Functions and mechanisms of green tea Catechins in regulating bone remodeling

Current Drug Targets

Volumn 14, Issue 13, 2013, Pages 1619-1630

  Shen, Chwan Li ^a   Kwun, In Sook ^a   Wang, Shu ^b   Mo, Huanbiao ^b   Chen, Lixia ^c   Jenkins, Marjorie ^a   Brackee, Gordon ^c   Chen, Chung Hwan ^d   Chyu, Ming Chien ^e  

^a Andong National University   (South Korea)

^b TEXAS WOMAN'S UNIVERSITY   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e Texas Tech University   (United States)

Author keywords

Animals; Bone remodeling; Cell; Human; Osteoporosis; Tea catechin

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BETA CATENIN; CATECHIN; CYSTEINE RICH PROTEIN 61; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GLUCURONOSYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; SULFOTRANSFERASE; TRANSCRIPTION FACTOR RUNX2; BONE DENSITY CONSERVATION AGENT; TEA;

ADIPOCYTE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BONE DENSITY; BONE REMODELING; CELL DIFFERENTIATION; HUMAN; INFLAMMATION; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); TEA; ANIMAL; BONE DEVELOPMENT; DRUG EFFECTS; ECONOMICS; FEMALE; MALE; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY;

ADIPOCYTES; ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; CATECHIN; FEMALE; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; TEA;

EID: 84888985524     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113146660216     Document Type: Article

References (131)

1. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a who study group. World Health Organ Tech Rep Ser 1994; 843: 1-129.
2. Nih consensus development panel on osteoporosis prevention, diagnosis, and therapy, march 7-29, 2000: Highlights of the conference. South Med J 2001; 94: 569-73.
3. Bone health and osteoporosis: A report of the surgeon general. Rockville (MD)2004.
4. Brian K Alldredge; Koda-Kimble May Lywakbj. Guglielmo applied therapeutics: The clinical use of drugs. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2009.
5. Lips P, Cooper C, Agnusdei D, et al. Quality of life in patients with vertebral fractures: Validation of the quality of life questionnaire of the european foundation for osteoporosis (qualeffo). Working party for quality of life of the european foundation for osteoporosis. Osteoporos Int 1999; 10: 150-60.
6. Holroyd C, Cooper C, Dennison E. Epidemiology of osteoporosis. Best Pract Res Clin Endocrinol Metab 2008; 22: 671-85.
7. Miller PD. Management of osteoporosis. Dis Mon 1999; 45: 21-54.
8. Banfi G, Iorio EL, Corsi MM. Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 2008; 46: 1550-5.
9. Garrett IR, Boyce BF, Oreffo RO, et al. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990; 85: 632-9.
10. Basu S, Michaelsson K, Olofsson H, Johansson S, Melhus H. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 2001; 288: 275-9.
11. Maggio D, Barabani M, Pierandrei M, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study. J Clin Endocrinol Metab 2003; 88: 1523-7.
12. Yalin S, Bagis S, Polat G, et al. Is there a role of free oxygen radicals in primary male osteoporosis? Clin Exp Rheumatol 2005; 23: 689-92.
13. Sontakke AN, Tare RS. A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin Chim Acta 2002; 318: 145-8.
14. Yang S, Madyastha P, Bingel S, Ries W, Key L. A new superoxide-generating oxidase in murine osteoclasts. J Biol Chem 2001; 276: 5452-8.
15. Bai XC, Lu D, Bai J, et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by erk and nf-kappab. Biochem Biophys Res Commun 2004; 314: 197-207.
16. Manolagas SC. De-fense! De-fense! De-fense: Scavenging h2o2 while making cholesterol. Endocrinology 2008; 149: 3264-6.
17. Alvehus M, Buren J, Sjostrom M, Goedecke J, Olsson T. The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring) 2010; 18: 879-83.
18. Halade GV, Rahman MM, Williams PJ, Fernandes G. High fat diet-induced animal model of age-associated obesity and osteoporosis. J Nutr Biochem 2010; 21: 1162-9.
19. Patsch JM, Kiefer FW, Varga P, et al. Increased bone resorption and impaired bone microarchitecture in short-term and extended high-fat diet-induced obesity. Metabolism 2011; 60: 243-9.
20. Russell M, Mendes N, Miller KK, et al. Visceral fat is a negative predictor of bone density measures in obese adolescent girls. J Clin Endocrinol Metab 2010; 95: 1247-55.
21. Cao JJ. Effects of obesity on bone metabolism. J Orthop Surg Res 2011; 6: 30.
22. Cao JJ, Gregoire BR, Gao H. High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice. Bone 2009; 44: 1097-104.
23. Cao JJ, Sun L, Gao H. Diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice. Ann N Y Acad Sci 2010; 1192: 292-7.
24. Chen JR, Lazarenko OP, Wu X, et al. Obesity reduces bone density associated with activation of ppargamma and suppression of wnt/beta-catenin in rapidly growing male rats. PLoS One 2010; 5: e13704.
25. Duque G. Bone and fat connection in aging bone. Curr Opin Rheumatol 2008; 20: 429-34.
26. Fu X, Ma X, Lu H, et al. Associations of fat mass and fat distribution with bone mineral density in preand postmenopausal chinese women. Osteoporos Int 2011; 22: 113-9.
27. Hsu YH, Venners SA, Terwedow HA, et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in chinese men and women. Am J Clin Nutr 2006; 83: 146-54.
28. Ionova-Martin SS, Do SH, Barth HD, et al. Reduced sizeindependent mechanical properties of cortical bone in high-fat dietinduced obesity. Bone 2010; 46: 217-25.
29. Ionova-Martin SS, Wade JM, Tang S, et al. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int 2011; 22: 2283-93.
