Ghrelin and obestatin in human neuroendocrine tumors: Expression and effect on obestatin levels after food intake

Neuroendocrinology

Volumn 97, Issue 4, 2013, Pages 291-299

  Grönberg, Malin ^a   Tsolakis, Apostolos V ^a   Holmbäck, Ulf ^b   Stridsberg, Mats ^a   Grimelius, Lars ^a   Janson, Eva T ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Ghrelin; Immunohistochemistry; Neuroendocrine tumors; Obestatin

Indexed keywords

GHRELIN; OBESTATIN; POLYCLONAL ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INSULINOMA; INTESTINE; MAJOR CLINICAL STUDY; NEUROENDOCRINE TUMOR; PANCREAS; PANCREATIC NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; CANCER PATIENT; CLINICAL ARTICLE; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; RADIOIMMUNOASSAY; STOMACH MUCOSA; TEST MEAL;

ADULT; DIETARY CARBOHYDRATES; EATING; GHRELIN; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEUROENDOCRINE TUMORS; STOMACH NEOPLASMS; TIME FACTORS; YOUNG ADULT;

EID: 84879129962     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000345366     Document Type: Article

References (31)

1. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E: Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 2000; 23: 493-495
2. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA et al: Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001; 120: 337-345
3. Inui A: Ghrelin: An orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2001; 2: 551-560
4. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growthhormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660
5. Tack J, Depoortere I, Bisschops R, Delporte C, Coulie B, Meulemans A, Janssens J, Peeters T: Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006; 55: 327-333
6. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-999
7. Tang SQ, Jiang QY, Zhang YL, Zhu XT, Shu G, Gao P, Feng DY, Wang XQ, Dong XY: Obestatin: Its physicochemical characteristics and physiological functions. Peptides 2008; 29: 639-645
8. Gronberg M, Tsolakis AV, Magnusson L, Janson ET, Saras J: Distribution of obestatin and ghrelin in human tissues: Immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem 2008; 56: 793-801
9. Rindi G, Necchi V, Savio A, Torsello A, Zoli M, Locatelli V, Raimondo F, Cocchi D, Solcia E: Characterisation of gastric ghrelin cells in man and other mammals: Ptudies in adult and fetal tissues. Histochem Cell Biol 2002; 117: 511-519
10. Tsolakis AV, Grimelius L, Stridsberg M, Falkmer SE, Waldum HL, Saras J, Janson ET: Obestatin/ghrelin cells in normal mucosa and endocrine tumours of the stomach. Eur J Endocrinol 2009; 160: 941-949
11. Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, Muccioli G, Ghigo E, Papotti M: Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002; 87: 1300-1308
12. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A, Papotti M: Ghrelin expression in fetal, infant, and adult human lung. J Histochem Cytochem 2002; 50: 1013-1021
13. Volante M, Rosas R, Ceppi P, Rapa I, Cassoni P, Wiedenmann B, Settanni F, Granata R, Papotti M: Obestatin in human neuroendocrine tissues and tumours: Expression and effect on tumour growth. J Pathol 2009; 218: 458-466
14. Iwakura H, Hosoda K, Doi R, Komoto I, Nishimura H, Son C, Fujikura J, Tomita T, Takaya K, Ogawa Y et al: Ghrelin expression in islet cell tumors: Augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I. J Clin Endocrinol Metab 2002; 87: 4885-4888
15. Jeffery PL, Murray RE, Yeh AH, McNamara JF, Duncan RP, Francis GD, Herington AC, Chopin LK: Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines. Endocr Relat Cancer 2005; 12: 839-850
16. Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E: Ghrelin-producing endocrine tumors of the stomach and intestine. J Clin Endocrinol Metab 2001; 86: 5052-5059
17. Tsolakis AV, Stridsberg M, Grimelius L, Portela-Gomes GM, Falkmer SE, Waldum HL, Janson ET: Ghrelin immunoreactive cells in gastric endocrine tumors and their relation to plasma ghrelin concentration. J Clin Gastroenterol 2008; 42: 381-388
18. Corbetta S, Peracchi M, Cappiello V, Lania A, Lauri E, Vago L, Beck-Peccoz P, Spada A: Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: Identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab 2003; 88: 3117-3120
19. Tsolakis AV, Portela-Gomes GM, Stridsberg M, Grimelius L, Sundin A, Eriksson BK, Oberg KE, Janson ET: Malignant gastric ghrelinoma with hyperghrelinemia. J Clin Endocrinol Metab 2004; 89: 3739-3744
20. Walter T, Chardon L, Hervieu V, Cohen R, Chayvialle JA, Scoazec JY, Lombard-Bohas C: Major hyperghrelinemia in advanced well-differentiated neuroendocrine carcinomas: Report of three cases. Eur J Endocrinol 2009; 161: 639-645
21. Rindi G, Savio A, Torsello A, Zoli M, Locatelli V, Cocchi D, Paolotti D, Solcia E: Ghrelin expression in gut endocrine growths. Histochem Cell Biol 2002; 117: 521-525
22. Srivastava A, Kamath A, Barry SA, Dayal Y: Ghrelin expression in hyperplastic and neoplastic proliferations of the enterochromaffin-like (ECL) cells. Endocr Pathol 2004; 15: 47-54
23. Skogseid B, Oberg K, Benson L, Lindgren PG, Lorelius LE, Lundquist G, Wide L, Wilander E: A standardized meal stimulation test of the endocrine pancreas for early detection of pancreatic endocrine tumors in multiple endocrine neoplasia type 1 syndrome: Five years experience. J Clin Endocrinol Metab 1987; 64: 1233-1240
24. Stridsberg M, Oberg K, Li Q, Engstrom U, Lundqvist G: Measurements of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours. J Endocrinol 1995; 144: 49-59
25. Ekeblad S, Lejonklou MH, Grimfjard P, Johansson T, Eriksson B, Grimelius L, Stridsberg M, Stalberg P, Skogseid B: Co-expression of ghrelin and its receptor in pancreatic endocrine tumours. Clin Endocrinol (Oxf) 2007; 66: 115-122
26. Seim I, Collet C, Herington AC, Chopin LK: Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics 2007; 8: 298
27. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M: The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988
28. La Rosa S, Boni L, Finzi G, Vigetti D, Papanikolaou N, Tenconi SM, Dionigi G, Clerici M, Garancini S, Capella C: Ghrelin-producing well-differentiated neuroendocrine tumor (carcinoid) of tailgut cyst. Morphological, immunohistochemical, ultrastructural, and RT-PCR study of a case and review of the literature. Endocr Pathol 2010; 21: 190-198
29. Volante M, Allia E, Fulcheri E, Cassoni P, Ghigo E, Muccioli G, Papotti M: Ghrelin in fetal thyroid and follicular tumors and cell lines: Expression and effects on tumor growth. Am J Pathol 2003; 162: 645-654
30. Sedlackova D, Dostalova I, Hainer V, Beranova L, Kvasnickova H, Hill M, Haluzik M, Nedvidkova J: Pimultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women. Physiol Res 2008; 57(suppl 1):S29-S37
31. Maier C, Riedl M, Vila G, Wolzt M, Clodi M, Ludvik B, Luger A: Differential regulation of plasma obestatin and ghrelin by meal intake and the cholinergic system in lean, but not obese individuals. J Clin Endocrinol Metab 2010; 95:E214-E218