Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG) Differentially Inhibits Interleukin-1β-Induced Expression of Matrix Metalloproteinase-1 and -13 in Human Chondrocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 2, 2004, Pages 767-773

  Ahmed, Salahuddin ^a   Wang, Naizhen ^a   Lalonde, Mathew ^a   Goldberg, Victor M ^a   Haqqi, Tariq M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATECHIN; COLLAGENASE; COLLAGENASE 3; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; FLAVONOID; GLYCOSAMINOGLYCAN; GREEN TEA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; PHENOL DERIVATIVE; POLYPHENOL; POLYPHENOLS; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR AP 1;

ARTHRITIS; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CHEMISTRY; CHRONIC INFLAMMATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG INHIBITION; DRUG INTERACTION; ENZYME ACTIVITY; ENZYMOLOGY; EXPLANT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEA;

ANTIOXIDANTS; CARTILAGE; CATECHIN; CELLS, CULTURED; CHONDROCYTES; COLLAGENASES; DOWN-REGULATION; DRUG INTERACTIONS; FLAVONOIDS; HUMANS; INTERLEUKIN-1; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; NF-KAPPA B; PHENOLS; RNA, MESSENGER; TEA; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTION FACTOR AP-1;

EID: 1642538979     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059220     Document Type: Article

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