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Volumn 8, Issue 5, 2013, Pages

Obestatin Enhances In Vitro Generation of Pancreatic Islets through Regulation of Developmental Pathways

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FIBROBLAST GROWTH FACTOR RECEPTOR; INSULIN; NESTIN; NEUROGENIN 3; NOTCH RECEPTOR; OBESTATIN;

EID: 84878595180     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064374     Document Type: Article
Times cited : (22)

References (50)
  • 2
    • 77955814966 scopus 로고    scopus 로고
    • Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells
    • Alipio Z, Liao W, Roemer EJ, Waner M, Fink LM, et al. (2010) Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A 107: 13426-13431.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13426-13431
    • Alipio, Z.1    Liao, W.2    Roemer, E.J.3    Waner, M.4    Fink, L.M.5
  • 3
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24: 1392-1401.
    • (2006) Nat Biotechnol , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1    Bang, A.G.2    Eliazer, S.3    Kelly, O.G.4    Agulnick, A.D.5
  • 4
    • 79958139078 scopus 로고    scopus 로고
    • Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice
    • Chandra V, Swetha G, Muthyala S, Jaiswal AK, Bellare JR, et al. (2011) Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice. PLoS One 6: e20615.
    • (2011) PLoS One , vol.6
    • Chandra, V.1    Swetha, G.2    Muthyala, S.3    Jaiswal, A.K.4    Bellare, J.R.5
  • 5
    • 78649565222 scopus 로고    scopus 로고
    • Induction of insulin-producing cells derived from endometrial mesenchymal stem-like cells
    • Li HY, Chen YJ, Chen SJ, Kao CL, Tseng LM, et al. (2010) Induction of insulin-producing cells derived from endometrial mesenchymal stem-like cells. J Pharmacol Exp Ther 335: 817-829.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 817-829
    • Li, H.Y.1    Chen, Y.J.2    Chen, S.J.3    Kao, C.L.4    Tseng, L.M.5
  • 6
    • 77952884832 scopus 로고    scopus 로고
    • Reprogramming into pancreatic endocrine cells based on developmental cues
    • Kordowich S, Mansouri A, Collombat P, (2010) Reprogramming into pancreatic endocrine cells based on developmental cues. Mol Cell Endocrinol 323: 62-69.
    • (2010) Mol Cell Endocrinol , vol.323 , pp. 62-69
    • Kordowich, S.1    Mansouri, A.2    Collombat, P.3
  • 7
    • 19944432634 scopus 로고    scopus 로고
    • Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice
    • Kodama S, Toyonaga T, Kondo T, Matsumoto K, Tsuruzoe K, et al. (2005) Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Biochem Biophys Res Commun 327: 1170-1178.
    • (2005) Biochem Biophys Res Commun , vol.327 , pp. 1170-1178
    • Kodama, S.1    Toyonaga, T.2    Kondo, T.3    Matsumoto, K.4    Tsuruzoe, K.5
  • 8
    • 71649092364 scopus 로고    scopus 로고
    • Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
    • Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, et al. (2009) Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell 17: 849-860.
    • (2009) Dev Cell , vol.17 , pp. 849-860
    • Solar, M.1    Cardalda, C.2    Houbracken, I.3    Martin, M.4    Maestro, M.A.5
  • 9
    • 77957606887 scopus 로고    scopus 로고
    • Beta-cell growth and regeneration: replication is only part of the story
    • Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, et al. (2010) Beta-cell growth and regeneration: replication is only part of the story. Diabetes 59: 2340-2348.
    • (2010) Diabetes , vol.59 , pp. 2340-2348
    • Bonner-Weir, S.1    Li, W.C.2    Ouziel-Yahalom, L.3    Guo, L.4    Weir, G.C.5
  • 10
    • 74949085342 scopus 로고    scopus 로고
    • Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury
    • Liu H, Guz Y, Kedees MH, Winkler J, Teitelman G, (2010) Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology 151: 520-528.
    • (2010) Endocrinology , vol.151 , pp. 520-528
    • Liu, H.1    Guz, Y.2    Kedees, M.H.3    Winkler, J.4    Teitelman, G.5
  • 11
    • 8644277274 scopus 로고    scopus 로고
    • Adult pancreas generates multipotent stem cells and pancreatic and nonpancreatic progeny
    • Choi Y, Ta M, Atouf F, Lumelsky N, (2004) Adult pancreas generates multipotent stem cells and pancreatic and nonpancreatic progeny. Stem Cells 22: 1070-1084.
