-
1
-
-
13944249618
-
DNA repair, genome stability, and aging
-
DOI 10.1016/j.cell.2005.01.028
-
Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability and aging. Cell 2005; 120:497-512. (Pubitemid 40269764)
-
(2005)
Cell
, vol.120
, Issue.4
, pp. 497-512
-
-
Lombard, D.B.1
Chua, K.F.2
Mostoslavsky, R.3
Franco, S.4
Gostissa, M.5
Alt, F.W.6
-
3
-
-
70349859881
-
DNA damage aging and cancer
-
Hoeijmakers JH. DNA damage, aging and cancer. N Engl J Med 2009; 361:1475-85.
-
(2009)
N Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
4
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007; 8:703-13.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
5
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell 2008; 132:681-96.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
6
-
-
70349559919
-
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
-
Ruzankina Y, Schoppy DW, Asare A, Clark CE, Vonderheide RH, Brown EJ. Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet 2009; 41:1144-9.
-
(2009)
Nat Genet
, vol.41
, pp. 1144-1149
-
-
Ruzankina, Y.1
Schoppy, D.W.2
Asare, A.3
Clark, C.E.4
Vonderheide, R.H.5
Brown, E.J.6
-
7
-
-
70349559751
-
P53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
-
Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, et al. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet 2009; 41:1138-43.
-
(2009)
Nat Genet
, vol.41
, pp. 1138-1143
-
-
Begus-Nahrmann, Y.1
Lechel, A.2
Obenauf, A.C.3
Nalapareddy, K.4
Peit, E.5
Hoffmann, E.6
-
8
-
-
75849137153
-
Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration
-
Yazinski SA, Westcott PM, Ong K, Pinkas J, Peters RM, Weiss RS. Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration. Proc Natl Acad Sci USA 2009.
-
(2009)
Proc Natl Acad Sci USA
-
-
Yazinski, S.A.1
Westcott, P.M.2
Ong, K.3
Pinkas, J.4
Peters, R.M.5
Weiss, R.S.6
-
9
-
-
60749125436
-
Epidermal homeostasis: A balancing act of stem cells in the skin
-
Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 2009; 10:207-17.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 207-217
-
-
Blanpain, C.1
Fuchs, E.2
-
10
-
-
39349096526
-
Hematopoiesis: An evolving paradigm for stem cell biology
-
Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 2008; 132:631-44.
-
(2008)
Cell
, vol.132
, pp. 631-644
-
-
Orkin, S.H.1
Zon, L.I.2
-
13
-
-
65349103899
-
Blinded by the Light: The Growing Complexity of p53
-
Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009; 137:413-31.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
14
-
-
0032523012
-
Role of p53 in hematopoietic recovery after cytotoxic treatment
-
Wlodarski P, Wasik M, Ratajczak MZ, Sevignani C, Hoser G, Kawiak J, et al. Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 1998; 91:2998-3006. (Pubitemid 28227552)
-
(1998)
Blood
, vol.91
, Issue.8
, pp. 2998-3006
-
-
Wlodarski, P.1
Wasik, M.2
Ratajczak, M.Z.3
Sevignani, C.4
Hoser, G.5
Kawiak, J.6
Gewirtz, A.M.7
Calabretta, B.8
Skorski, T.9
-
15
-
-
0036713424
-
S/S mice
-
DOI 10.1101/gad.1007902
-
Bender CF, Sikes ML, Sullivan R, Huye LE, Le Beau MM, Roth DB, et al. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev 2002; 16:2237-51. (Pubitemid 35013087)
-
(2002)
Genes and Development
, vol.16
, Issue.17
, pp. 2237-2251
-
-
Bender, C.F.1
Sikes, M.L.2
Sullivan, R.3
Huye, L.E.4
Le Beau, M.M.5
Roth, D.B.6
Mirzoeva, O.K.7
Oltz, E.M.8
Petrini, J.H.J.9
-
16
-
-
0033553516
-
P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
DOI 10.1016/S0092-8674(00)80762-X
-
Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999; 97:527-38. (Pubitemid 29231175)
-
(1999)
Cell
, vol.97
, Issue.4
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.-L.5
Gottlieb, G.J.6
Greider, C.W.7
DePinho, R.A.8
-
17
-
-
0033634973
-
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
-
Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, et al. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 2000; 5:993-1002.
