • 7
    • 77957374080 scopus 로고    scopus 로고
    • Unraveling the role of the ghrelin gene peptides in the endocrine pancreas
    • Granata R., Baragli A., Settanni F., Scarlatti F., Ghigo E. Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol: 2010; 45 107 118
    • (2010) J Mol Endocrinol , vol.45 , pp. 107-118
    • Granata, R.1    Baragli, A.2    Settanni, F.3    Scarlatti, F.4    Ghigo, E.5
  • 10
    • 35948975083 scopus 로고    scopus 로고
    • Heterogeneity of ghrelin/growth hormone secretagogue receptors: Toward the understanding of the molecular identity of novel ghrelin/GHS receptors
    • DOI 10.1159/000105141
    • Muccioli G., Baragli A., Granata R., Papotti M., Ghigo E. Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors. Neuroendocrinology: 2007; 86 147 164 (Pubitemid 350073603)
    • (2007) Neuroendocrinology , vol.86 , Issue.3 , pp. 147-164
    • Muccioli, G.1    Baragli, A.2    Granata, R.3    Papotti, M.4    Ghigo, E.5
  • 14
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: Involvement of 3β,5β-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • DOI 10.1210/en.2006-0266
    • Granata R., Settanni F., Biancone L., Trovato L., Nano R., Bertuzzi F., Destefanis S., Annunziata M., Martinetti M., Catapano F., Ghe C., Isgaard J., Papotti M., Ghigo E., Muccioli G. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling. Endocrinology: 2007; 148 512 529 (Pubitemid 46143157)
    • (2007) Endocrinology , vol.148 , Issue.2 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3    Trovato, L.4    Nano, R.5    Bertuzzi, F.6    Destefanis, S.7    Annunziata, M.8    Martinetti, M.9    Catapano, F.10    Ghe, C.11    Isgaard, J.12    Papotti, M.13    Ghigo, E.14    Muccioli, G.15
  • 15
    • 27744600963 scopus 로고    scopus 로고
    • Medicine: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • DOI 10.1126/science.1117255
    • Zhang J. V., Ren P. G., Avsian-Kretchmer O., Luo C. W., Rauch R., Klein C., Hsueh A. J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science: 2005; 310 996 999 (Pubitemid 41611907)
    • (2005) Science , vol.310 , Issue.5750 , pp. 996-999
    • Zhang, J.V.1    Ren, P.-G.2    Avsian-Kretchmer, O.3    Luo, C.-W.4    Rauch, R.5    Klein, C.6    Hsueh, A.J.W.7
  • 16
    • 33846904900 scopus 로고    scopus 로고
    • Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents
    • DOI 10.1210/en.2006-1231
    • Zizzari P., Longchamps R., Epelbaum J., Bluet-Pajot M. T. Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology: 2007; 148 1648 1653 (Pubitemid 46457120)
    • (2007) Endocrinology , vol.148 , Issue.4 , pp. 1648-1653
    • Zizzari, P.1    Longchamps, R.2    Epelbaum, J.3    Bluet-Pajot, M.T.4
  • 17
    • 84870881497 scopus 로고    scopus 로고
    • A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice
    • Hassouna R., Zizzari P., Viltart O., Yang S. K., Gardette R., Videau C., Badoer E., Epelbaum J., Tolle V. A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice. PLoS ONE: 2012; 7 e51135
