Tissue transglutaminase: An emerging target for therapy and imaging Dedicated to Professor Jörg Steinbach, Dresden-Rossendorf, on the occasion of his 60th birthday

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6528-6543

  Pietsch, Markus ^a   Wodtke, Robert ^b,c   Pietzsch, Jens ^b,c   Löser, Reik ^b,c  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Activity assays; Biomaterial tissue interface; Cancer; Imaging probes; Inhibitors; Tissue transglutaminase (TGase 2)

Indexed keywords

BIOMATERIAL; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

ARTICLE; CHEMICAL MODIFICATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; HUMAN; IMAGING; MOLECULAR PROBE; NONHUMAN; PROTEIN TARGETING; RELIABILITY; TISSUE INTERACTION; TUMOR GROWTH;

ANIMALS; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HUMANS; KINETICS; NEOPLASMS; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSGLUTAMINASES;

EID: 84888865396     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.060     Document Type: Review

References (224)

1. M. Griffin, R. Casadio, and C.M. Bergamini Biochem. J. 368 2002 377
2. Z. Nemes, L.N. Marekov, L. Fésüs, and P.M. Steinert Proc. Natl. Acad. Sci. U.S.A. 96 1999 8402
3. K.N. Parameswaran, X.-F. Cheng, E.C. Chen, P.T. Velasco, J.H. Wilson, and L. Lorand J. Biol. Chem. 272 1997 10311
4. L. Lorand, and R.M. Graham Nat. Rev. Mol. Cell Biol. 4 2003 140
5. K. Mehta Prog. Exp. Tumor Res. 38 2005 1
6. Z. Wang, and M. Griffin Amino Acids 42 2012 939
7. S. Gundemir, G. Colak, J. Tucholski, and G.V. Johnson Biochim. Biophys. Acta 1823 2012 406
8. R. Kiraly, E. Csosz, T. Kurtan, S. Antus, K. Szigeti, Z. Simon-Vecsei, I.R. Korponay-Szabo, Z. Keresztessy, and L. Fesüs FEBS J. 276 2009 7083
9. T.S. Lai, T.F. Slaughter, K.A. Peoples, J.M. Hettasch, and C.S. Greenberg J. Biol. Chem. 273 1998 1776
10. H. Nakaoka, D. Perez, K. Baek, T. Das, A. Husain, K. Misono, M. Im, and R. Graham Science 264 1994 1593
11. K.J. Baek, N.S. Kwon, H.S. Lee, M.S. Kim, P. Muralidhar, and M.-J. Im Biochem. J. 315 1996 739
12. R. Vezza J. Biol. Chem. 274 1999 12774
13. S. Liu, R.A. Cerione, and J. Clardy Proc. Natl. Acad. Sci. U.S.A. 99 2002 2743
14. D.M. Pinkas, P. Strop, A.T. Brunger, and C. Khosla PLoS Biol. 5 2007 2788
15. C.M. Clouthier, G.G. Mironov, V. Okhonin, M.V. Berezovski, and J.W. Keillor Angew. Chem., Int. Ed. 51 2012 12464
16. G. Hasegawa, M. Suwa, Y. Ichikawa, T. Ohtsuka, S. Kumagai, M. Kikuchi, Y. Sato, and Y. Saito Biochem. J. 373 2003 793
17. P.G. Mastroberardino, M.G. Farrace, I. Viti, F. Pavone, G.M. Fimia, G. Melino, C. Rodolfo, and M. Piacentini Biochim. Biophys. Acta 1757 2006 1357
18. S. Mishra, and L.J. Murphy J. Biol. Chem. 279 2004 23863
19. S. Mishra, G. Melino, and L.J. Murphy J. Biol. Chem. 282 2007 18108
20. Y. Takeuchi, H. Ohashi, P.J. Birckbichler, and T. Ikejima Z. Naturforsch., C: Biosci. 53 1998 352
