Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Chen, Jin Ran ^a,b   Lazarenko, Oxana P ^a,b   Wu, Xianli ^a,b   Tong, Yudong ^b   Blackburn, Michae L ^a,b   Shankar, Kartik ^a,b   Badger, Thomas M ^a,b   Ronis, Martin J J ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FATTY ACID; LEPTIN; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR RUNX2; WNT PROTEIN;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MARROW CELL; BONE MASS; BONE TURNOVER; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENTERIC FEEDING; FAT BODY; FATTY ACID BLOOD LEVEL; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HORMONE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; LIPID DIET; LOW FAT DIET; MALE; MALE ANIMAL; MASS FRAGMENTOGRAPHY; MESENCHYME CELL; NONHUMAN; OBESITY; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; POSTNATAL DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN SYNTHESIS REGULATION; RAT; SIGNAL TRANSDUCTION; STROMA CELL; UPREGULATION; WEIGHT GAIN; ANIMAL; FAT INTAKE; GROWTH; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TOTAL PARENTERAL NUTRITION;

ANIMALIA; RATTUS;

ANIMALS; BETA CATENIN; BONE DENSITY; CELL DIFFERENTIATION; DIETARY FATS; GROWTH; MALE; OBESITY; OSTEOBLASTS; PARENTERAL NUTRITION, TOTAL; PPAR GAMMA; RATS; WNT PROTEINS;

EID: 78149450352     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013704     Document Type: Article

References (36)

1. Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, et al. (2007) Relationship of obesity with osteoporosis. J Clin Endocrinol Metab 92: 1640-1646.
2. Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, et al. (2008) Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res 23: 17-29.
3. Cao JJ, Gregoire BR, Gao H (2009) High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice. Bone 44: 1097-1104.
4. Weiler HA, Janzen L, Green K, Grabowski J, Seshia MM, et al. (2000) Percentage body fat and bone mass in healthy Canadian females 10 to 19 years of age. Bone 27: 203-207.
5. Leonard MB, Shults J, Wilson BA, Tershakovec AM, Zemel BS (2004) Obesity during childhood and adolescence augments bone mass and bone dimensions. Am J Clin Nutr 80: 514-523.
6. Chan G, Chen CT (2009) Musculoskeletal effects of obesity. Curr Opin Pediatr 21: 65-70.
7. Krishnan V, Bryant HU, Macdougald OA (2006) Regulation of bone mass by Wnt signaling. J Clin Invest 116: 1202-1209.
8. Smas CM, Chen L, Zhao L, Latasa MJ, Sul HS (1999) Transcriptional repression of pref-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation. J Biol Chem 274: 12632-12641.
9. Oh SR, Sul OJ, Kim YY, Kim HJ, Yu R, et al. (2009) Saturated fatty acids enhance osteoclast survival. J Lipid Res Apr 11 [Epub ahead of print].
10. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, et al. (2001) Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res 16: 182-188.
11. Tintut Y, Morony S, Demer LL (2004) Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol 24: e6-e10.
12. Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, et al. (2005) Association between bone mineral densities and serum lipid profiles of pre-and postmenopausal rural women in South Korea. Osteoporosis Int 16: 1975-1981.
13. Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, et al. (2008) Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats. J Bone Miner Res 23: 338-349.
14. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ (2002) Adipositic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55: 693-698.
15. Yeung DK, Griffith JF, Antonio GE, Lee FK, Woo J, et al. (2005) Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging 22:279-285.
16. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, et al. (2002) Le ptinregulates bone formation via the sympathetic nervous system. Cell 111: 305-317.
17. Scheller LE, Song J, Dishowitz MI, Soki NF, Hankenson KD, et al. (2010) Leptin functions peripherally to regulate differentiation of mesenchymal progeitor cells. Stem Cells (In Press).
18. Kyung TW, Lee JE, Phan TV, Yu R, Choi HS (2009) Osteoclastogenesis by bone marrow-derived macrophages is enhanced in obese mice. J Nutr 139: 502-506.
19. Zhou Q, Leeman SE, Amar S (2009) Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A 106: 10740-10745.
20. Felson DT, Zhang Y, Hannan MT, Anderson JJ (1993) Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res 8: 567-573.
21. Akridge M, Hilgers KK, Silveira AM, Scarfe W, Scheetz JP, et al. (2007) Childhood obesity and skeletal maturation assessed with Fishman's hand-wrist analysis. Am J Orthod Dentofacial Orthop 132: 185-190.
22. Rosen CJ, Bouxsein ML (2006) Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2: 35-43.
23. Yajnik CS, Yudkin JS (2004) The Y-Y paradox. Lancet 363: 163.
24. Bielohuby M, Matsuura M, Herbach N, Kienzle E, Slawik M, et al. (2010) Short Term Exposure to Low-Carbohydrate/High Fat Diets Induces Low Bone Mineral Density and Reduces Bone Formation in Rats. J Bone Miner Res 25: 275-284.
25. Kennedy ET, Bowman SA, Powell R (1999) Dietary-fat intake in the US population. J Am Coll Nutr 18: 207-212.
26. Chen JR, Singhal R, Lazarenko OP, Liu X, Hogue WR, et al. (2008) Short term effects on bone quality associated with consumption of soy protein isolate and other dietary protein sources in rapidly growing female rats. Exp Biol Med (Maywood) 233: 1348-1358.
27. Chen JR, Lazarenko OP, Blackburn ML, Badeaux JV, Badger TM, et al. (2009) Infant formula promotes bone growth in neonatal piglets by enhancing osteoblastogenesis through bone morphogenic protein signaling. J Nutr 139: 1839-1847.
28. Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME (2006) Playing with bone and fat. J Cell Biochem 98: 251-266.
29. Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, et al. (2004) Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem 279: 36093-36102.
30. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309: 1074-1078.
31. Reeves PG, Nielsen FH, Fahey GC, Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.
32. Shankar K, Kang P, Harrell A, Zhong Y, Marecki JC, et al. (2010) Maternal Overweight Programs Insulin and Adiponectin Signaling in the Offspring. Endocrinology 151: 2577-2589.
33. Marecki JC, Ronis MJJ, Badger TM (2010) Ectopic fat disposition and insulin resistance develop after overfeeding of a high fat diet to prepubertal rats despite increased adiponectin signaling. J Nutr Biochem (In Press).
34. Chen JR, Haley RL, Hidestrand M, Shankar K, Liu X, et al. (2006) Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts. J Pharmacol Exp Ther 319: 1182-1190.
35. Chen JR, Lazarenko OP, Haley RL, Blackburn ML, Badger TM, et al. (2009) Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways While Estradiol Attenuates the Effects of Ethanol in Osteoblasts. J Bone Miner Res 24: 221-230.
36. Chen JR, Shankar K, Nagarajan S, Badger TM, Ronis MJ (2008) Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J Pharmacol Exp Ther 324: 50-59.