    • (2012) PLoS ONE , vol.7
    • Hassouna, R.1    Zizzari, P.2    Viltart, O.3    Yang, S.K.4    Gardette, R.5    Videau, C.6    Badoer, E.7    Epelbaum, J.8    Tolle, V.9
  • 19
    • 34247499960 scopus 로고    scopus 로고
    • Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice
    • DOI 10.1016/j.peptides.2007.02.003, PII S0196978107000629
    • Green B. D., Irwin N., Flatt P. R. Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice. Peptides: 2007; 28 981 987 (Pubitemid 46654435)
    • (2007) Peptides , vol.28 , Issue.5 , pp. 981-987
    • Green, B.D.1    Irwin, N.2    Flatt, P.R.3
  • 20
    • 37549054328 scopus 로고    scopus 로고
    • Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat
    • Nagaraj S., Peddha M. S., Manjappara U. V. Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat. Biochem Biophys Res Commun: 2008; 366 731 737
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 731-737
    • Nagaraj, S.1    Peddha, M.S.2    Manjappara, U.V.3
  • 21
    • 44649103391 scopus 로고    scopus 로고
    • Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39
    • DOI 10.1210/me.2007-0569
    • Zhang J. V., Jahr H., Luo C. W., Klein C., Van Kolen K., Ver Donck L., De A., Baart E., Li J., Moechars D., Hsueh A. J. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39. Mol Endocrinol: 2008; 22 1464 1475 (Pubitemid 351787005)
    • (2008) Molecular Endocrinology , vol.22 , Issue.6 , pp. 1464-1475
    • Zhang, J.V.1    Jahr, H.2    Luo, C.-W.3    Klein, C.4    Van Kolen, K.5    Ver Donck, L.6    De, A.7    Baart, E.8    Li, J.9    Moechars, D.10    Hsueh, A.J.W.11
  • 23
    • 33846263052 scopus 로고    scopus 로고
    • Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract
    • DOI 10.1038/sj.bjp.0706969, PII 0706969
    • Bassil A. K., Haglund Y., Brown J., Rudholm T., Hellstrom P. M., Naslund E., Lee K., Sanger G. J. Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract. Br J Pharmacol: 2007; 150 58 64 (Pubitemid 46094669)
    • (2007) British Journal of Pharmacology , vol.150 , Issue.1 , pp. 58-64
    • Bassil, A.K.1    Haglund, Y.2    Brown, J.3    Rudholm, T.4    Hellstrom, P.M.5    Naslund, E.6    Lee, K.7    Sanger, G.J.8
  • 24
    • 33846902046 scopus 로고    scopus 로고
    • Effect of peripheral obestatin on gastric emptying and intestinal contractility in rodents
    • DOI 10.1111/j.1365-2982.2006.00883.x
    • De Smet B., Thijs T., Peeters T. L., Depoortere I. Effect of peripheral obestatin on gastric emptying and intestinal contractility in rodents. Neurogastroenterol Motil: 2007; 19 211 217 (Pubitemid 46239433)
    • (2007) Neurogastroenterology and Motility , vol.19 , Issue.3 , pp. 211-217
    • De Smet, B.1    Thijs, T.2    Peeters, T.L.3    Depoortere, I.4
  • 25
    • 33846926049 scopus 로고    scopus 로고
    • Lack of obestatin effects on food intake: Should obestatin be renamed ghrelin-associated peptide (GAP)?