21. T.S. Lai, A. Hausladen, T.F. Slaughter, J.P. Eu, J.S. Stamler, and C.S. Greenberg Biochemistry 40 2001 4904
22. C. Klöck, and C. Khosla Protein Sci. 21 2012 1781
23. J. Stamnaes, D.M. Pinkas, B. Fleckenstein, C. Khosla, and L.M. Sollid J. Biol. Chem. 285 2010 25402
24. X. Jin, J. Stamnaes, C. Klöck, T.R. DiRaimondo, L.M. Sollid, and C. Khosla J. Biol. Chem. 286 2011 37866
25. S. Mishra, and L.J. Murphy Biochem. Biophys. Res. Commun. 347 2006 1166
26. T.S. Lai, C. Davies, and C.S. Greenberg Protein Sci. 19 2010 229
27. Y. Nakano, J. Forsprecher, and M.T. Kaartinen J. Cell Physiol. 223 2010 260
28. B.M. Fraij J. Cell. Biochem. 112 2011 3469
29. R. Kiraly, M. Demeny, and L. Fesüs FEBS J. 278 2011 4717
30. T.S. Lai, and C.S. Greenberg Front. Biosci. 18 2013 504
31. P.A. Smethurst, and M. Griffin Biochem. J. 313 1996 803
32. M. Siegel, P. Strnad, R.E. Watts, K. Choi, B. Jabri, M.B. Omary, and C. Khosla PLoS One 3 2008 e1861
33. M. Piacentini, A. Amendola, F. Ciccosanti, L. Falasca, M.G. Farrace, P.G. Mastroberardino, R. Nardacci, S. Oliverio, L. Piredda, C. Rodolfo, and F. Autuori Prog. Exp. Tumor Res. 38 2005 58
34. M.V. Nurmiskaya, and A.M. Belkin Int. Rev. Cell Mol. Biol. 294 2012 1
35. D. Park, S.S. Choi, and K.S. Ha Amino Acids 39 2010 619
36. E.A. Zemskov, I. Mikhailenko, R.-C. Hsia, L. Zaritskaya, and A.M. Belkin PLoS One 6 2011 e19414
37. V. Malhotra EMBO J. 32 2013 1660
38. A.M. Belkin FEBS J. 278 2011 4704
39. R.J. Collighan, and M. Griffin Amino Acids 36 2009 659
40. A. Di Sabatino, A. Vanoli, P. Giuffrida, O. Luinetti, E. Solcia, and G.R. Corazza Autoimmun. Rev. 11 2012 746
41. H. Grosso, and M.M. Mouradian Pharmacol. Ther. 133 2012 392
42. K. Mehta, A. Kumar, and H.I. Kim Biochem. Pharmacol. 80 2010 1921
43. D. Caccamo, M. Curro, and R. Ientile Expert Opin. Ther. Targets 14 2010 989
44. L.M. Sollid Annu. Rev. Immunol. 18 2000 53
45. C. Klöck, T.R. DiRaimondo, and C. Khosla Semin. Immunopathol. 34 2012 513
46. O. Molberg, S.N. McAdam, R. Körner, H. Quarsten, C. Kristiansen, L. Madsen, L. Fugger, H. Scott, O. Norén, P. Roepstorff, K.E.A. Lundin, H. Sjöström, and L.M. Sollid Nat. Med. 4 1998 713
47. S.E. Iismaa, B.M. Mearns, L. Lorand, and R.M. Graham Physiol. Rev. 89 2009 991
48. W. Dieterich, T. Ehnis, M. Bauer, P. Donner, U. Volta, E.O. Riecken, and D. Schuppan Nat. Med. 3 1997 797
49. K.A. Jellinger J. Neural Transm. 116 2009 1111
50. T.M. Jeitner, J.T. Pinto, B.F. Krasnikov, M. Horswill, and A.J. Cooper J. Neurochem. 109 Suppl. 1 2009 160
51. M. Siegel, and C. Khosla Pharmacol. Ther. 115 2007 232
52. P.G. Mastroberardino, C. Iannicola, R. Nardacci, F. Bernassola, V. De Laurenzi, G. Melino, S. Moreno, F. Pavone, S. Oliverio, L. Fesüs, and M. Piacentini Cell Death Differ. 9 2002 873
53. L. Lorand, L.K.H. Hsu, G.E.J. Siefring, and N.S. Rafferty Proc. Natl. Acad. Sci. U.S.A. 78 1981 1356
54. P. Shridas, Y. Sharma, and D. Balasubramanian FEBS Lett. 499 2001 245
55. A. Lentini, C. Tabolacci, P. Mattioli, B. Provenzano, and S. Beninati Protein J. 30 2011 109
