메뉴 건너뛰기




Volumn 4, Issue , 2013, Pages

Cdkn1b overexpression in adult mice alters the balance between genome and tissue ageing

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; DOXYCYCLINE;

EID: 84889238482     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3626     Document Type: Article
Times cited : (33)

References (48)
  • 1
    • 0002235236 scopus 로고
    • On the nature of the aging process
    • Szilard, L. On the nature of the aging process. Proc. Natl Acad. Sci. USA 45, 30-45 (1959).
    • (1959) Proc. Natl Acad. Sci. USA , vol.45 , pp. 30-45
    • Szilard, L.1
  • 3
    • 0029895383 scopus 로고    scopus 로고
    • Refining the telomere-telomerase hypothesis of aging and cancer
    • Holt, S. E., Shay, J. W. & Wright, W. E. Refining the telomere-telomerase hypothesis of aging and cancer. Nat. Biotechnol. 14, 836-839 (1996). (Pubitemid 26239180)
    • (1996) Nature Biotechnology , vol.14 , Issue.7 , pp. 836-839
    • Holt, S.E.1    Shay, J.W.2    Wright, W.E.3
  • 6
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • DOI 10.1038/nrm2233, PII NRM2233
    • Campisi, J. & d'Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729-740 (2007). (Pubitemid 47312822)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 7
    • 77953589055 scopus 로고    scopus 로고
    • Removing all obstacles: A critical role for p53 in promoting tissue renewal
    • Schoppy, D. W., Ruzankina, Y. & Brown, E. J. Removing all obstacles: a critical role for p53 in promoting tissue renewal. Cell Cycle 9, 1313-1319 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 1313-1319
    • Schoppy, D.W.1    Ruzankina, Y.2    Brown, E.J.3
  • 8
    • 84871302192 scopus 로고    scopus 로고
    • Senescent cells: A novel therapeutic target for aging and age-related diseases
    • Naylor, R. M., Baker, D. J. & van Deursen, J. M. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin. Pharmacol. Ther. 93, 105-116 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 105-116
    • Naylor, R.M.1    Baker, D.J.2    Van Deursen, J.M.3
  • 12
    • 33749171885 scopus 로고    scopus 로고
    • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    • Molofsk, A. V. et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443, 448-452 (2006).
    • (2006) Nature , vol.443 , pp. 448-452
    • Molofsk, A.V.1
  • 14
    • 15444377643 scopus 로고    scopus 로고
    • P21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
    • DOI 10.1101/gad.1272305
    • Kippin, T. E., Martens, D. J. & van der Kooy, D. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev. 19, 756-767 (2005). (Pubitemid 40395086)
    • (2005) Genes and Development , vol.19 , Issue.6 , pp. 756-767
    • Kippin, T.E.1    Martens, D.J.2    Van Der Kooy, D.3
  • 16
    • 0034629129 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    • Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804-1808 (2000).
    • (2000) Science , vol.287 , pp. 1804-1808
    • Cheng, T.1
  • 17
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak, K. et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59-66 (1994).
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1
  • 18
    • 0028179669 scopus 로고
    • P27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak, K. et al. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8, 9-22 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 9-22
    • Polyak, K.1
  • 19
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama, K. et al. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-720 (1996).
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1
  • 20
    • 15844415946 scopus 로고    scopus 로고
    • Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
    • Kiyokawa, H. et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85, 721-732 (1996).
    • (1996) Cell , vol.85 , pp. 721-732
    • Kiyokawa, H.1
  • 22
    • 42149099447 scopus 로고    scopus 로고
    • Complex hair cycle domain patterns and regenerative hair waves in living rodents
    • DOI 10.1038/sj.jid.5701180, PII 5701180
    • Plikus, M. V. & Chuong, C. M. Complex hair cycle domain patterns and regenerative hair waves in living rodents. J. Invest. Dermatol. 128, 1071-1080 (2008). (Pubitemid 351543215)
    • (2008) Journal of Investigative Dermatology , vol.128 , Issue.5 , pp. 1071-1080
    • Plikus, M.V.1    Chuong, C.-M.2
  • 23
    • 1242341960 scopus 로고    scopus 로고
    • Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice
    • DOI 10.1523/JNEUROSCI.4608-03.2004
    • Maslov, A. Y., Barone, T. A., Plunkett, R. J. & Pruitt, S. C. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J. Neurosci. 24, 1726-1733 (2004). (Pubitemid 38240970)
    • (2004) Journal of Neuroscience , vol.24 , Issue.7 , pp. 1726-1733
    • Maslov, A.Y.1    Barone, T.A.2    Plunkett, R.J.3    Pruitt, S.C.4
  • 24
    • 20544441737 scopus 로고    scopus 로고
    • Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    • Relaix, F., Rocancourt, D., Mansouri, A. & Buckingham, M. A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature 435, 898-899 (2005).
    • (2005) Nature , vol.435 , pp. 898-899
    • Relaix, F.1    Rocancourt, D.2    Mansouri, A.3    Buckingham, M.A.4
  • 26
    • 77957223906 scopus 로고    scopus 로고
    • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    • Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134-144 (2010).
    • (2010) Cell , vol.143 , pp. 134-144
    • Snippert, H.J.1
  • 27
    • 77954829183 scopus 로고    scopus 로고
    • Cell cycle heterogeneity in the small intestinal crypt and maintenance of genome integrity