    • DOI 10.1016/j.regpep.2006.12.023, PII S0167011507000031
    • Gourcerol G., St-Pierre D. H., Tache Y. Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)? Regul Pept: 2007; 141 1 7 (Pubitemid 46505037)
    • (2007) Regulatory Peptides , vol.141 , Issue.1-3 , pp. 1-7
    • Gourcerol, G.1    St-Pierre, D.H.2    Tache, Y.3
  • 28
    • 33645420927 scopus 로고    scopus 로고
    • Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin
    • Pan W., Tu H., Kastin A. J. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides: 2006; 27 911 916
    • (2006) Peptides , vol.27 , pp. 911-916
    • Pan, W.1    Tu, H.2    Kastin, A.J.3
  • 29
    • 84877248400 scopus 로고    scopus 로고
    • Peripheral administration of TAT-obestatin can influence the expression of liporegulatory genes but fails to affect food intake in mice
    • Ren G., He Z., Cong P., Chen H., Guo Y., Yu J., Liu Z., Ji Q., Song Z., Chen Y. Peripheral administration of TAT-obestatin can influence the expression of liporegulatory genes but fails to affect food intake in mice. Peptides: 2013; 42C 8 14
    • (2013) Peptides , vol.42 C , pp. 8-14
    • Ren, G.1    He, Z.2    Cong, P.3    Chen, H.4    Guo, Y.5    Yu, J.6    Liu, Z.7    Ji, Q.8    Song, Z.9    Chen, Y.10
  • 31
    • 49749084909 scopus 로고    scopus 로고
    • Distribution of obestatin and ghrelin in human tissues: Immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands
    • Gronberg M., Tsolakis A. V., Magnusson L., Janson E. T., Saras J. Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem: 2008; 56 793 801
    • (2008) J Histochem Cytochem , vol.56 , pp. 793-801
    • Gronberg, M.1    Tsolakis, A.V.2    Magnusson, L.3    Janson, E.T.4    Saras, J.5
  • 33
    • 39149138127 scopus 로고    scopus 로고
    • Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: An immunohistochemical and electron-microscopic study
    • Zhao C. M., Furnes M. W., Stenstrom B., Kulseng B., Chen D. Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study. Cell Tissue Res: 2008; 331 575 587
    • (2008) Cell Tissue Res , vol.331 , pp. 575-587
    • Zhao, C.M.1    Furnes, M.W.2    Stenstrom, B.3    Kulseng, B.4    Chen, D.5
  • 34
    • 44649138499 scopus 로고    scopus 로고
    • Different responses of circulating ghrelin, obestatin levels to fasting, re-feeding and different food compositions, and their local expressions in rats
    • Guo Z. F., Ren A. J., Zheng X., Qin Y. W., Cheng F., Zhang J., Wu H., Yuan W. J., Zou L. Different responses of circulating ghrelin, obestatin levels to fasting, re-feeding and different food compositions, and their local expressions in rats. Peptides: 2008; 29 1247 1254
    • (2008) Peptides , vol.29 , pp. 1247-1254
    • Guo, Z.F.1    Ren, A.J.2    Zheng, X.3    Qin, Y.W.4    Cheng, F.5    Zhang, J.6    Wu, H.7    Yuan, W.J.8    Zou, L.9
  • 38
    • 46449120007 scopus 로고    scopus 로고
    • Plasma Obestatin Concentrations Are Negatively Correlated with Body Mass Index, Insulin Resistance Index, and Plasma Leptin Concentrations in Obesity and Anorexia Nervosa
    • DOI 10.1016/j.biopsych.2007.08.005, PII S0006322307007767
    • Nakahara T., Harada T., Yasuhara D., Shimada N., Amitani H., Sakoguchi T., Kamiji M. M., Asakawa A., Inui A. Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa. Biol Psychiatry: 2008; 64 252 255 (Pubitemid 351927261)
    • (2008) Biological Psychiatry , vol.64 , Issue.3 , pp. 252-255
    • Nakahara, T.1    Harada, T.2    Yasuhara, D.3    Shimada, N.4    Amitani, H.5    Sakoguchi, T.6    Kamiji, M.M.7    Asakawa, A.8    Inui, A.9
  • 40
    • 57349151755 scopus 로고    scopus 로고
    • Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa
    • DOI 10.1210/jc.2008-1138
    • Monteleone P., Serritella C., Martiadis V., Scognamiglio P., Maj M. Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa. J Clin Endocrinol Metab: 2008; 93 4418 4421 (Pubitemid 352789541)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.11 , pp. 4418-4421
    • Monteleone, P.1    Serritella, C.2    Martiadis, V.3    Scognamiglio, P.4    Maj, M.5
  • 42
    • 79955884141 scopus 로고    scopus 로고
    • Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast
    • Sedlackova D., Kopeckova J., Papezova H., Vybiral S., Kvasnickova H., Hill M., Nedvidkova J. Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast. Physiol Res: 2011; 60 165 173
    • (2011) Physiol Res , vol.60 , pp. 165-173
    • Sedlackova, D.1    Kopeckova, J.2    Papezova, H.3    Vybiral, S.4    Kvasnickova, H.5    Hill, M.6    Nedvidkova, J.7
  • 44
    • 84870978374 scopus 로고    scopus 로고
    • Decreased serum obestatin consequent upon TRIB3 Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
    • Cui A. D., Gai N. N., Zhang X. H., Jia K. Z., Yang Y. L., Song Z. J. Decreased serum obestatin consequent upon TRIB3 Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome. Diabetol Metab Syndr: 2012; 4 52
    • (2012) Diabetol Metab Syndr , vol.4 , pp. 52
    • Cui, A.D.1    Gai, N.N.2    Zhang, X.H.3    Jia, K.Z.4    Yang, Y.L.5    Song, Z.J.6
  • 46
    • 52049109182 scopus 로고    scopus 로고
    • Plasma obestatin levels in men with chronic atrophic gastritis
    • Gao X. Y., Kuang H. Y., Liu X. M., Ma Z. B., Nie H. J., Guo H. Plasma obestatin levels in men with chronic atrophic gastritis. Peptides: 2008; 29 1749 1754
    • (2008) Peptides , vol.29 , pp. 1749-1754
    • Gao, X.Y.1    Kuang, H.Y.2    Liu, X.M.3    Ma, Z.B.4    Nie, H.J.5    Guo, H.6
  • 48
    • 84879129962 scopus 로고    scopus 로고
    • Ghrelin and obestatin in human neuroendocrine tumors: Expression and effect on obestatin levels after food intake
    • Gronberg M., Tsolakis A. V., Holmback U., Stridsberg M., Grimelius L., Janson E. T. Ghrelin and obestatin in human neuroendocrine tumors: expression and effect on obestatin levels after food intake. Neuroendocrinology: 2013; 97 291 299
    • (2013) Neuroendocrinology , vol.97 , pp. 291-299
    • Gronberg, M.1    Tsolakis, A.V.2    Holmback, U.3    Stridsberg, M.4    Grimelius, L.5    Janson, E.T.6
  • 51
    • 84872398448 scopus 로고    scopus 로고
    • Obestatin receptor in energy homeostasis and obesity pathogenesis
    • Zhang J. V., Li L., Huang Q., Ren P. G. Obestatin receptor in energy homeostasis and obesity pathogenesis. Prog Mol Biol Transl Sci: 2013; 114 89 107
    • (2013) Prog Mol Biol Transl Sci , vol.114 , pp. 89-107
    • Zhang, J.V.1    Li, L.2    Huang, Q.3    Ren, P.G.4
  • 52
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker D. J. The biology of incretin hormones. Cell Metab: 2006; 3 153 165
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 53
    • 77955455608 scopus 로고    scopus 로고
    • Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes
    • Alloatti G., Arnoletti E., Bassino E., Penna C., Perrelli M. G., Ghe C., Muccioli G. Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes. Am J Physiol Heart Circ Physiol: 2010; 299 H470 H481
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Alloatti, G.1    Arnoletti, E.2    Bassino, E.3    Penna, C.4    Perrelli, M.G.5    Ghe, C.6    Muccioli, G.7
  • 56
  • 57
    • 33745982941 scopus 로고    scopus 로고
    • Obestatin alters sleep in rats
    • DOI 10.1016/j.neulet.2006.05.053, PII S0304394006005568
