메뉴 건너뛰기




Volumn , Issue , 2005, Pages 359-377

New Strategies for the Implementation and Support of Bioanalysis in a Drug Metabolism Environment

Author keywords

Drug metabolism (DM) environment and matrix ion suppression; High throughput bioanalytical support; Triple quadrupole HPLC MS MS system

Indexed keywords


EID: 84889489376     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0471721034.ch12     Document Type: Chapter
Times cited : (3)

References (63)
  • 1
    • 1842833762 scopus 로고    scopus 로고
    • Recent Advances in Use of LC/MS/MS for Quantitative High-Throughput Bioanalytical Support of Drug Discovery
    • Ackermann, B.L.; Berna, M.J.; Murphy, A.T. "Recent Advances in Use of LC/MS/MS for Quantitative High-Throughput Bioanalytical Support of Drug Discovery," Curr. Top. Med. Chem. 2(1), 53-66 (2002).
    • (2002) Curr. Top. Med. Chem. , vol.2 , Issue.1 , pp. 53-66
    • Ackermann, B.L.1    Berna, M.J.2    Murphy, A.T.3
  • 2
    • 0033824707 scopus 로고    scopus 로고
    • High-Throughput Quantitative Bioanalysis by LC/MS/MS
    • Jemal, M. "High-Throughput Quantitative Bioanalysis by LC/MS/MS," Biomed. Chromatogr. 14(6), 422-429 (2000).
    • (2000) Biomed. Chromatogr. , vol.14 , Issue.6 , pp. 422-429
    • Jemal, M.1
  • 3
    • 0030813705 scopus 로고    scopus 로고
    • HPLCAPI/MS/MS: A Powerful Tool for Integrating Drug Metabolism into the Drug Discovery Process
    • Korfmacher, W.A.; Cox, K.A.; Bryant, M.S.; Veals, J.; Ng, K.; Lin, C.C. "HPLCAPI/MS/MS: A Powerful Tool for Integrating Drug Metabolism into the Drug Discovery Process," Drug Discov. Today 2, 532-537 (1997).
    • (1997) Drug Discov. Today , vol.2 , pp. 532-537
    • Korfmacher, W.A.1    Cox, K.A.2    Bryant, M.S.3    Veals, J.4    Ng, K.5    Lin, C.C.6
  • 4
    • 0036783410 scopus 로고    scopus 로고
    • The Influence of DMPK as an Integrated Partner in Modern Drug Discovery
    • Riley, R.J.; Martin, I.J.; Cooper, A.E. "The Influence of DMPK as an Integrated Partner in Modern Drug Discovery," Curr. Drug Metab. 3(5), 527-550 (2002).
    • (2002) Curr. Drug Metab. , vol.3 , Issue.5 , pp. 527-550
    • Riley, R.J.1    Martin, I.J.2    Cooper, A.E.3
  • 5
    • 0034329374 scopus 로고    scopus 로고
    • Early ADME in Support of Drug Discovery: The Role of Metabolic Stability Studies
    • Thompson, T.N. "Early ADME in Support of Drug Discovery: The Role of Metabolic Stability Studies," Curr. Drug Metab. 1(3), 215-241 (2000).
    • (2000) Curr. Drug Metab. , vol.1 , Issue.3 , pp. 215-241
    • Thompson, T.N.1
  • 6
    • 0034890106 scopus 로고    scopus 로고
    • Optimization of Metabolic Stability as a Goal of Modern Drug Design
    • Thompson, T.N. "Optimization of Metabolic Stability as a Goal of Modern Drug Design," Med. Res. Rev. 21(5), 412-449 (2001).
    • (2001) Med. Res. Rev. , vol.21 , Issue.5 , pp. 412-449
    • Thompson, T.N.1
  • 7
    • 0034885012 scopus 로고    scopus 로고
    • Role of Drug Metabolism in Drug Discovery and Development
    • Kumar, G.N.; Surapaneni, S. "Role of Drug Metabolism in Drug Discovery and Development," Med. Res. Rev. 21(5), 397-411 (2001).
    • (2001) Med. Res. Rev. , vol.21 , Issue.5 , pp. 397-411
    • Kumar, G.N.1    Surapaneni, S.2
  • 8
    • 0035416240 scopus 로고    scopus 로고
    • Prediction of Pharmacokinetic Properties Using Experimental Approaches During Early Drug Discovery
    • Chaturvedi, P.R.; Decker, C.J.; Odinecs, A. "Prediction of Pharmacokinetic Properties Using Experimental Approaches During Early Drug Discovery," Curr. Opin. Chem. Biol. 5(4), 452-463 (2001).
    • (2001) Curr. Opin. Chem. Biol. , vol.5 , Issue.4 , pp. 452-463
    • Chaturvedi, P.R.1    Decker, C.J.2    Odinecs, A.3
  • 9
    • 0034283752 scopus 로고    scopus 로고
    • ADME/PK as Part of a Rational Approach to Drug Discovery
    • Eddershaw, P.J.; Beresford, A.P.; Bayliss, M.K. "ADME/PK as Part of a Rational Approach to Drug Discovery," Drug Discov. Today 5(9), 409-414 (2000).
