Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin

Growth Factors

Volumn 25, Issue 6, 2007, Pages 373-381

  Pazos, Yolanda ^a,b   Alvarez, Carlos J P ^c   Camiña, Jesus ^a,b   Casanueva, Felipe F ^a,b,c  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

KATO III; MAPK; Obestatin

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OBESTATIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C EPSILON; PROTEIN TYROSINE KINASE; STAUROSPORINE; WORTMANNIN;

ARTICLE; CANCER CELL; CELL LINE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; HORMONE ACTION; HUMAN; HUMAN CELL; KATO III CELL LINE; PRIORITY JOURNAL; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STOMACH CANCER;

CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; ENZYME ACTIVATION; GASTRIC MUCOSA; GHRELIN; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 41449114267     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.1080/08977190801889313     Document Type: Article

References (39)

1. Bagrodia, S., Chackalaparampil, I., Kmiecik, TE and Shalloway, D. (1991) Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src. Nature, 349, pp. 172-175.
2. Batterham, RL, Cowley, MA, Small, CJ, Herzog, H., Cohen, MA, Dakin, CL, Wren, AM, Brynes, AE, Low, MJ, Ghatei, MA, Cone, RD and Bloom, SR (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature, 418, pp. 650-654.
3. Batterham, RL, Cohen, MA, Ellis, SM, Roux, CW Le, Withers, DJ, Frost, GS, Ghatei, MA and Bloom, SR (2003) Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med, 349, pp. 941-948.
4. Boggiano, MM, Chandler, PC, Oswald, KD, Rodgers, RJ, Blundell, JE, Ishii, Y., Beattie, AH, Holch, P., Allison, DB, Schindler, M., Arndt, K., Rudolf, K., Mark, M., Schoelch, C., Joost, HG, Klaus, S., Thóne-Reineke, C., Benoit, SC, Seeley, RJ, Beck-Sickinger, AG, Koglin, N., Raun, K., Madsen, K., Wulff, BS, Stidsen, CE, Birringer, M., Kreuzer, OJ, Deng, XY, Whitcomb, DC, Halem, H., Taylor, J., Dong, J., Datta, R., Culler, M., Ortmann, S., Castañeda, TR and Tschóp, M. (2005) PYY3-36 as an anti-obesity drug target. Obes Rev, 6, pp. 307-322.
5. Brandt, DT, Goerke, A., Heuer, M., Gimona, M., Leitges, M., Kremmer, E., Lammers, R., Haller, H. and Mischak, H. (2003) Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem, 278, pp. 34073-34078.
6. Bresciani, E., Rapetti, D., Dòna, F., Bulgarelli, I., Tamiazzo, L., Locatelli, V. and Torsello, A. (2006) Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J Endocrinol Invest, 29, pp. RC16-RC18.
7. Camiña, JP, Campos, JF, Caminos, JE, Dieguez, C. and Casanueva, FF (2007) Obestatin-mediated proliferation of human retinal pigment epithelial cells: Regulatory mechanisms. J Cell Physiol, 211, pp. 1-9.
8. Carlini, VP, Schioth, HB and Debarioglio, SR (2007) Obestatin improves memory performance and causes anxiolytic effects in rats. Biochem Biophys Res Commun, 352, pp. 907-912.
9. Coll, AP, Farooqi, IS, Challis, BG, Yeo, GS and O'Rahilly, S. (2004) Proopiomelanocortin and energy balance: Insights from human and murine genetics. J Clin Endocrinol Metab, 89, pp. 2557-2562.
10. Chartrel, N., Alvear-Perez, R., Leprince, J., Iturrioz, X., Goazigo, A Reaux-Le, Audinot, V., Chomarat, P., Coge, F., Nosjean, O., Rodriguez, M., Galizzi, JP, Boutin, JA, Vaudry, H. and Llorens-Cortes, C. (2007) Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science, 315, p. 766.
11. Cummings, DE and Overduin, J. (2007) Gastrointestinal regulation of food intake. J Clin Invest, 117, pp. 13-23.
12. Dun, SL, Brailoiu, GC, Brailoiu, E., Yang, J., Chang, JK and Dun, NJ (2006) Distribution and biological activity of obestatin in the rat. J Endocrinol, 191, pp. 481-489.
13. Frame, MC (2002) Src in cancer: Deregulation and consequences for cell behaviour. Biochim Biophys Acta, 1602, pp. 114-130.
14. Gould, KL, Woodgett, JR, Cooper, JA, Buss, JE, Shalloway, D. and Hunter, T. (1985) Protein kinase C phosphorylates pp60src at a novel site. Cell, 42, pp. 849-857.
15. Gourcerol, G., Million, M., Adelson, DW, Wang, Y., Wang, L., Rivier, J., St-Pierre, DH and Taché, Y. (2006) Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents. Peptides, 27, pp. 2811-2819.