56. B. Li, R.A. Cerione, and M.A. Antonyak Adv. Enzymol. Relat. Areas Mol. Biol. 78 2011 247
57. A. Verma, H. Wang, B. Manavathi, J.Y. Fok, A.P. Mann, R. Kumar, and K. Mehta Cancer Res. 66 2006 10525
58. K. Mehta, J. Fok, F.R. Miller, D. Koul, and A.A. Sahin Clin. Cancer Res. 10 2004 8068
59. J.Y. Fok, S. Ekmekcioglu, and K. Mehta Mol. Cancer Ther. 5 2006 1493
60. J.F. Herman, L.S. Mangala, and K. Mehta Oncogene 25 2006 3049
61. S. Kumar, and K. Mehta Amino Acids 44 2013 81
62. A. Verma, S. Guha, P. Diagaradjane, A.B. Kunnumakkara, A.M. Sanguino, G. Lopez-Berestein, A.K. Sood, B.B. Aggarwal, S. Krishnan, J.G. Gelovani, and K. Mehta Clin. Cancer Res. 14 2008 2476
63. S.S. Park, J.M. Kim, D.S. Kim, I.H. Kim, and S.Y. Kim J. Biol. Chem. 281 2006 34965
64. A.P. Mann, A. Verma, G. Sethi, B. Manavathi, H. Wang, J.Y. Fok, A.B. Kunnumakkara, R. Kumar, B.B. Aggarwal, and K. Mehta Cancer Res. 66 2006 8788
65. S. Kumar, and K. Mehta PLoS One 7 2012 e49321
66. Y. Wang, S.R. Ande, and S. Mishra BMC Cancer 12 2012 277
67. B. Yakubov, B. Chelladurai, J. Schmitt, R. Emerson, J.J. Turchi, and D. Matei Neoplasia 15 2013 609
68. K.D. Brown Breast Cancer Res. Treat. 137 2013 329
69. L. Cao, D.N. Petrusca, M. Satpathy, H. Nakshatri, I. Petrache, and D. Matei Carcinogenesis 29 2008 1893
70. S. Datta, M.A. Antonyak, and R.A. Cerione Biochemistry 45 2006 13163
71. L. Ai, R.R. Skehan, J. Saydi, T. Lin, and K.D. Brown J. Biol. Chem. 287 2012 18330
72. A. Budillon, C. Carbone, and E. Di Gennaro Amino Acids 44 2013 63
73. A. Kumar, J. Xu, S. Brady, H. Gao, D. Yu, J. Reuben, and K. Mehta PLoS One 5 2010 e13390
74. B. Li, M.A. Antonyak, J.E. Druso, L. Cheng, A.Y. Nikitin, and R.A. Cerione Proc. Natl. Acad. Sci. U.S.A. 107 2010 1408
75. J. Zhang, M.A. Antonyak, G. Singh, and R.A. Cerione Cell Rep. 3 2013 2008
76. S.N. Karagiannis, Z. Wang, and M. Griffin PLoS One 8 2013 e57017
77. K. Al-Nedawi, B. Meehan, and J. Rak Cell Cycle 13 2009 2014
78. M.A. Antonyak, B. Li, L.K. Boroughs, J.L. Johnson, J.E. Druso, K.L. Bryant, D.A. Holowka, and R.A. Cerione Proc. Natl. Acad. Sci. U.S.A. 108 2011 4852
79. M. Shao, L. Cao, C. Shen, M. Satpathy, B. Chelladurai, R.M. Bigsby, H. Nakshatri, and D. Matei Cancer Res. 69 2009 9192
80. C.Y. Lin, P.H. Tsai, C.C. Kandaswami, G.D. Chang, C.H. Cheng, C.J. Huang, P.P. Lee, J.J. Hwang, and M.T. Lee Mol. Cancer 10 2011 87
81. M.K. Park, H.J. You, H.J. Lee, J.H. Kang, S.H. Oh, S.Y. Kim, and C.H. Lee Eur. J. Cancer 49 2013 1692
82. P. Kotsakis, and M. Griffin Amino Acids 33 2007 373
83. L. Xu, S. Begum, J.D. Hearn, and R.O. Hynes Proc. Natl. Acad. Sci. U.S.A. 103 2006 9023
84. L. Yang, and L. Xu Future Oncol. 8 2012 431
85. R.A. Jones, P. Kotsakis, T.S. Johnson, D.Y. Chau, S. Ali, G. Melino, and M. Griffin Cell Death Differ. 13 2006 1442
86. P. Kotsakis, Z. Wang, R.J. Collighan, and M. Griffin Amino Acids 41 2011 909
