On-line H/D exchange LC-MS strategy for structural elucidation of pharmaceutical impurities

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 2, 2007, Pages 320-329

  Liu, David Q ^a   Wu, Lianming ^a   Sun, Mingjiang ^a   MacGregor, Paul A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Active hydrogen; Deuterated mobile phase; Deuterium oxide; Exchangeable hydrogen; LC MS; Mass spectrometry; On line (or on column) H D exchange; Pharmaceutical impurities; Structural elucidation

Indexed keywords

DEUTERIUM OXIDE;

ACCURACY; ALCOHOLYSIS; DRUG IMPURITY; DRUG MANUFACTURE; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GAS EXCHANGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; ISOMER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; MICHAEL ADDITION; MOLECULAR WEIGHT; ONLINE ANALYSIS; OXIDATION KINETICS; PHASE TRANSITION; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DEUTERIUM; DRUG CONTAMINATION; HYDROGEN; MASS SPECTROMETRY; ONLINE SYSTEMS; PHARMACEUTICAL PREPARATIONS;

EID: 34249948356     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.01.019     Document Type: Review

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