-
(2000)
Mol Cell
, vol.5
, pp. 993-1002
-
-
Frank, K.M.1
Sharpless, N.E.2
Gao, Y.3
Sekiguchi, J.M.4
Ferguson, D.O.5
Zhu, C.6
-
18
-
-
0034690249
-
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
-
DOI 10.1038/35009138
-
Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 2000; 404:897-900. (Pubitemid 30230344)
-
(2000)
Nature
, vol.404
, Issue.6780
, pp. 897-900
-
-
Gao, Y.1
Ferguson, D.O.2
Xie, W.3
Manis, J.P.4
Sekiguchi, J.5
Frank, K.M.6
Chaudhuri, J.7
Horner, J.8
DePinho, R.A.9
Alt, F.W.10
-
19
-
-
0030981170
-
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation
-
Hakem R, de la Pompa JL, Elia A, Potter J, Mak TW. Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet 1997; 16:298-302.
-
(1997)
Nat Genet
, vol.16
, pp. 298-302
-
-
Hakem, R.1
De La Pompa, J.L.2
Elia, A.3
Potter, J.4
Mak, T.W.5
-
20
-
-
0029909565
-
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
-
Lim DS, Hasty P. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol 1996; 16:7133-43. (Pubitemid 26389773)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.12
, pp. 7133-7143
-
-
Lim, D.-S.1
Hasty, P.2
-
21
-
-
0034106125
-
Analysis of ku80-mutant mice and cells with deficient levels of p53
-
DOI 10.1128/MCB.20.11.3772-3780.2000
-
Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 2000; 20:3772-80. (Pubitemid 30314477)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.11
, pp. 3772-3780
-
-
Lim, D.-S.1
Vogel, H.2
Willerford, D.M.3
Sands, A.T.4
Platt, K.A.5
Hasty, P.6
-
22
-
-
0034946638
-
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
-
DOI 10.1038/90108
-
Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 2001; 28:266-71. (Pubitemid 32626030)
-
(2001)
Nature Genetics
, vol.28
, Issue.3
, pp. 266-271
-
-
Xu, X.1
Qiao, W.2
Linke, S.P.3
Cao, L.4
Li, W.-M.5
Furth, P.A.6
Harris, C.C.7
Deng, C.-X.8
-
24
-
-
0034665162
-
p53 is essential for chemotherapy-induced hair loss
-
Botchkarev VA, Komarova EA, Siebenhaar F, Botchkareva NV, Komarov PG, Maurer M, et al. p53 is essential for chemotherapy-induced hair loss. Cancer Res 2000; 60:5002-6.
-
(2000)
Cancer Res
, vol.60
, pp. 5002-5006
-
-
Botchkarev, V.A.1
Komarova, E.A.2
Siebenhaar, F.3
Botchkareva, N.V.4
Komarov, P.G.5
Maurer, M.6
-
25
-
-
33745628782
-
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
-
Orii KE, Lee Y, Kondo N, McKinnon PJ. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci USA 2006; 103:10017-22.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10017-10022
-
-
Orii, K.E.1
Lee, Y.2
Kondo, N.3
McKinnon, P.J.4
-
26
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
-
27
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev 2004; 18:306-19.
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
-
28
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, et al. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 2007; 448:375-9.
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
-
29
-
-
33745223517
-
Increased p53 activity does not accelerate telomere-driven ageing
-
Garcia-Cao I, Garcia-Cao M, Tomas-Loba A, Martin-Caballero J, Flores JM, Klatt P, et al. Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep 2006; 7:546-52.
-
(2006)
EMBO Rep
, vol.7
, pp. 546-552
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Tomas-Loba, A.3
Martin-Caballero, J.4
Flores, J.M.5
Klatt, P.6
-
30
-
-
34548179310
-
Cancer and ageing: Convergent and divergent mechanisms
-
Serrano M, Blasco MA. Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol 2007; 8:715-22.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 715-722
-
-
Serrano, M.1
Blasco, M.A.2
-
31
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007; 445:656-60.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
-
32
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006; 443:214-7.
