Heterogeneity of TLR-induced responses in dendritic cells: From innate to adaptive immunity

Immunobiology

Volumn 209, Issue 1-2, 2004, Pages 191-198

  Re, Fabio ^a,c   Strominger, Jack L ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Dendritic cells; Toll like receptors

Indexed keywords

ADAPTOR PROTEIN; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; DENDRITIC CELL; HELPER CELL; HUMAN; IMMUNITY; IMMUNOTHERAPY; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VACCINATION;

EID: 4544379278     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2004.03.005     Document Type: Article

References (50)

1. Agrawal, S., Agrawal, A., Doughty, B., Gerwitz, A., Blenis, J., Van Dyke, T., Pulendran, B., 2003. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J. Immunol. 171, 4984-4989.
2. Akira, S., Sato, S., 2003. Toll-like receptors and their signaling mechanisms. Scand. J. Infect. Dis. 35, 555-562.
3. Becker, I., Salaiza, N., Aguirre, M., Delgado, J., Carrillo-Carrasco, N., Kobeh, L.G., Ruiz, A., Cervantes, R., Torres, A.P., Cabrera, N., Gonzalez, A., Maldonado, C., Isibasi, A., 2003. Leishmania lipophosphoglycan (LPG) activates NK cells through Toll-like receptor-2. Mol. Biochem. Parasitol. 130, 65-74.
4. Beutler, B., Hoebe, K., Du, X., Ulevitch, R.J., 2003. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukocyte Biol. 74, 479-485.
5. Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M., Demengeot, J., 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197, 403-411.
6. Carson, W.E., Ross, M.E., Baiocchi, R.A., Marien, M.J., Boiani, N., Grabstein, K., Caligiuri, M.A., 1995. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J. Clin. Invest. 96, 2578-2582.
7. Constant, S.L., Bottomly, K., 1997. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15, 297-322.
8. Diebold, S.S., Montoya, M., Unger, H., Alexopoulou, L., Roy, P., Haswell, L.E., Al-Shamkhani, A., Flavell, R., Borrow, P., Reis e Sousa, C., 2003. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424, 324-328.
9. d'Ostiani, C.F., Del Sero, G., Bacci, A., Montagnoli, C., Spreca, A., Mencacci, A., Ricciardi-Castagnoli, P., Romani, L., 2000. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. 191, 1661-1674.
10. Doyle, S., Vaidya, S., O'Connell, R., Dadgostar, H., Dempsey, P., Wu, T., Rao, G., Sun, R., Haberland, M., Modlin, R., Cheng, G., 2002. IRF3 mediates a TLR3/TLR4-specific antiviral gene. program. Immunity 17, 251-263.
11. Fitzgerald, K.A., Palsson-McDermott, E.M., Bowie, A.G., Jefferies, C.A., Mansell, A.S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M.T., McMurray, D., Smith, D.E., Sims, J.E., Bird, T.A., O'Neill, L.A., 2001. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83.
12. Fitzgerald, K.A., McWhirter, S.M., Faia, K.L., Rowe, D.C., Latz, E., Golenbock, D.T., Coyle, A.J., Liao, S.M., Maniatis, T., 2003. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496.
13. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S., 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3, 196-200.
14. Hirschfeld, M., Weis, J.J., Toshchakov, V., Salkowski, C.A., Cody, M.J., Ward, D.C., Qureshi, N., Michalek, S.M., Vogel, S.N., 2001. Signaling by Toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect. Immun. 69, 1477-1482.
15. Hoffmann, J.A., Kafatos, F.C., Janeway, C.A., Ezekowitz, R.A., 1999. Phylogenetic perspectives in innate immunity. Science 284, 1313-1318.
16. Horng, T., Barton, G.M., Medzhitov, R., 2001. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835-841.
17. Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., Akira, S., 2002. Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. Int. Immunol. 14, 1225-1231.
18. Ito, T., Amakawa, R., Kaisho, T., Hemmi, H., Tajima, K., Uehira, K., Ozaki, Y., Tomizawa, H., Akira, S., Fukuhara, S., 2002. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195, 1507-1512.
19. Janeway Jr., C.A., Medzhitov, R., 2002. Innate immune recognition. Annu. Rev. Immunol. 20, 197-216.
20. Jotwani, R., Pulendran, B., Agrawal, S., Cutler, C.W., 2003. Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro. Eur. J. Immunol. 33, 2980-2986.
21. Kadowaki, N., Ho, S., Antonenko, S., Malefyt, R.W., Kastelein, R.A., Bazan, F., Liu, Y.J., 2001. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194, 863-869.
22. Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K., Akira, S., 2001. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166, 5688-5694.
