Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 825, Issue 2, 2005, Pages 98-110

  Gao, Songmei ^a,b   Zhang, Zong Ping ^a,b   Karnes, H T ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Pharmaceutical Product Development   (United States)

Author keywords

Derivatization; Mobile phase additives; Reviews; Sensitivity improvement

Indexed keywords

ADDITIVES; ATMOSPHERIC PRESSURE; CHEMICAL ANALYSIS; ELECTRONS; IONIZATION; MASS SPECTROMETRY; PH EFFECTS; PROTONS; SENSITIVITY ANALYSIS;

DERIVATIZATION; MOBILE PHASE ADDITIVES; REVIEWS; SENSITIVITY IMPROVEMENT;

LIQUID CHROMATOGRAPHY;

ALCOHOL DERIVATIVE; ALDEHYDE DERIVATIVE; ALIPHATIC AMINE; AMIDE; AMINE; CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; COLECALCIFEROL DERIVATIVE; HALIDE; KETONE DERIVATIVE; METAL; PHENOL DERIVATIVE; PROTON; SODIUM; THIOL DERIVATIVE;

BINDING AFFINITY; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; ELECTRON; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY ANALYSIS;

ALCOHOLS; ALDEHYDES; AMIDES; AMINES; ATMOSPHERIC PRESSURE; BUFFERS; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; KETONES; MASS SPECTROMETRY; METALS, ALKALI; PHENOLS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS;

EID: 26444543861     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.04.021     Document Type: Review

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