메뉴 건너뛰기




Volumn 26, Issue 20, 2012, Pages 2431-2442

Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from labile artemisinin-based anti-malarial drugs using a QTRAP® mass spectrometer

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC CHEMISTRY; ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BIOMOLECULES; CHEMICAL DETECTION; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHOTOIONIZATION; SIGNAL TO NOISE RATIO;

EID: 84866388227     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6359     Document Type: Article
Times cited : (14)

References (43)
  • 1
    • 84856408211 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Switzerland, ISBN 9789241564403.
    • World Malaria Report 2011, World Health Organization, Geneva, Switzerland, 2011, ISBN 9789241564403.
    • (2011) World Malaria Report 2011
  • 2
    • 79959959354 scopus 로고    scopus 로고
    • The state of the art in anti-malarial drug discovery and development
    • J. N. Burrows, K. Chibale, T. N. C. Wells,. The state of the art in anti-malarial drug discovery and development. Curr. Topics Med. Chem. 2011, 11, 1226.
    • (2011) Curr. Topics Med. Chem. , vol.11 , pp. 1226
    • Burrows, J.N.1    Chibale, K.2    Wells, T.N.C.3
  • 3
    • 2542640961 scopus 로고    scopus 로고
    • A medicinal chemistry perspective on artemisinin and related endoperoxides
    • P. M. O'Neill, G. H. Posner,. A medicinal chemistry perspective on artemisinin and related endoperoxides. J. Med. Chem. 2004, 47, 2945.
    • (2004) J. Med. Chem. , vol.47 , pp. 2945
    • O'Neill, P.M.1    Posner, G.H.2
  • 5
    • 85153994264 scopus 로고    scopus 로고
    • Available: http://www.mmv.org/newsroom/publications/synthetic-ozonide- drug-candidate-oz439-offers-new-hope-single-dose-cure-uncomp.
  • 7
    • 0037420914 scopus 로고    scopus 로고
    • Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupole-linear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique
    • P. Marquet, F. Saint-Marcoux, T. N. Gamble, J. C. Y. Leblanc,. Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupole-linear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique. J. Chromatogr. B 2003, 789, 9.
    • (2003) J. Chromatogr. B , vol.789 , pp. 9
    • Marquet, P.1    Saint-Marcoux, F.2    Gamble, T.N.3    Leblanc, J.C.Y.4
  • 8
    • 34247542644 scopus 로고    scopus 로고
    • 'N-in-one' strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan
    • A. C. Li, M. A. Gohdes, W. Z. Shou,. 'N-in-one' strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan. Rapid Commun. Mass Spectrom. 2007, 21, 1421.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 1421
    • Li, A.C.1    Gohdes, M.A.2    Shou, W.Z.3
  • 9
    • 40549117170 scopus 로고    scopus 로고
    • Optimization of an LC-MS method for the determination of artesunate and dihydroartemisinin plasma levels using liquid-liquid extraction
    • S. A. A. Van Quekelberghe, S. A. Soomro, J. A. Cordonnier, R. H. Jansen,. Optimization of an LC-MS method for the determination of artesunate and dihydroartemisinin plasma levels using liquid-liquid extraction. J. Anal. Toxicol. 2008, 32, 133.
    • (2008) J. Anal. Toxicol. , vol.32 , pp. 133
    • Van Quekelberghe, S.A.A.1    Soomro, S.A.2    Cordonnier, J.A.3    Jansen, R.H.4
  • 10
    • 56849111997 scopus 로고    scopus 로고
    • Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma
    • L. T. D. Thuy, L. N. Hung, P. T. Danh, K. Na-Bangchang,. Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma. Southeast Asian J. Trop. Med. Public Health 2008, 39, 963.
    • (2008) Southeast Asian J. Trop. Med. Public Health , vol.39 , pp. 963
    • Thuy, L.T.D.1    Hung, L.N.2    Danh, P.T.3    Na-Bangchang, K.4
  • 11
    • 62249195491 scopus 로고    scopus 로고
    • A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma
    • E. M. Hodel, B. Zanolari, T. Mercier, J. Biollaz, J. Keiser, P. Olliaro, B. Genton, L. A. Decosterd,. A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. J. Chromatogr. B 2009, 877, 867.