    • (2000) Drug Discov. Today , vol.5 , Issue.9 , pp. 409-414
    • Eddershaw, P.J.1    Beresford, A.P.2    Bayliss, M.K.3
  • 10
    • 0032088562 scopus 로고    scopus 로고
    • High-Throughput Approaches for Evaluating Absorption, Metabolism and Excretion Properties of Lead Compounds
    • Tarbit, M.H.; Berman, J. "High-Throughput Approaches for Evaluating Absorption, Metabolism and Excretion Properties of Lead Compounds," Curr. Opin. Chem. Biol. 2, 411-416 (1998).
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , pp. 411-416
    • Tarbit, M.H.1    Berman, J.2
  • 11
    • 0030886937 scopus 로고    scopus 로고
    • Managing the Drug Discovery/Developmement Interface
    • Kennedy, T. "Managing the Drug Discovery/Developmement Interface," Drug Dis. Today 2(10), 436-444 (1997).
    • (1997) Drug Dis. Today , vol.2 , Issue.10 , pp. 436-444
    • Kennedy, T.1
  • 12
    • 0034837087 scopus 로고    scopus 로고
    • High-Throughput Screening Approaches for Investigating Drug Metabolism and Pharmacokinetics
    • Roberts, S.A. "High-Throughput Screening Approaches for Investigating Drug Metabolism and Pharmacokinetics," Xenobiotica 31(8-9), 557-589 (2001).
    • (2001) Xenobiotica , vol.31 , Issue.8-9 , pp. 557-589
    • Roberts, S.A.1
  • 13
    • 0035031472 scopus 로고    scopus 로고
    • In Vitro High Throughput Screening of Compounds for Favorable Metabolic Properties in Drug Discovery
    • Masimirembwa, C.M.; Thompson, R.; Andersson, T.B. "In Vitro High Throughput Screening of Compounds for Favorable Metabolic Properties in Drug Discovery," Comb. Chem. High Throughput Screen. 4(3), 245-263 (2001).
    • (2001) Comb. Chem. High Throughput Screen. , vol.4 , Issue.3 , pp. 245-263
    • Masimirembwa, C.M.1    Thompson, R.2    Andersson, T.B.3
  • 14
    • 0032960474 scopus 로고    scopus 로고
    • Development of an Automated Mass Spectrometry System for the Quantitative Analysis of Liver Microsomal Incubation Samples:ATool for Rapid Screening of NewCompounds for Metabolic Stability
    • Korfmacher, W.A.; Palmer, C.A.; Nardo, C.; Dunn-Meynell, K.; Grotz, D.; Cox, K.; Lin, C.C.; Elicone, C.; Liu, C.; Duchoslav, E. "Development of an Automated Mass Spectrometry System for the Quantitative Analysis of Liver Microsomal Incubation Samples:ATool for Rapid Screening of NewCompounds for Metabolic Stability," Rapid Commun. Mass Spectrom. 13(10), 901-907 (1999).
    • (1999) Rapid Commun. Mass Spectrom. , vol.13 , Issue.10 , pp. 901-907
    • Korfmacher, W.A.1    Palmer, C.A.2    Nardo, C.3    Dunn-Meynell, K.4    Grotz, D.5    Cox, K.6    Lin, C.C.7    Elicone, C.8    Liu, C.9    Duchoslav, E.10
  • 15
    • 0036112196 scopus 로고    scopus 로고
    • Application of Parallel Liquid Chromatography/Mass Spectrometry for High Throughput Microsomal Stability Screening of Compound Libraries
    • Xu, R.; Nemes, C.; Jenkins, K.M.; Rourick, R.A.; Kassel, D.B.; Liu, C.Z. "Application of Parallel Liquid Chromatography/Mass Spectrometry for High Throughput Microsomal Stability Screening of Compound Libraries," J. Am. Soc. Mass Spectrom. 13(2), 155-165 (2002).
    • (2002) J. Am. Soc. Mass Spectrom. , vol.13 , Issue.2 , pp. 155-165
    • Xu, R.1    Nemes, C.2    Jenkins, K.M.3    Rourick, R.A.4    Kassel, D.B.5    Liu, C.Z.6
  • 16
    • 0033800945 scopus 로고    scopus 로고
    • Rapid Assessment of Drug Metabolism in the Drug Discovery Process
    • Bertrand, M.; Jackson, P.; Walther, B. "Rapid Assessment of Drug Metabolism in the Drug Discovery Process," Eur. J. Pharm. Sci. 11 (Suppl 2), S61-S72 (2000).
