메뉴 건너뛰기




Volumn , Issue , 2006, Pages 175-189

Small Molecule Immunopotentiators as Vaccine Adjuvants

Author keywords

Innate and adaptive immunity control by TLR signaling; Small molecule immunopotentiators (SMIPs) vaccine adjuvants; Toll like receptors (TLRs) and leucine rich repeat (LRR)

Indexed keywords


EID: 84889367411     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470134931.ch8     Document Type: Chapter
Times cited : (3)

References (100)
  • 1
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Jan
    • Takea, K. & Akira, S. Toll-like receptors in innate immunity. Int Immunol 2005 Jan, 17(1), 1-14.
    • (2005) Int Immunol , vol.17 , Issue.1 , pp. 1-14
    • Takea, K.1    Akira, S.2
  • 2
    • 0142031430 scopus 로고    scopus 로고
    • Role of Toll-like receptors in pathogen recognition
    • Oct
    • Janssens, S. & Beyaert, R. Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 2003 Oct, 16(4), 637-646.
    • (2003) Clin Microbiol Rev , vol.16 , Issue.4 , pp. 637-646
    • Janssens, S.1    Beyaert, R.2
  • 3
    • 20544442412 scopus 로고    scopus 로고
    • NOD proteins: An intracellular pathogen-recognition system or signal transduction modifiers?
    • Aug
    • Murray, P.J. NOD proteins: An intracellular pathogen-recognition system or signal transduction modifiers? Curr Opin Immunol 2005 Aug, 17(4), 352-358.
    • (2005) Curr Opin Immunol , vol.17 , Issue.4 , pp. 352-358
    • Murray, P.J.1
  • 4
    • 17644366913 scopus 로고    scopus 로고
    • NOD-LRR proteins: role in host-microbial interactions and inflammatory disease
    • Inohara, N., Chamaillard, M., McDonald, C. & Nunez, G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 2005, 74, 355-383.
    • (2005) Annu Rev Biochem , vol.74 , pp. 355-383
    • Inohara, N.1    Chamaillard, M.2    McDonald, C.3    Nunez, G.4
  • 5
    • 23844438864 scopus 로고    scopus 로고
    • Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    • Sep 1
    • Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K. et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005 Sep 1, 175(5), 2851-2858.
    • (2005) J Immunol , vol.175 , Issue.5 , pp. 2851-2858
    • Yoneyama, M.1    Kikuchi, M.2    Matsumoto, K.3    Imaizumi, T.4    Miyagishi, M.5    Taira, K.6
  • 6
    • 22544455673 scopus 로고    scopus 로고
    • Cell type-specific involvement of RIG-I in antiviral response
    • Jul
    • Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K. et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005 Jul, 23(1), 19-28.
    • (2005) Immunity , vol.23 , Issue.1 , pp. 19-28
    • Kato, H.1    Sato, S.2    Yoneyama, M.3    Yamamoto, M.4    Uematsu, S.5    Matsui, K.6
  • 7
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • May 4
    • Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K. et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 May 4, 441(7089), 101-105.
    • (2006) Nature , vol.441 , Issue.7089 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3    Yoneyama, M.4    Yamamoto, M.5    Matsui, K.6
  • 8
    • 27844541797 scopus 로고    scopus 로고
    • Control of B-cell responses by Toll-like receptors
    • Nov 17
    • Pasare, C. & Medzhitov, R. Control of B-cell responses by Toll-like receptors. Nature 2005 Nov 17, 438(7066), 364-368.
    • (2005) Nature , vol.438 , Issue.7066 , pp. 364-368
    • Pasare, C.1    Medzhitov, R.2
  • 9
    • 21344465240 scopus 로고    scopus 로고
    • TLR signalling and the function of dendritic cells
    • Hemmi, H. & Akira, S. TLR signalling and the function of dendritic cells. Chem Immunol Allergy 2005, 86, 120-135.
    • (2005) Chem Immunol Allergy , vol.86 , pp. 120-135
    • Hemmi, H.1    Akira, S.2
  • 10
    • 11144233242 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling (SOCS) proteins indirectly regulate Toll-like receptor signaling in innate immune cells
    • Dec 24
    • Baetz, A., Frey, M., Heeg, K. & Dalpke, A.H. Suppressor of cytokine signaling (SOCS) proteins indirectly regulate Toll-like receptor signaling in innate immune cells. J Biol Chem 2004 Dec 24, 279(52), 54708-54715.
    • (2004) J Biol Chem , vol.279 , Issue.52 , pp. 54708-54715
    • Baetz, A.1    Frey, M.2    Heeg, K.3    Dalpke, A.H.4
  • 11
    • 0042733592 scopus 로고    scopus 로고
    • SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
    • Sep
    • Wald, D., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L. et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2003 Sep, 4(9), 920-927.
    • (2003) Nat Immunol , vol.4 , Issue.9 , pp. 920-927
    • Wald, D.1    Qin, J.2    Zhao, Z.3    Qian, Y.4    Naramura, M.5    Tian, L.6
  • 12
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Jul
    • Fukao, T. & Koyasu, S. PI3K and negative regulation of TLR signaling. Trends Immunol 2003 Jul, 24(7), 358-363.
    • (2003) Trends Immunol , vol.24 , Issue.7 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 13
    • 28844460239 scopus 로고    scopus 로고
    • The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for Toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7
    • Dec 9
    • Yoshida, H., Jono, H., Kai, H. & Li, J.D. The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for Toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. J Biol Chem 2005 Dec 9, 280(49), 41111-41121.
    • (2005) J Biol Chem , vol.280 , Issue.49 , pp. 41111-41121
    • Yoshida, H.1    Jono, H.2    Kai, H.3    Li, J.D.4
  • 14
    • 31344463886 scopus 로고    scopus 로고
    • Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    • Feb
    • Wang, Y., Tang, Y., Teng, L., Wu, Y., Zhao, X. & Pei, G. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2006 Feb, 7(2), 139-147.