23. Kawai, T., Adachi, O., Ogawa, T., Takeda, K., Akira, S., 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122.
24. Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Muhlradt, P.F., Sato, S., Hoshino, K., Akira, S., 2001. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167, 5887-5894.
25. Komai-Koma, M., Jones, L., Ogg, G.S., Xu, D., Liew, F.Y., 2004. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc. Natl. Acad. Sci. USA 101, 3029-3034.
26. Leadbetter, E.A., Rifkin, I.R., Hohlbaum, A.M., Beaudette, B.C., Shlomchik, M.J., Marshak-Rothstein, A., 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607.
27. Liu, N., Ohnishi, N., Ni, L., Akira, S., Bacon, K.B., 2003. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4, 687-693.
28. McCurdy, J.D., Olynych, T.J., Maher, L.H., Marshall, J.S., 2003. Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J. Immunol. 170, 1625-1629.
29. Mink, M., Fogelgren, B., Olszewski, K., Maroy, P., Csiszar, K., 2001. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics 74, 234-244.
30. Moore, K.W., de Waal Malefyt, R., Coffman, R.L., O'Garra, A., 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683-765.
31. Moser, M., Murphy, K.M., 2000. Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. 1, 199-205.
32. Muzio, M., Ni, J., Feng, P., Dixit, V.M., 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615.
33. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., Seya, T., 2003. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 4, 161-167.
34. Ozinsky, A., Underhill, D.M., Fontenot, J.D., Hajjar, A.M., Smith, K.D., Wilson, C.B., Schroeder, L., Aderem, A., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl. Acad. Sci. USA 97, 13766-13771.
35. Parronchi, P., De Carli, M., Manetti, R., Simonelli, C., Sampognaro, S., Piccinni, M.P., Macchia, D., Maggi, E., Del Prete, G., Romagnani, S., 1992. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J. Immunol. 149, 2977-2983.
36. Pulendran, B., Kumar, P., Cutler, C.W., Mohamadzadeh, M., Van Dyke, T., Banchereau, J., 2001. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167, 5067-5076.
37. Qi, H., Denning, T.L., Soong, L., 2003. Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial Toll-like receptor activators and skewing of T-cell cytokine profiles. Infect. Immun. 71, 3337-3342.
38. Re, F., Strominger, J.L., 2001. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J. Biol. Chem. 276, 37692-37699.
39. Redecke, V., Hacker, H., Datta, S.K., Fermin, A., Pitha, P.M., Broide, D.H., Raz, E., 2004. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J. Immunol. 172, 2739-2743.
40. Sallusto, F., Lenig, D., Mackay, C.R., Lanzavecchia, A., 1998. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875-883.
41. Sharma, S., tenOever, B.R., Grandvaux, N., Zhou, G.P., Lin, R., Hiscott, J., 2003. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148-1151.
42. Spies, B., Hochrein, H., Vabulas, M., Huster, K., Busch, D.H., Schmitz, F., Heit, A., Wagner, H., 2003. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J. Immunol. 171, 5908-5912.
43. Supajatura, V., Ushio, H., Nakao, A., Akira, S., Okumura, K., Ra, C., Ogawa, H., 2002. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J. Clin. Invest. 109, 1351-1359.
44. Toshchakov, V., Jones, B.W., Perera, P.Y., Thomas, K., Cody, M.J., Zhang, S., Williams, B.R., Major, J., Hamilton, T.A., Fenton, M.J., Vogel, S.N., 2002. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 3, 392-398.
45. Trinchieri, G., 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133-146.
46. Underhill, D.M., Ozinsky, A., Hajjar, A.M., Stevens, A., Wilson, C.B., Bassetti, M., Aderem, A., 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811-815.
47. Varadaradjalou, S., Feger, F., Thieblemont, N., Hamouda, N.B., Pleau, J.M., Dy, M., Arock, M., 2003. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur. J. Immunol. 33, 899-906.
48. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., Akira, S., 2003a. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301, 640-643.
49. Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., Akira, S., 2003b. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4, 1144-1150.
50. Zhang, D., Zhang, G., Hayden, M.S., Greenblatt, M.B., Bussey, C., Flavell, R.A., Ghosh, S., 2004. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 303, 1522-1526.