Simultaneous LC-MS/MS determination of reference pharmaceuticals as a method for the characterization of the caco-2 cell monolayer absorption properties

Analytical Chemistry

Volumn 74, Issue 20, 2002, Pages 5273-5281

  Larger, Patrice ^a,b   Altamura, Maria ^a   Catalioto, Rose Marie ^a   Giuliani, Sandro ^a   Maggi, Carlo Alberto ^a   Valenti, Claudio ^a   Triolo, Antonio ^a  

^a Menarini Ricerche SpA   (Italy)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MONOLAYERS;

ABSORPTION; ALCOHOLS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MECHANICAL PERMEABILITY; MONOLAYERS; RADIOACTIVE MATERIALS;

DRUG PRODUCTS;

ATENOLOL; FLUORESCENT DYE; PHENYLALANINE; PROPRANOLOL; RADIOACTIVE MATERIAL;

ABSORPTION; ARTICLE; CELL STRAIN CACO 2; DRUG INDUSTRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEASUREMENT; MONOLAYER CULTURE; REPRODUCIBILITY;

ABSORPTION; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRIC CONDUCTIVITY; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MASS SPECTROMETRY; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS;

EID: 0037108931     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac020265r     Document Type: Article

References (27)

1. Hidalgo, I. J.; Raub, T. J.; Borchardt, R. T. Gastroenterology 1989, 96, 736-749.
2. Artursson, P.; Karlsson, J. Biochem. Biophys. Res. Commun. 1991, 175, 880-885.
3. Yee, S. Pharm. Res. 1997, 14, 763-766.
4. Artursson, P. J. Pharm. Sci. 1989, 79, 476-482.
5. Gres, M.-C.; Julian, B.; Bourrie, M.; Meunier, V.; Roques, C.; Beger, M.; Boulenc, X.; Berger, Y.; Fabre, G. Pharm. Res. 1998, 15, 726-733.
6. Taylor, E. W.; Gibbons, J. A.; Braeckman, R. A. Pharm. Res. 1997, 14, 572-577.
7. Caldwell, G. W.; Easlick, S. M.; Gunnet, J.; Masucci J. A.; Demarest, K. J. Mass Spectrom. 1998, 33, 607-614.
8. V. D. Waterbeemd, H.; Smith, D. A.; Beaumont, K., Walker, D. K. J Med. Chem 2001, 44, 1313-1333.
9. Gao, J.; Hugger, E. D.; Beck-Westermeyer M. S.; Borchardt, R. T. Curr. Protoc. Pharmacol. 2000, (Suppl. 8), 7.2.1-7.2.23.
10. Anderle, P.; Niederer, E.;. Rubas, W.; Hilgendorf, C.; Spahn-Langguth, H.; Wunderli-Allenspach, H.; Merkle, H. P.; Langguth, P. J. Pharm. Sci. 1998, 87, 757-762.
11. Yee S.; Day, W. W. Handbook of Drug Metabolism; Marcel Dekker: New York, 1999; Chapter 19.
12. Döppenschmitt, S.; Langguth, P.; Regårdh, C. G.; Andersson, T. B.; Hiulgendorf, C.; Spahn-Langguth, H. J. Pharmacol. Exp. Ther. 1999, 228, 348-357.
13. Rousset, M.; Laburthe, M.; Pinto, M.; Chevalier, G.; Rouyer-Fessard, C.; Dussaulx, E.; Trugnan, G.; Boige, N.; Brun, J.-L; Zweibaum., A. J. Cell. Physiol. 1985, 123, 377-385.
14. Liang, E.; Chessic, K.; Yadanian, M. J. Pharm. Sci. 2000, 89, 336-345.
15. Artursson, P.; Magnusson, C. J. Pharm. Sci. 1990, 79, 595-600.
16. Wang, Z.; Hop, C. E. C. A.; Leung, K. H.; Pang, J. M. J. Mass Spectrom. 2000, 35, 71-76.
17. Delie, F.; Rubas, W. Crit. Rev. Ther. Drug Carrier Syst. 1997, 14, 221-286.
18. Hediger, M. A.; Yoshikatsu, K.; Guofeng, Y.; Nussberger, S. J. Physiol. 1995, 482P, 7S-17S.
19. Hogenboom, A. C.; Niessen, W. M. A.; Brinkman, U. A. Th. J. Chromatgr., A 1998, 794, 201-210.
20. Wieboldt, R.; Campbell, D. A.; Henion, J. J. Chromatogr., B 1998, 708, 121-129.
21. Bartolucci, G.; Pieraccini, G.; Villanelli, F.; Moneti, G.; Triolo, A. Rapid Commun. Mass Spectrom. 2000, 14, 967-973.
22. Olah, T. V.; McLoughlin, D. A.; Gilbert, J. D. Rapid Commun. Mass Spectrom. 1997, 11, 17-23.
23. Tannergren, C.; Langguth, P.; Hoffmann, K.-J., Pharmazie 2001, 56, 337-342.
24. Karlsson, J.; Kuo, S.-M.; Ziemniak J.; Artursson, P. Br. J. Pharmacol. 1993, 110, 1009-1016.
25. Daoud, R.; Kast, C.; Gros, P.; Georges, E. Biochemistry 2000, 39, 15344-15352.
26. Ludescher, C.; Gattringer, D. J.; Hofmann, J.; Grunicke, H. Blood 1991, 78, 1385-1387.
27. Yumoto, R.; Murakami, T.; Nakamoto, Y.; Hasegawa, R.; Nagai, J.; Takano, M. J. Pharm. Exp. Ther. 1999, 289, 149-155.