87. S. Beninati, A. Abbruzzese, and M. Cardinali Int. J. Cancer 53 1993 792
88. C. Tabolacci, A. Lentini, B. Provenzano, and S. Beninati Amino Acids 42 2012 975
89. A. Lentini, A. Abbruzzese, B. Provenzano, C. Tabolacci, and S. Beninati Amino Acids 44 2012 25
90. Y. Song, L.L. Kirkpatrick, A.B. Schilling, D.L. Helseth, N. Chabot, J.W. Keillor, G.V. Johnson, and S.T. Brady Neuron 78 2013 109
91. E.S. Place, N.D. Evans, and M.M. Stevens Nat. Mater. 8 2009 457
92. L.-Q. Wu, W.E. Bentley, and G.F. Payne Int. J. Artif. Organs 34 2011 215
93. P. Gentile, V. Chiono, C. Tonda-Turo, S. Sartori, and G. Ciardelli Adv. Biochem. Eng. Biotechnol. 125 2011 181
94. M. De Colli, M. Massimi, A. Barbetta, B.L. Di Rosario, S. Nardecchia, L. Conti Devirgiliis, and M. Dentini Biomed. Mater. 7 2012 055005
95. D.Y. Chau, S.V. Brown, M.L. Mather, V. Hutter, N.L. Tint, H.S. Dua, F.R. Rose, and A.M. Ghaemmaghami Biomed. Mater. 7 2012 045011
96. E. Verderio, A. Coombes, R.A. Jones, X. Li, D. Heath, S. Downes, and M. Griffin J. Biomed. Mater. Res. 54 2001 294
97. T. Isobe, H. Takahashi, S. Ueki, J. Takagi, and Y. Saito Eur. J. Cell Biol. 78 1999 876
98. F. Reno, M. Rizzi, and M. Cannas J. Mater. Sci. Mater. Med. 23 2012 565
99. N. Hakimzadeh, D.J. Stewart, and D.W. Courtman Biomaterials 31 2010 9256
100. E.A. Verderio, D. Telci, A. Okoye, G. Melino, and M. Griffin J. Biol. Chem. 278 2003 42604
101. D.J. Heath, S. Downes, E. Verderio, and M. Griffin J. Bone Miner. Res. 16 2001 1477
102. D. Telci, Z. Wang, X. Li, E.A. Verderio, M.J. Humphries, M. Baccarini, H. Basaga, and M. Griffin J. Biol. Chem. 283 2008 20937
103. A. Scarpellini, R. Germack, H. Lortat-Jacob, T. Muramatsu, E. Billett, T. Johnson, and E.A. Verderio J. Biol. Chem. 284 2009 18411
104. Z. Wang, R.J. Collighan, K. Pytel, D.L. Rathbone, X. Li, and M. Griffin J. Biol. Chem. 287 2012 13063
105. H. Lortat-Jacob, I. Burhan, A. Scarpellini, A. Thomas, A. Imberty, R.R. Vives, T. Johnson, A. Gutierrez, and E.A. Verderio J. Biol. Chem. 287 2012 18005
106. T.A. Spurlin, K. Bhadriraju, K.H. Chung, A. Tona, and A.L. Plant Biomaterials 30 2009 5486
107. M. Salmeron-Sanchez, P. Rico, D. Moratal, T.T. Lee, J.E. Schwarzbauer, and A.J. Garcia Biomaterials 32 2011 2099
108. C. Nadalutti, K.M. Viiri, K. Kaukinen, M. Maki, and K. Lindfors Cell Prolif. 44 2011 49
109. R.A. Jones, Z. Wang, S. Dookie, and M. Griffin Amino Acids 44 2013 89
110. S.E. Iismaa, S. Holman, M.A. Wouters, L. Lorand, R.M. Graham, and A. Husain Proc. Natl. Acad. Sci. U.S.A. 100 2003 12636
111. S. Schaertl, M. Prime, J. Wityak, C. Dominguez, I. Munoz-Sanjuan, R.E. Pacifici, S. Courtney, A. Scheel, and D. Macdonald J. Biomol. Screen. 15 2010 478
112. N. Day, and J.W. Keillor Anal. Biochem. 274 1999 141
113. B. Fleckenstein, O. Molberg, S.W. Qiao, D.G. Schmid, F. von der Mulbe, K. Elgstoen, G. Jung, and L.M. Sollid J. Biol. Chem. 277 2002 34109
114. L. Muszbek, J. Polgár, and L. Fésüs Clin. Chem. 31 1985 35