16. Hawes, BE, Luttrell, LM, van Biesen, T. and Lefkowitz, RJ (1996) Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem, 271, pp. 12133-12136.
17. Holst, B., Egerod, KL, Schild, E., Vickers, SP, Cheetham, S., Gerlach, LO, Storjohann, L., Stidsen, CE, Jones, R., Beck-Sickinger, AG and Schwartz, TW (2007) GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology, 148, pp. 13-20.
18. Kaech, S., Covic, L., Wyss, A. and Ballmer-Hofer, K. (1991) Association of p60c-src with polyoma virus middle-T antigen abrogating mitosis-specific activation. Nature, 350, pp. 431-433.
19. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H. and Kangawa, K. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, pp. 656-660.
20. Lagaud, GJ, Young, A., Acena, A., Morton, MF, Barrett, TD and Shankley, NP (2007) Obestatin reduces food intake and suppresses body weight gain in rodents. Biochem Biophys Res Commun, 357, pp. 264-269.
21. Moyers, JS, Bouton, AH and Parsons, SJ (1993) The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src. Mol Cell Biol, 13, pp. 2391-2400.
22. Nogueiras, R., Pfluger, P., Tovar, S., Arnold, M., Mitchell, S., Morris, A., Perez-Tilve, D., Vazquez, MJ, Wiedmer, P., Castañeda, TR, DiMarchi, R., Tschó;p, M., Schurmann, A., Joost, HG, Williams, LM, Langhans, W. and Dieguez, C. (2007) Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology, 148, pp. 21-26.
23. Parker, PJ and Murray-Rust, J. (2004) PKC at a glance. J Cell Sci, 117, pp. 131-132.
24. Piiper, A., Elez, R., You, SJ, Kronenberger, B., Loitsch, S., Roche, S. and Zeuzem, S. (2003) Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor. Yes and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. J Biol Chem, 278, pp. 7065-7072.
25. Raffin-Sanson, ML, de Keyzer, Y. and Bertagna, X. (2003) Proopiomelanocortin, a polypeptide precursor with multiple functions: From physiology to pathological conditions. Eur J Endocrinol, 149, pp. 79-90.
26. Roskoski Jr, R. (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun, 331, pp. 1-14.
27. Samson, WK, White, MM, Price, C. and Ferguson, AV (2007) Obestatin acts in brain to inhibit thirst. Am J Physiol Regul Integr Comp Physiol, 292, pp. R637-R643.
28. Seoane, LM, Al-Massadi, O., Pazos, Y., Pagotto, U. and Casanueva, FF (2006) Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. J Endocrinol Invest, 29, pp. RC13-RC15.
29. Szentirmai, E. and Krueger, JM (2006) Obestatin alters sleep in rats. Neurosci Lett, 404, pp. 222-226.
30. Thomas, SM and Brugge, JS (1997) Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol, 13, pp. 513-609.
31. Tremblay, F., Perreault, M., Klaman, LD, Tobin, JF, Smith, E. and Gimeno, RE (2007) Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39. Endocrinology, 148, pp. 501-506.
32. van der Lely, AJ, Tschóp, M., Heiman, ML and Ghigo, E. (2004) Biological, physiological, pathophysiological and pharmacological aspects of ghrelin. Endocr Rev, 25, pp. 426-457.
33. Yamamoto, D., Ikeshita, N., Daito, R., Herningtyas, EH, Toda, K., Takahashi, K., Iida, K., Takahashi, Y., Kaji, H., Chihara, K. and Okimura, Y. (2007) Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Pept, 138, pp. 141-144.
34. Yart, A., Chap, H. and Raynal, P. (2002) Phosphoinositide 3-kinases in lysophosphatidic acid signaling: Regulation and cross-talk with the Ras/ mitogen-activated protein kinase pathway. Biochim Biophys Acta, 1582, pp. 107-111.
35. Yeatman, TJ (2004) A renaissance for SRC. Nat Rev Cancer, 4, pp. 470-480.
36. Zhang, JV, Ren, PG, Avsian-Kretchmer, O., Luo, CW, Rauch, R., Klein, C. and Hsueh, AJ (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science, 310, pp. 996-999.
37. Zheng, XM, Wang, Y. and Pallen, CJ (1992) Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature, 359, pp. 336-339.
38. Zheng, XM, Resnick, RJ and Shalloway, D. (2002) Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation. J Biol Chem, 277, pp. 21922-21929.
39. Zizzari, P., Longchamps, R., Epelbaum, J. and Bluet-Pajot, MT (2007) Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology, 148, pp. 1648-1653.