Obestatin in human neuroendocrine tissues and tumours: Expression and effect on tumour growth

Journal of Pathology

Volumn 218, Issue 4, 2009, Pages 458-466

  Volante, Marco ^a   Rosas, Rosj ^a   Ceppi, Paolo ^a   Rapa, Ida ^a   Cassoni, Paola ^a   Wiedenmann, Bertram ^b   Settanni, Fabio ^c   Granata, Riccarda ^c   Papotti, Mauro ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Cell growth; Ghrelin; Immunohistochemistry; Neuroendocrine tumours; Obestatin; Real time PCR

Indexed keywords

CHROMOGRANIN A; GHRELIN; MESSENGER RNA; OBESTATIN;

ARTICLE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENDOCRINE CELL; FETUS (ANATOMY); GASTROINTESTINAL TUMOR; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS; IMMUNOREACTIVITY; LUNG PARENCHYMA; NEUROENDOCRINE TUMOR; NORMAL HUMAN; PANCREAS TUMOR; PARATHYROID TUMOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; THYROID TUMOR; TUMOR CELL; TUMOR GROWTH;

ABORTED FETUS; ADULT; ANALYSIS OF VARIANCE; ANTIBODIES; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA PROBES; FLUORESCENT ANTIBODY TECHNIQUE; GHRELIN; HUMANS; IMMUNOHISTOCHEMISTRY; NEUROENDOCRINE CELLS; NEUROENDOCRINE TUMORS; NEUROSECRETORY SYSTEMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

EID: 67650878954     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2551     Document Type: Article

