Ubiquitin is associated with early truncation of tau protein at aspartic acid 421 during the maturation of neurofibrillary tangles in Alzheimer's disease

Brain Pathology

Volumn 22, Issue 2, 2012, Pages 240-250

  García Sierra, Francisco ^a,b   Jarero Basulto, Jose J ^a,b   Kristofikova, Zdena ^b   Majer, Emerich ^c   Binder, Lester I ^d   Ripova, Daniela ^b  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^c Patol Sro   (Czech Republic)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; neurofibrillary tangles; phosphorylated tau; proteasome; truncation; ubiquitin

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID; PROTEASOME; TAU PROTEIN; UBIQUITIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; NEUROFIBRILLARY TANGLE; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TARGETING;

AGED; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; APOPTOSIS; ASPARTIC ACID; HUMANS; MUTATION; NEUROFIBRILLARY TANGLES; PEPTIDE FRAGMENTS; TAU PROTEINS; UBIQUITIN;

EID: 84857641625     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2011.00525.x     Document Type: Article

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