    • (2006) Nat Immunol , vol.7 , Issue.2 , pp. 139-147
    • Wang, Y.1    Tang, Y.2    Teng, L.3    Wu, Y.4    Zhao, X.5    Pei, G.6
  • 15
    • 5444223519 scopus 로고    scopus 로고
    • The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    • Oct
    • Boone, D.L., Turer, E.E., Lee, E.G., Ahmad, R.C., Wheeler, M.T., Tsui, C. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 2004 Oct, 5(10), 1052-1060.
    • (2004) Nat Immunol , vol.5 , Issue.10 , pp. 1052-1060
    • Boone, D.L.1    Turer, E.E.2    Lee, E.G.3    Ahmad, R.C.4    Wheeler, M.T.5    Tsui, C.6
  • 16
    • 30044441094 scopus 로고    scopus 로고
    • Limiting inflammatory responses during activation of innate immunity
    • Dec
    • Han, J. & Ulevitch, R.J. Limiting inflammatory responses during activation of innate immunity. Nat Immunol 2005 Dec, 6(12), 1198-1205.
    • (2005) Nat Immunol , vol.6 , Issue.12 , pp. 1198-1205
    • Han, J.1    Ulevitch, R.J.2
  • 17
    • 0036679732 scopus 로고    scopus 로고
    • Of mice and men: species variations of Toll-like receptor expression
    • Aug
    • Rehli, M. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol 2002 Aug, 23(8), 375-378.
    • (2002) Trends Immunol , vol.23 , Issue.8 , pp. 375-378
    • Rehli, M.1
  • 18
    • 33744978765 scopus 로고    scopus 로고
    • Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment
    • Jun
    • Nagai, Y., Garrett, K.P., Ohta, S., Bahrun, U., Kouro, T., Akira, S. et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 2006 Jun, 24(6), 801-812.
    • (2006) Immunity , vol.24 , Issue.6 , pp. 801-812
    • Nagai, Y.1    Garrett, K.P.2    Ohta, S.3    Bahrun, U.4    Kouro, T.5    Akira, S.6
  • 19
    • 4544379278 scopus 로고    scopus 로고
    • Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunity
    • Re, F. & Strominger, J.L. Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunity. Immunobiology 2004, 209(1-2), 191-198.
    • (2004) Immunobiology , vol.209 , Issue.1-2 , pp. 191-198
    • Re, F.1    Strominger, J.L.2
  • 20
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Feb 14
    • Pasare, C. & Medzhitov, R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003 Feb 14, 299(5609), 1033-1036.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 21
    • 33645956556 scopus 로고    scopus 로고
    • Toll-like receptor stimulation as a third signal required for activation of human naive B cells
    • Apr
    • Ruprecht, C.R. & Lanzavecchia, A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 2006 Apr, 36(4), 810-816.
    • (2006) Eur J Immunol , vol.36 , Issue.4 , pp. 810-816
    • Ruprecht, C.R.1    Lanzavecchia, A.2
  • 22
    • 33744977003 scopus 로고    scopus 로고
    • Efficient T cell activation via a Toll-interleukin 1 receptor-independent pathway
    • Jun
    • Janssen, E., Tabeta, K., Barnes, M.J., Rutschmann, S., McBride, S., Bahjat, K.S. et al. Efficient T cell activation via a Toll-interleukin 1 receptor-independent pathway. Immunity 2006 Jun, 24(6), 787-799.
    • (2006) Immunity , vol.24 , Issue.6 , pp. 787-799
    • Janssen, E.1    Tabeta, K.2    Barnes, M.J.3    Rutschmann, S.4    McBride, S.5    Bahjat, K.S.6
  • 23
    • 33744999388 scopus 로고    scopus 로고
    • Immunology: Toll-like receptors and antibody responses
    • May 18, discussion, E
    • Nemazee, D., Gavin, A., Hoebe, K. & Beutler, B. Immunology: Toll-like receptors and antibody responses. Nature 2006 May 18, 441(7091), E4, discussion, E.
    • (2006) Nature , vol.441 , Issue.7091
    • Nemazee, D.1    Gavin, A.2    Hoebe, K.3    Beutler, B.4
  • 24
    • 33744969558 scopus 로고    scopus 로고
    • Pasare and Medzhitov reply
    • 18 May
    • Pasare, C. & Medzhitov, R. Pasare and Medzhitov reply. Nature 2006 18 May, 441, E4.
    • (2006) Nature , vol.441
    • Pasare, C.1    Medzhitov, R.2
  • 25
    • 0000520727 scopus 로고
    • Virus interference: I. The interferon
    • Sep 12
    • Isaacs, A. & Lindenmann, J. Virus interference: I. The interferon. Proc R Soc Lond B Biol Sci 1957 Sep 12, 147(927), 258-267.
    • (1957) Proc R Soc Lond B Biol Sci , vol.147 , Issue.927 , pp. 258-267
    • Isaacs, A.1    Lindenmann, J.2
  • 26
    • 0014954333 scopus 로고
    • Tilorone hydrochloride: an orally active antiviral agent
    • Sep 18
    • Krueger, R.E. & Mayer, G.D. Tilorone hydrochloride: an orally active antiviral agent. Science 1970 Sep 18, 169(951), 1213-1214.
    • (1970) Science , vol.169 , Issue.951 , pp. 1213-1214
    • Krueger, R.E.1    Mayer, G.D.2
  • 28
    • 0015624918 scopus 로고
    • Antiviral activity and induction of interferon-like substance by quinacrine and acranil
    • May
    • Glaz, E.T., Szolgay, E., Stoger, I. & Talas, M. Antiviral activity and induction of interferon-like substance by quinacrine and acranil. Antimicrob Agents Chemother 1973 May, 3(5), 537-541.
    • (1973) Antimicrob Agents Chemother , vol.3 , Issue.5 , pp. 537-541
    • Glaz, E.T.1    Szolgay, E.2    Stoger, I.3    Talas, M.4
  • 29
    • 0015613438 scopus 로고
    • N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)propanediamine: antiviral activity and interferon stimulation in mice
    • Apr
    • Hoffman, W.W., Korst, J.J., Niblack, J.F. & Cronin, T.H. N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)propanediamine: antiviral activity and interferon stimulation in mice. Antimicrob Agents Chemother 1973 Apr, 3(4), 498-502.