115. L. Kárpáti, B. Penke, É. Katona, I. Balogh, G. Vámosi, and L. Muszbek Clin. Chem. 46 2000 1946
116. A. Case, and R.L. Stein Biochemistry 42 2003 9466
117. D.B. Cleary, and M.C. Maurer Biochim. Biophys. Acta 1764 2006 1207
118. A. Kappel, S. Stephan, G. Christ, L. Pechmann, C. Duwe, B. Fischer, M. Hahn, H. Althaus, M. Ehm, H. Schwarz, and F. Vitzthum Clin. Chem. Lab. Med. 48 2010 1739
119. K. Choi, M. Siegel, J.L. Piper, L. Yuan, E. Cho, P. Strnad, B. Omary, K.M. Rich, and C. Khosla Chem. Biol. 12 2005 469
120. F. Hausch, T. Halttunen, M. Mäki, and C. Khosla Chem. Biol. 10 2003 225
121. L. Dafik, and C. Khosla Chem. Biol. 18 2011 58
122. C. Klöck, X. Jin, K. Choi, C. Khosla, P.B. Madrid, A. Spencer, B.C. Raimundo, P. Boardman, G. Lanza, and J.H. Griffin Bioorg. Med. Chem. Lett. 21 2011 2692
123. M. Siegel, J. Xia, and C. Khosla Bioorg. Med. Chem. 15 2007 6253
124. J. Flanagan, and R.J. FitzGerald Nahrung 47 2003 207
125. D.A. Clare, G. Gharst, and T.H. Sanders J. Agric. Food Chem. 55 2007 432
126. G. Gharst, D.A. Clare, J.P. Davis, and T.H. Sanders J. Food Sci. 72 2007 C369
127. D.A. Clare, and C.R. Daubert J. Food Sci. 75 2010 C369
128. F.C. Church, H.E. Swaisgood, D.H. Porter, and G.L. Catignani J. Dairy Sci. 66 1983 1219
129. K.B. Lewis, D.C. Teller, J. Fry, G.W. Lasser, and P.D. Bishop Biochemistry 36 1997 995
130. Y. Furutani, A. Kato, M. Notoya, M.A. Ghoneim, and S. Hirose J. Histochem. Cytochem. 49 2001 247
131. M. Griffin, and J. Wilson Mol. Cell. Biochem. 58 1984 37
132. G.R. Lilley, M. Griffin, and P.L. Bonner J. Biochem. Biophys. Methods 34 1997 31
133. N. Kamiya, T. Tanaka, T. Suzuki, T. Takazawa, S. Takeda, K. Watanabe, and T. Nagamune Bioconjug. Chem. 14 2003 351
134. T. Tanaka, N. Kamiya, and T. Nagamune Bioconjug. Chem. 15 2004 491
135. J.H. Lee, E. Song, S.G. Lee, and B.G. Kim Biotechnol. Bioeng. 2013 http://dx.doi.org/10.1002/bit.24970
136. J.E. Folk, and P.W. Cole Biochim. Biophys. Acta 122 1966 244
137. L. Lorand, L.K. Campbell-Wilkes, and L. Cooperstein Anal. Biochem. 50 1972 623
138. L. Lorand, K.N. Parameswaran, P. Stenberg, Y.S. Tong, P.T. Velasco, N.A. Jonsson, L. Mikiver, and P. Moses Biochemistry 18 1979 1756
139. J.J. Gorman, and J.E. Folk J. Biol. Chem. 255 1980 419
140. C.C. Miraglia, and C.S. Greenberg Anal. Biochem. 144 1985 165
141. G.V. Johnson, T.M. Cox, J.P. Lockhart, M.D. Zinnerman, M.L. Miller, and R.E. Powers Brain Res. 751 1997 323
142. A. Levitzki, M. Willingham, and I. Pastan Proc. Natl. Acad. Sci. U.S.A. 77 1980 2706
143. T.F. Slaughter, K.E. Achyuthan, T.S. Lai, and C.S. Greenberg Anal. Biochem. 205 1992 166
144. Y.C. Song, D. Sheng, S.M. Taubenfeld, and G.R. Matsueda Anal. Biochem. 223 1994 88
145. S.M. Trigwell, P.T. Lynch, M. Griffin, A.J. Hargreaves, and P.L. Bonner Anal. Biochem. 330 2004 164
146. M.H. Kwon, S.H. Jung, Y.M. Kim, and K.S. Ha Anal. Chem. 83 2011 8718
147. M.-H. Kwon, J.-W. Jung, S.-H. Jung, J.-Y. Park, Y.-M. Kim, and K.-S. Ha Mol. Cells 27 2009 337