30. Kawai M, Rosen CJ. Bone: Adiposity and bone accrual-still an established paradigm? Nat Rev Endocrinol 2010; 6: 63-4.
31. Lorincz C, Reimer RA, Boyd SK, Zernicke RF. High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice. Br J Nutr 2010; 103: 1302-8.
32. Reid IR. Relationships between fat and bone. Osteoporos Int 2008; 19: 595-606.
33. Rosen CJ, Bouxsein ML. Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006; 2: 35-43.
34. Zhao LJ, Jiang H, et al. Correlation of obesity and osteoporosis: Effect of fat mass on the determination of osteoporosis. J Bone Miner Res 2008; 23: 17-29.
35. Shen CL CM, Wang JS. Tea and bone health: Steps forward in translational nutrition. Am J Clin Nutr 2013; in press.
36. Yang CS, Landau JM. Effects of tea consumption on nutrition and health. J Nutr 2000; 130: 2409-12.
37. Wang S, Noh SK, Koo SI. Green tea catechins inhibit pancreatic phospholipase a(2) and intestinal absorption of lipids in ovariectomized rats. J Nutr Biochem 2006; 17: 492-8.
38. Basu A, Lucas EA. Mechanisms and effects of green tea on cardiovascular health. Nutr Rev 2007; 65: 361-75.
39. Ananingsih VK, Sharma, A., Zhou, W. B Green tea catechins during food processing and storage: A review on stability and detection. Food Res Int 2013; 50: 469-79.
40. Chen Z, Wang S, Lee K, Huang Y, Ho W. Preparation of flavanolrich green tea extract by precipitation with alcl3. J Sci Food Agric 2001; 81: 1034-8.
41. Rains TM, Agarwal S, Maki KC. Antiobesity effects of green tea catechins: A mechanistic review. J Nutr Biochem 2011; 22: 1-7.
42. Barras A, Mezzetti A, Richard A, et al. Formulation and characterization of polyphenol-loaded lipid nanocapsules. Int J Pharm 2009; 379: 270-7.
43. Lambert JD, Lee MJ, Lu H, et al. Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice. J Nutr 2003; 133: 4172-7.
44. Ullmann U, Haller J, Decourt JP, et al. A single ascending dose study of epigallocatechin gallate in healthy volunteers. J Int Med Res 2003; 31: 88-101.
45. Proniuk S, Liederer BM, Blanchard J. Preformulation study of epigallocatechin gallate, a promising antioxidant for topical skin cancer prevention. J Pharm Sci 2002; 91: 111-6.
46. Warden BA, Smith LS, Beecher GR, Balentine DA, Clevidence BA. Catechins are bioavailable in men and women drinking black tea throughout the day. J Nutr 2001; 131: 1731-7.
47. Lambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents. J Nutr 2003; 133: 3262S-7S.
48. Lee MJ, Maliakal P, Chen L, et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: Formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev 2002; 11: 1025-32.
49. Dou QP. Molecular mechanisms of green tea polyphenols. Nutr Cancer 2009; 61: 827-35.
50. Lu H, Meng X, Li C, et al. Glucuronides of tea catechins: Enzymology of biosynthesis and biological activities. Drug Metab Dispos 2003; 31: 452-61.
51. Lu H, Meng X, Yang CS. Enzymology of methylation of tea catechins and inhibition of catechol-o-methyltransferase by (-)epigallocatechin gallate. Drug Metab Dispos 2003; 31: 572-9.
52. Vaidyanathan JB, Walle T. Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes. Drug Metab Dispos 2002; 30: 897-903.
53. Boutin JA, Antoine B, Siest G. Heterogeneity of hepatic microsomal udp-glucuronosyltransferase(s) activities: A new kinetic approach for the study of induction and specificity. J Pharm Sci 1994; 83: 591-6.
54. Strassburg CP, Nguyen N, Manns MP, Tukey RH. Udpglucuronosyltransferase activity in human liver and colon. Gastroenterology 1999; 116: 149-60.
55. Shali NA, Curtis CG, Powell GM, Roy AB. Sulphation of the flavonoids quercetin and catechin by rat liver. Xenobiotica 1991; 21: 881-93.
56. Matsui M, Homma H. Biochemistry and molecular biology of drug-metabolizing sulfotransferase. Int J Biochem 1994; 26: 1237-47.
57. Miller RJ, Jackson KG, Dadd T, et al. A preliminary investigation of the impact of catechol-o-methyltransferase genotype on the absorption and metabolism of green tea catechins. Eur J Nutr 2012; 51: 47-55.
58. Clarke BL, Khosla S. Physiology of bone loss. Radiol Clin North Am 2010; 48: 483-95.