    • (1973) Antimicrob Agents Chemother , vol.3 , Issue.4 , pp. 498-502
    • Hoffman, W.W.1    Korst, J.J.2    Niblack, J.F.3    Cronin, T.H.4
  • 30
    • 0017159490 scopus 로고
    • Stimulation of murine interferon by a substituted pyrimidine
    • Mar
    • Nichol, F.R., Weed, S.D. & Underwood, G.E. Stimulation of murine interferon by a substituted pyrimidine. Antimicrob Agents Chemother 1976 Mar, 9(3), 433-439.
    • (1976) Antimicrob Agents Chemother , vol.9 , Issue.3 , pp. 433-439
    • Nichol, F.R.1    Weed, S.D.2    Underwood, G.E.3
  • 31
    • 0017340802 scopus 로고
    • A comparative study of the effects of certain halogenated benzimidazole ribosides on RNA synthesis, cell proliferation, and interferon production
    • Feb 1
    • Tamm, I. & Sehgal, P.B. A comparative study of the effects of certain halogenated benzimidazole ribosides on RNA synthesis, cell proliferation, and interferon production. J Exp Med 1977 Feb 1, 145(2), 344-356.
    • (1977) J Exp Med , vol.145 , Issue.2 , pp. 344-356
    • Tamm, I.1    Sehgal, P.B.2
  • 32
    • 0018933441 scopus 로고
    • High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters
    • Jul
    • Taylor, J.L., Schoenherr, C.K. & Grossberg, S.E. High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters. Antimicrob Agents Chemother 1980 Jul, 18(1), 20-26.
    • (1980) Antimicrob Agents Chemother , vol.18 , Issue.1 , pp. 20-26
    • Taylor, J.L.1    Schoenherr, C.K.2    Grossberg, S.E.3
  • 33
    • 0018904738 scopus 로고
    • 5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral-and interferon-inducing agents
    • Mar
    • Wierenga, W., Skulnick, H.I., Stringfellow, D.A., Weed, S.D., Renis, H.E. & Eidson, E.E. 5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral-and interferon-inducing agents. J Med Chem 1980 Mar, 23(3), 237-239.
    • (1980) J Med Chem , vol.23 , Issue.3 , pp. 237-239
    • Wierenga, W.1    Skulnick, H.I.2    Stringfellow, D.A.3    Weed, S.D.4    Renis, H.E.5    Eidson, E.E.6
  • 34
    • 0022330577 scopus 로고
    • Antiviral and other bioactivities of pyrimidinones
    • Wierenga, W. Antiviral and other bioactivities of pyrimidinones. Pharmacol Ther 1985, 30(1), 67-89.
    • (1985) Pharmacol Ther , vol.30 , Issue.1 , pp. 67-89
    • Wierenga, W.1
  • 35
    • 28444446958 scopus 로고
    • Synthetic Adjuvants, 4th ed
    • Wiley, New York
    • Adam, A., Ed. Synthetic Adjuvants, 4th ed., Wiley, New York, 1985.
    • (1985)
    • Adam, A.1
  • 37
    • 0024367133 scopus 로고
    • Stimulation of phosphoinositide signaling pathway in murine B lymphocytes by a novel guanosine analog, 7-thia-8-oxoguanosine
    • Sep 29
    • Parandoosh, Z., Ojo-Amaize, E., Robins, R.K., Jolley, W.B. & Rubalcava, B. Stimulation of phosphoinositide signaling pathway in murine B lymphocytes by a novel guanosine analog, 7-thia-8-oxoguanosine. Biochem Biophys Res Commun 1989 Sep 29, 163(3), 1306-1311.
    • (1989) Biochem Biophys Res Commun , vol.163 , Issue.3 , pp. 1306-1311
    • Parandoosh, Z.1    Ojo-Amaize, E.2    Robins, R.K.3    Jolley, W.B.4    Rubalcava, B.5
  • 38
    • 0025220677 scopus 로고
    • A novel guanosine analog, 7-thia-8-oxoguanosine, enhances macrophage and lymphocyte antibody-dependent cell-mediated cytotoxicity
    • Apr 1
    • Jin, A., Mhaskar, S., Jolley, W.B., Robins, R.K. & Ojo-Amaize, E.A. A novel guanosine analog, 7-thia-8-oxoguanosine, enhances macrophage and lymphocyte antibody-dependent cell-mediated cytotoxicity. Cell Immunol 1990 Apr 1, 126(2), 414-419.
    • (1990) Cell Immunol , vol.126 , Issue.2 , pp. 414-419
    • Jin, A.1    Mhaskar, S.2    Jolley, W.B.3    Robins, R.K.4    Ojo-Amaize, E.A.5
  • 39
    • 0026545042 scopus 로고
    • Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice
    • Sharma, B.S., Mhaskar, S., Balazs, L. & Siaw, M. Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice. Immunopharmacol Immunotoxicol 1992, 14(1-2), 1-19.
    • (1992) Immunopharmacol Immunotoxicol , vol.14 , Issue.1-2 , pp. 1-19
    • Sharma, B.S.1    Mhaskar, S.2    Balazs, L.3    Siaw, M.4
  • 41
    • 0028909886 scopus 로고
    • Broadspectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats
    • Mar
    • Smee, D.F., Alaghamandan, H.A., Ramasamy, K. & Revankar, G.R. Broadspectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats. Antiviral Res 1995 Mar, 26(2), 203-209.
    • (1995) Antiviral Res , vol.26 , Issue.2 , pp. 203-209
    • Smee, D.F.1    Alaghamandan, H.A.2    Ramasamy, K.3    Revankar, G.R.4
  • 42
    • 0025911721 scopus 로고
    • Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency
    • Apr
    • Goodman, M.G., Gupta, S., Rosenthale, M.E., Capetola, R.J., Bell, S.C. & Weigle, W.O. Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency. Clin Immunol Immunopathol 1991 Apr, 59(1), 26-36.