    • (2009) J. Chromatogr. B , vol.877 , pp. 867
    • Hodel, E.M.1    Zanolari, B.2    Mercier, T.3    Biollaz, J.4    Keiser, J.5    Olliaro, P.6    Genton, B.7    Decosterd, L.A.8
  • 12
    • 77949304853 scopus 로고    scopus 로고
    • Determination of beta-artemether and its main metabolite dihydroartemisinin in plasma employing liquid-phase microextraction prior to liquid chromatographic-tandem mass spectrometric analysis
    • I. R. S. Magalhaes, V. A. P. Jabor, A. M. Faria, C. H. Collins, I. C. S. F. Jardim, P. S. Bonato,. Determination of beta-artemether and its main metabolite dihydroartemisinin in plasma employing liquid-phase microextraction prior to liquid chromatographic-tandem mass spectrometric analysis. Talanta 2010, 81, 941.
    • (2010) Talanta , vol.81 , pp. 941
    • Magalhaes, I.R.S.1    Jabor, V.A.P.2    Faria, A.M.3    Collins, C.H.4    Jardim, I.C.S.F.5    Bonato, P.S.6
  • 13
    • 56249128216 scopus 로고    scopus 로고
    • A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma
    • W. Hanpithakpong, B. Kamanikom, A. M. Dondorp, P. Singhasivanon, N. J. White, N. P. J. Day, N. Lindegardh,. A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B 2008, 876, 61.
    • (2008) J. Chromatogr. B , vol.876 , pp. 61
    • Hanpithakpong, W.1    Kamanikom, B.2    Dondorp, A.M.3    Singhasivanon, P.4    White, N.J.5    Day, N.P.J.6    Lindegardh, N.7
  • 16
    • 79952246237 scopus 로고    scopus 로고
    • A liquid-liquid LC/MS/MS assay for the determination of artemether and DHA in malaria patient samples
    • L. Wiesner, K. Govender, S. A. Meredith, J. Norman, P. J. Smith,. A liquid-liquid LC/MS/MS assay for the determination of artemether and DHA in malaria patient samples. J. Pharm. Biomed. Anal. 2011, 55, 373.
    • (2011) J. Pharm. Biomed. Anal. , vol.55 , pp. 373
    • Wiesner, L.1    Govender, K.2    Meredith, S.A.3    Norman, J.4    Smith, P.J.5
  • 17
    • 77957016229 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of artemether and lumefantrine in human plasma: Application for a pharmacokinetic study
    • I. C. Cesar, J. A. D. Ribeiro, L. D. Teixeira, K. B. Bellorio, F. C. de Abreu, J. M. Moreira, P. R. Chellini, G. A. Pianetti,. Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of artemether and lumefantrine in human plasma: Application for a pharmacokinetic study. J. Pharmaceut. Biomed. Anal. 2011, 54, 114.
    • (2011) J. Pharmaceut. Biomed. Anal. , vol.54 , pp. 114
    • Cesar, I.C.1    Ribeiro, J.A.D.2    Teixeira, L.D.3    Bellorio, K.B.4    De Abreu, F.C.5    Moreira, J.M.6    Chellini, P.R.7    Pianetti, G.A.8
  • 18
    • 79960508944 scopus 로고    scopus 로고
    • Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique
    • T. Liu, F. Du, Y. Wan, F. Zhu, J. Xing,. Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique. J. Mass Spectrom. 2011, 46, 725.
    • (2011) J. Mass Spectrom. , vol.46 , pp. 725
    • Liu, T.1    Du, F.2    Wan, Y.3    Zhu, F.4    Xing, J.5
  • 19
    • 80055022996 scopus 로고    scopus 로고
    • Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique
    • T. Liu, F. Y. Du, F. P. Zhu, J. Xing,. Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique. Rapid Commun. Mass Spectrom. 2011, 25, 3303.
    • (2011) Rapid Commun. Mass Spectrom. , vol.25 , pp. 3303
    • Liu, T.1    Du, F.Y.2    Zhu, F.P.3    Xing, J.4
  • 20
    • 0024512810 scopus 로고
    • Thermospray mass-spectroscopy high-performance liquid-chromatographic identification of the metabolites formed from arteether using a rat-liver microsome preparation
    • J. K. Baker, R. H. Yarber, C. D. Hufford, I. S. Lee, H. N. Elsohly, J. D. McChesney,. Thermospray mass-spectroscopy high-performance liquid- chromatographic identification of the metabolites formed from arteether using a rat-liver microsome preparation. Biomed. Environ. Mass Spectrom. 1989, 18, 337.
