Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 780, Issue 2, 2002, Pages 451-457

  Wang, Gangfeng ^a   Hsieh, Yunsheng ^a   Lau, YauYi ^a   Cheng, K C ^a   Ng, Kwokei ^a   Korfmacher, Walter A ^a   White, Ronald E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Drug stability

Indexed keywords

CARBOXYLIC ACIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMA STABILITY; PROTEINS; SAMPLING;

DRUG DISCOVERY;

DRUG PRODUCTS;

CARBOXYLIC ACID DERIVATIVE; DRUG METABOLITE; NEW DRUG; SODIUM THIOSULFATE; DRUG;

ANALYTIC METHOD; ARTICLE; AUTOMATION; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DEGRADATION; DRUG STABILITY; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INCUBATION TIME; MONITORING; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SAMPLER; SEPARATION TECHNIQUE; SPECIES DIFFERENCE; SPECTROMETER; TANDEM MASS SPECTROMETRY; TEMPERATURE; THERMOSTABILITY; BLOOD; MASS SPECTROMETRY; METHODOLOGY;

ANIMALIA;

AUTOMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS;

EID: 0037175444     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00467-1     Document Type: Article

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