    • (1991) Clin Immunol Immunopathol , vol.59 , Issue.1 , pp. 26-36
    • Goodman, M.G.1    Gupta, S.2    Rosenthale, M.E.3    Capetola, R.J.4    Bell, S.C.5    Weigle, W.O.6
  • 43
    • 0029071254 scopus 로고
    • Selective modulation of elements of the immune system by low molecular weight nucleosides
    • Sep
    • Goodman, M.G., Reitz, A.B., Chen, R., Bobardt, M.D., Goodman, J.H. & Pope, B.L. Selective modulation of elements of the immune system by low molecular weight nucleosides. J Pharmacol Exp Ther 1995 Sep, 274(3), 1552-1557.
    • (1995) J Pharmacol Exp Ther , vol.274 , Issue.3 , pp. 1552-1557
    • Goodman, M.G.1    Reitz, A.B.2    Chen, R.3    Bobardt, M.D.4    Goodman, J.H.5    Pope, B.L.6
  • 44
    • 0025939234 scopus 로고
    • Substituted guanine ribonucleosides as B cell activators
    • Nov
    • Gupta, S., Vayuvegula, B. & Gollapudi, S. Substituted guanine ribonucleosides as B cell activators. Clin Immunol Immunopathol 1991 Nov, 61(2 Pt 2), S21-S27.
    • (1991) Clin Immunol Immunopathol , vol.61 , Issue.2 PT. 2
    • Gupta, S.1    Vayuvegula, B.2    Gollapudi, S.3
  • 45
    • 0026497279 scopus 로고
    • In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine)
    • Nov
    • Pope, B.L., Chourmouzis, E., Sigindere, J., Capetola, R.J. & Lau, C.Y. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol 1992 Nov, 14(8), 1375-1382.
    • (1992) Int J Immunopharmacol , vol.14 , Issue.8 , pp. 1375-1382
    • Pope, B.L.1    Chourmouzis, E.2    Sigindere, J.3    Capetola, R.J.4    Lau, C.Y.5
  • 46
    • 0027998236 scopus 로고
    • Small-molecule immunostimulants: synthesis and activity of 7,8-disubstituted guanosines and structurally related compounds
    • Oct 14
    • Reitz, A.B., Goodman, M.G., Pope, B.L., Argentieri, D.C., Bell, S.C., Burr, L.E. et al. Small-molecule immunostimulants: synthesis and activity of 7,8-disubstituted guanosines and structurally related compounds. J Med Chem 1994 Oct 14, 37(21), 3561-3578.
    • (1994) J Med Chem , vol.37 , Issue.21 , pp. 3561-3578
    • Reitz, A.B.1    Goodman, M.G.2    Pope, B.L.3    Argentieri, D.C.4    Bell, S.C.5    Burr, L.E.6
  • 47
    • 20844452063 scopus 로고    scopus 로고
    • Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production
    • May 19
    • Gerster, J.F., Lindstrom, K.J., Miller, R.L., Tomai, M.A., Birmachu, W., Bomersine, S.N. et al. Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production. J Med Chem 2005 May 19, 48(10), 3481-3491.
    • (2005) J Med Chem , vol.48 , Issue.10 , pp. 3481-3491
    • Gerster, J.F.1    Lindstrom, K.J.2    Miller, R.L.3    Tomai, M.A.4    Birmachu, W.5    Bomersine, S.N.6
  • 49
    • 0036396070 scopus 로고    scopus 로고
    • Alopecia of IFN-gamma knockout mouse as a model for disturbance of the hair cycle: a unique arrest of the hair cycle at the anagen phase accompanied by mitosis
    • Sep
    • Hirota, R., Tajima, S., Yoneda, Y., Tamayama, T., Watanabe, M., Ueda, K. et al. Alopecia of IFN-gamma knockout mouse as a model for disturbance of the hair cycle: a unique arrest of the hair cycle at the anagen phase accompanied by mitosis. J Interferon Cytokine Res 2002 Sep, 22(9), 935-945.
    • (2002) J Interferon Cytokine Res , vol.22 , Issue.9 , pp. 935-945
    • Hirota, R.1    Tajima, S.2    Yoneda, Y.3    Tamayama, T.4    Watanabe, M.5    Ueda, K.6
  • 50
    • 0344851553 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of 2-amino-8-hydroxyadenines as orally active interferon inducing agents
    • Dec 1
    • Kurimoto, A., Ogino, T., Ichii, S., Isobe, Y., Tobe, M., Ogita, H. et al. Synthesis and structure-activity relationships of 2-amino-8-hydroxyadenines as orally active interferon inducing agents. Bioorg Med Chem 2003 Dec 1, 11(24), 5501-5508.
    • (2003) Bioorg Med Chem , vol.11 , Issue.24 , pp. 5501-5508
    • Kurimoto, A.1    Ogino, T.2    Ichii, S.3    Isobe, Y.4    Tobe, M.5    Ogita, H.6
  • 51
    • 33746222920 scopus 로고    scopus 로고
    • Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists
    • Sep 1
    • Jin, G., Wu, C.C., Tawatao, R.I., Chan, M., Carson, D.A. & Cottam, H.B. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. Bioorg Med Chem Lett 2006 Sep 1, 16(17), 4559-4563.
    • (2006) Bioorg Med Chem Lett , vol.16 , Issue.17 , pp. 4559-4563
    • Jin, G.1    Wu, C.C.2    Tawatao, R.I.3    Chan, M.4    Carson, D.A.5    Cottam, H.B.6
  • 52
    • 33645393217 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers
    • Mar 23
    • Isobe, Y., Kurimoto, A., Tobe, M., Hashimoto, K., Nakamura, T., Norimura, K. et al. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem 2006 Mar 23, 49(6), 2088-2095.
    • (2006) J Med Chem , vol.49 , Issue.6 , pp. 2088-2095
    • Isobe, Y.1    Kurimoto, A.2    Tobe, M.3    Hashimoto, K.4    Nakamura, T.5    Norimura, K.6
  • 53
    • 0033450879 scopus 로고    scopus 로고
    • Proliferation of spleen cells in culture stimulated by 7-thia-8-oxoguanosine: evidence that both B-and T-cells are the targets of its action
    • Nov
    • Colic, M., Vucevic, D., Vasilijic, S., Popovic, L., Pejanovic, V., Jandric, D. et al. Proliferation of spleen cells in culture stimulated by 7-thia-8-oxoguanosine: evidence that both B-and T-cells are the targets of its action. Methods Find Exp Clin Pharmacol 1999 Nov, 21(9), 583-590.
