Unusual Mass Spectrometric Dissociation Pathway of Protonated Isoquinoline-3-Carboxamides Due to Multiple Reversible Water Adduct Formation in the Gas Phase

Journal of the American Society for Mass Spectrometry

Volumn 20, Issue 11, 2009, Pages 2034-2048

  Beuck, Simon ^a   Schwabe, Tobias ^b   Grimme, Stefan ^b   Schlörer, Nils ^c   Kamber, Matthias ^d   Schänzer, Wilhelm ^a   Thevis, Mario ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d Antidoping Switzerland   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; ACYLIUM; ADDUCT FORMATION; ANALYTICAL TOOL; CARBOXAMIDES; COLLISION-INDUCED DISSOCIATION; DENSITY FUNCTIONAL THEORY CALCULATIONS; DISSOCIATION PATHWAYS; DRUG CANDIDATES; DRUG TESTING; FRAGMENTATION BEHAVIOR; FRAGMENTATION PATTERNS; GAS-PHASE INTERMEDIATES; GASPHASE; ISOQUINOLINES; ORBITRAP; PRECURSOR IONS; PROTONATED; STABLE ISOTOPES; TANDEM MASS SPECTROMETRY; WATER ADDITION;

CARBON MONOXIDE; CARBOXYLIC ACIDS; DISSOCIATION; IONS; ISOTOPES; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC ACIDS; PROPYLENE;

DENSITY FUNCTIONAL THEORY;

ANTIANEMIC AGENT; CARBON MONOXIDE; CARBOXYLIC ACID DERIVATIVE; ISOQUINOLINE 3 CARBOXAMIDE; ISOQUINOLINE 3 CARBOXYLIC ACID; PROPYLENE; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANALYTIC METHOD; ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DISSOCIATION; DRUG SCREENING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; PROTON TRANSPORT; STRUCTURE ANALYSIS; SYNTHESIS; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; DOPING IN SPORTS; GASES; HUMANS; IONS; ISOQUINOLINES; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; PROTONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY; WATER;

EID: 70349776354     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.07.016     Document Type: Article

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