    • Pruitt, S. C., Freeland, A. & Kudla, A. Cell cycle heterogeneity in the small intestinal crypt and maintenance of genome integrity. Stem Cells 28, 1250-1259 (2010).
    • (2010) Stem Cells , vol.28 , pp. 1250-1259
    • Pruitt, S.C.1    Freeland, A.2    Kudla, A.3
  • 29
    • 62649115931 scopus 로고    scopus 로고
    • Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
    • Greenow, K. R., Clarke, A. R. & Jones, R. H. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 28, 1443-1453 (2009).
    • (2009) Oncogene , vol.28 , pp. 1443-1453
    • Greenow, K.R.1    Clarke, A.R.2    Jones, R.H.3
  • 31
    • 61349150537 scopus 로고    scopus 로고
    • Transcription factor achaete scute-like 2 controls intestinal stem cell fate
    • van der Flier, L. G. et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 136, 903-912 (2009).
    • (2009) Cell , vol.136 , pp. 903-912
    • Van Der Flier, L.G.1
  • 32
    • 70349559751 scopus 로고    scopus 로고
    • P53 deletion impairs clearance of chromosomalinstable stem cells in aging telomere-dysfunctional mice
    • Begus-Nahrmann, Y. et al. p53 deletion impairs clearance of chromosomalinstable stem cells in aging telomere-dysfunctional mice. Nat. Genet. 41, 1138-1143 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1138-1143
    • Begus-Nahrmann, Y.1
  • 33
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signaling triggers senescenceassociated inflammatory cytokine secretion
    • Rodier, F. et al. Persistent DNA damage signaling triggers senescenceassociated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1
  • 34
    • 1942466518 scopus 로고    scopus 로고
    • Kip1 modulates cell migration through the regulation of RhoA activation
    • DOI 10.1101/gad.1185504
    • Besson, A., Gurian-West, M., Schmidt, A., Hall, A. & Roberts, J. M. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18, 862-876 (2004). (Pubitemid 38529656)
    • (2004) Genes and Development , vol.18 , Issue.8 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 35
    • 84861463956 scopus 로고    scopus 로고
    • P27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes
    • Pippa, R. et al. p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes. Oncogene 31, 4207-4220 (2012).
    • (2012) Oncogene , vol.31 , pp. 4207-4220
    • Pippa, R.1
  • 36
    • 84870871133 scopus 로고    scopus 로고
    • P27(Kip1) directly represses Sox2 during embryonic stem cell differentiation
    • Li, H. et al. p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation. Cell Stem Cell 11, 845-852 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 845-852
    • Li, H.1
  • 38
    • 84872033338 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression
    • Marqués-Torrejón, M. Á . et al. Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression. Cell Stem Cell 12, 88-100 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 88-100
    • Má, M.1
  • 39
    • 84871886143 scopus 로고    scopus 로고
    • Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites
    • Sachs, P. C. et al. Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites. Cell Tissue Res. 349, 505-515 (2012).
    • (2012) Cell Tissue Res , vol.349 , pp. 505-515
    • Sachs, P.C.1
  • 42
    • 60549109842 scopus 로고    scopus 로고
    • Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
    • Hinkal, G. W., Gatza, C. E., Parikh, N. & Donehower, L. A. Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging. Mech. Ageing Dev. 130, 262-271 (2009).
    • (2009) Mech. Ageing Dev. , vol.130 , pp. 262-271
    • Hinkal, G.W.1    Gatza, C.E.2    Parikh, N.3    Donehower, L.A.4
  • 43
    • 84871717211 scopus 로고    scopus 로고
    • Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    • Baker, D. J. et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat. Cell Biol. 15, 96-102 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 96-102
    • Baker, D.J.1
  • 44
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageingassociated disorders
    • Baker, D. J. et al. Clearance of p16Ink4a-positive senescent cells delays ageingassociated disorders. Nature 479, 232-2366 (2011).
    • (2011) Nature , vol.479 , pp. 232-2366
    • Baker, D.J.1
  • 45
    • 84867676626 scopus 로고    scopus 로고
    • The aged niche disrupts muscle stem cell quiescence
    • Chakkalakal, J. V., Jones, K. M., Basson, M. A. & Brack, A. S. The aged niche disrupts muscle stem cell quiescence. Nature 490, 355-360 (2012).
    • (2012) Nature , vol.490 , pp. 355-360
    • Chakkalakal, J.V.1    Jones, K.M.2    Basson, M.A.3    Brack, A.S.4
  • 46
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • DOI 10.1016/j.cell.2005.01.027
    • Kirkwood, T. B. Understanding the odd science of aging. Cell 120, 437-447 (2005). (Pubitemid 40269759)
    • (2005) Cell , vol.120 , Issue.4 , pp. 437-447
    • Kirkwood, T.B.L.1
  • 47
    • 0033694302 scopus 로고    scopus 로고
    • Stem cell repopulation efficiency but not pool size is governed by p27(kip1)
    • Cheng, T., Rodrigues, N., Dombkowski, D., Stier, S. & Scadden, D. T. Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nat. Med. 6, 1235-1240 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 1235-1240
    • Cheng, T.1    Rodrigues, N.2    Dombkowski, D.3    Stier, S.4    Scadden, D.T.5
  • 48
    • 84871647883 scopus 로고    scopus 로고
    • Flow cytometry analysis of murine hematopoietic stem cells
    • Mayle, A., Luo, M., Jeong, M. & Goodell, M. A. Flow cytometry analysis of murine hematopoietic stem cells. Cytometry 83, 27-37 (2013).
    • (2013) Cytometry , vol.83 , pp. 27-37
    • Mayle, A.1    Luo, M.2    Jeong, M.3    Goodell, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.