Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products

Journal of Pharmaceutical and Biomedical Analysis

Volumn 87, Issue , 2013, Pages 191-217

  Narayanam, Mallikarjun ^a   Handa, Tarun ^a   Sharma, Parul ^a   Jhajra, Shalu ^a   Muthe, Praveen Kumar ^a   Dappili, Pavan Kumar ^a   Shah, Ravi P ^a,b   Singh, Saranjit ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Characterization; Degradation products; Impurities; LC MS; Practical aspects; Strategy

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIFUNGAL AGENT; ANTIMALARIAL AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN; EZETIMIBE; HISTAMINE H2 RECEPTOR ANTAGONIST; LOOP DIURETIC AGENT; PENICILLIN DERIVATIVE; PHOSPHODIESTERASE V INHIBITOR; PIOGLITAZONE; PROTEINASE INHIBITOR; PROTON PUMP INHIBITOR; PSYCHOTROPIC AGENT; PYRAZINAMIDE; RIFAMPICIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFONAMIDE; UNINDEXED DRUG; VASODILATOR AGENT;

CALIBRATION; DERIVATIZATION; DRUG CONTAMINATION; DRUG DEGRADATION; DRUG IMPURITY; DRUG SOLUTION; DRUG SYNTHESIS; FLOW RATE; IONIZATION; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATERIALS HANDLING; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; REVIEW;