    • (2000) Eur. J. Pharm. Sci , vol.11 , Issue.SUPPL. 2
    • Bertrand, M.1    Jackson, P.2    Walther, B.3
  • 17
    • 0036007823 scopus 로고    scopus 로고
    • In Vitro Metabolite Identification Using Fast Gradient High Performance Liquid Chromatography Combined with Tandem Mass Spectrometry
    • Hop, C.E.; Tiller, P.R.; Romanyshyn, L. "In Vitro Metabolite Identification Using Fast Gradient High Performance Liquid Chromatography Combined with Tandem Mass Spectrometry," Rapid Commun. Mass Spectrom. 16(3), 212-219 (2002).
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , Issue.3 , pp. 212-219
    • Hop, C.E.1    Tiller, P.R.2    Romanyshyn, L.3
  • 18
    • 0035983382 scopus 로고    scopus 로고
    • Liquid Chromatography/Tandem Mass Spectrometric Quantification with Metabolite Screening as a Strategy to Enhance the Early Drug Discovery Process
    • Tiller, P.R.; Romanyshyn, L.A. "Liquid Chromatography/Tandem Mass Spectrometric Quantification with Metabolite Screening as a Strategy to Enhance the Early Drug Discovery Process," Rapid Commun. Mass Spectrom. 16(12), 1225-1231 (2002).
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , Issue.12 , pp. 1225-1231
    • Tiller, P.R.1    Romanyshyn, L.A.2
  • 19
    • 0035416421 scopus 로고    scopus 로고
    • Systematic LC/MS Metabolite Identification in Drug Discovery
    • Clarke, N.J.; Rindgen, D.; Korfmacher, W.A.; Cox, K.A. "Systematic LC/MS Metabolite Identification in Drug Discovery," Anal. Chem. 73(15), 430A-439A (2001).
    • (2001) Anal. Chem. , vol.73 , Issue.15
    • Clarke, N.J.1    Rindgen, D.2    Korfmacher, W.A.3    Cox, K.A.4
  • 20
    • 0034794936 scopus 로고    scopus 로고
    • An Intelligent Data Acquisition System for Simultaneous Screening of Microsomal Stability and Metabolite Profiling by Liquid Chromatography/Mass Spectrometry
    • Gu, M.; Lim, H.K. "An Intelligent Data Acquisition System for Simultaneous Screening of Microsomal Stability and Metabolite Profiling by Liquid Chromatography/Mass Spectrometry," J. Mass Spectrom. 36(9), 1053-1061 (2001).
    • (2001) J. Mass Spectrom. , vol.36 , Issue.9 , pp. 1053-1061
    • Gu, M.1    Lim, H.K.2
  • 21
    • 0035326323 scopus 로고    scopus 로고
    • Simultaneous Screen for Microsomal Stability and Metabolite Profile by Direct Injection Turbulent-Laminar Flow LC-LC and Automated Tandem Mass Spectrometry
    • Lim, H.K.; Chan, K.W.; Sisenwine, S.; Scatina, J.A. "Simultaneous Screen for Microsomal Stability and Metabolite Profile by Direct Injection Turbulent-Laminar Flow LC-LC and Automated Tandem Mass Spectrometry," Anal. Chem. 73(9), 2140-2146 (2001).
    • (2001) Anal. Chem. , vol.73 , Issue.9 , pp. 2140-2146
    • Lim, H.K.1    Chan, K.W.2    Sisenwine, S.3    Scatina, J.A.4
  • 22
    • 0002102760 scopus 로고    scopus 로고
    • Higher Throughput Metabolite Identification in Drug Discovery: Current Capabilities and Future Trends
    • Cox, K.A.; Clarke, N.J.; Rindgen, D.; Korfmacher, W.A. "Higher Throughput Metabolite Identification in Drug Discovery: Current Capabilities and Future Trends," Amer. Pharm. Rev. 4(1), 45-52 (2001).
    • (2001) Amer. Pharm. Rev. , vol.4 , Issue.1 , pp. 45-52
    • Cox, K.A.1    Clarke, N.J.2    Rindgen, D.3    Korfmacher, W.A.4
  • 23
    • 0035524138 scopus 로고    scopus 로고
    • Assessing the Absorption of New Pharmaceuticals
    • Hidalgo, I.J. "Assessing the Absorption of New Pharmaceuticals," Curr. Top. Med. Chem. 1(5), 385-401 (2001).
    • (2001) Curr. Top. Med. Chem. , vol.1 , Issue.5 , pp. 385-401
    • Hidalgo, I.J.1
  • 24
    • 0036896911 scopus 로고    scopus 로고
    • Predicting Drug Absorption: How Nature Made It a Difficult Problem
    • Burton, P.S.; Goodwin, J.T.; Vidmar, T.J.; Amore, B.M. "Predicting Drug Absorption: How Nature Made It a Difficult Problem," J. Pharmacol. Exp. Ther. 303(3), 889-895 (2002).
