A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins

European Journal of Nutrition

Volumn 51, Issue 1, 2012, Pages 47-55

  Miller, Rosalind J ^a   Jackson, Kim G ^a   Dadd, Tony ^b   Nicol, Beate ^b   Dick, Joanne L ^b   Mayes, Andrew E ^b   Louise Brown, A ^b   Minihane, Anne M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

COMT; Flavan 3 ol; Green tea; Pharmacokinetics

Indexed keywords

4' O METHYL EPIGALLOCATECHIN GALLATE; CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GREEN TEA EXTRACT; METHIONINE; UNCLASSIFIED DRUG; VALINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; METHYLATION; NORMAL HUMAN; PHARMACOGENETICS; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMINO ACID SUBSTITUTION; CATECHIN; CATECHOL O-METHYLTRANSFERASE; DIETARY SUPPLEMENTS; FEMALE; GENETIC ASSOCIATION STUDIES; HOMOZYGOTE; HUMANS; INTESTINAL ABSORPTION; KINETICS; MALE; METHYLATION; MIDDLE AGED; PHENOLS; PILOT PROJECTS; PLANT EXTRACTS; POLYMORPHISM, SINGLE NUCLEOTIDE; TEA;

EID: 84860656618     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-011-0189-0     Document Type: Article

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