Synthesis of potent water-soluble tissue transglutaminase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5559-5562

  Griffin, Martin ^a   Mongeot, Alexandre ^b   Collighan, Russell ^a   Saint, Robert E ^c   Jones, Richard A ^c   Coutts, Ian G C ^c   Rathbone, Daniel L ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b X Link   (United Kingdom)

^c NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

Author keywords

Dipeptide; Inhibitors; Transglutaminase

Indexed keywords

6 DIAZO 5 OXO NORLEUCINE DERIVATIVE; N BENZYLOXYCARBONYLPHENYLALANYL 6 DIMETHYLSULFONIUM 5 OXONORLEUCINE BROMIDE; NORLEUCINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; SULFONIUM DERIVATIVE; TRANSGLUTAMINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; DIAZOOXONORLEUCINE; DRUG DESIGN; ETHANOL; GTP-BINDING PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; KETONES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PEPTIDES; SOLUBILITY; SPECTROPHOTOMETRY; TRANSGLUTAMINASES; WATER;

EID: 53349166956     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.006     Document Type: Article

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