148. T.S. Lai, Y. Liu, T. Tucker, K.R. Daniel, D.C. Sane, E. Toone, J.R. Burke, W.J. Strittmatter, and C.S. Greenberg Chem. Biol. 15 2008 969
149. M. Griffin, A. Mongeot, R. Collighan, R.E. Saint, R.A. Jones, I.G. Coutts, and D.L. Rathbone Bioorg. Med. Chem. Lett. 18 2008 5559
150. W.M. Jeon, K.N. Lee, P.J. Birckbichler, E. Conway, and M.K. Patterson Jr. Anal. Biochem. 182 1989 170
151. J. Zhang, M. Lesort, R.P. Guttmann, and G.V. Johnson J. Biol. Chem. 273 1998 2288
152. J.H. Jeon, G.Y. Jang, C.W. Kim, D.M. Shin, S.Y. Cho, J.C. Kwon, H.J. Lee, K.H. Choi, and I.G. Kim Anal. Biochem. 333 2004 399
153. J.Y. Park, S.H. Jung, J.W. Jung, M.H. Kwon, J.O. Yoo, Y.M. Kim, and K.S. Ha Anal. Biochem. 394 2009 217
154. L. Lorand, O.M. Lockridge, L.K. Campbell, R. Myhrman, and J. Bruner-Lorand Anal. Biochem. 44 1971 221
155. L.J. Jones, R.H. Upson, R.P. Haugland, N. Panchuk-Voloshina, and M. Zhou Anal. Biochem. 251 1997 144
156. Y.W. Wu, and Y.H. Tsai J. Biomol. Screening 11 2006 836
157. K. Yamada, and T. Meguro Thromb. Res. 11 1977 557
158. A. Case, J. Ni, L.A. Yeh, and R.L. Stein Anal. Biochem. 338 2005 237
159. D.H. Pliura, B.J. Bonaventura, H.W. Pauls, J.F. Killackey, and A. Krantz J. Enzyme Inhib. 6 1992 181
160. S. Ozaki, E. Ebisui, K. Hamada, J. Goto, A.Z. Suzuki, A. Terauchi, and K. Mikoshiba Bioorg. Med. Chem. Lett. 20 2010 1141
161. S. Ozaki, E. Ebisui, K. Hamada, A.Z. Suzuki, A. Terauchi, and K. Mikoshiba Bioorg. Med. Chem. Lett. 21 2011 377
162. E. Duval, A. Case, R.L. Stein, and G.D. Cuny Bioorg. Med. Chem. Lett. 15 2005 1885
163. M.E. Prime, O.A. Andersen, J.J. Barker, M.A. Brooks, R.K. Cheng, I. Toogood-Johnson, S.M. Courtney, F.A. Brookfield, C.J. Yarnold, R.W. Marston, P.D. Johnson, S.F. Johnsen, J.J. Palfrey, D. Vaidya, S. Erfan, O. Ichihara, B. Felicetti, S. Palan, A. Pedret-Dunn, S. Schaertl, I. Sternberger, A. Ebneth, A. Scheel, D. Winkler, L. Toledo-Sherman, M. Beconi, D. Macdonald, I. Muñoz-Sanjuan, C. Dominguez, and J. Wityak J. Med. Chem. 55 2012 1021
164. M.E. Prime, F.A. Brookfield, S.M. Courtney, S. Gaines, R.W. Marston, O. Ichihara, M. Li, D. Vaidya, H. Williams, A. Pedret-Dunn, L. Reed, S. Schaertl, L. Toledo-Sherman, M. Beconi, D. Macdonald, I. Muñoz-Sanjuan, C. Dominguez, and J. Wityak ACS Med. Chem. Lett. 3 2012 731
165. J. Wityak, M.E. Prime, F.A. Brookfield, S.M. Courtney, S. Erfan, S. Johnsen, P.D. Johnson, M. Li, R.W. Marston, L. Reed, D. Vaidya, S. Schaertl, A. Pedret-Dunn, M. Beconi, D. Macdonald, I. Muñoz-Sanjuan, and C. Dominguez ACS Med. Chem. Lett. 3 2012 1024
166. L. Lorand, A.M. Stern, and P.T. Velasco Exp. Eye Res. 66 1998 531
167. W.A. Lea, and A. Simeonov Expert Opin. Drug Discovery 6 2011 17
168. J.A. Kenniston, G.P. Conley, D.J. Sexton, and A.E. Nixon Anal. Biochem. 436 2013 13
169. J.E. Folk, and P.W. Cole J. Biol. Chem. 240 1965 2951
170. M. Gross, N.K. Whetzel, and J.E. Folk J. Biol. Chem. 250 1975 4648
