Immunoelectron microscopic and biochemical studies of caspase-cleaved tau in a mouse model of tauopathy

Journal of Neuropathology and Experimental Neurology

Volumn 70, Issue 9, 2011, Pages 779-787

  Lin, Wen Lang ^a   Dickson, Dennis W ^a   Sahara, Naruhiko ^b  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Caspase cleaved tau; Immunoelectron microscopy; Mouse model of tauopathy; Neurofibrillary tangles

Indexed keywords

CASPASE; CASPASE 3; SERINE; TAU PROTEIN; THREONINE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN LEVEL; CARBOXY TERMINAL SEQUENCE; CELL COUNT; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TAUOPATHY; TRANSGENIC MOUSE;

ANIMALS; CASPASES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MAP KINASE KINASE KINASE 1; MICE; MICE, TRANSGENIC; MICROSCOPY, IMMUNOELECTRON; NEUROBLASTOMA; NEUROFIBRILLARY TANGLES; TAU PROTEINS; TAUOPATHIES; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 80052163592     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31822ac9c9     Document Type: Article

References (28)

1. Gervais FG, Xu D, Robertson GS, et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 1999;97:395-406
2. Nakagawa T, Zhu H,Morishima N, et al. Caspase-12 mediates endoplasmicreticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98-103 (Pubitemid 30038529)
3. Troy CM, Rabacchi SA, Friedman WJ, et al. Caspase-2 mediates neuronal cell death induced by beta-amyloid. J Neurosci 2000;20:1386-92 (Pubitemid 30220418)
4. Gamblin TC, Chen F, Zambrano A, et al. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci USA 2003;100:10032-37 (Pubitemid 37087063)
5. Rissman RA, Poon WW, Blurton-Jones M, et al. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest 2004;114:121-30 (Pubitemid 39071651)
6. Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR, et al. Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiol Aging 2005;26:1015-22 (Pubitemid 40312665)
7. Binder LI, Guillozet-Bongaarts AL, Garcia-Sierra F, et al. Tau, tangles, and Alzheimer's disease. Biochim Biophys Acta 2005;1739:216-23 (Pubitemid 40018540)
8. Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997;41:17-24 (Pubitemid 27057088)
9. Santacruz K, Lewis J, Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005; 309:476-81 (Pubitemid 40994688)
10. Spires-Jones TL, de Calignon A, Matsui T, et al. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci 2008;28:862-67 (Pubitemid 351158993)
11. de Calignon A, Fox LM, Pitstick R, et al. Caspase activation precedes and leads to tangles. Nature 2010;464:1201-4
12. Kenessey A, Nacharaju P, Ko LW, et al. Degradation of tau by lysosomal enzyme cathepsin D: Implication for Alzheimer neurofibrillary degeneration. J Neurochem 1997;69:2026-38 (Pubitemid 27452750)
13. Takashima A, Murayama M, Murayama O, et al. Presenilin 1 associates with glycogen synthase kinase-3A and its substrate tau. Proc Natl Acad Sci USA 1998;95:9637-41 (Pubitemid 28506284)
14. Jicha GA, Bowser R, Kazam IG, et al. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J Neurosci Res 1997;48:128-32 (Pubitemid 27181338)
15. Jicha GA, Berenfeld B, Davies P. Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease. J Neurosci Res 1999;55:713-23 (Pubitemid 29173485)
16. Sato S, Tatebayashi Y, Akagi T, et al. Aberrant tau phosphorylation by glycogen synthase kinase-3A and JNK3 induces oligomeric tau fibrils in COS-7 cells. J Biol Chem 2002;277:42060-65 (Pubitemid 35257520)
17. Sahara N, Murayama M, Lee B, et al. Active c-Jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3A is required for tau aggregation. European J Neurosci 2008;27: 2897-906 (Pubitemid 351832217)
18. Berger Z, Roder H, Hanna A, et al. Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. J Neurosci 2007;27:3650-62 (Pubitemid 46557687)
19. Ramsden M, Kotilinek L, Forster C, et al. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 2005;25:10637-47 (Pubitemid 41681911)
20. Lin WL, Lewis J, Yen SH, et al. Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau. J Neurocytol 2003;32:1091-105 (Pubitemid 39004719)
21. Ramalho RM, Viana RJ, Castro RE, et al. Apoptosis in transgenic mice expressing the P301L mutated form of human tau. Mol Med 2008;14: 309-17 (Pubitemid 351785704)
22. Newman J, Rissman RA, Sarsoza F, et al. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alphasynuclein pathology. Acta Neuropathol (Berl) 2005;110:135-44 (Pubitemid 41245202)
23. Berry RW, Abraha A, Lagalwar S, et al. Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment. Biochemistry 2003; 42:8325-31 (Pubitemid 36858993)
24. Alnemri ES, Livingston DJ, Nicholson DW, et al. Human ICE/CED-3 protease nomenclature. Cell 1996;87:171
25. Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 2004;5:897-907 (Pubitemid 39486541)
26. Madden SD, Cotter TG. Cell death in brain development and degeneration: Control of caspase expression may be key! Mol Neurobiol 2008; 37:1-6
27. Delobel P, Lavenir I, Fraser G, et al. Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. Am J Pathol 2008;172: 123-31 (Pubitemid 351186374)
28. Guillozet-Bongaarts AL, Cahill ME, Cryns VL, et al. Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: In vitro evidence and implications for tangle formation in vivo. J Neurochem 2006;97: 1005-14