    • (1999) Methods Find Exp Clin Pharmacol , vol.21 , Issue.9 , pp. 583-590
    • Colic, M.1    Vucevic, D.2    Vasilijic, S.3    Popovic, L.4    Pejanovic, V.5    Jandric, D.6
  • 54
    • 0028990317 scopus 로고
    • The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines
    • May
    • Pope, B.L., MacIntyre, J.P., Kimball, E., Lee, S., Zhou, L., Taylor, G.R. et al. The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines. Cell Immunol 1995 May, 162(2), 333-339.
    • (1995) Cell Immunol , vol.162 , Issue.2 , pp. 333-339
    • Pope, B.L.1    MacIntyre, J.P.2    Kimball, E.3    Lee, S.4    Zhou, L.5    Taylor, G.R.6
  • 55
    • 0033543947 scopus 로고    scopus 로고
    • Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848
    • Oct 10
    • Ahonen, C.L., Gibson, S.J., Smith, R.M., Pederson, L.K., Lindh, J.M., Tomai, M.A. et al. Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848. Cell Immunol 1999 Oct 10, 197(1), 62-72.
    • (1999) Cell Immunol , vol.197 , Issue.1 , pp. 62-72
    • Ahonen, C.L.1    Gibson, S.J.2    Smith, R.M.3    Pederson, L.K.4    Lindh, J.M.5    Tomai, M.A.6
  • 56
    • 0033540341 scopus 로고    scopus 로고
    • Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod
    • Jan 10
    • Wagner, T.L., Ahonen, C.L., Couture, A.M., Gibson, S.J., Miller, R.L., Smith, R.M. et al. Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol 1999 Jan 10, 191(1), 10-19.
    • (1999) Cell Immunol , vol.191 , Issue.1 , pp. 10-19
    • Wagner, T.L.1    Ahonen, C.L.2    Couture, A.M.3    Gibson, S.J.4    Miller, R.L.5    Smith, R.M.6
  • 57
    • 0034669965 scopus 로고    scopus 로고
    • Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848
    • Nov 15
    • Bishop, G.A., Hsing, Y., Hostager, B.S., Jalukar, S.V., Ramirez, L.M. & Tomai, M.A. Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848. J Immunol 2000 Nov 15, 165(10), 5552-5557.
    • (2000) J Immunol , vol.165 , Issue.10 , pp. 5552-5557
    • Bishop, G.A.1    Hsing, Y.2    Hostager, B.S.3    Jalukar, S.V.4    Ramirez, L.M.5    Tomai, M.A.6
  • 58
    • 0035945902 scopus 로고    scopus 로고
    • The immune response modifier resiquimod mimics CD40-induced B cell activation
    • Feb 25
    • Bishop, G.A., Ramirez, L.M., Baccam, M., Busch, L.K., Pederson, L.K. & Tomai, M.A. The immune response modifier resiquimod mimics CD40-induced B cell activation. Cell Immunol 2001 Feb 25, 208(1), 9-17.
    • (2001) Cell Immunol , vol.208 , Issue.1 , pp. 9-17
    • Bishop, G.A.1    Ramirez, L.M.2    Baccam, M.3    Busch, L.K.4    Pederson, L.K.5    Tomai, M.A.6
  • 59
    • 32444441329 scopus 로고    scopus 로고
    • Activation of anti-hepatitis C virus responses via Toll-like receptor 7
    • Feb 7
    • Lee, J., Wu, C.C., Lee, K.J., Chuang, T.H., Katakura, K., Liu, Y.T. et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci USA 2006 Feb 7, 103(6), 1828-1833.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.6 , pp. 1828-1833
    • Lee, J.1    Wu, C.C.2    Lee, K.J.3    Chuang, T.H.4    Katakura, K.5    Liu, Y.T.6
  • 60
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • Jan 22
    • Akira, S. & Hemmi, H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett 2003 Jan 22, 85(2), 85-95.
    • (2003) Immunol Lett , vol.85 , Issue.2 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 61
    • 0037738569 scopus 로고    scopus 로고
    • Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines
    • Apr
    • Edwards, A.D., Diebold, S.S., Slack, E.M., Tomizawa, H., Hemmi, H., Kaisho, T. et al. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol 2003 Apr, 33(4), 827-833.
    • (2003) Eur J Immunol , vol.33 , Issue.4 , pp. 827-833
    • Edwards, A.D.1    Diebold, S.S.2    Slack, E.M.3    Tomizawa, H.4    Hemmi, H.5    Kaisho, T.6
  • 62
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Feb
    • Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002 Feb, 3(2), 196-200.
    • (2002) Nat Immunol , vol.3 , Issue.2 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6
  • 63
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7
    • May 27
    • Lee, J., Chuang, T.H., Redecke, V., She, L., Pitha, P.M., Carson, D.A. et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003 May 27, 100(11), 6646-6651.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.11 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3    She, L.4    Pitha, P.M.5    Carson, D.A.6
  • 64
    • 12444341806 scopus 로고    scopus 로고
    • Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8
    • Feb 1
    • Gorden, K.B., Gorski, K.S., Gibson, S.J., Kedl, R.M., Kieper, W.C., Qiu, X. et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 2005 Feb 1, 174(3), 1259-1268.
    • (2005) J Immunol , vol.174 , Issue.3 , pp. 1259-1268
    • Gorden, K.B.1    Gorski, K.S.2    Gibson, S.J.3    Kedl, R.M.4    Kieper, W.C.5    Qiu, X.6
  • 65
    • 33745241135 scopus 로고    scopus 로고
    • Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
    • Jul
    • Gorski, K.S., Waller, E.L., Bjornton-Severson, J., Hanten, J.A., Riter, C.L., Kieper, W.C. et al. Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol 2006 Jul, 18(7), 1115-1126.
