Column-switching high-performance liquid chromatography combined with ionspray tandem mass spectrometry for the simultaneous determination of the platelet inhibitor Ro 44-3888 and its pro-drug and precursor metabolite in plasma

Journal of Mass Spectrometry

Volumn 32, Issue 1, 1997, Pages 23-32

  Zell, M ^a   Husser, C ^a   Hopfgartner, G ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Column switching solid phase extraction; Ionspray; Liquid chromatography mass spectrometry; Platelet inhibitor; Selected reaction monitoring

Indexed keywords

FIBRINOGEN RECEPTOR ANTAGONIST; PRODRUG; RO 443888; RO 483656; RO 483657; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOMATION; CALIBRATION; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MASS SPECTROMETRY; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TECHNIQUE;

AMIDINES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; OXIMES; PIPERIDINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRODRUGS; RATS; REFERENCE STANDARDS;

EID: 0031030955     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199701)32:1<23::AID-JMS449>3.0.CO;2-P     Document Type: Article

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