    • Szentirmai E., Krueger J. M. Obestatin alters sleep in rats. Neurosci Lett: 2006; 404 222 226 (Pubitemid 44063607)
    • (2006) Neuroscience Letters , vol.404 , Issue.1-2 , pp. 222-226
    • Szentirmai, E.1    Krueger, J.M.2
  • 58
    • 33847642830 scopus 로고    scopus 로고
    • Obestatin-mediated proliferation of human retinal pigment epithelial cells: Regulatory mechanisms
    • DOI 10.1002/jcp.20925
    • Camina J. P., Campos J. F., Caminos J. E., Dieguez C., Casanueva F. F. Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms. J Cell Physiol: 2007; 211 1 9 (Pubitemid 46363890)
    • (2007) Journal of Cellular Physiology , vol.211 , Issue.1 , pp. 1-9
    • Camina, J.P.1    Campos, J.F.2    Caminos, J.E.3    Dieguez, C.4    Casanueva, F.F.5
  • 59
    • 41449114267 scopus 로고    scopus 로고
    • Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin
    • DOI 10.1080/08977190801889313, PII 791708869
    • Pazos Y., Alvarez C. J., Camina J. P., Casanueva F. F. Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. Growth Factors: 2007; 25 373 381 (Pubitemid 351455003)
    • (2007) Growth Factors , vol.25 , Issue.6 , pp. 373-381
    • Pazos, Y.1    Alvarez, C.J.P.2    Camina, J.3    Casanueva, F.F.4
  • 61
    • 84862576179 scopus 로고    scopus 로고
    • The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways
    • Favaro E., Granata R., Miceli I., Baragli A., Settanni F., Cavallo Perin P., Ghigo E., Camussi G., Zanone M. M. The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways. Diabetologia: 2012; 55 1058 1070
    • (2012) Diabetologia , vol.55 , pp. 1058-1070
    • Favaro, E.1    Granata, R.2    Miceli, I.3    Baragli, A.4    Settanni, F.5    Cavallo Perin, P.6    Ghigo, E.7    Camussi, G.8    Zanone, M.M.9
  • 64
    • 79251634954 scopus 로고    scopus 로고
    • Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes
    • Miegueu P. St, Pierre D., Broglio F., Cianflone K. Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes. J Cell Biochem: 2011; 112 704 714
    • (2011) J Cell Biochem , vol.112 , pp. 704-714
    • St, M.P.1    Pierre, D.2    Broglio, F.3    Cianflone, K.4
  • 67
    • 79958788035 scopus 로고    scopus 로고
    • Cardiovascular actions of the ghrelin gene-derived peptides and growth hormone-releasing hormone
    • Granata R., Isgaard J., Alloatti G., Ghigo E. Cardiovascular actions of the ghrelin gene-derived peptides and growth hormone-releasing hormone. Exp Biol Med (Maywood): 2011; 236 505 514
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 505-514
    • Granata, R.1    Isgaard, J.2    Alloatti, G.3    Ghigo, E.4
  • 68
    • 70449728066 scopus 로고    scopus 로고
    • Ghrelin and obestatin modulate early atherogenic processes on cells: Enhancement of monocyte adhesion and oxidized low-density lipoprotein binding
    • Kellokoski E., Kunnari A., Jokela M., Makela S., Kesaniemi Y. A., Horkko S. Ghrelin and obestatin modulate early atherogenic processes on cells: enhancement of monocyte adhesion and oxidized low-density lipoprotein binding. Metabolism: 2009; 58 1572 1580
    • (2009) Metabolism , vol.58 , pp. 1572-1580
    • Kellokoski, E.1    Kunnari, A.2    Jokela, M.3    Makela, S.4    Kesaniemi, Y.A.5    Horkko, S.6
  • 70
    • 84877974356 scopus 로고    scopus 로고
    • Products of the Ghrelin Gene, the Pancreatic beta-Cell and the Adipocyte
    • Granata R., Ghigo E. Products of the Ghrelin Gene, the Pancreatic beta-Cell and the Adipocyte. Endocr Dev: 2013; 25 144 156
    • (2013) Endocr Dev , vol.25 , pp. 144-156
    • Granata, R.1    Ghigo, E.2
  • 71
    • 58149391763 scopus 로고    scopus 로고
    • Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach
