Liquid chromatography-mass spectrometry using the hydrogen/deuterium exchange reaction as a tool for impurity identification in pharmaceutical process development

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 825, Issue 2, 2005, Pages 161-168

  Novak, T J ^a   Helmy, R ^a   Santos, I ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hydrogen Deuterium exchange; LC MS; Structural determination

Indexed keywords

AMINES; DEUTERIUM; DRUG PRODUCTS; HEAVY WATER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN; ION EXCHANGE; IONIZATION; MASS SPECTROMETRY;

HYDROGEN/DEUTERIUM EXCHANGE; LC-MS; PHARMACEUTICALLY ACTIVE AGENTS; STRUCTURAL DETERMINATION;

LIQUID CHROMATOGRAPHY;

AMIDE; AMINE; DEUTERIUM; DIMETHYL SULFONE; HYDROGEN; INDOLE; LIPOPEPTIDE;

ARTICLE; CHEMICAL REACTION; DEUTERIUM HYDROGEN EXCHANGE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM; HYDROGEN; INDOLES; PEPTIDES, CYCLIC; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONES; TECHNOLOGY, PHARMACEUTICAL;

EID: 26444572354     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.05.039     Document Type: Article

References (30)

1. A. Guarini, G. Guglielmetti, and N. Andriollo Anal. Chem. 64 1992 204
2. D.F. Hunt, C.N. McEwen, and R.A. Upham Anal. Chem. 44 1979 1292
3. S.K. Sethi, and D.F. Hunt J. Am. Chem Soc 102 1980 6953
4. M.V. Buchanan Anal. Chem. 54 1982 570
5. S. Akashi, and K. Takio J. Am. Soc. Mass Spectrom. 12 2001 1247
6. T. Solouki, R.C. Fort, A. Alomary, and A. Fattahi J. Am. Soc. Mass Spectrom. 12 2001 1272
7. A. Miranker, C.V. Robinson, S.E. Radford, R.T. Aplin, and C.M. Dobson Science 262 1993 896
8. M.A. Freitas, and A.G. Marshall J. Am. Soc. Mass Spectrom. 12 2001 780
9. M.M. Siegel Anal. Chem. 60 1988 2090
10. L. Gianelli, G.G. Mellerio, E. Siviero, A. Rossi, W. Cabri, and L. Sogli Rapid Comm. Mass Spectrom. 14 2000 1260
11. M. Takayama J. Am. Soc. Mass Spectrom. 12 2001 1044
12. D.R. Reed, and S.R. Kass J. Am. Soc. Mass Spectrom. 12 2001 1163
13. S.A. Lorenz, E.P. Maziarz, and T.D. Wood J. Am. Soc. Mass Spectrom. 12 2001 795
14. C. Marzolini, A. Beguin, A. Telenti, A. Schreyer, T. Buclin, J. Biolaz, and L.A. Decosterd J. Chromatogr. B 774 2002 127
15. S. Joshi J. Pharm. Biomed. Anal. 28 2002 795
16. J. Karpinska, and B. Starczewska J. Pharm. Biomed. Anal. 29 2002 519
17. M. Beljean, and A.-M. Siouffi J. Chromatogr. Sci. 39 2001 229
18. K. Jinno HRC CC 5 1982 364
19. C.G. Edmonds, S.C. Pomerantz, F.F. Hsu, and J.A. McCloskey Anal. Chem. 60 1988 2314
20. K.-E. Karlsson J. Chromatogr. 647 1993 31
21. N. Ohashi, S. Furuuchi, and M. Yoshikawa J. Pharm. Biomed. Anal. 18 1993 325
22. M.A. Olsen, P.G. Cummings, S. Kennedy-Gabb, B.M. Wagner, G.R. Nicol, and B. Munson Anal. Chem. 72 2000 5070
23. A.M. Kamel, K.S. Zandi, and W.W. Massefski J. Pharm. Biomed. Anal. 31 2003 1211
24. W. Blum, R. Aichholz, P. Ramstein, J. Kuhnol, J. Bruggen, T. O'Reilly, and A. Florsheimer Rapid Commun. Mass Spectrom. 15 2001 41
25. D.Q. Liu, C.E.C.A. Hop, M.G. Beconi, A. Mao, and S.-H. Lee Chiu Rapid Commun. Mass Spectrom. 15 2001 1832
26. A.-E.F. Nassar J. Chrom. Sci. 41 2003 398
27. W. Lam, and R. Ramanathan J. Am. Soc. Mass Spectrom. 13 2002 345
28. Sj. Van der Wai J. Liq. Chrom. 8 1985 2003
29. N.E. Tayar, H. van de Waterbeemd, M. Gryllaki, B. Testa, and W.F. Trager Int. J. Pharm. 19 1984 271
30. X.-Z. Qin, Y. Wu, Z. Zhao, and X. Chen J. Mass Spectrom. 34 1999 733