    • (2004) Stem Cells , vol.22 , pp. 1070-1084
    • Choi, Y.1    Ta, M.2    Atouf, F.3    Lumelsky, N.4
  • 12
    • 37349097054 scopus 로고    scopus 로고
    • Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo
    • Davani B, Ikonomou L, Raaka BM, Geras-Raaka E, Morton RA, et al. (2007) Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells 25: 3215-3222.
    • (2007) Stem Cells , vol.25 , pp. 3215-3222
    • Davani, B.1    Ikonomou, L.2    Raaka, B.M.3    Geras-Raaka, E.4    Morton, R.A.5
  • 13
    • 11144315998 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
    • Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, et al. (2004) Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306: 2261-2264.
    • (2004) Science , vol.306 , pp. 2261-2264
    • Gershengorn, M.C.1    Hardikar, A.A.2    Wei, C.3    Geras-Raaka, E.4    Marcus-Samuels, B.5
  • 14
    • 34247589600 scopus 로고    scopus 로고
    • Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells
    • Morton RA, Geras-Raaka E, Wilson LM, Raaka BM, Gershengorn MC, (2007) Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells. Mol Cell Endocrinol 270: 87-93.
    • (2007) Mol Cell Endocrinol , vol.270 , pp. 87-93
    • Morton, R.A.1    Geras-Raaka, E.2    Wilson, L.M.3    Raaka, B.M.4    Gershengorn, M.C.5
  • 15
    • 33749063267 scopus 로고    scopus 로고
    • The defined combination of growth factors controls generation of long-term-replicating islet progenitor-like cells from cultures of adult mouse pancreas
    • Ta M, Choi Y, Atouf F, Park CH, Lumelsky N, (2006) The defined combination of growth factors controls generation of long-term-replicating islet progenitor-like cells from cultures of adult mouse pancreas. Stem Cells 24: 1738-1749.
    • (2006) Stem Cells , vol.24 , pp. 1738-1749
    • Ta, M.1    Choi, Y.2    Atouf, F.3    Park, C.H.4    Lumelsky, N.5
  • 16
    • 37349051445 scopus 로고    scopus 로고
    • The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression
    • Mutskov V, Raaka BM, Felsenfeld G, Gershengorn MC, (2007) The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression. Stem Cells 25: 3223-3233.
    • (2007) Stem Cells , vol.25 , pp. 3223-3233
    • Mutskov, V.1    Raaka, B.M.2    Felsenfeld, G.3    Gershengorn, M.C.4
  • 18
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, et al. (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310: 996-999.
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3    Luo, C.W.4    Rauch, R.5
  • 19
    • 33846995594 scopus 로고    scopus 로고
    • Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake"
    • author reply 766
    • Chartrel N, Alvear-Perez R, Leprince J, Iturrioz X, Reaux-Le Goazigo A, et al. (2007) Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science 315: 766; author reply 766.
    • (2007) Science , vol.315 , pp. 766
    • Chartrel, N.1    Alvear-Perez, R.2    Leprince, J.3    Iturrioz, X.4    Reaux-Le Goazigo, A.5
  • 20
    • 77957374080 scopus 로고    scopus 로고
    • Unraveling the role of the ghrelin gene peptides in the endocrine pancreas
    • Granata R, Baragli A, Settanni F, Scarlatti F, Ghigo E, (2010) Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 45: 107-118.
    • (2010) J Mol Endocrinol , vol.45 , pp. 107-118
    • Granata, R.1    Baragli, A.2    Settanni, F.3    Scarlatti, F.4    Ghigo, E.5
  • 21
    • 42449124783 scopus 로고    scopus 로고
    • Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function
    • Granata R, Settanni F, Gallo D, Trovato L, Biancone L, et al. (2008) Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function. Diabetes 57: 967-979.
    • (2008) Diabetes , vol.57 , pp. 967-979
    • Granata, R.1    Settanni, F.2    Gallo, D.3    Trovato, L.4    Biancone, L.5
  • 22
    • 84864768395 scopus 로고    scopus 로고
    • Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation
    • Granata R, Gallo D, Luque RM, Baragli A, Scarlatti F, et al. (2012) Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation. FASEB J 26: 3393-3411.
    • (2012) FASEB J , vol.26 , pp. 3393-3411
    • Granata, R.1    Gallo, D.2    Luque, R.M.3    Baragli, A.4    Scarlatti, F.5
  • 23
    • 57249115880 scopus 로고    scopus 로고
    • Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas
    • Egido EM, Hernandez R, Marco J, Silvestre RA, (2009) Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas. Regul Pept 152: 61-66.