References (44)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Science 1999;402:656-658.
2. Ghigo E, Arvat E, Muccoli G, Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol 1997;136:445-460.
3. Muccioli G, Ghè C, Ghigo MC, Papotti M, Arvat E, Boghen MF, et al. Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland. J. Endocrinol 1998;157:99-106.
4. Bowers CY. Growth hormone releasing peptides: physiology and clinical applications. Curr Opin Endocrinol Diabetes 2000;7:168-174.
5. Cassoni P, Ghe C, Marrocco T, Tarabra E, Allia E, Catapano F, et al. Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur J Endocrinol 2004;150:173-184.
6. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a non-natural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 2001;86:1169-1174.
7. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 2001;86:5083-5086.
8. Papotti M, Ghè C, Cassoni P, Catapano F, Deghenghi R, Ghigo E, et al. Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 2000;85:3803-3807.
9. Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E. Ghrelin-producing endocrine tumors of the stomach and intestine. J Clin Endocrinol Metab 2001;86:5052-5059.
10. Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002;87:1300-1308.
11. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A, Papotti M. Ghrelin expression in fetal, infant, and adult human lung. J Histochem Cytochem 2002;50:1013-1021.
12. Volante M, Allia E, Fulcheri E, Cassoni P, Ghigo E, Muccioli G, et al. Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth. Am J Pathol 2003;162:645- 654.
13. Allia E, Tarabra E, Volante M, Cerrato M, Ghigo E, Muccioli G, et al. Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours. J Pathol 2005;207:336-345.
14. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005;310:996-999.
15. Gualillo O, Lago F, Casanueva FF, Dieguez C. One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects. Mol Cell Endocrinol 2006;256:1-8.
16. Seim I, Collet C, Herington AC, Chopin LK. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics 2007;8:298.
17. Green BD, Irwin N, Flatt PR. Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice. Peptides 2007;28:981-987.
18. Lagaud GJ, Young A, Acena A, Morton MF, Barrett TD, Shankley NP. Obestatin reduces food intake and suppresses body weight gain in rodents. Biochem Biophys Res Commun 2007;357:264-269.
19. Lauwers E, Landuyt B, Arckens L, Schoofs L, Luyten W. Obestatin does not activate orphan G protein-coupled receptor GPR39. Biochem Biophys Res Commun 2006;351:21-25.
20. Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, et al. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 2007;148:13-20.
21. Chartrel N, Alvear-Perez R, Leprince J, Iturrioz X, Reaux-Le Goazigo A, Audinot V, et al. Comment on 'Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake'. Science 2007;315:766.
22. Tremblay F, Perreault M, Klaman LD, Tobin JF, Smith E, Gimeno RE. Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39. Endocrinology 2007;148:501-506.
23. Zhang JV, Jahr H, Luo CW, Klein C, Van Kolen K, Ver Donck L, et al. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39. Mol Endocrinol 2008;22:1464-1475.
24. de Smet B, Thijs T, Peeters TL, Depoortere I. Effect of peripheral obestatin on gastric emptying and intestinal contractility in rodents. Neurogastroenterol Motil 2007;19:211-217.
25. Bassil AK, Haglund Y, Brown J, Rudholm T, Hellström PM, Näslund E, et al. Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract. Br J Pharmacol 2007;150:58-64.
26. Gourcerol G, St-Pierre DH, Tache Y. Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)? Regul Pept 2007;141:1-7.
27. Sibilia V, Bresciani E, Lattuada N, Rapetti D, Locatelli V, De Luca V, et al. Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat. J Endocrinol Invest 2006;29:RC31-34.
28. Yamamoto D, Ikeshita N, Daito R, Herningtyas EH, Toda K, Takahashi K, et al. Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Pept 2007;138:141-144.
29. Samson WK, White MM, Price C. Obestatin acts in brain to inhibit thirst. Am J Physiol Regul Integr Comp Physiol 2007;292:R637-643.
30. Szentirmai E, Krueger JM. Obestatin alters sleep in rats. Neurosci Lett 2006;404:222-226.
31. Carlini VP, Schioth HB, Debarioglio SR. Obestatin improves memory performance and causes anxiolytic effects in rats. Biochem Biophys Res Commun 2007;352:907-912.
32. Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK, Dun NJ. Distribution and biological activity of obestatin in the rat. J Endocrinol 2006;191:481-489.
33. Chanoine JP, Wong AC, Barrios V. Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Horm Res 2006;66:81-88.
34. Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, et al. Obestatin promotes survival of pancreatic β cells and human islets and induces expression of genes involved in the regulation of β cell mass and function. Diabetes 2008;57:967-979.
35. Grönberg M, Tsolakis AV, Magnusson L, Janson ET, Saras J. Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem 2008;56:793-801.
36. Solcia E, Kloppel G, Sobin LH (eds). World Health Organization International Histological Classification of Tumors. Histological Typing of Endocrine Tumors. Springer: Berlin, 2000; 56-68.
37. DeLellis RA, LLoyd R, Heitz PU (eds). World Health Organization Classification of Tumors, Pathology and Genetics - Tumors of Endocrine Organs. IARC Press: Lyon, 2004.
38. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC (eds). World Health Organization Classification of Tumors, Pathology and Genetics - Tumors of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon, 2004; 19-20; 31-34.
39. Ceppi P, Volante M, Saviozzi S, Rapa I, Novello S, Cambieri A, et al. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer 2006;107:1589-1596.
40. Rapa I, Ceppi P, Bollito E, Rosas R, Cappia S, Bacillo E, et al. Human ASH1 expression in prostate cancer with neuroendocrine differentiation. Mod Pathol 2008;21:700-707.
41. Fleige S, Walf V, Huch S, Prgomet C, Sehm J, Pfaffl MW. Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR. Biotechnol Lett 2006;28:1601-1613.
42. Vicennati V, Genghini S, De Iasio R, Pasqui F, Pagotto U, Pasquali R. Circulating obestatin levels and the ghrelin/obestatin ratio in obese women. Eur J Endocrinol 200;157:295-301.
43. Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 2008;29:1255-7120.
44. Zhao CM, Furnes MW, Stenström B, Kulseng B, Chen D. Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study. Cell Tissue Res 2008;331:575-587.