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
33
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007; 445:661-5.
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
-
34
-
-
41149118513
-
How dying cells alert the immune system to danger
-
Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 2008; 8:279-89.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 279-289
-
-
Kono, H.1
Rock, K.L.2
-
36
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008; 134:657-67.
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
Hearn, S.4
Simon, J.5
Miething, C.6
-
37
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 2008; 9:616-27.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
38
-
-
34247257202
-
The structural determinants of checkpoint activation
-
MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. The structural determinants of checkpoint activation. Genes Dev 2007; 21:898-903.
-
(2007)
Genes Dev
, vol.21
, pp. 898-903
-
-
MacDougall, C.A.1
Byun, T.S.2
Van, C.3
Yee, M.C.4
Cimprich, K.A.5
-
39
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005; 19:1040-52.
-
(2005)
Genes Dev
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
40
-
-
0042466524
-
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1
-
Cobb JA, Bjergbaek L, Shimada K, Frei C, Gasser SM. DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J 2003; 22:4325-36.
-
(2003)
EMBO J
, vol.22
, pp. 4325-4336
-
-
Cobb, J.A.1
Bjergbaek, L.2
Shimada, K.3
Frei, C.4
Gasser, S.M.5
-
42
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14:397-402.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
43
-
-
0034177408
-
Targeted disruption of the cell cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, Carr AM, et al. Targeted disruption of the cell cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol 2000; 10:479-82.
-
(2000)
Curr Biol
, vol.10
, pp. 479-482
-
-
De Klein, A.1
Muijtjens, M.2
Van Os, R.3
Verhoeven, Y.4
Smit, B.5
Carr, A.M.6
-
44
-
-
70449707748
-
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis
-
Smith KD, Fu MA, Brown EJ. Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol 2009; 187:15-23.
-
(2009)
J Cell Biol
, vol.187
, pp. 15-23
-
-
Smith, K.D.1
Fu, M.A.2
Brown, E.J.3
-
45
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown EJ, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 2003; 17:615-28.
-
(2003)
Genes Dev
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
46
-
-
0035941021
-
ATR and ATRIP: Partners in checkpoint signaling
-
Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: partners in checkpoint signaling. Science 2001; 294:1713-6.
-
(2001)
Science
, vol.294
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S.J.4
-
47
-
-
34249885603
-
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
-
Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 2007; 1:113-26.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 113-126
-
-
Ruzankina, Y.1
Pinzon-Guzman, C.2
Asare, A.3
Ong, T.4
Pontano, L.5
Cotsarelis, G.6
-
48
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447:725-9.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
49
-
-
34250001450
-
DNA repair is limiting for haematopoietic stem cells during ageing
-
Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007; 447:686-90.
-
(2007)
Nature
, vol.447
, pp. 686-690
-
-
Nijnik, A.1
Woodbine, L.2
Marchetti, C.3
Dawson, S.4
Lambe, T.5
Liu, C.6
-
50
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91:25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
-
51
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee HW, Blasco MA, Gottlieb GJ, Horner JW, 2nd, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392:569-74.
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
Blasco, M.A.2
Gottlieb, G.J.3
Horner II, J.W.4
Greider, C.W.5
DePinho, R.A.6
-
52
-
-
0033525558
-
Longevity, stress response and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, et al. Longevity, stress response and cancer in aging telomerase-deficient mice. Cell 1999; 96:701-12.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
-
53
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 2007; 39:99-105.
-
(2007)
Nat Genet
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
Schienke, A.4
Lechel, A.5
Schaetzlein, S.6
-
54
-
-
0034632717
-
Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice
-
Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, et al. Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice. Nature 2000; 406:641-5.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.L.3
Alson, S.4
Gottlieb, G.J.5
Chin, L.6
-
55
-
-
3342986735
-
Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects
-
Bao S, Lu T, Wang X, Zheng H, Wang LE, Wei Q, et al. Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. Oncogene 2004; 23:5586-93.