    • (2009) Regul Pept , vol.152 , pp. 61-66
    • Egido, E.M.1    Hernandez, R.2    Marco, J.3    Silvestre, R.A.4
  • 24
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling
    • Granata R, Settanni F, Biancone L, Trovato L, Nano R, et al. (2007) Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling. Endocrinology 148: 512-529.
    • (2007) Endocrinology , vol.148 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3    Trovato, L.4    Nano, R.5
  • 25
    • 77954749961 scopus 로고    scopus 로고
    • Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats
    • Granata R, Volante M, Settanni F, Gauna C, Ghe C, et al. (2010) Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J Mol Endocrinol 45: 9-17.
    • (2010) J Mol Endocrinol , vol.45 , pp. 9-17
    • Granata, R.1    Volante, M.2    Settanni, F.3    Gauna, C.4    Ghe, C.5
  • 26
    • 33746336541 scopus 로고    scopus 로고
    • Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas
    • Chanoine JP, Wong AC, Barrios V, (2006) Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Horm Res 66: 81-88.
    • (2006) Horm Res , vol.66 , pp. 81-88
    • Chanoine, J.P.1    Wong, A.C.2    Barrios, V.3
  • 27
    • 0033135799 scopus 로고    scopus 로고
    • Large-scale isolation of islets by tissue culture of adult mouse pancreas
    • Shewade YM, Umrani M, Bhonde RR, (1999) Large-scale isolation of islets by tissue culture of adult mouse pancreas. Transplant Proc 31: 1721-1723.
    • (1999) Transplant Proc , vol.31 , pp. 1721-1723
    • Shewade, Y.M.1    Umrani, M.2    Bhonde, R.R.3
  • 28
    • 79953321898 scopus 로고    scopus 로고
    • Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration
    • Rukstalis JM, Habener JF, (2009) Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration. Islets 1: 177-184.
    • (2009) Islets , vol.1 , pp. 177-184
    • Rukstalis, J.M.1    Habener, J.F.2
  • 29
    • 4644222526 scopus 로고    scopus 로고
    • Artifactual insulin release from differentiated embryonic stem cells
    • Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, et al. (2004) Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53: 2603-2609.
    • (2004) Diabetes , vol.53 , pp. 2603-2609
    • Hansson, M.1    Tonning, A.2    Frandsen, U.3    Petri, A.4    Rajagopal, J.5
  • 31
    • 78651107400 scopus 로고    scopus 로고
    • Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a
    • Miyatsuka T, Kosaka Y, Kim H, German MS, (2011) Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a. Proc Natl Acad Sci U S A 108: 185-190.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 185-190
    • Miyatsuka, T.1    Kosaka, Y.2    Kim, H.3    German, M.S.4
  • 32
    • 33750542712 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells conditionally expressing neurogenin 3
    • Treff NR, Vincent RK, Budde ML, Browning VL, Magliocca JF, et al. (2006) Differentiation of embryonic stem cells conditionally expressing neurogenin 3. Stem Cells 24: 2529-2537.
    • (2006) Stem Cells , vol.24 , pp. 2529-2537
    • Treff, N.R.1    Vincent, R.K.2    Budde, M.L.3    Browning, V.L.4    Magliocca, J.F.5
  • 33
    • 67649865643 scopus 로고    scopus 로고
    • Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
    • Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, et al. (2009) Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A 106: 9715-9720.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9715-9720
    • Wang, S.1    Jensen, J.N.2    Seymour, P.A.3    Hsu, W.4    Dor, Y.5
  • 34
    • 44749087001 scopus 로고    scopus 로고
    • In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing
    • Russ HA, Bar Y, Ravassard P, Efrat S, (2008) In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes 57: 1575-1583.
    • (2008) Diabetes , vol.57 , pp. 1575-1583
    • Russ, H.A.1    Bar, Y.2    Ravassard, P.3    Efrat, S.4
  • 35
    • 0031854251 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 promotes pancreatic epithelial cell proliferation via functional fibroblast growth factor receptors during embryonic life
    • Le Bras S, Miralles F, Basmaciogullari A, Czernichow P, Scharfmann R, (1998) Fibroblast growth factor 2 promotes pancreatic epithelial cell proliferation via functional fibroblast growth factor receptors during embryonic life. Diabetes 47: 1236-1242.
    • (1998) Diabetes , vol.47 , pp. 1236-1242
    • Le Bras, S.1    Miralles, F.2    Basmaciogullari, A.3    Czernichow, P.4    Scharfmann, R.5
  • 36
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, et al. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292: 1389-1394.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5
  • 37
    • 0037795466 scopus 로고    scopus 로고
    • Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates
    • Hardikar AA, Marcus-Samuels B, Geras-Raaka E, Raaka BM, Gershengorn MC, (2003) Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates. Proc Natl Acad Sci U S A 100: 7117-7122.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7117-7122
    • Hardikar, A.A.1    Marcus-Samuels, B.2    Geras-Raaka, E.3    Raaka, B.M.4    Gershengorn, M.C.5
  • 39
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, et al. (2010) Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464: 1149-1154.
