Proteolytic cleavage of polymeric tau protein by caspase-3: Implications for Alzheimer disease

Journal of Neuropathology and Experimental Neurology

Volumn 72, Issue 12, 2013, Pages 1145-1161

  Jarero Basulto, Jose J ^a   Luna Muñoz, Jose ^b   Mena, Raul ^b   Kristofikova, Zdena ^c   Ripova, Daniela ^c   Perry, George ^d   Binder, Lester I ^e   Garcia Sierra, Francisco ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^d University of San Antonio   (United States)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Caspase 3; Immunohistochemistry; Neurofibrillary tangles; Tau oligomers; Tau polymerization; Tau proteolysis; Tau truncation

Indexed keywords

ASPARTIC ACID; BRAIN EXTRACT; CASPASE 3; CASPASE 6; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN SLICE; BRAIN TISSUE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONFOCAL MICROSCOPY; CONSENSUS SEQUENCE; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; NERVE CELL; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NEUROPIL THREAD; OLIGOMERIZATION; OPTICAL RESOLUTION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; PROTEIN POLYMERIZATION; SOLUBILIZATION; WESTERN BLOTTING;

AGED, 80 AND OVER; ALZHEIMER DISEASE; AMINO ACID CHLOROMETHYL KETONES; ASPARTIC ACID; BRAIN; CASPASE 3; FEMALE; HUMANS; MALE; MICROSCOPY, ELECTRON; MOLECULAR WEIGHT; NEUROFIBRILLARY TANGLES; NEUROFIBRILS; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; TAU PROTEINS;

EID: 84889093019     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0000000000000013     Document Type: Article

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