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , Issue.3 , pp. 889-895
    • Burton, P.S.1    Goodwin, J.T.2    Vidmar, T.J.3    Amore, B.M.4
  • 25
    • 0033977587 scopus 로고    scopus 로고
    • Determination of InVitro Permeability of Drug Candidates through a Caco-2 Cell Monolayer by Liquid Chromatography/Tandem Mass Spectrometry
    • Wang, Z.; Hop, C.E.; Leung, K.H.; Pang, J. "Determination of InVitro Permeability of Drug Candidates through a Caco-2 Cell Monolayer by Liquid Chromatography/Tandem Mass Spectrometry," J. Mass Spectrom. 35(1), 71-76 (2000).
    • (2000) J. Mass Spectrom. , vol.35 , Issue.1 , pp. 71-76
    • Wang, Z.1    Hop, C.E.2    Leung, K.H.3    Pang, J.4
  • 26
    • 0037108931 scopus 로고    scopus 로고
    • Simultaneous LC-MS/MS Determination of Reference Pharmaceuticals as a Method for the Characterization of the Caco-2 Cell Monolayer Absorption Properties
    • Larger, P.; Altamura, M.; Catalioto, R.M.; Giuliani, S.; Maggi, C.A.; Valenti, C.; Triolo, A. "Simultaneous LC-MS/MS Determination of Reference Pharmaceuticals as a Method for the Characterization of the Caco-2 Cell Monolayer Absorption Properties," Anal. Chem. 74(20), 5273-5281 (2002).
    • (2002) Anal. Chem. , vol.74 , Issue.20 , pp. 5273-5281
    • Larger, P.1    Altamura, M.2    Catalioto, R.M.3    Giuliani, S.4    Maggi, C.A.5    Valenti, C.6    Triolo, A.7
  • 28
    • 0035048583 scopus 로고    scopus 로고
    • Compound Mixtures in Caco-2 Cell Permeability Screens as a Means to Increase Screening Capacity
    • Tannergren, C.; Langguth, P.; Hoffmann, K.J. "Compound Mixtures in Caco-2 Cell Permeability Screens as a Means to Increase Screening Capacity," Pharmazie 56(4), 337-342 (2001).
    • (2001) Pharmazie , vol.56 , Issue.4 , pp. 337-342
    • Tannergren, C.1    Langguth, P.2    Hoffmann, K.J.3
  • 29
    • 0034461768 scopus 로고    scopus 로고
    • Drug-Like Properties and the Causes of Poor Solubility and Poor Permeability
    • Lipinski, C.A. "Drug-Like Properties and the Causes of Poor Solubility and Poor Permeability," J. Pharmacol. Toxicol. Methods 44(1), 235-249 (2000).
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , Issue.1 , pp. 235-249
    • Lipinski, C.A.1
  • 30
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
    • Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. "Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings," Adv. Drug Deliv. Rev. 46(1-3), 3-26 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 31
    • 0034835463 scopus 로고    scopus 로고
    • Prediction of Human Hepatic Clearance from In Vivo Animal Experiments and In Vitro Metabolic Studies with Liver Microsomes from Animals and Humans
    • Naritomi, Y.; Terashita, S.; Kimura, S.; Suzuki, A.; Kagayama, A.; Sugiyama, Y. "Prediction of Human Hepatic Clearance from In Vivo Animal Experiments and In Vitro Metabolic Studies with Liver Microsomes from Animals and Humans," Drug Metab. Dispos. 29(10), 1316-1324 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , Issue.10 , pp. 1316-1324
    • Naritomi, Y.1    Terashita, S.2    Kimura, S.3    Suzuki, A.4    Kagayama, A.5    Sugiyama, Y.6
  • 32
    • 0037122748 scopus 로고    scopus 로고
    • Graphical Model for Estimating Oral Bioavailability of Drugs in Humans and Other Species from Their Caco-2 Permeability and In Vitro Liver Enzyme Metabolic Stability Rates
    • Mandagere, A.K.; Thompson, T.N.; Hwang, K.K. "Graphical Model for Estimating Oral Bioavailability of Drugs in Humans and Other Species from Their Caco-2 Permeability and In Vitro Liver Enzyme Metabolic Stability Rates," J. Med. Chem. 45(2), 304-311 (2002).
    • (2002) J. Med. Chem. , vol.45 , Issue.2 , pp. 304-311
    • Mandagere, A.K.1    Thompson, T.N.2    Hwang, K.K.3
  • 33
    • 0037175444 scopus 로고    scopus 로고
    • Semi-Automated Determination of Plasma Stability of Drug Discovery Compounds Using Liquid Chromatography-Tandem Mass Spectrometry
    • Wang, G.; Hsieh, Y.; Lau, Y.; Cheng, K.C.; Ng, K.;Korfmacher, W.A.; White, R.E. "Semi-Automated Determination of Plasma Stability of Drug Discovery Compounds Using Liquid Chromatography-Tandem Mass Spectrometry," J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 780(2), 451-457 (2002).
    • (2002) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.780 , Issue.2 , pp. 451-457
    • Wang, G.1    Hsieh, Y.2    Lau, Y.3    Cheng, K.C.4    Ng, K.5    Korfmacher, W.A.6    White, R.E.7
  • 34
    • 10444274218 scopus 로고    scopus 로고
    • Utilization of Direct HPLC-MS-MS for Drug Stability Measurement
    • Wang, G.; Hsieh, Y. "Utilization of Direct HPLC-MS-MS for Drug Stability Measurement," Am. Lab. 34(24), 24-27 (2002).
