Optimizing Caco-2 cell monolayers to increase throughput in drug intestinal absorption analysis

Journal of Pharmacological and Toxicological Methods

Volumn 46, Issue 1, 2001, Pages 51-55

  Markowska, Maria ^a   Oberle, Rebecca ^a   Juzwin, Steve ^a   Hsu, Cheng Pang ^a   Gryszkiewicz, Margaret ^b   Streeter, Anthony J ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Caco 2 monolayers; High throughput screening; Intestinal transport; LC MS MS analysis; Methods; Permeability; Polycarbonate membrane

Indexed keywords

3 [1 [3 (4 PIPERIDINYL)PROPIONYL]NIPECOTOYLAMINO] 3 (3 PYRIDYL)PROPIONIC ACID; ATENOLOL; FUROSEMIDE; METOPROLOL; NADOLOL; NAPROXEN; PIROXICAM; POLYCARBONATE; PROPRANOLOL; TERBUTALINE; TOPIRAMATE;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; LIQUID SCINTILLATION COUNTING; MASS SPECTROMETRY;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, LIQUID; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; ELECTRIC IMPEDANCE; HUMANS; INTESTINAL ABSORPTION; MASS SPECTROMETRY; MEMBRANES, ARTIFICIAL; PHARMACEUTICAL PREPARATIONS; POLYCARBOXYLATE CEMENT; SCINTILLATION COUNTING;

EID: 0035724848     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(01)00161-7     Document Type: Article

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