    • (2006) Int Immunol , vol.18 , Issue.7 , pp. 1115-1126
    • Gorski, K.S.1    Waller, E.L.2    Bjornton-Severson, J.3    Hanten, J.A.4    Riter, C.L.5    Kieper, W.C.6
  • 66
    • 15444364398 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN
    • Apr 1
    • Bekeredjian-Ding, I.B., Wagner, M., Hornung, V., Giese, T., Schnurr, M., Endres, S. et al. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J Immunol 2005 Apr 1, 174(7), 4043-4050.
    • (2005) J Immunol , vol.174 , Issue.7 , pp. 4043-4050
    • Bekeredjian-Ding, I.B.1    Wagner, M.2    Hornung, V.3    Giese, T.4    Schnurr, M.5    Endres, S.6
  • 67
    • 23944509107 scopus 로고    scopus 로고
    • Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    • Aug 26
    • Peng, G., Guo, Z., Kiniwa, Y., Voo, K.S., Peng, W., Fu, T. et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 2005 Aug 26, 309(5739), 1380-1384.
    • (2005) Science , vol.309 , Issue.5739 , pp. 1380-1384
    • Peng, G.1    Guo, Z.2    Kiniwa, Y.3    Voo, K.S.4    Peng, W.5    Fu, T.6
  • 68
    • 33747201640 scopus 로고    scopus 로고
    • Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells
    • Aug 15
    • Levy, O., Suter, E.E., Miller, R.L. & Wessels, M.R. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood 2006 Aug 15, 108(4), 1284-1290.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1284-1290
    • Levy, O.1    Suter, E.E.2    Miller, R.L.3    Wessels, M.R.4
  • 69
    • 33746266273 scopus 로고    scopus 로고
    • Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides
    • Jul
    • Jurk, M., Kritzler, A., Schulte, B., Tluk, S., Schetter, C., Krieg, A.M. et al. Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides. Eur J Immunol 2006 Jul, 36(7), 1815-1826.
    • (2006) Eur J Immunol , vol.36 , Issue.7 , pp. 1815-1826
    • Jurk, M.1    Kritzler, A.2    Schulte, B.3    Tluk, S.4    Schetter, C.5    Krieg, A.M.6
  • 70
    • 33745521238 scopus 로고    scopus 로고
    • The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7-and TLR8-independent fashion
    • Jun
    • Schon, M.P., Schon, M. & Klotz, K.N. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7-and TLR8-independent fashion. J Invest Dermatol 2006 Jun, 126(6), 1338-1347.
    • (2006) J Invest Dermatol , vol.126 , Issue.6 , pp. 1338-1347
    • Schon, M.P.1    Schon, M.2    Klotz, K.N.3
  • 71
    • 0028330004 scopus 로고
    • Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression
    • Apr
    • Kono, T., Kondo, S., Pastore, S., Shivji, G.M., Tomai, M.A., McKenzie, R.C. et al. Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression. Lymphokine Cytokine Res 1994 Apr, 13(2), 71-76.
    • (1994) Lymphokine Cytokine Res , vol.13 , Issue.2 , pp. 71-76
    • Kono, T.1    Kondo, S.2    Pastore, S.3    Shivji, G.M.4    Tomai, M.A.5    McKenzie, R.C.6
  • 72
    • 3342911554 scopus 로고    scopus 로고
    • Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod
    • May
    • Schon, M.P. & Schon, M. Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod. Apoptosis 2004 May, 9(3), 291-298.
    • (2004) Apoptosis , vol.9 , Issue.3 , pp. 291-298
    • Schon, M.P.1    Schon, M.2
  • 73
    • 2442555760 scopus 로고    scopus 로고
    • Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod
    • May
    • Schon, M.P., Wienrich, B.G., Drewniok, C., Bong, A.B., Eberle, J., Geilen, C.C. et al. Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod. J Invest Dermatol 2004 May, 122(5), 1266-1276.
    • (2004) J Invest Dermatol , vol.122 , Issue.5 , pp. 1266-1276
    • Schon, M.P.1    Wienrich, B.G.2    Drewniok, C.3    Bong, A.B.4    Eberle, J.5    Geilen, C.C.6
  • 74
    • 9644282821 scopus 로고    scopus 로고
    • Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells
    • Nov
    • Barnetson, R.S., Satchell, A., Zhuang, L., Slade, H.B. & Halliday, G.M. Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells. Clin Exp Dermatol 2004 Nov, 29(6), 639-643.
    • (2004) Clin Exp Dermatol , vol.29 , Issue.6 , pp. 639-643
    • Barnetson, R.S.1    Satchell, A.2    Zhuang, L.3    Slade, H.B.4    Halliday, G.M.5
  • 75
    • 32944462834 scopus 로고    scopus 로고
    • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    • Mar 9
    • Kanneganti, T.D., Ozoren, N., Body-Malapel, M., Amer, A., Park, J.H., Franchi, L. et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 2006 Mar 9, 440(7081), 233-236.
    • (2006) Nature , vol.440 , Issue.7081 , pp. 233-236
    • Kanneganti, T.D.1    Ozoren, N.2    Body-Malapel, M.3    Amer, A.4    Park, J.H.5    Franchi, L.6
  • 76
    • 0035046111 scopus 로고    scopus 로고
    • Immunopharmacology of antibiotics: direct and indirect immunomodulation of defence mechanisms
    • Apr
    • Hamilton-Miller, J.M. Immunopharmacology of antibiotics: direct and indirect immunomodulation of defence mechanisms. J Chemother 2001 Apr, 13(2), 107-111.
    • (2001) J Chemother , vol.13 , Issue.2 , pp. 107-111
    • Hamilton-Miller, J.M.1
  • 77
    • 0037865212 scopus 로고    scopus 로고
    • Immunomodulatory effects of quinolones
    • Jun
    • Dalhoff, A. & Shalit, I. Immunomodulatory effects of quinolones. Lancet Infect Dis 2003 Jun, 3(6), 359-371.