59. Matsuo K, Irie N. Osteoclast-osteoblast communication. Arch Biochem Biophys 2008; 473: 201-9.
60. Nijweide PJ, Burger EH, Feyen JH. Cells of bone: Proliferation, differentiation, and hormonal regulation. Physiol Rev 1986; 66: 855-86.
61. Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate (egcg) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and-13 in human chondrocytes. J Pharmacol Exp Ther 2004; 308: 767-73.
62. Kamon M, Zhao R, Sakamoto K. Green tea polyphenol (-)epigallocatechin gallate suppressed the differentiation of murine osteoblastic mc3t3-e1 cells. Cell Biol Int 2010; 34: 109-16.
63. Lee YL, Hong CY, Kok SH, et al. An extract of green tea, epigallocatechin-3-gallate, reduces periapical lesions by inhibiting cysteine-rich 61 expression in osteoblasts. J Endod 2009; 35: 206-11.
64. Lin SK, Chang HH, Chen YJ, et al. Epigallocatechin-3-gallate diminishes ccl2 expression in human osteoblastic cells via upregulation of phosphatidylinositol 3-kinase/akt/raf-1 interaction: A potential therapeutic benefit for arthritis. Arthritis Rheum 2008; 58: 3145-56.
65. Natsume H, Adachi S, Takai S, et al. (-)-epigallocatechin gallate attenuates the induction of hsp27 stimulated by sphingosine 1phosphate via suppression of phosphatidylinositol 3-kinase/akt pathway in osteoblasts. Int J Mol Med 2009; 24: 197-203.
66. Takai S, Matsushima-Nishiwaki R, Adachi S, et al. (-)epigallocatechin gallate reduces platelet-derived growth factor-bb-stimulated interleukin-6 synthesis in osteoblasts: Suppression of sapk/jnk. Mediators Inflamm 2008; 2008: 291808.
67. Tokuda H, Takai S, Matsushima-Nishiwaki R, et al. (-)epigallocatechin gallate enhances prostaglandin f2alpha-induced vegf synthesis via upregulating sapk/jnk activation in osteoblasts. J Cell Biochem 2007; 100: 1146-53.
68. Vali B, Rao LG, El-Sohemy A. Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells. J Nutr Biochem 2007; 18: 341-7.
69. Wu PH, Lin SK, Lee BS, et al. Epigallocatechin-3-gallate diminishes cytokine-stimulated cyr61 expression in human osteoblastic cells: A therapeutic potential for arthritis. Rheumatology (Oxford) 2012; 51: 1953-65.
70. Ko CH, Lau KM, Choy WY, Leung PC. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem 2009; 57: 7293-7.
71. Lee YS, Kim YS, Lee SY, et al. Amp kinase acts as a negative regulator of rankl in the differentiation of osteoclasts. Bone 2010; 47: 926-37.
72. Lin RW, Chen CH, Wang YH, et al. (-)-epigallocatechin gallate inhibition of osteoclastic differentiation via nf-kappab. Biochem Biophys Res Commun 2009; 379: 1033-7.
73. Morinobu A, Biao W, Tanaka S, et al. (-)-epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice. Arthritis Rheum 2008; 58: 2012-8.
74. Yun JH, Kim CS, Cho KS, et al. (-)-epigallocatechin gallate induces apoptosis, via caspase activation, in osteoclasts differentiated from raw 264.7 cells. J Periodontal Res 2007; 42: 212-8.
75. Bickford PC, Tan J, Shytle RD, et al. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev 2006; 15: 118-23.
76. Chen CH, Ho ML, Chang JK, Hung SH, Wang GJ. Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporos Int 2005; 16: 2039-45.
77. Ko CH, Siu WS, Wong HL, et al. Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. J Agric Food Chem 2011; 59: 9870-6.
78. Liu P, Wang DX, Chen RY, et al. [effect of catechin on bone marrow cell cycle and gene expression of hematopoietic growth factors]. Yao Xue Xue Bao 2004; 39: 424-8.
79. Wei YJ, Tsai KS, Lin LC, et al. Catechin stimulates osteogenesis by enhancing pp2a activity in human mesenchymal stem cells. Osteoporos Int 2011; 22: 1469-79.
80. Chan CY, Wei L, Castro-Munozledo F, Koo WL. (-)-epigallocatechin-3-gallate blocks 3t3-l1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression. Life Sci 2011; 89: 779-85.
81. Hwang JT, Park IJ, Shin JI, et al. Genistein, egcg, and capsaicin inhibit adipocyte differentiation process via activating ampactivated protein kinase. Biochem Biophys Res Commun 2005; 338: 694-9.
82. Kim H, Hiraishi A, Tsuchiya K, Sakamoto K. (-)-epigallocatechin gallate suppresses the differentiation of 3t3-l1 preadipocytes through transcription factors foxo1 and srebp1c. Cytotechnology 2010; 62: 245-55.
