Pharmacokinetic theory of cassette dosing in drug discovery screening

Drug Metabolism and Disposition

Volumn 29, Issue 7, 2001, Pages 957-966

  White, Ronald E ^a   Manitpisitkul, Prasarn ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; NEW DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG SCREENING; MICHAELIS CONSTANT; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; THEORY;

ANIMALS; BLOOD PROTEINS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; PHARMACOKINETICS; PROTEIN BINDING;

ANIMALIA;

EID: 0034955150     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kinetics of drug-drug interactions
2. 1A antagonist
3. Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: Methods and application
4. High-throughput pharmacokinetics: Cassette dosing
5. In vivo pharmacokinetic screening in cassette dosing experiments; the use of on-line Prospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery
6. Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput
7. Technological advances in high-throughput screening
8. Cassette dosing: Rapid in vivo assessment of pharmacokinetics
9. Cassette dosing: Rapid estimation of in vivo pharmacokinetics
10. In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model
11. Prediction of drug-drug interactions: Metabolic interaction in the liver
12. Pharmacokinetics of capacity-limited systems
13. Cassette-accelerated rapid rat assay: A systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery
14. A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system
15. The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure
16. Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance
17. Combinatorial diversification of indinavir: In vivo mixture dosing of an HIV protease inhibitor library
18. Clearance concepts in pharmacokinetics
19. Use of "N-in One" dosing to create an in vivo pharmacokinetics database for use in developing structure-pharmacokinetic relationships
20. Interaction of diclofenac and quinidine in monkeys: Stimulation of diclofenac metabolism
21. High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds
22. Characterization of a technique for rapid pharmacokinetic studies of multiple co-eluting compounds by LC/MS/MS
23. Human cytochrome P-450 3A4: In vitro drug-drug interaction patterns are substrate-dependent
24. Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics
25. Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery
26. Direct plasma sample injection in multiple-component LC-MS-MS assays for high-throughput pharmacokinetic screening