4-[2-(6,7-DIMETHOXY-4-METHYL-3-OXO-3,4-DIHYDROQUINOXALYL)ETHYL]-1,2,4-TRIAZOLINE-3,5-DIONE; (4-HYDRAZINO-4-OXOBUTYL) TRIS(2,4,6-TRIMETHOXYPHENYL) PHOSPHONIUM BROMIDE; 1,2-DIMETHYLIMIDAZOLE-4-SULFONYL; 1-(2,4-DINITRO-5-FLUOROPHENYL)-4-METHYLPIPERAZINE; 1-(CARBOXYMETHYL) PYRIDIUM CHLORIDE HYDRAZIDE; 1-(CARBOXYMETHYL) TRIMETHYLAMMONIUM CHLORIDE HYDRAZIDE; 2,2,2-TRIFLUOROETHANOL; 2,2′-AZOBIS(2-AMIDINOPROPANE) DIHYDROCHLORIDE; 2,4-DINITROPHENYLHYDRAZINE; 2-(N,N-DIMETHYL-AMINO) ETHYL ACRYLATE; 2-ACRYLAMINO-2-METHYL-PROPANESULFONIC ACID; 2-HYDRAZINO-1-METHYL-PYRIDINE; 2-HYDRAZINOPYRIDINE; 2-METHF; 2-METHYLTETRAHYDROFURAN; 2-NITRO-4-TRIFLUOROMETHYLPHENYLHYDRAZINE; 2-NITROBENZALDEHYDE; 2NFP-APB; 4-(1H-PYRAZOL-1-YL) BENZENESULFONYL; 4-(2-((4-BROMOPHENETHYL) DIMETHYLAMMONIO) ETHOXY) BENZENAMINIUM DIBROMIDE; 4-(4-METHYL-1-PIPERAZYL)-3-NITROBENZOYL AZIDE; 4-(4-NITROPHENYL)-1,2,4-TRIAZOLINE-3,5-DIONE; 4-(TRIMETHYLAMMONIUM) ANILYL-N-HYDROXYSUCCIDIMIDYL CARBAMATE IODIDE; 4-APEBA; 4-BROMOMETHYL-7-METHOXYCOUMARIN; 4-NITRO-7-PIPERAZION-2,1,3-BENZOXADIAZOLE; 4-[2-(N,N-DIMETHYLAMINO) ETHYLAMINOSULFONYL]-7-(2-AMINOETHYLAMINO)-2,1,3-BENZOXADIAZOLE; 4-[2-(N,N-DIMETHYLAMINO) ETHYLAMINOSULFONYL]-7-N-METHYLHYDRAZINO-2,1,3-BENZOXADIAZOLE; 4-[4-(6-METHOXY-2-BENZOXAZOLYL) PHENYL]-1,2,4-TRIAZOLINE-3,5-DIONE; 7-CHLORO-4-NITRO-2,1,3-BENZOXADIAZOLE; 7-FLUORO-4-NITRO-2,1,3-BENZOXADIAZOLE; AAPH; ACETONITRILE; ACN; AIBN; AMDSA; AMMONIUM HYDROXIDE; APCI; API; APPI; APZ; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; ATMOSPHERIC PRESSURE IONIZATION; ATMOSPHERIC PRESSURE PHOTOIONIZATION; AZOBISISOBUTYRONITRILE; BMC; CHARACTERIZATION; CHEFOG; CHEMICAL FORMULA GENERATOR; CID; COLLISION-INDUCED DISSOCIATION; DA; DAABD-AE; DAABD-MHZ; DALTON; DANSYL CHLORIDE; DANSYL HYDRAZINE; DANSYL-3-AMINOPHENYLBORONIC ACID; DAPB; DBA; DCU; DEGRADATION PRODUCTS; DENSITY FUNCTIONAL THEORY; DFT; DI-N-BUTYL AMINE; DICYCLOHEXYL UREA; DIISOPROPYLETHYLAMINE; DIMETHYL AMINO PYRIDINE; DIMETHYL SULFOXIDE; DIMETHYLFORMAMIDE; DIPEA; DMAE; DMAP; DMEQTAD; DMF; DMIS; DMSO; DNPH; DNS-CL; DNS-HZ; DPS; ELECTROSPRAY IONIZATION; ELECTROSPRAY IONIZATION MASS SPECTROMETRY/TIME OF FLIGHT; ELECTROSPRAY IONIZATION-MASS SPECTROMETRY; ESI; ESI-MS; ESI-MS/TOF; FOURIER TRANSFORM-ION CYCLOTRON RESONANCE; FT-ICR; GIRP; GIRT; H/D; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RESOLUTION MASS SPECTROMETRY; HILIC; HMP; HP; HPLC; HRMS; HYDROGEN/DEUTERIUM; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY; IHD; IMPS; IMPURITIES; INDEX OF HYDROGEN DEFICIENCY; INFRARED; INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY; IR; ISONICOTINOYL AZIDE; IUPAC; LC; LC-ESI-MS; LC-MS; LIMIT OF QUANTIFICATION; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LOQ; MASS SPECTROMETRY; MASS SPECTROMETRY-TIME OF FLIGHT; MBOTAD; MDMAES; MILLI MASS UNIT; MILLIMOLAR; MM; MMU; MNBDH; MOLECULAR ION; MONO(DIMETHYLAMINOETHYL) SUCCINYL IMIDAZOLIDE; MS; MS(N); MS-TOF; MULTI STAGE MASS SPECTROMETRY; N-METHYL-4-HYDRAZINO-7-NITROBENZOFURAZAN; NA; NAPHTHYLISOTHIOCYANATE; NBA; NBD-CL; NBD-F; NBDPZ; NFPH; NH(4)OH; NIT; NMR; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NPTAD; NSAIDS; NUCLEAR MAGNETIC RESONANCE; P-TOLUENESULFONYLHYDRAZIDE; PABA; PAHS; PARA-AMINO BENZOIC ACID; PARTS PER MILLION; PBS; PENTAFLUOROBENZYL BROMIDE; PENTAFLUOROPROPIONIC ACID ANHYDRIDE; PFB-BR; PFPA; PGF2Α; POLYCYCLIC AROMATIC HYDROCARBONS; PPM; PPZ; PRACTICAL ASPECTS; PROSTAGLANDIN F2Α; PS; PYRIDINE-3-SULFONYL; Q-TOF; QUADRUPOLE-TIME OF FLIGHT; RDB; REVERSED PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RING PLUS DOUBLE BONDS; RP-HPLC; S-PENTAFLUOROPHENYL TRIS(2,4,6-TRIMETHOXYPHENYL) PHOSPHONIUM ACETATE BROMIDE; SELECTED REACTION MONITORING; SRM; STRATEGY; TETRAHYDROFURAN; TFA; TFE; THAS; THF; TIME OF FLIGHT; TMAE; TMPP; TMPP-ACPFP; TMPP-PRG; TOF; TRIFLUOROACETIC ACID; TRIMETHYL AMINO-ETHYLALCOHOL; TRIS(2,4,6-TRIMETHOXYPHENYL) PHOSPHINE; TSH; ULTRA VIOLET; UV; X-RAY DIFFRACTION; XRD; [3-(2-NITRO-4-TRIFLUOROMETHYLPHENYL) AMINOPHENYL] DIHYDROXYBORANE; [M+H](+);

CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS;

EID: 84889592115     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.04.027     Document Type: Review

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