83. Lee MS, Kim CT, Kim IH, Kim Y. Inhibitory effects of green tea catechin on the lipid accumulation in 3t3-l1 adipocytes. Phytother Res 2009; 23: 1088-91.
84. Lee MS, Kim Y. (-)-epigallocatechin-3-gallate enhances uncoupling protein 2 gene expression in 3t3-l1 adipocytes. Biosci Biotechnol Biochem 2009; 73: 434-6.
85. Lin J, Della-Fera MA, Baile CA. Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3t3-l1 adipocytes. Obes Res 2005; 13: 982-90.
86. Liu HS, Chen YH, Hung PF, Kao YH. Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3t3-l1 adipocytes depends on the erk pathway. Am J Physiol Endocrinol Metab 2006; 290: E273-81.
87. Moon HS, Chung CS, Lee HG, et al. Inhibitory effect of (-)epigallocatechin-3-gallate on lipid accumulation of 3t3-l1 cells. Obesity (Silver Spring) 2007; 15: 2571-82.
88. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: Target for metabolic syndrome. J Lipid Res 2009; 50 Suppl: S138-43.
89. Wu BT, Hung PF, Chen HC, et al. The apoptotic effect of green tea (-)-epigallocatechin gallate on 3t3-l1 preadipocytes depends on the cdk2 pathway. J Agric Food Chem 2005; 53: 5695-701.
90. Prockop DJ. Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy. J Cell Biochem 1998: 30-31: 284-5.
91. Tae SK, Lee SH, Park JS, Im GI. Mesenchymal stem cells for tissue engineering and regenerative medicine. Biomed Mater 2006; 1: 63-71.
92. Nelson-Dooley C, Della-Fera MA, Hamrick M, Baile CA. Novel treatments for obesity and osteoporosis: Targeting apoptotic pathways in adipocytes. Curr Med Chem 2005; 12: 2215-25.
93. Choi JH, Rhee IK, Park KY, et al. Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats. Life Sci 2003; 73: 1479-89.
94. Hamdaoui MH, Chahed A, Ellouze-Chabchoub S, et al. Effect of green tea decoction on long-term iron, zinc and selenium status of rats. Ann Nutr Metab 2005; 49: 118-24.
95. Shen CL, Cao JJ, Dagda RY, et al. Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats. Calcif Tissue Int 2011; 88: 455-63.
96. Shen CL, Wang P, Guerrieri J, Yeh JK, Wang JS. Protective effect of green tea polyphenols on bone loss in middle-aged female rats. Osteoporos Int 2008; 19: 979-90.
97. Shen CL, Yeh JK, Stoecker BJ, Chyu MC, Wang JS. Green tea polyphenols mitigate deterioration of bone microarchitecture in middle-aged female rats. Bone 2009; 44: 684-90.
98. Shen CL, Yeh JK, Cao JJ, et al. Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model. J Nutr Biochem 2010; 21: 968-74.
99. Shen CL, Yeh JK, Cao JJ, et al. Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats. Osteoporos Int 2010; 21: 1841-52.
100. Shen CL, Yeh JK, Samathanam C, et al. Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation. Osteoporos Int 2011; 22: 327-37.
101. Shen CL, Yeh JK, Samathanam C, et al. Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation. J Nutr Biochem 2011; 22: 673-80.
102. Shen CL, Cao JJ, Dagda RY, et al. Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats. Nutr Res 2012; 32: 448-57.
103. Shen CL, Chyu MC, Cao JJ, Yeh JK. Green tea polyphenols improve bone microarchitecture in high-fat-diet-induced obese female rats through suppressing bone formation and erosion. J Med Food 2013; 16: 421-7.
104. Chen CH, Kang L, Lin RW, et al. (-)-epigallocatechin-3-gallate improves bone microarchitecture in ovariectomized rats. Menopause 2013; 20: 687-94.
105. Bakhsh A, Mustapha NM, Mohamed S. Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats. Nutrition 2013; 29: 667-72.
106. Nakamura H, Ukai T, Yoshimura A, et al. Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo. J Periodontal Res 2010; 45: 23-30.
107. Rodriguez R, Kondo H, Nyan M, et al. Implantation of green tea catechin alpha-tricalcium phosphate combination enhances bone repair in rat skull defects. J Biomed Mater Res B Appl Biomater 2011; 98: 263-71.
108. Jin S, Park JY, Hong JM, et al. Inhibitory effect of (-)epigallocatechin gallate on titanium particle-induced tnf-alpha release and in vivo osteolysis. Exp Mol Med 2011; 43: 411-8.