    • (2003) Lancet Infect Dis , vol.3 , Issue.6 , pp. 359-371
    • Dalhoff, A.1    Shalit, I.2
  • 78
    • 16244421044 scopus 로고    scopus 로고
    • Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of Toll-like receptors 1 and 2
    • Apr
    • Razonable, R.R., Henault, M., Lee, L.N., Laethem, C., Johnston, P.A., Watson, H.L. et al. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of Toll-like receptors 1 and 2. Antimicrob Agents Chemother 2005 Apr, 49(4), 1617-1621.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.4 , pp. 1617-1621
    • Razonable, R.R.1    Henault, M.2    Lee, L.N.3    Laethem, C.4    Johnston, P.A.5    Watson, H.L.6
  • 79
    • 23044434898 scopus 로고    scopus 로고
    • Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a Toll-like receptor-dependent mechanism
    • Aug
    • Razonable, R.R., Henault, M., Watson, H.L. & Paya, C.V. Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a Toll-like receptor-dependent mechanism. Antimicrob Agents Chemother 2005 Aug, 49(8), 3546-3549.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.8 , pp. 3546-3549
    • Razonable, R.R.1    Henault, M.2    Watson, H.L.3    Paya, C.V.4
  • 80
    • 24144448068 scopus 로고    scopus 로고
    • Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
    • Sep
    • Horsmans, Y., Berg, T., Desager, J.P., Mueller, T., Schott, E., Fletcher, S.P. et al. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology 2005 Sep, 42(3), 724-731.
    • (2005) Hepatology , vol.42 , Issue.3 , pp. 724-731
    • Horsmans, Y.1    Berg, T.2    Desager, J.P.3    Mueller, T.4    Schott, E.5    Fletcher, S.P.6
  • 81
    • 0035654396 scopus 로고    scopus 로고
    • Imiquimod and resiquimod as novel immunomodulators
    • Dec
    • Dockrell, D.H. & Kinghorn, G.R. Imiquimod and resiquimod as novel immunomodulators. J Antimicrob Chemother 2001 Dec, 48(6), 751-755.
    • (2001) J Antimicrob Chemother , vol.48 , Issue.6 , pp. 751-755
    • Dockrell, D.H.1    Kinghorn, G.R.2
  • 82
    • 0035879830 scopus 로고    scopus 로고
    • Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: a pilot study
    • Jul 15
    • Spruance, S.L., Tyring, S.K., Smith, M.H. & Meng, T.C. Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: a pilot study. J Infect Dis 2001 Jul 15, 184(2), 196-200.
    • (2001) J Infect Dis , vol.184 , Issue.2 , pp. 196-200
    • Spruance, S.L.1    Tyring, S.K.2    Smith, M.H.3    Meng, T.C.4
  • 83
    • 0035825571 scopus 로고    scopus 로고
    • Reduction of recurrent HSV disease using imiquimod alone or combined with a glycoprotein vaccine
    • Feb 8
    • Harrison, C.J., Miller, R.L. & Bernstein, D.I. Reduction of recurrent HSV disease using imiquimod alone or combined with a glycoprotein vaccine. Vaccine 2001 Feb 8, 19(13-14), 1820-1826.
    • (2001) Vaccine , vol.19 , Issue.13-14 , pp. 1820-1826
    • Harrison, C.J.1    Miller, R.L.2    Bernstein, D.I.3
  • 84
    • 0033775777 scopus 로고    scopus 로고
    • Adjuvant activities of immune response modifier R-848: comparison with CpG ODN
    • Aug 25
    • Vasilakos, J.P., Smith, R.M., Gibson, S.J., Lindh, J.M., Pederson, L.K., Reiter, M.J. et al. Adjuvant activities of immune response modifier R-848: comparison with CpG ODN. Cell Immunol 2000 Aug 25, 204(1), 64-74.
    • (2000) Cell Immunol , vol.204 , Issue.1 , pp. 64-74
    • Vasilakos, J.P.1    Smith, R.M.2    Gibson, S.J.3    Lindh, J.M.4    Pederson, L.K.5    Reiter, M.J.6
  • 85
    • 0034631779 scopus 로고    scopus 로고
    • The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes
    • Jul 10
    • Tomai, M.A., Imbertson, L.M., Stanczak, T.L., Tygrett, L.T. & Waldschmidt, T.J. The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cell Immunol 2000 Jul 10, 203(1), 55-65.
    • (2000) Cell Immunol , vol.203 , Issue.1 , pp. 55-65
    • Tomai, M.A.1    Imbertson, L.M.2    Stanczak, T.L.3    Tygrett, L.T.4    Waldschmidt, T.J.5
  • 86
    • 0343485063 scopus 로고    scopus 로고
    • The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells
    • Jan
    • Burns, R.P., Jr., Ferbel, B., Tomai, M., Miller, R. & Gaspari, A.A. The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells. Clin Immunol 2000 Jan, 94(1), 13-23.
    • (2000) Clin Immunol , vol.94 , Issue.1 , pp. 13-23
    • Burns Jr, R.P.1    Ferbel, B.2    Tomai, M.3    Miller, R.4    Gaspari, A.A.5
  • 87
    • 32544451284 scopus 로고    scopus 로고
    • Topical imiquimod is a potent adjuvant to a weaklyimmunogenic protein prototype vaccine
    • Mar 10
    • Johnston, D. & Bystryn, J.C. Topical imiquimod is a potent adjuvant to a weaklyimmunogenic protein prototype vaccine. Vaccine 2006 Mar 10, 24(11), 1958-1965.
    • (2006) Vaccine , vol.24 , Issue.11 , pp. 1958-1965
    • Johnston, D.1    Bystryn, J.C.2
  • 88
    • 14044265101 scopus 로고    scopus 로고
    • Cutting edge: priming of CTL by transcutaneous peptide immunization with imiquimod
    • Mar 1
    • Rechtsteiner, G., Warger, T., Osterloh, P., Schild, H. & Radsak, M.P. Cutting edge: priming of CTL by transcutaneous peptide immunization with imiquimod. J Immunol 2005 Mar 1, 174(5), 2476-2480.
    • (2005) J Immunol , vol.174 , Issue.5 , pp. 2476-2480
    • Rechtsteiner, G.1    Warger, T.2    Osterloh, P.3    Schild, H.4    Radsak, M.P.5
  • 89
    • 22544433125 scopus 로고    scopus 로고
    • The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine
    • Aug 1
    • Craft, N., Bruhn, K.W., Nguyen, B.D., Prins, R., Lin, J.W., Liau, L.M. et al. The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine. J Immunol 2005 Aug 1, 175(3), 1983-1990.