    • (2002) Am. Lab. , vol.34 , Issue.24 , pp. 24-27
    • Wang, G.1    Hsieh, Y.2
  • 35
    • 0035523337 scopus 로고    scopus 로고
    • Metabolism Profiling, and Cytochrome P450 Inhibition and Induction in Drug Discovery
    • Yan, Z.; Caldwell, G.W. "Metabolism Profiling, and Cytochrome P450 Inhibition and Induction in Drug Discovery," Curr. Top. Med. Chem. 1(5), 403-425 (2001).
    • (2001) Curr. Top. Med. Chem. , vol.1 , Issue.5 , pp. 403-425
    • Yan, Z.1    Caldwell, G.W.2
  • 36
    • 0033976657 scopus 로고    scopus 로고
    • Validation of Higher-Throughput High-Performance Liquid Chromatography/Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry Assays to Conduct Cytochrome P450s CYP2D6 and CYP3A4 Enzyme Inhibition Studies in Human Liver Microsomes
    • Chu, I.; Favreau, L.; Soares, T.; Lin, C.; Nomeir, A.A. "Validation of Higher-Throughput High-Performance Liquid Chromatography/Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry Assays to Conduct Cytochrome P450s CYP2D6 and CYP3A4 Enzyme Inhibition Studies in Human Liver Microsomes," Rapid Commun. Mass Spectrom. 14(4), 207-214 (2000).
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , Issue.4 , pp. 207-214
    • Chu, I.1    Favreau, L.2    Soares, T.3    Lin, C.4    Nomeir, A.A.5
  • 37
    • 0037212558 scopus 로고    scopus 로고
    • High-Throughput Inhibition Screening of Major Human Cytochrome P450 Enzymes Using an In Vitro Cocktail and Liquid Chromatography-Tandem Mass Spectrometry
    • Testino, S.A., Jr.; Patonay, G. "High-Throughput Inhibition Screening of Major Human Cytochrome P450 Enzymes Using an In Vitro Cocktail and Liquid Chromatography-Tandem Mass Spectrometry," J. Pharm. Biomed. Anal. 30(5), 1459-1467 (2003).
    • (2003) J. Pharm. Biomed. Anal. , vol.30 , Issue.5 , pp. 1459-1467
    • Testino Jr., S.A.1    Patonay, G.2
  • 38
    • 0036218957 scopus 로고    scopus 로고
    • Rapid Determination of Pharmacokinetic Properties of New Chemical Entities: In Vivo Approaches
    • Cox, K.A.; White, R.E.;Korfmacher, W.A. "Rapid Determination of Pharmacokinetic Properties of New Chemical Entities: In Vivo Approaches," Comb. Chem. High Throughput Screen. 5(1), 29-37 (2002).
    • (2002) Comb. Chem. High Throughput Screen. , vol.5 , Issue.1 , pp. 29-37
    • Cox, K.A.1    White, R.E.2    Korfmacher, W.A.3
  • 39
    • 0036234877 scopus 로고    scopus 로고
    • Automated Sample Preparation and LC-MS for High-Throughput ADME Quantification
    • O'Connor, D. "Automated Sample Preparation and LC-MS for High-Throughput ADME Quantification," Curr. Opin. Drug Disc. Devel. 5(1), 52-58 (2002).
    • (2002) Curr. Opin. Drug Disc. Devel. , vol.5 , Issue.1 , pp. 52-58
    • O'Connor, D.1
  • 40
    • 0031030955 scopus 로고    scopus 로고
    • Column-Switching High-Performance Liquid Chromatography Combined with Ionspray Tandem Mass Spectrometry for the Simultaneous Determination of the Platelet Inhibitor Ro 44-3888 and Its Pro-Drug and Precursor Metabolite in Plasma
    • Zell, M.; Husser, C.; Hopfgartner, G. "Column-Switching High-Performance Liquid Chromatography Combined with Ionspray Tandem Mass Spectrometry for the Simultaneous Determination of the Platelet Inhibitor Ro 44-3888 and Its Pro-Drug and Precursor Metabolite in Plasma," J. Mass Spectrom. 32(1), 23-32 (1997).
    • (1997) J. Mass Spectrom. , vol.32 , Issue.1 , pp. 23-32
    • Zell, M.1    Husser, C.2    Hopfgartner, G.3
  • 41
    • 0036498075 scopus 로고    scopus 로고
    • The Investigation and the Use of High Flow Column-Switching LC/MS/MS as a High-Throughput Approach for Direct Plasma Sample Analysis of Single and Multiple Components in Pharmacokinetic Studies
    • Zeng, H.; Wu, J.T.; Unger, S.E. "The Investigation and the Use of High Flow Column-Switching LC/MS/MS as a High-Throughput Approach for Direct Plasma Sample Analysis of Single and Multiple Components in Pharmacokinetic Studies," J. Pharm. Biomed. Anal. 27(6), 967-982 (2002).