171. F. Lipmann, and L.C. Tuttle J. Biol. Chem. 159 1945 21
172. N. Grossowicz, E. Wainfan, E. Borek, and H. Waelsch J. Biol. Chem. 187 1950 111
173. J.E. Folk, and M. Gross J. Biol. Chem. 246 1971 6683
174. M. Gross, N.K. Whetzel, and J.E. Folk J. Biol. Chem. 250 1975 7693
175. M. Perez Alea, M. Kitamura, G. Martin, V. Thomas, K. Hitomi, and S. El Alaoui Anal. Biochem. 389 2009 150
176. K. Hitomi, M. Kitamura, M.P. Alea, I. Ceylan, V. Thomas, and S. El Alaoui Anal. Biochem. 394 2009 281
177. C. Gnaccarini, W. Ben-Tahar, W.D. Lubell, J.N. Pelletier, and J.W. Keillor Bioorg. Med. Chem. 17 2009 6354
178. M. Kusch, C. Grundmann, S. Keitel, R. Seitz, and H. König Blood Coagul. Fibrinolysis 17 2006 575
179. R. Pasternack, H.P. Laurent, T. Rüth, A. Kaiser, N. Schön, and H.L. Fuchsbauer Anal. Biochem. 249 1997 54
180. M.L. Fink, Y.Y. Shao, and G.J. Kersh Anal. Biochem. 201 1992 270
181. R. Pasternack, S. Dorsch, J.T. Otterbach, I.R. Robenek, S. Wolf, and H.-L. Fuchsbauer Eur. J. Biochem. 257 1998 570
182. C.G. Curtis, P. Stenberg, C.H. Chou, A. Gray, K.L. Brown, and L. Lorand Biochem. Biophys. Res. Commun. 52 1973 51
183. P. Stenberg, C.G. Curtis, D. Wing, Y.S. Tong, R.B. Credo, A. Gray, and L. Lorand Biochem. J. 147 1975 155
184. C.G. Curtis, P. Stenberg, K.L. Brown, A. Baron, K. Chen, A. Gray, I. Simpson, and L. Lorand Biochemistry 13 1974 3257
185. P. de Macedo, C. Marrano, and J.W. Keillor Anal. Biochem. 285 2000 16
186. S.M. Gillet, R.A. Chica, J.W. Keillor, and J.N. Pelletier Protein Expr. Purif. 33 2004 256
187. C. Marrano, P. de Macedo, P. Gagnon, D. Lapierre, C. Gravel, and J.W. Keillor Bioorg. Med. Chem. 9 2001 3231
188. C. Marrano, P. de Macedo, and J.W. Keillor Bioorg. Med. Chem. 9 2001 1923
189. T.M. Jeitner, H.L. Fuchsbauer, J.P. Blass, and A.J.L. Cooper Anal. Biochem. 292 2001 198
190. S.I. Chung, R.I. Shrager, and J.E. Folk J. Biol. Chem. 245 1970 6424
191. A. Leblanc, C. Gravel, J. Labelle, and J.W. Keillor Biochemistry 40 2001 8335
192. C. Gravel, D. Lapierre, J. Labelle, and J.W. Keillor Can. J. Chem. 85 2007 164
193. R. Castonguay, C. Lherbet, and J.W. Keillor J. Neurochem. 10 2002 4185
194. K. Hardes, G.L. Becker, M.Z. Hammamy, and T. Steinmetzer Anal. Biochem. 428 2012 73
195. S.M. Gillet, J.N. Pelletier, and J.W. Keillor Anal. Biochem. 347 2005 221
196. J.W. Keillor, R.A. Chica, N. Chabot, V. Vinci, C. Pardin, E. Fortin, S.M.F.G. Gillet, Y. Nakano, M.T. Kaartinen, J.N. Pelletier, and W.D. Lubell Can. J. Chem. 86 2008 271
197. K. Hardes, M. Zouhir Hammamy, and T. Steinmetzer Anal. Biochem. 2013 http://dx.doi.org/10.1016/j.ab.2013.07.043
198. C. Gnaccarini, W. Ben-Tahar, A. Mulani, I. Roy, W.D. Lubell, J.N. Pelletier, and J.W. Keillor Org. Biomol. Chem. 10 2012 5258
199. K. Oertel, A. Hunfeld, E. Specker, C. Reiff, R. Seitz, R. Pasternack, and J. Dodt Anal. Biochem. 367 2007 152
200. (b) Pasternack, R.; Oertel, K. WO 2006018164 A2 20060223, PCT Int. Appl. 2006.