    • (1989) Biomed. Environ. Mass Spectrom. , vol.18 , pp. 337
    • Baker, J.K.1    Yarber, R.H.2    Hufford, C.D.3    Lee, I.S.4    Elsohly, H.N.5    McChesney, J.D.6
  • 21
    • 0026239217 scopus 로고
    • Identification of the in vivo metabolites of the antimalarial arteether by thermospray high-performance liquid chromatography/mass spectrometry
    • H. T. Chi, K. Ramu, J. K. Baker, C. D. Hufford, I. S. Lee, Y. L. Zeng, J. D. McChesney,. Identification of the in vivo metabolites of the antimalarial arteether by thermospray high-performance liquid chromatography/mass spectrometry. Biol. Mass Spectrom. 1991, 20, 609.
    • (1991) Biol. Mass Spectrom. , vol.20 , pp. 609
    • Chi, H.T.1    Ramu, K.2    Baker, J.K.3    Hufford, C.D.4    Lee, I.S.5    Zeng, Y.L.6    McChesney, J.D.7
  • 22
    • 0032511205 scopus 로고    scopus 로고
    • Rapid characterization of artemether and its in vitro metabolites on incubation with bovine hemoglobin, rat blood and dog blood by capillary gas chromatography chemical ionization mass spectrometry
    • W. Blum, U. Pfaar, J. Kuhnol,. Rapid characterization of artemether and its in vitro metabolites on incubation with bovine hemoglobin, rat blood and dog blood by capillary gas chromatography chemical ionization mass spectrometry. J. Chromatogr. B 1998, 710, 101.
    • (1998) J. Chromatogr. B , vol.710 , pp. 101
    • Blum, W.1    Pfaar, U.2    Kuhnol, J.3
  • 23
    • 0027270085 scopus 로고
    • A rapid screening method for artemisinin and its congeners using MS/MS: Search for new analogs in Artemisia annua
    • A. Ranasinghe, J. D. Sweatlock, R. G. Cooks,. A rapid screening method for artemisinin and its congeners using MS/MS: search for new analogs in Artemisia annua. J. Nat. Prod. 1993, 56, 552.
    • (1993) J. Nat. Prod. , vol.56 , pp. 552
    • Ranasinghe, A.1    Sweatlock, J.D.2    Cooks, R.G.3
  • 24
    • 0030879988 scopus 로고    scopus 로고
    • The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide
    • J. L. Maggs, S. Madden, L. P. Bishop, P. M. O'Neill, B. K. Park,. The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug Metab. Dispos. 1997, 25, 1200.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1200
    • Maggs, J.L.1    Madden, S.2    Bishop, L.P.3    O'Neill, P.M.4    Park, B.K.5
  • 26
    • 33646259966 scopus 로고    scopus 로고
    • A high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemisinin in rat plasma
    • J. Xing, H. X. Yan, S. Q. Zhang, G. L. Ren, Y. H. Gao,. A high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemisinin in rat plasma. Rapid Commun. Mass Spectrom. 2006, 20, 1463.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 1463
    • Xing, J.1    Yan, H.X.2    Zhang, S.Q.3    Ren, G.L.4    Gao, Y.H.5
  • 27
    • 58149112644 scopus 로고    scopus 로고
    • Effect of eluent on the ionization process in liquid chromatography-mass spectrometry
    • R. Kostiainen, T. J. Kauppila,. Effect of eluent on the ionization process in liquid chromatography-mass spectrometry. J. Chromatogr. A 2009, 1216, 685.
    • (2009) J. Chromatogr. A , vol.1216 , pp. 685
    • Kostiainen, R.1    Kauppila, T.J.2
  • 28
    • 0008249099 scopus 로고
    • Ammonium adduct ion in ammonia chemical ionisation mass spectrometry - Formation of adduct ion
    • H. Nakata, H. Konishi, N. Takeda, A. Tatematsu, M. Suzuki,. Ammonium adduct ion in ammonia chemical ionisation mass spectrometry-formation of adduct ion. Mass Spectrosc. 1983, 31.
    • (1983) Mass Spectrosc. , vol.31
    • Nakata, H.1    Konishi, H.2    Takeda, N.3    Tatematsu, A.4    Suzuki, M.5
  • 30
    • 0037099763 scopus 로고    scopus 로고
    • Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma
    • C. Souppart, N. Gauducheau, N. Sandrenan, F. Richard,. Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B 2002, 774, 195.