-
(2004)
Oncogene
, vol.23
, pp. 5586-5593
-
-
Bao, S.1
Lu, T.2
Wang, X.3
Zheng, H.4
Wang, L.E.5
Wei, Q.6
-
56
-
-
33947145194
-
Increased common fragile site expression, cell proliferation defects and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells
-
Zhu M, Weiss RS. Increased common fragile site expression, cell proliferation defects and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol Biol Cell 2007; 18:1044-55.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1044-1055
-
-
Zhu, M.1
Weiss, R.S.2
-
57
-
-
62649115931
-
Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
-
Greenow KR, Clarke AR, Jones RH. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 2009; 28:1443-53.
-
(2009)
Oncogene
, vol.28
, pp. 1443-1453
-
-
Greenow, K.R.1
Clarke, A.R.2
Jones, R.H.3
-
58
-
-
33747176844
-
Compensatory proliferation in Drosophila imaginal discs requires Droncdependent p53 activity
-
Wells BS, Yoshida E, Johnston LA. Compensatory proliferation in Drosophila imaginal discs requires Droncdependent p53 activity. Curr Biol 2006; 16:1606-15.
-
(2006)
Curr Biol
, vol.16
, pp. 1606-1615
-
-
Wells, B.S.1
Yoshida, E.2
Johnston, L.A.3
-
59
-
-
33749256648
-
Growth control: P53, the guardian angel of compensatory proliferation
-
Baehrecke EH. Growth control: p53, the guardian angel of compensatory proliferation. Curr Biol 2006; 16:840-2.
-
(2006)
Curr Biol
, vol.16
, pp. 840-842
-
-
Baehrecke, E.H.1
-
60
-
-
3342881896
-
Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role
-
Huh JR, Guo M, Hay BA. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol 2004; 14:1262-6.
-
(2004)
Curr Biol
, vol.14
, pp. 1262-1266
-
-
Huh, J.R.1
Guo, M.2
Hay, B.A.3
-
61
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11:973-9.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppe, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Munoz, D.P.5
Raza, S.R.6
-
62
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6:2853-68.
-
(2008)
PLoS Biol
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Munoz, D.P.5
Goldstein, J.6
-
63
-
-
58849154235
-
Senescence-messaging secretome: SMS-ing cellular stress
-
Kuilman T, Peeper DS. Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 2009; 9:81-94.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 81-94
-
-
Kuilman, T.1
Peeper, D.S.2
-
64
-
-
44649101304
-
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
-
Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008; 133:1019-31.
-
(2008)
Cell
, vol.133
, pp. 1019-1031
-
-
Kuilman, T.1
Michaloglou, C.2
Vredeveld, L.C.3
Douma, S.4
Van Doorn, R.5
Desmet, C.J.6
-
65
-
-
44649120132
-
Chemokine signaling via the CXCR2 receptor reinforces senescence
-
Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008; 133:1006-18.
-
(2008)
Cell
, vol.133
, pp. 1006-1018
-
-
Acosta, J.C.1
O'Loghlen, A.2
Banito, A.3
Guijarro, M.V.4
Augert, A.5
Raguz, S.6
-
66
-
-
0035979213
-
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
-
Nghiem P, Park PK, Kim Y, Vaziri C, Schreiber SL. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci USA 2001; 98:9092-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9092-9097
-
-
Nghiem, P.1
Park, P.K.2
Kim, Y.3
Vaziri, C.4
Schreiber, S.L.5
-
69
-
-
1542725073
-
Targeting the checkpoint kinases: Chemosensitization versus chemoprotection
-
Zhou BB, Bartek J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer 2004; 4:216-25.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 216-225
-
-
Zhou, B.B.1
Bartek, J.2
-
70
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 2003; 33:497-501.
-
(2003)
Nat Genet
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
71
-
-
68149161607
-
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
-
Murga M, Bunting S, Montana MF, Soria R, Mulero F, Canamero M, et al. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet 2009; 41:891-8.
-
(2009)
Nat Genet
, vol.41
, pp. 891-898
-
-
Murga, M.1
Bunting, S.2
Montana, M.F.3
Soria, R.4
Mulero, F.5
Canamero, M.6
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