The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways

Diabetologia

Volumn 55, Issue 4, 2012, Pages 1058-1070

  Favaro, E ^a   Granata, R ^a   Miceli, I ^a   Baragli, A ^a   Settanni, F ^a   Cavallo Perin, P ^a   Ghigo, E ^a   Camussi, G ^a   Zanone, M M ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Akt; CAMP. Endothelial cells; ERK1 2; Exendin 4; Ghrelin; Hyperglycaemia; Obestatin; Pancreatic islets of Langerhans; VEGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CD40 LIGAND; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXENDIN 4; GHRELIN; GLUCOSE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; OBESTATIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; VASCULOTROPIN A;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERGLYCEMIA; PANCREAS ISLET CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SUPERNATANT; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GHRELIN; GLUCOSE; HUMANS; ISLETS OF LANGERHANS; PEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, GHRELIN; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENOMS;

EID: 84862576179     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2423-y     Document Type: Article

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