    • (2002) J. Pharm. Biomed. Anal. , vol.27 , Issue.6 , pp. 967-982
    • Zeng, H.1    Wu, J.T.2    Unger, S.E.3
  • 42
    • 0001965973 scopus 로고    scopus 로고
    • Rapid Chromatography Coupled with Direct Injection Lc/Ms/Ms for Quantitative Bioanalysis
    • Powell, M.L.; Jemal, M. "Rapid Chromatography Coupled with Direct Injection Lc/Ms/Ms for Quantitative Bioanalysis," Am. Pharm. Rev. 4(3), 63-69 (2001).
    • (2001) Am. Pharm. Rev. , vol.4 , Issue.3 , pp. 63-69
    • Powell, M.L.1    Jemal, M.2
  • 43
    • 0036253527 scopus 로고    scopus 로고
    • The Resurgence of Column Switching Techniques to Facilitate Rapid LC/MS/MS Based Bioanalysis in Drug Discovery
    • Ackermann, B.L.; Murphy, A.T.; Berna, M.J. "The Resurgence of Column Switching Techniques to Facilitate Rapid LC/MS/MS Based Bioanalysis in Drug Discovery," Am. Pharm. Rev. 5(1), 54-63 (2002).
    • (2002) Am. Pharm. Rev. , vol.5 , Issue.1 , pp. 54-63
    • Ackermann, B.L.1    Murphy, A.T.2    Berna, M.J.3
  • 44
    • 0036148841 scopus 로고    scopus 로고
    • High-Throughput Quantification of Drugs and Their Metabolites in Biosamples by LC-MS/MS and CE-MS/MS: Possibilities and Limitations
    • Hopfgartner, G.; Husser, C.; Zell, M. "High-Throughput Quantification of Drugs and Their Metabolites in Biosamples by LC-MS/MS and CE-MS/MS: Possibilities and Limitations," Ther. Drug Monit. 24(1), 134-143 (2002).
    • (2002) Ther. Drug Monit. , vol.24 , Issue.1 , pp. 134-143
    • Hopfgartner, G.1    Husser, C.2    Zell, M.3
  • 45
    • 0036027719 scopus 로고    scopus 로고
    • Direct Simultaneous Determination of Drug Discovery Compounds in Monkey Plasma Using Mixed-Function Column Liquid Chromatography/Tandem Mass Spectrometry
    • Hsieh, Y.; Brisson, J.M.; Ng, K.; Korfmacher, W.A. "Direct Simultaneous Determination of Drug Discovery Compounds in Monkey Plasma Using Mixed-Function Column Liquid Chromatography/Tandem Mass Spectrometry," J. Pharm. Biomed. Anal. 27(1-2), 285-293 (2002).
    • (2002) J. Pharm. Biomed. Anal. , vol.27 , Issue.1-2 , pp. 285-293
    • Hsieh, Y.1    Brisson, J.M.2    Ng, K.3    Korfmacher, W.A.4
  • 46
    • 0035664170 scopus 로고    scopus 로고
    • Direct Simultaneous Analysis of Plasma Samples for a Drug Discovery Compound and Its Hydroxyl Metabolite Using Mixed-Function Column Liquid Chromatography-Tandem Mass Spectrometry
    • Hsieh, Y.; Brisson, J.M.; Ng, K.; White, R.E.; Korfmacher, W.A. "Direct Simultaneous Analysis of Plasma Samples for a Drug Discovery Compound and Its Hydroxyl Metabolite Using Mixed-Function Column Liquid Chromatography-Tandem Mass Spectrometry," Analyst 126(12), 2139-2143 (2001).
    • (2001) Analyst , vol.126 , Issue.12 , pp. 2139-2143
    • Hsieh, Y.1    Brisson, J.M.2    Ng, K.3    White, R.E.4    Korfmacher, W.A.5
  • 47
    • 0036164807 scopus 로고    scopus 로고
    • Direct Cocktail Analysis of Drug Discovery Compounds in Pooled Plasma Samples Using Liquid Chromatography-Tandem Mass Spectrometry
    • Hsieh, Y.; Bryant, M.S.; Brisson, J.M.; Ng, K.; Korfmacher, W.A. "Direct Cocktail Analysis of Drug Discovery Compounds in Pooled Plasma Samples Using Liquid Chromatography-Tandem Mass Spectrometry," J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 767(2), 353-362 (2002).
    • (2002) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.767 , Issue.2 , pp. 353-362
    • Hsieh, Y.1    Bryant, M.S.2    Brisson, J.M.3    Ng, K.4    Korfmacher, W.A.5
  • 48
    • 0033861328 scopus 로고    scopus 로고
    • Direct Analysis of Plasma Samples for Drug Discovery Compounds Using Mixed-Function Column Liquid Chromatography Tandem Mass Spectrometry
    • Hsieh, Y.; Bryant, M.S.; Gruela, G.; Brisson, J.M.; Korfmacher, W.A. "Direct Analysis of Plasma Samples for Drug Discovery Compounds Using Mixed-Function Column Liquid Chromatography Tandem Mass Spectrometry," Rapid Commun. Mass Spectrom. 14(15), 1384-1390 (2000).
