A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences

Volumn 25, Issue 1, 2005, Pages 155-162

  Tolonen, Ari ^a   Turpeinen, Miia ^b   Uusitalo, Jouko ^a   Pelkonen, Olavi ^b  

^a Novamass Analytical Ltd   (Finland)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

Biotransformation; Hydrogen deuterium exchange; New chemical entities; Post column infusion; Time of flight

Indexed keywords

10 HYDROXYIMIPRAMINE; 2 HYDROXYIMIPRAMINE; 5 HYDROXYOMEPRAZOLE; AMINE; CARBOXYLIC ACID; DEUTERIUM OXIDE; DRUG METABOLITE; HYDROXYL GROUP; IMIPRAMINE; ISOTOPE; NITRIC OXIDE IMIPRAMINE; OMEPRAZOLE; OMEPRAZOLE SULFONE; PROTON; THIOL; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL TISSUE; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; DIFFERENTIATION; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INFUSION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 18044397167     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.02.005     Document Type: Article

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