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3    Kohno, K.4    Desgraz, R.5
  • 40
    • 41849151748 scopus 로고    scopus 로고
    • Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    • Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, et al. (2008) Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 26: 443-452.
    • (2008) Nat Biotechnol , vol.26 , pp. 443-452
    • Kroon, E.1    Martinson, L.A.2    Kadoya, K.3    Bang, A.G.4    Kelly, O.G.5
  • 41
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation is severely restricted with advanced age
    • Rankin MM, Kushner JA, (2009) Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 58: 1365-1372.
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 42
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu X, D'Hoker J, Stange G, Bonne S, De Leu N, et al. (2008) Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132: 197-207.
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1    D'Hoker, J.2    Stange, G.3    Bonne, S.4    De Leu, N.5
  • 43
    • 59649085435 scopus 로고    scopus 로고
    • Promotion of beta-cell differentiation in pancreatic precursor cells by adult islet cells
    • Chen W, Begum S, Opare-Addo L, Garyu J, Gibson TF, et al. (2009) Promotion of beta-cell differentiation in pancreatic precursor cells by adult islet cells. Endocrinology 150: 570-579.
    • (2009) Endocrinology , vol.150 , pp. 570-579
    • Chen, W.1    Begum, S.2    Opare-Addo, L.3    Garyu, J.4    Gibson, T.F.5
  • 44
    • 0032991511 scopus 로고    scopus 로고
    • Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas
    • Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R, (1999) Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 96: 6267-6272.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6267-6272
    • Miralles, F.1    Czernichow, P.2    Ozaki, K.3    Itoh, N.4    Scharfmann, R.5
  • 45
    • 0037133681 scopus 로고    scopus 로고
    • Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation
    • Elghazi L, Cras-Meneur C, Czernichow P, Scharfmann R, (2002) Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. Proc Natl Acad Sci U S A 99: 3884-3889.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3884-3889
    • Elghazi, L.1    Cras-Meneur, C.2    Czernichow, P.3    Scharfmann, R.4
  • 46
    • 79959805601 scopus 로고    scopus 로고
    • A variant of fibroblast growth factor receptor 2 (Fgfr2) regulates left-right asymmetry in zebrafish
    • Liu DW, Hsu CH, Tsai SM, Hsiao CD, Wang WP, (2011) A variant of fibroblast growth factor receptor 2 (Fgfr2) regulates left-right asymmetry in zebrafish. PLoS One 6: e21793.
    • (2011) PLoS One , vol.6
    • Liu, D.W.1    Hsu, C.H.2    Tsai, S.M.3    Hsiao, C.D.4    Wang, W.P.5
  • 47
    • 33847068767 scopus 로고    scopus 로고
    • FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells
    • Arnaud-Dabernat S, Kritzik M, Kayali AG, Zhang YQ, Liu G, et al. (2007) FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. Diabetes 56: 96-106.
    • (2007) Diabetes , vol.56 , pp. 96-106
    • Arnaud-Dabernat, S.1    Kritzik, M.2    Kayali, A.G.3    Zhang, Y.Q.4    Liu, G.5
  • 48
    • 79951590737 scopus 로고    scopus 로고
    • Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development
    • Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A, (2011) Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev Dyn 240: 589-604.
    • (2011) Dev Dyn , vol.240 , pp. 589-604
    • Gouzi, M.1    Kim, Y.H.2    Katsumoto, K.3    Johansson, K.4    Grapin-Botton, A.5
  • 49
    • 70450202720 scopus 로고    scopus 로고
    • Islet formation during the neonatal development in mice
    • Miller K, Kim A, Kilimnik G, Jo J, Moka U, et al. (2009) Islet formation during the neonatal development in mice. PLoS One 4: e7739.
    • (2009) PLoS One , vol.4
    • Miller, K.1    Kim, A.2    Kilimnik, G.3    Jo, J.4    Moka, U.5
  • 50
    • 0037098974 scopus 로고    scopus 로고
    • The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
    • Wierup N, Svensson H, Mulder H, Sundler F, (2002) The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 107: 63-69.
    • (2002) Regul Pept , vol.107 , pp. 63-69
    • Wierup, N.1    Svensson, H.2    Mulder, H.3    Sundler, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.