LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: A comprehensive approach during drug development

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 10, 2013, Pages 3215-3231

  Shah, Ravi P ^a,b   Sahu, Archana ^a   Singh, Saranjit ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Degradation product; LC MS TOF; LC NMR; MSn studies; Rosuvastatin; Stress studies

Indexed keywords

DEGRADATION PRODUCTS; LC-MS/TOF; LC-NMR; MSN STUDIES; ROSUVASTATIN; STRESS STUDIES;

TISSUE; TOXICITY;

DEGRADATION;

FLUOROBENZENE; PYRIMIDINE DERIVATIVE; ROSUVASTATIN; SULFONAMIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG STABILITY; EVALUATION; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CHROMATOGRAPHY, LIQUID; DRUG DESIGN; DRUG STABILITY; FLUOROBENZENES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PYRIMIDINES; SULFONAMIDES;

EID: 84876098439     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-6760-1     Document Type: Article

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