109. Iwaniec UT, Turner RT, Koo SI, et al. Consumption of green tea extract results in osteopenia in growing male mice. J Nutr 2009; 139: 1914-9.
110. Chen Z, Pettinger MB, Ritenbaugh C, et al. Habitual tea consumption and risk of osteoporosis: A prospective study in the women's health initiative observational cohort. Am J Epidemiol 2003; 158: 772-81.
111. Devine A, Hodgson JM, Dick IM, Prince RL. Tea drinking is associated with benefits on bone density in older women. Am J Clin Nutr 2007; 86: 1243-7.
112. Hamdi Kara I, Aydin S, Gemalmaz A, et al. Habitual tea drinking and bone mineral density in postmenopausal turkish women: Investigation of prevalence of postmenopausal osteoporosis in turkey (ippot study). Int J Vitam Nutr Res 2007; 77: 389-97.
113. Hegarty VM, May HM, Khaw KT. Tea drinking and bone mineral density in older women. Am J Clin Nutr 2000; 71: 1003-7.
114. Hernandez-Avila M, Stampfer MJ, Ravnikar VA, et al. Caffeine and other predictors of bone density among preand perimenopausal women. Epidemiology 1993; 4: 128-34.
115. Hoover PA, Webber CE, Beaumont LF, Blake JM. Postmenopausal bone mineral density: Relationship to calcium intake, calcium absorption, residual estrogen, body composition, and physical activity. Can J Physiol Pharmacol 1996; 74: 911-7.
116. Keramat A, Patwardhan B, Larijani B, et al. The assessment of osteoporosis risk factors in iranian women compared with indian women. BMC Musculoskelet Disord 2008; 9: 28.
117. Muraki S, Yamamoto S, Ishibashi H, et al. Diet and lifestyle associated with increased bone mineral density: Cross-sectional study of japanese elderly women at an osteoporosis outpatient clinic. J Orthop Sci 2007; 12: 317-20.
118. Vestergaard P, Hermann AP, Gram J, et al. Evaluation of methods for prediction of bone mineral density by clinical and biochemical variables in perimenopausal women. Maturitas 2001; 40: 211-20.
119. Wu CH, Yang YC, Yao WJ, et al. Epidemiological evidence of increased bone mineral density in habitual tea drinkers. Arch Intern Med 2002; 162: 1001-6.
120. Hong X, Lü H, Yang J, et al. An analysis on the forearm bone mass density of rural female and the environmental risk factors. Wei Sheng Yan Jiu 2001; 30(4): 227-30.
121. Kyriazopoulos P, Trovas G, Charopoulos J, et al. Lifestyle factors and forearm bone density in young Greek men. Clin Endocrinol (Oxf) 2006; 65(2): 234-8.
122. Saitoglu M, Ardicoglu O, Ozgocmen S, et al. Osteoporosis risk factors and association with somatotypes in males. Arch Med Res 2007; 38(7): 746-51.
123. Johnell O, Gullberg B, Kanis JA, et al. Risk factors for hip fracture in european women: The medos study. Mediterranean osteoporosis study. J Bone Miner Res 1995; 10: 1802-15.
124. Kanis J, Johnell O, Gullberg B, et al. Risk factors for hip fracture in men from southern europe: The medos study. Mediterranean osteoporosis study. Osteoporos Int 1999; 9: 45-54.
125. Hallström H, Wolk A, Glynn A, et al. Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women. Osteoporos Int 2006; 17(7): 1055-64.
126. Hallanger Johnson JE, Kearns AE, Doran PM, Khoo TK, Warmers RA. Fluoride-related bone disease associated with habitual tea consumption. Mayo Clin Proc 2007; 82: 719-24.
127. Tomata Y, Kakizaki M, Nakaya N, et al. Green tea consumption and the risk of incident functional disability in elderly japanese: The ohsaki cohort 2006 study. Am J Clin Nutr 2012; 95: 732-9.
128. Shen CL, Chyu MC, Yeh JK, et al. Effect of green tea and tai chi on bone health in postmenopausal osteopenic women: A 6-month randomized placebo-controlled trial. Osteoporos Int 2012; 23: 1541-52.
129. Shen CL, Chyu MC, Pence BC, et al. Green tea polyphenols supplementation and tai chi exercise for postmenopausal osteopenic women: Safety and quality of life report. BMC Complement Altern Med 2010; 10: 76.
130. Qian G, Xue K, Tang L, et al. Mitigation of oxidative damage by green tea polyphenols and tai chi exercise in postmenopausal women with osteopenia. PLoS One 2012; 7: e48090.
131. Bellido T. Osteocyte-driven bone remodeling. Calcif Tissue Int. 2013 Sept 4 [Epub ahead of print].