    • (2002) J. Chromatogr. B , vol.774 , pp. 195
    • Souppart, C.1    Gauducheau, N.2    Sandrenan, N.3    Richard, F.4
  • 31
    • 12444261827 scopus 로고    scopus 로고
    • Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroarternisinin in human plasma
    • H. Naik, D. J. Murry, L. E. Kirsch, L. Fleckenstein,. Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroarternisinin in human plasma. J. Chromatogr. B 2005, 816, 233.
    • (2005) J. Chromatogr. B , vol.816 , pp. 233
    • Naik, H.1    Murry, D.J.2    Kirsch, L.E.3    Fleckenstein, L.4
  • 32
    • 71949108766 scopus 로고    scopus 로고
    • Screening strategy for the rapid detection of in vitro generated glutathione conjugates using high-performance liquid chromatography and low-resolution mass spectrometry in combination with LightSight® software for data processing
    • C. Ramirez-Molina, L. Burton,. Screening strategy for the rapid detection of in vitro generated glutathione conjugates using high-performance liquid chromatography and low-resolution mass spectrometry in combination with LightSight® software for data processing. Rapid Commun. Mass Spectrom. 2009, 23, 3501.
    • (2009) Rapid Commun. Mass Spectrom. , vol.23 , pp. 3501
    • Ramirez-Molina, C.1    Burton, L.2
  • 35
    • 0036913119 scopus 로고    scopus 로고
    • Evaluation of protocols for reproducible electrospray in-source collisionally induced dissociation on various liquid chromatography/mass spectrometry instruments and the development of spectral libraries
    • A. W. T. Bristow, W. F. Nichols, K. S. Webb, B. Conway,. Evaluation of protocols for reproducible electrospray in-source collisionally induced dissociation on various liquid chromatography/mass spectrometry instruments and the development of spectral libraries. Rapid Commun. Mass Spectrom. 2002, 16, 2374.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 2374
    • Bristow, A.W.T.1    Nichols, W.F.2    Webb, K.S.3    Conway, B.4
  • 36
    • 1642391525 scopus 로고    scopus 로고
    • High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument
    • J. W. Hager, J. C. Y. Le Blanc,. High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument. J. Chromatogr. A 2003, 1020, 3.
    • (2003) J. Chromatogr. A , vol.1020 , pp. 3
    • Hager, J.W.1    Le Blanc, J.C.Y.2
  • 37
    • 51249120304 scopus 로고    scopus 로고
    • State-of-the-art in atmospheric pressure photoionization for LC/MS
    • D. B. Robb, M. W. Blades,. State-of-the-art in atmospheric pressure photoionization for LC/MS. Anal. Chim. Acta 2008, 627, 34.
    • (2008) Anal. Chim. Acta , vol.627 , pp. 34
    • Robb, D.B.1    Blades, M.W.2
  • 39
    • 0034254295 scopus 로고    scopus 로고
    • Atmospheric pressure photoionisation: An ionization method for liquid chromatography-mass spectrometry
    • D. B. Robb, T. R. Covey, A. P. Bruins,. Atmospheric pressure photoionisation: An ionization method for liquid chromatography-mass spectrometry. Anal. Chem. 2000, 72, 3653.
    • (2000) Anal. Chem. , vol.72 , pp. 3653
    • Robb, D.B.1    Covey, T.R.2    Bruins, A.P.3
  • 40
    • 33845329917 scopus 로고    scopus 로고
    • Atmospheric pressure photoionization for ionization of both polar and nonpolar compounds in reversed-phase LC/MS
    • D. B. Robb, M. W. Blades,. Atmospheric pressure photoionization for ionization of both polar and nonpolar compounds in reversed-phase LC/MS. Anal. Chem. 2006, 78, 8162.
    • (2006) Anal. Chem. , vol.78 , pp. 8162
    • Robb, D.B.1    Blades, M.W.2
  • 41
    • 77949592420 scopus 로고    scopus 로고
    • Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro - Amitriptyline and verapamil as model compounds
    • T. Rousu, J. Herttuainen, A. Tolonen,. Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro-amitriptyline and verapamil as model compounds. Rapid Commun. Mass Spectrom. 2010, 24, 939.
    • (2010) Rapid Commun. Mass Spectrom. , vol.24 , pp. 939
    • Rousu, T.1    Herttuainen, J.2    Tolonen, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.