    • (2005) J Immunol , vol.175 , Issue.3 , pp. 1983-1990
    • Craft, N.1    Bruhn, K.W.2    Nguyen, B.D.3    Prins, R.4    Lin, J.W.5    Liau, L.M.6
  • 90
    • 29644446061 scopus 로고    scopus 로고
    • The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity
    • Jan 1
    • Prins, R.M., Craft, N., Bruhn, K.W., Khan-Farooqi, H., Koya, R.C., Stripecke, R. et al. The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. J Immunol 2006 Jan 1, 176(1), 157-164.
    • (2006) J Immunol , vol.176 , Issue.1 , pp. 157-164
    • Prins, R.M.1    Craft, N.2    Bruhn, K.W.3    Khan-Farooqi, H.4    Koya, R.C.5    Stripecke, R.6
  • 91
    • 1842578532 scopus 로고    scopus 로고
    • Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model
    • Apr 16
    • Otero, M., Calarota, S.A., Felber, B., Laddy, D., Pavlakis, G., Boyer, J.D. et al. Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model. Vaccine 2004 Apr 16, 22(13-14), 1782-1790.
    • (2004) Vaccine , vol.22 , Issue.13-14 , pp. 1782-1790
    • Otero, M.1    Calarota, S.A.2    Felber, B.3    Laddy, D.4    Pavlakis, G.5    Boyer, J.D.6
  • 92
    • 11144356241 scopus 로고    scopus 로고
    • Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA
    • Apr 16
    • Zuber, A.K., Brave, A., Engstrom, G., Zuber, B., Ljungberg, K., Fredriksson, M. et al. Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA. Vaccine 2004 Apr 16, 22(13-14), 1791-1798.
    • (2004) Vaccine , vol.22 , Issue.13-14 , pp. 1791-1798
    • Zuber, A.K.1    Brave, A.2    Engstrom, G.3    Zuber, B.4    Ljungberg, K.5    Fredriksson, M.6
  • 93
    • 30644467155 scopus 로고    scopus 로고
    • Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma
    • Sep
    • Smorlesi, A., Papalini, F., Orlando, F., Donnini, A., Re, F. & Provinciali, M. Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma. Gene Ther 2005 Sep, 12(17), 1324-1332.
    • (2005) Gene Ther , vol.12 , Issue.17 , pp. 1324-1332
    • Smorlesi, A.1    Papalini, F.2    Orlando, F.3    Donnini, A.4    Re, F.5    Provinciali, M.6
  • 94
    • 1842479742 scopus 로고    scopus 로고
    • Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery
    • Apr 16
    • Thomsen, L.L., Topley, P., Daly, M.G., Brett, S.J. & Tite, J.P. Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery. Vaccine 2004 Apr 16, 22(13-14), 1799-1809.
    • (2004) Vaccine , vol.22 , Issue.13-14 , pp. 1799-1809
    • Thomsen, L.L.1    Topley, P.2    Daly, M.G.3    Brett, S.J.4    Tite, J.P.5
  • 95
    • 26644447379 scopus 로고    scopus 로고
    • TLR agonists as vaccine adjuvants: comparison of CpG ODN and resiquimod (R-848)
    • Nov 1
    • Weeratna, R.D., Makinen, S.R., McCluskie, M.J. & Davis, H.L. TLR agonists as vaccine adjuvants: comparison of CpG ODN and resiquimod (R-848). Vaccine 2005 Nov 1, 23(45), 5263-5270.
    • (2005) Vaccine , vol.23 , Issue.45 , pp. 5263-5270
    • Weeratna, R.D.1    Makinen, S.R.2    McCluskie, M.J.3    Davis, H.L.4
  • 96
    • 27244443079 scopus 로고    scopus 로고
    • HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    • Oct 18
    • Wille-Reece, U., Flynn, B.J., Lore, K., Koup, R.A., Kedl, R.M., Mattapallil, J.J. et al. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc Natl Acad Sci USA 2005 Oct 18, 102(42), 15190-15194.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.42 , pp. 15190-15194
    • Wille-Reece, U.1    Flynn, B.J.2    Lore, K.3    Koup, R.A.4    Kedl, R.M.5    Mattapallil, J.J.6
  • 97
    • 20444430129 scopus 로고    scopus 로고
    • Immunization with HIV-1 gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 gag-specific Th1 and CD8+ T cell responses
    • Jun 15
    • Wille-Reece, U., Wu, C.Y., Flynn, B.J., Kedl, R.M. & Seder, R.A. Immunization with HIV-1 gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 gag-specific Th1 and CD8+ T cell responses. J Immunol 2005 Jun 15, 174(12), 7676-7683.
    • (2005) J Immunol , vol.174 , Issue.12 , pp. 7676-7683
    • Wille-Reece, U.1    Wu, C.Y.2    Flynn, B.J.3    Kedl, R.M.4    Seder, R.A.5
  • 98
    • 33646697743 scopus 로고    scopus 로고
    • Tolllike receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
    • May 15
    • Wille-Reece, U., Flynn, B.J., Lore, K., Koup, R.A., Miles, A.P., Saul, A. et al. Tolllike receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med 2006 May 15, 203(5), 1249-1258.
    • (2006) J Exp Med , vol.203 , Issue.5 , pp. 1249-1258
    • Wille-Reece, U.1    Flynn, B.J.2    Lore, K.3    Koup, R.A.4    Miles, A.P.5    Saul, A.6
  • 99
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Jul
    • Ulevitch, R.J. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004 Jul, 4(7), 512-520.
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 512-520
    • Ulevitch, R.J.1
  • 100
    • 17644416719 scopus 로고    scopus 로고
    • Targeting the innate immune response with improved vaccine adjuvants
    • Apr
    • Pashine, A., Valiante, N.M. & Ulmer, J.B. Targeting the innate immune response with improved vaccine adjuvants. Nat Med 2005 Apr, 11(4 Suppl), S63-S68.
    • (2005) Nat Med , vol.11 , Issue.4 SUPPL.
    • Pashine, A.1    Valiante, N.M.2    Ulmer, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.