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , Issue.15 , pp. 1384-1390
    • Hsieh, Y.1    Bryant, M.S.2    Gruela, G.3    Brisson, J.M.4    Korfmacher, W.A.5
  • 49
    • 0036918663 scopus 로고    scopus 로고
    • Development and Application of Single-Column Direct Plasma Injection Procedures for Drug Candidate Assays Using HPLC-MS/MS
    • Hsieh, Y.; Ng, K.; Korfmacher, W. "Development and Application of Single-Column Direct Plasma Injection Procedures for Drug Candidate Assays Using HPLC-MS/MS," Am. Pharm. Rev. 5(4), 88-93 (2002).
    • (2002) Am. Pharm. Rev. , vol.5 , Issue.4 , pp. 88-93
    • Hsieh, Y.1    Ng, K.2    Korfmacher, W.3
  • 50
    • 0037446554 scopus 로고    scopus 로고
    • Direct Plasma Analysis of Drug Compounds Using Monolithic Column Liquid Chromatography and Tandem Mass Spectrometry
    • Hsieh, Y.; Wang, G.; Wang, Y.; Chackalamannil, S.; Korfmacher, W.A. "Direct Plasma Analysis of Drug Compounds Using Monolithic Column Liquid Chromatography and Tandem Mass Spectrometry," Anal. Chem. 75(8), 1812-1818 (2003).
    • (2003) Anal. Chem. , vol.75 , Issue.8 , pp. 1812-1818
    • Hsieh, Y.1    Wang, G.2    Wang, Y.3    Chackalamannil, S.4    Korfmacher, W.A.5
  • 51
    • 0031048025 scopus 로고    scopus 로고
    • The Simultaneous Determination of Mixtures of Drug Candidates by Liquid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry as an In Vivo Drug Screening Procedure
    • Olah, T.V.; McLoughlin, D.A.; Gilbert, J.D. "The Simultaneous Determination of Mixtures of Drug Candidates by Liquid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry as an In Vivo Drug Screening Procedure," Rapid Commun. Mass Spectrom. 11(1), 17-23 (1997).
    • (1997) Rapid Commun. Mass Spectrom. , vol.11 , Issue.1 , pp. 17-23
    • Olah, T.V.1    McLoughlin, D.A.2    Gilbert, J.D.3
  • 52
    • 0031000066 scopus 로고    scopus 로고
    • Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased Throughput
    • Berman, J.; Halm, K.; Adkison, K.; Shaffer, J. "Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased Throughput," J. Med. Chem. 40(6), 827-829 (1997).
    • (1997) J. Med. Chem. , vol.40 , Issue.6 , pp. 827-829
    • Berman, J.1    Halm, K.2    Adkison, K.3    Shaffer, J.4
  • 54
    • 0031873679 scopus 로고    scopus 로고
    • Plasma-Pooling Methods to Increase Throughput for In Vivo Pharmacokinetic Screening
    • Hop, C.E.; Wang, Z.; Chen, Q.; Kwei, G. "Plasma-Pooling Methods to Increase Throughput for In Vivo Pharmacokinetic Screening," J. Pharm. Sci. 87(7), 901-903 (1998).
    • (1998) J. Pharm. Sci. , vol.87 , Issue.7 , pp. 901-903
    • Hop, C.E.1    Wang, Z.2    Chen, Q.3    Kwei, G.4
  • 55
    • 0035100437 scopus 로고    scopus 로고
    • Cassette-Accelerated Rapid Rat Screen: A Systematic Procedure for the Dosing and Liquid Chromatography/Atmospheric Pressure Ionization Tandem Mass Spectrometric Analysis of New Chemical Entities as Part of New Drug Discovery
    • Korfmacher, W.A.; Cox, K.A.; Ng, K.J.; Veals, J.; Hsieh, Y.; Wainhaus, S.; Broske, L.; Prelusky, D.; Nomeir, A.; White, R.E. "Cassette-Accelerated Rapid Rat Screen: A Systematic Procedure for the Dosing and Liquid Chromatography/Atmospheric Pressure Ionization Tandem Mass Spectrometric Analysis of New Chemical Entities as Part of New Drug Discovery," Rapid Commun. Mass Spectrom. 15(5), 335-340 (2001).
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , Issue.5 , pp. 335-340
    • Korfmacher, W.A.1    Cox, K.A.2    Ng, K.J.3    Veals, J.4    Hsieh, Y.5    Wainhaus, S.6    Broske, L.7    Prelusky, D.8    Nomeir, A.9    White, R.E.10
  • 56
    • 0034954468 scopus 로고    scopus 로고
    • Mass Spectrometry Innovations in Drug Discovery and Development
    • Papac, D.I.; Shahrokh, Z. "Mass Spectrometry Innovations in Drug Discovery and Development," Pharm. Res. 18(2), 131-145 (2001).
