In vitro and in vivo investigation of metabolic fate of rifampicin using an optimized sample preparation approach and modern tools of liquid chromatography-mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 3, 2009, Pages 475-490

  Prasad, Bhagwat ^a   Singh, Saranjit ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Characterization; HR MS; LC MS; Metabolite enrichment; Metabolite identification; Rifampicin

Indexed keywords

ACETONITRILE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIFAMPICIN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIVER; MALE; MICROSOME; NONHUMAN; PH; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; SPRAGUE DAWLEY RAT; STRUCTURE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; ANTIBIOTICS, ANTITUBERCULAR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RIFAMPIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 67650232953     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.05.009     Document Type: Article

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