    • Walia P., Asadi A., Kieffer T. J., Johnson J. D., Chanoine J. P. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatr Res: 2009; 65 39 44
    • (2009) Pediatr Res , vol.65 , pp. 39-44
    • Walia, P.1    Asadi, A.2    Kieffer, T.J.3    Johnson, J.D.4    Chanoine, J.P.5
  • 72
    • 84858797260 scopus 로고    scopus 로고
    • Obestatin and insulin in pancreas of newborn diabetic rats treated with exogenous ghrelin
    • Turk N., Dagistanli F. K., Sacan O., Yanardag R., Bolkent S. Obestatin and insulin in pancreas of newborn diabetic rats treated with exogenous ghrelin. Acta Histochem: 2012; 114 349 357
    • (2012) Acta Histochem , vol.114 , pp. 349-357
    • Turk, N.1    Dagistanli, F.K.2    Sacan, O.3    Yanardag, R.4    Bolkent, S.5
  • 73
    • 1842844414 scopus 로고    scopus 로고
    • Decreased beta-cell mass in diabetes: Significance, mechanisms and therapeutic implications
    • DOI 10.1007/s00125-004-1336-4
    • Donath M. Y., Halban P. A. Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia: 2004; 47 581 589 (Pubitemid 38491259)
    • (2004) Diabetologia , vol.47 , Issue.3 , pp. 581-589
    • Donath, M.Y.1    Halban, P.A.2
  • 77
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagon-like peptide 1 in the pancreas
    • DOI 10.1016/j.pharmthera.2006.11.007, PII S0163725806002038
    • Doyle M. E., Egan J. M. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther: 2007; 113 546 593 (Pubitemid 46365961)
    • (2007) Pharmacology and Therapeutics , vol.113 , Issue.3 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 79
    • 0037098974 scopus 로고    scopus 로고
    • The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas
    • DOI 10.1016/S0167-0115(02)00067-8, PII S0167011502000678
    • Wierup N., Svensson H., Mulder H., Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept: 2002; 107 63 69 (Pubitemid 34876446)
    • (2002) Regulatory Peptides , vol.107 , Issue.1-3 , pp. 63-69
    • Wierup, N.1    Svensson, H.2    Mulder, H.3    Sundler, F.4
  • 81
    • 38149098503 scopus 로고    scopus 로고
    • Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas
    • Qader S. S., Hakanson R., Rehfeld J. F., Lundquist I., Salehi A. Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: a study on isolated islets from mouse and rat pancreas. Regul Pept: 2008; 146 230 237
    • (2008) Regul Pept , vol.146 , pp. 230-237
    • Qader, S.S.1    Hakanson, R.2    Rehfeld, J.F.3    Lundquist, I.4    Salehi, A.5
  • 83
    • 57249115880 scopus 로고    scopus 로고
    • Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas
    • Egido E. M., Hernandez R., Marco J., Silvestre R. A. Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas. Regul Pept: 2009; 152 61 66
    • (2009) Regul Pept , vol.152 , pp. 61-66
    • Egido, E.M.1    Hernandez, R.2    Marco, J.3    Silvestre, R.A.4
  • 85
    • 77949268951 scopus 로고    scopus 로고
    • Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase
    • Bourron O., Daval M., Hainault I., Hajduch E., Servant J. M., Gautier J. F., Ferre P., Foufelle F. Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase. Diabetologia: 2010; 53 768 778
    • (2010) Diabetologia , vol.53 , pp. 768-778
    • Bourron, O.1    Daval, M.2    Hainault, I.3    Hajduch, E.4    Servant, J.M.5    Gautier, J.F.6    Ferre, P.7    Foufelle, F.8
  • 88
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • DOI 10.1172/JCI29126
    • Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest: 2006; 116 1784 1792 (Pubitemid 44033298)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6


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