201. A.J. Cooper, K.F. Sheu, J.R. Burke, O. Onodera, W.J. Strittmatter, A.D. Roses, and J.P. Blass J. Neurochem. 69 1997 431
202. B. Wilhelm, A. Meinhardt, and J. Seitz J. Chromatogr. B: Biomed. Appl. 684 1996 163
203. E. Badarau, A. Mongeot, R. Collighan, D. Rathbone, and M. Griffin Eur. J. Med. Chem. 66 2013 526
204. C. Pardin, S.M. Gillet, and J.W. Keillor Bioorg. Med. Chem. 14 2006 8379
205. D. Halim, K. Caron, and J.W. Keillor Bioorg. Med. Chem. Lett. 17 2007 305
206. C. Pardin, J.N. Pelletier, W.D. Lubell, and J.W. Keillor J. Org. Chem. 73 2008 5766
207. C. Pardin, I. Roy, W.D. Lubell, and J.W. Keillor Chem. Biol. Drug Des. 72 2008 189
208. N. Chabot, S. Moreau, A. Mulani, P. Moreau, and J.W. Keillor Chem. Biol. 17 2010 1143
209. Oertel, K. WO 2008055488 A1 20080515, PCT Int. Appl. 2008.
210. K.N. Parameswaran, X.F. Cheng, E.C. Chen, P.T. Velasco, J.H. Wilson, and L. Lorand J. Biol. Chem. 272 1997 10311
211. J.W. Keillor, N. Chabot, I. Roy, A. Mulani, O. Leogane, and C. Pardin Adv. Enzymol. Relat. Areas Mol. Biol. 78 2011 415
212. E. Badarau, R.J. Collighan, and M. Griffin Amino Acids 44 2013 119
213. Lindemann, I.; Boettcher, J.; Oertel, K.; Weber, J.; Hils, M.; Pasternack, R.; Heine, A.; Klebe, G. Transglutaminase 2 in complex with a novel inhibitor, PDB code: 3S3P, 2012, doi: 10.2210/pdb3s3p/pdb
214. Lindemann, I.; Heine, A.; Klebe, G., Transglutaminase 2 in complex with a novel inhibitor, PDB code: 3S3S; 2012, doi: 10.2210/pdb3s3s/pdb.
215. M.S. Pavlyukov, N.V. Antipova, M.V. Balashova, and M.I. Shakhparonov Biochem. Biophys. Res. Commun. 421 2012 773
216. N.S. Caron, L.N. Munsie, J.W. Keillor, and R. Truant PLoS One 7 2012 e44159
217. M. Lajemi, S. Demignot, L. Borge, S. Thenet-Gauci, and M. Adolphe Histochem. J. 29 1997 593
218. R. van Geel, M.F. Debets, D.W. Lowik, G.J. Pruijn, and W.C. Boelens Amino Acids 43 2012 1251
219. B. van der Wildt, B. Drukarch, C.A.M. Jongenelen, C. Büchold, R. Pasternack, A.A. Lammertsma, and A.D. Windhorst J. Label. Compd. Radiopharm. 56 2013 S342
220. J. Pietzsch, K. Knop, K. Rode, F. Wuest, R. Bergmann, and J. van den Hoff Nuklearmedizin 43 2004 A78
221. K. Knop, C. Hultsch, K. Rode, T. Kniess, F. Wüst, R. Bergmann, and J. Pietzsch H. Spies, Annual Report 2003, Institute of Bioinorganic and Radiopharmaceutical Chemistry 2004 Research Center Rossendorf Dresden 36
222. J. Pietzsch, K. Knop, K. Rode, and R. Bergmann H. Spies, Annual Report 2003, Institute of Bioinorganic and Radiopharmaceutical Chemistry 2004 Research Center Rossendorf Dresden 37
223. J. Pietzsch, R. Bergmann, K. Knop, K. Rode, F. Wüst, and J. van den Hoff H. Spies, Annual Report 2003, Institute of Bioinorganic and Radiopharmaceutical Chemistry 2004 Research Center Rossendorf Dresden 37
224. R. Wodtke, J. Steinbach, J. Pietzsch, and R. Löser Nuklearmedizin 52 2013 A71