    • (2001) Pharm. Res. , vol.18 , Issue.2 , pp. 131-145
    • Papac, D.I.1    Shahrokh, Z.2
  • 57
    • 0034955150 scopus 로고    scopus 로고
    • Pharmacokinetic Theory of Cassette Dosing in Drug Discovery Screening
    • White, R.E.; Manitpisitkul, P. "Pharmacokinetic Theory of Cassette Dosing in Drug Discovery Screening," Drug Metab. Dispos. 29(7), 957-966 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , Issue.7 , pp. 957-966
    • White, R.E.1    Manitpisitkul, P.2
  • 59
    • 0037089947 scopus 로고    scopus 로고
    • Comparison of SPE and Fast LC to Eliminate Mass Spectrometric Matrix Effects from Microsomal Incubation Products
    • Zheng, J.J.; Lynch, E.D.; Unger, S.E. "Comparison of SPE and Fast LC to Eliminate Mass Spectrometric Matrix Effects from Microsomal Incubation Products," J. Pharm. Biomed. Anal. 28(2), 279-285 (2002).
    • (2002) J. Pharm. Biomed. Anal. , vol.28 , Issue.2 , pp. 279-285
    • Zheng, J.J.1    Lynch, E.D.2    Unger, S.E.3
  • 60
    • 0036009111 scopus 로고    scopus 로고
    • Effects of Flow Rate on High-Throughput Quantitative Analysis of Protein-Precipitated Plasma Using Liquid Chromatography/Tandem Mass Spectrometry
    • Murphy, A.T.; Berna, M.J.; Holsapple, J.L.; Ackermann, B.L., "Effects of Flow Rate on High-Throughput Quantitative Analysis of Protein-Precipitated Plasma Using Liquid Chromatography/Tandem Mass Spectrometry," Rapid Commun. Mass Spectrom. 16(6), 537-543 (2002).
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , Issue.6 , pp. 537-543
    • Murphy, A.T.1    Berna, M.J.2    Holsapple, J.L.3    Ackermann, B.L.4
  • 61
    • 0037097063 scopus 로고    scopus 로고
    • Ion Suppression Effects in Liquid Chromatography-Electrospray-Ionisation Transport-Region Collision Induced Dissociation Mass Spectrometry with Different Serum Extraction Methods for Systematic Toxicological Analysis with Mass Spectra Libraries
    • Muller, C.; Schafer, P.; Stortzel, M.;Vogt, S.;Weinmann, W. "Ion Suppression Effects in Liquid Chromatography-Electrospray-Ionisation Transport-Region Collision Induced Dissociation Mass Spectrometry with Different Serum Extraction Methods for Systematic Toxicological Analysis with Mass Spectra Libraries," J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 773(1), 47-52 (2002).
    • (2002) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.773 , Issue.1 , pp. 47-52
    • Muller, C.1    Schafer, P.2    Stortzel, M.3    Vogt, S.4    Weinmann, W.5
  • 62
    • 0037115384 scopus 로고    scopus 로고
    • Effect of Signal Interference from Dosing Excipients on Pharmacokinetic Screening of Drug Candidates by Liquid Chromatography/Mass Spectrometry
    • Tong, X.S.;Wang, J.; Zheng, S.; Pivnichny, J.V.; Griffin, P.R.; Shen, X.; Donnelly, M.;Vakerich, K.; Nunes, C.; Fenyk-Melody, J. "Effect of Signal Interference from Dosing Excipients on Pharmacokinetic Screening of Drug Candidates by Liquid Chromatography/Mass Spectrometry," Anal. Chem. 74(24), 6305-6313 (2002).
    • (2002) Anal. Chem. , vol.74 , Issue.24 , pp. 6305-6313
    • Tong, X.S.1    Wang, J.2    Zheng, S.3    Pivnichny, J.V.4    Griffin, P.R.5    Shen, X.6    Donnelly, M.7    Vakerich, K.8    Nunes, C.9    Fenyk-Melody, J.10
  • 63
    • 0037214121 scopus 로고    scopus 로고
    • Investigation of Matrix Effects in Bioanalytical High-Performance Liquid Chromatography/Tandem Mass Spectrometric Assays: Application to Drug Discovery
    • Mei, H.; Hsieh, Y.; Nardo, C.; Xu, X.; Wang, S.; Ng, K.; Korfmacher, W.A. "Investigation of Matrix Effects in Bioanalytical High-Performance Liquid Chromatography/Tandem Mass Spectrometric Assays: Application to Drug Discovery," Rapid Commun. Mass Spectrom. 17(1), 97-103 (2003).
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , Issue.1 , pp. 97-103
    • Mei, H.1    Hsieh, Y.2    Nardo, C.3    Xu, X.4    Wang, S.5    Ng, K.6    Korfmacher, W.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.